Curriculum Vitae

Mark William Tibbitt, Ph.D.

Work Address
Koch Institute for Integrative Cancer Research
Massachusetts Institute of Technology
500 Main Street Cambridge, MA 02139

Contact
Phone: 720-951-7217
E-mail: tibbitt@mit.edu
Website: www.marktibbitt.com

EDUCATION and TRAINING

Postdoctoral Fellow, Chemical Engineering
Massachusetts Institute of Technology under the direction of Prof. Robert Langer
Project Title: Injectable biomaterials for local drug delivery

March 2013 - present

PhD, Chemical Engineering

Dec 2012
University of Colorado Boulder under the direction of Prof. Kristi S. Anseth
Thesis Dissertation Title:
Fundamental characterization of photodegradable hydrogels: Spatiotemporal control of the cellular microenvironment
Certificate in Molecular Biophysics
BA, Integrated Science Program and Mathematics
Northwestern University
Magna Cum Laude, Phi Beta Kappa, Pi Mu Epsilon

June 2007

AWARDS and FELLOWSHIPS

NIH F32 NRSA Postdoctoral Fellowship, NHLBI; National Institutes of Health
AHA Postdoctoral Fellowship (declined), Founders Affiliate; American Heart Association
Fund for Medical Discovery Award, Executive Committee on Research; Massachusetts General Hospital
Misrock Postdoctoral Fellowship, Misrock Foundation; Massachusetts Institute of Technology
AkzoNobel Student Award in Applied Polymer Science, American Chemical Society
Outstanding Biomaterials Thesis Award 2012, Max Bergmann Center; Dresden, Germany
Student Award for Outstanding Research - PhD Candidate, Society for Biomaterials; Chengdu, China
Excellence in Graduate Polymer Research Award, American Chemical Society
Max S. Peters Outstanding Ph.D. Graduate Award, University of Colorado Boulder
American Institute of Chemists Graduate Student Award, University of Colorado Boulder
Lindau Fellow (U.S. Delegation), 61st Lindau Nobel Laureate Meeting, Lindau, Germany
Graduate Student Faculty Leadership Award, University of Colorado Boulder
Student Travel Achievement Award, Society for Biomaterials
Best Should Teach Silver Award, University of Colorado Boulder
Teets Family Endowed Doctoral Fellowship, University of Colorado Boulder
Outstanding Graduate Teaching Award, University of Colorado Boulder
Molecular Biophysics Training Grant, National Institutes of Health
U.S. DoEd GAANN Fellowship, University of Colorado Boulder
Inductee of Phi Beta Kappa, Northwestern University
NOAA Ernest F. Hollings Scholarship, National Oceanic and Atmospheric Administration

2014
2014
2014
2014
2013
2013
2012
2012
2012
2012
2011
2011
2011
2010, 2011
2010 - 2012
2010
2009 - 2011
2008 - 2010
2007
2006 - 2007

PUBLICATIONS (* indicates equally contributing authors)

Peer-reviewed publications:
22. Fenton, O.S.; Kauffman, K.J.; McClellan, R.L.; Appel, E.A.; Dorkin, J.R.; Tibbitt, M.W.; Heartlein, M.W.; DeRosa, F.;
Langer, R.; Anderson, D.G. Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo
mRNA delivery, Advanced Materials, 2016, in press.
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Mark William Tibbitt, Ph.D.

21. Patel, A.K.; Tibbitt, M.W.; Celiz, A.D.; Langer, R.; Davies, M.C.; Denning, C.; Alexander, M.R.; Anderson, D.G. High
throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State and Materials
Science, 2016, in press.
20. Tibbitt, M.W.; Dahlman, J.E.; Langer, R. Emerging frontiers in drug delivery, Journal of the American Chemical Society, 2016, 138, 704-717.
19. Tibbitt, M.W.*; Rodell, C.B.*; Burdick, J.A.; Anseth, K.S. Progress in material design for biomedical applications,
Proceedings of the National Academies of Science, 2015, 112, 14444-14451.
18. Appel, E.A.; Tibbitt, M.W.; Greer, J.M.; Fenton, O.S.; Kreuels, K.; Anderson, D.G.; Langer, R. Exploiting electrostatic
interactions in polymer-nanoparticle hydrogels, ACS Macro Letters, 2015, 4, 848-852.
17. Lewis, K.J.; Tibbitt, M.W.; Zhao, Y.; Branchfield, K.; Sun, X.; Balasubramaniam, V.; Anseth, K.S. In vitro model alveoli
from photodegradable microsphere templates, Biomaterials Science, 2015, 3, 821-832. (Front cover)
16. Appel, E.A.*; Tibbitt, M.W.*; Webber, M.J.; Mattix, B.A.; Veiseh, O.; Langer, R. Self-assembled hydrogels utilizing
polymer-nanoparticle interactions, Nature Communications, 2015, 6, #6295.
15. Yang, C.*; Tibbitt, M.W.*; Basta, L.; Anseth K.S. Reversible and irreversible effects of mechanical dosing on stem cell
fate, Nature Materials, 2014, 13, 645-652.
14. Wang, H.; Tibbitt, M.W.; Langer, S.; Leinwand, L.A.; Anseth, K.S. Hydrogels preserve native phenotypes of valvular
fibroblasts through an elasticity-regulated PI3K/AKT pathway, Proceedings of the National Academies of Science, 2013,
110, 19336-19341.
13. Tibbitt, M.W.; Sawicki, L.A.; Kloxin, A.M.; Anseth, K.S. Characterization of material properties and photodegradation in chain and step polymerized hydrogels, Macromolecules, 2013, 46, 2785-2792.
12. Shenoy, R.; Tibbitt, M.W.; Anseth, K.S.; Bowman, C.N. Formation of core-shell particles by interfacial radical polymerization initiated by a glucose oxidase-mediated redox system, Chemistry of Materials, 2013, 25, 761-767.
11. Tibbitt, M.W.; Kloxin, A.M.; Anseth, K.S. Modeling photodegradation in thick polymer networks for the predictable
control of network evolution, Journal of Polymer Science Part A: Polymer Chemistry, 2013, 51, 1899-1911. (Spotlight article)
10. Tibbitt, M.W.; Anseth, K.S. Dynamic microenvironments: the fourth dimension, Science Translational Medicine, 2012,
14, 160ps24. (Front cover)
9. Kloxin, A.M.; Lewis, K.J.; DeForest, C.A.; Seersdorf, G.; Tibbitt, M.W., Balasubramaniam, V.; Anseth K.S. Responsive culture platform to examine the influence of microenvironment geometry on cell function, Integrative Biology,
2012, 4, 1540-1549.
8. Guo, Q.; Wang, X.; Tibbitt, M.W.; Anseth K.S.; Montell, D.; Elisseeff, J.H. Light activated cell migration in synthetic
extracellular matrices, Biomaterials, 2012, 33, 8040-8046.
7. Azargarsamy, M.A.; Alge, D.L.; Radakrishnan, S.J.; Tibbitt, M.W.; Anseth K.S. Photocontrolled nanoparticles for
on-demand release of proteins, Biomacromolecules, 2012, 13, 2219-2224.
6. Tibbitt, M.W.; Han, B.W.; Kloxin, A.M.; Anseth, K.S. Synthesis and application of photodegradable microparticles
for spatiotemporal control of protein delivery, Journal of Biomedical Materials Research Part A, 2012, 100A, 1647-1654.
Student award for outstanding research Ph.D. category, 9th World Biomaterials Congress; Chengdu, China.
5. Kloxin, A.M.; Tibbitt, M.W.; Anseth, K.S. Synthesis of photodegradable hydrogels as dynamically tunable materials
for 2D and 3D cell culture, Nature Protocols, 2010, 5, 1867-1887.
4. Tibbitt, M.W.; Kloxin, A.M.; Dyamenahalli, K.U.; Anseth, K.S. Controlled two-photon photo degradation of PEG
hydrogels to study and manipulate sub cellular interactions on soft materials, Soft Matter, 2010, 6, 5100-5108.
3. Kloxin, A.M.; Tibbitt, M.W.; Kasko, A.M.; Fairbairn, J.; Anseth K.S. Controlled degradation of photolabile PEGbased hydrogels, Advanced Materials, 2010, 22, 61-66.
2. Tibbitt, M.W.; Anseth, K.S. Hydrogels as extracellular mimics for 3D cell culture, Biotechnology and Bioengineering,
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Mark William Tibbitt, Ph.D.

2009, 44, 4828-4835.

1. Aimetti, A.A.; Tibbitt, M.W.; Anseth, K.S. Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels, Biomacromolecules, 2009, 10, 1484-1489.

Book chapters:
1. Tibbitt, M.W.; Shadish, J.; DeForest, C.A. Photopolymers in biomaterials and hydrogels, In: Ovsianikov, A.;
Stampfl, J.; Liska, R. (Eds.) Nano- and microstructuring using multiphoton lithography. 2015, in press.

Research highlights: (published commentary on recent journal articles)

6. Tibbitt, M.W.; Fathi, A.; Dehghani, F.; Dokmeci, M.R.; Khademhosseini, A. Research highlights, Lab on a Chip, 2013,
13, 3148-3151.
5. Tibbitt, M.W.; Bae, H.; Dokmeci, M.R.; Khademhosseini, A. Research highlights, Lab on a Chip, 2013, 13, 2179-2182.
4. Ribas, J.; Tibbitt, M.W.; Dokmeci, M.R.; Khademhosseini, A. Research highlights, Lab on a Chip, 2013, 13, 1842-1845.
Tibbitt, M.W.; Dokmeci, M.R.; Khademhosseini, A. Research highlights, Lab on a Chip, 2013, 13, 14533. Selimovic, S.;
1456.
2. Abbas, Y.; Tibbitt, M.W.; Dokmeci, M.R.; Khademhosseini, A. Research highlights, Lab on a Chip, 2013, 13, 11971200.
Tibbitt, M.W.; Dokmeci, M.R.; Khademhosseini, A. Research highlights, Lab on a Chip, 2013, 13,
1. Selimovic, S.;
999-1002.

Patents:
3. Appel, E.A.; Tibbitt, M.W.; Langer, R. Biodegradable shear-thinning injectable hydrogels Submitted
2. Tibbitt, M.W.; Anseth, K.S.; Kloxin, A.M.; Toner, M.; Oakey, J.; Shah, A. Selective capture and release of rare mammalian cells using photodegradable hydrogels in a microfluidic platform WO2015010019A1
1. Anseth, K.S.; Kasko, A.M.; Tibbitt, M.W.; Kloxin, A.M.; Sridhar, B. Photodegradable groups for tunable polymeric
materials US20140031285A1

INVITED SEMINARS
Responsive hydrogels for cell culture and drug delivery Tibbitt, M.W. Squishy Physics Seminar, Harvard University,
Cambridge, MA, Sept 2015.
Macromolecular engineering of responsive materials Tibbitt, M.W. MIT Koch Insitute, Cambridge, MA, April 2015.
Valve cell response to substrate stiffness: molecular pathways; Does stiffness beget stiffness, as MR begets MR? Tibbitt,
M.W. Leducq TransAtlantic Network, London, England, Dec 2013.
Fundamental characterization of photodegradable hydrogels: Spatiotemporal control of the cellular microenvironment
Tibbitt, M.W. Engineering Life 2013, Dresden, Germany, Sept 2013. (Award Lecture)
Photodegradable PEG-based hydrogels: Dynamic control of the cellular microenvironment Tibbitt, M.W. University of
Wyoming Department of Chemical and Petroleum Engineering, Laramie, WY, Dec 2012.

SELECTED MEETING and CONFERENCE PRESENTATIONS

Macromolecular engineering of responsive hydrogels Tibbitt, M.W.; Appel, E.A.; Langer, R. BASF Research Forum,
Research Triangle Park, NC, June 2015.
Self-assembled hydrogels utilizing polymer-nanoparticle interactions Tibbitt, M.W.; Appel, E.A.; Langer, R. American
Institute of Chemical Engineering Annual Meeting, Atlanta, GA, Nov 2014.
Photoresponsive hydrogels with tunable mechanical properties for selective cell capture and release Tibbitt, M.W.;
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Mark William Tibbitt, Ph.D.

Anseth, K.S. American Chemical Society Annual Meeting, Indianapolis, IN, Sept 2013 (Award Lecture).
Click-based, MMP-degradable and photodegradable hydrogels for 3D cell culture and cell recovery Tibbitt, M.W.;
Anseth, K.S. American Institute of Chemical Engineering Annual Meeting, Pittsburgh, PA, Nov 2012 (Oral).
Photodegradable microspheres for spatiotemporal control of protein delivery Tibbitt, M.W.; Anseth, K.S. Society for
Biomaterial Annual Meeting, New Orleans, LA, Oct 2012 (Award Lecture).
Photodegradable microspheres for spatiotemporal control of protein delivery Tibbitt, M.W.; Han B.W.; Kloxin, A.M.;
Anseth K.S. 9th World Biomaterials Congress, Chengdu, Sichuan, China, June 2012 (Oral).
Photoresponsive PEG-based hydrogels: Precise and predictable tuning of the mechanical and biochemical nature of the
stem cell niche Tibbitt, M.W.; Anseth K.S. Excellence in Graduate Polymer Research Symposium at the American Chemical
Society Annual Meeting, San Diego, CA, March 2012 (Award Lecture).
Spatiotemporal control of cell-ECM interactions with photoactive PEG-based hydrogels Tibbitt, M.W.; Kloxin, A.M.;
Dyamenahalli, K.U.; Anseth, K.S. Howard Hughes Medical Institute Science Meeting, Ashburn, Virginia, May 2011 (Poster).
Two-photon irradiation of photo responsive hydrogels to control cell-material interactions Tibbitt, M.W.; Kloxin, A.M.;
Anseth K.S. 32nd Australasian Polymer Society Meeting, Coffs Harbour, New South Wales, Australia, Feb 2011 (Oral).
Spatiotemporal control of cell-ECM interactions with photoactive PEG-based hydrogels Tibbitt, M.W.; Kloxin, A.M.;
Dyamenahalli, K.U.; Anseth, K.S. Gordon Research Conference: Signal Transduction in Engineered Extracellular Matrices, Biddeford, ME, Jun 2010 (Oral and Poster).
Photodegradable hydrogels to investigate the effect of ECM mechanics on encapsulated cell function Tibbitt, M.W.;
Kloxin, A.M.; Anseth, K.S. CalTech Soft Materials Workshop, Pasadena, CA, Feb 2010 (Poster).
Photodegradable hydrogels to investigate the effect of network structure on encapsulated cell function Tibbitt, M.W.;
Kloxin, A.M.; Dyamenahalli, K.U.; Anseth, K.S. Materials Research Society Fall Meeting, Boston, MA, Dec 2009 (Oral).
Spatial patterning of structural properties in a photodegradable PEG-based hydrogel for cell culture Tibbitt, M.W.;
Kloxin, A.M.; Anseth, K.S. Society for Biomaterials Annual Meeting, San Antonio, TX, April 2009 (Oral).

PROFESSIONAL EXPERIENCE
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Mar 2013 - current
Research Advisor: Prof. Robert S. Langer
- Synthesis and characterization of shear-thinning and self-healing nano-network for local drug delivery applications
- Design and implementation of drug-eluting annuloplasty ring to treat ischemic mitral regurgitation
Nanoly Bioscience, Inc., Co-Founder & CTO
May 2012 - current
- Polymeric nano shield for vaccine thermoprotection during vaccine delivery to the 3rd world
Intels Top Social Innovation; Dells Global Social Innovation Challenge Winner; Tech Awards Young Innovator;
Airbuss Materials and Manufacturing Award at Hello Tomorrow Challenge
Chemical & Biological Engineering, University of Colorado Boulder
Jan 2008 - Feb 2013
Research Advisor: Prof. Kristi S. Anseth
- Synthesis and quantitative characterization of phototunable hydrogel networks
- Develop prescriptive models of single or multi-photon effects on network properties
- Exploit user-tunable hydrogels to better understand stem cell mechanobiology and response to ECM dynamics
Holling Marine Laboratory, NOAA
Research Advisors: Dr. A. Fred Holland and Dr. Guy DiDonato
- Tracking of point source contaminants in tidal estuaries
- Collect and analyze water and soil samples for pollution quality
Physics and Astronomy, Northwestern University
Research Advisor: Prof. Fred A. Rasio
- Small N-body simulations of planetary formation and stability
- Develop code in FORTRAN and C++ to model stellar dust coalescence with a massive center
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June 2006 - Aug 2006

Jan 2006 - Sept 2007

Curriculum Vitae

Mark William Tibbitt, Ph.D.

TEACHING and MENTORING EXPERIENCE

Guest Lecturer, Polymer Physics, University of Colorado Boulder:
Spring 2011
- Prepared and presented lectures on scaling laws in polymer physics, the Flory construction of polymer extension, and
rubber elasticity theory
- Wrote and graded quiz and test questions pertaining to these lectures
Lead Graduate Teaching Assistant, University of Colorado Boulder:
Fall 2010 - Spring 2012
- Liaison between Department of Chemical and Biological Engineering and the Graduate Teaching Program
- Organized and trained incoming and advanced teaching assistants, provided support during the teaching semester
- Developed a series of pedagogical seminars for the Department of Chemical and Biological Engineering graduate
students and postdocs
Advanced Teaching Assistant, Statistical Thermodynamics, University of Colorado Boulder:
- Presented lectures and 2 recitation session per week throughout the course
- Assisted in text and homework problem preparation and grading
- Developed a series of interactive computer simulations to complement the standard curriculum
- FCQ: 5.5/6.0; Outstanding Graduate Teaching Award

Fall 2009

Teaching Assistant, Creative Technology, University of Colorado Boulder:

Spring 2008
- Hosted weekly recitation hours on the topics of biotechnology, alternative energy, and nanotechnology
Teaching Assistant, Intro to Computing, Northwestern University:
Fall 2004 - Spring 2006
- Reformed the curriculum for the Intro to Computing course for the Integrated Science Program
- Organized lab and recitation sessions Introduction to Organic Synthesis (Oct 2008 - Mar 2009)
Research Mentor: (bold name indicates co-authored publication)
Massachusetts Institute of Technology
Michael Castillo, UROP
Klaus Kreuels, Masters student
Casper van der Ven, Masters student
Jessica Greer, UROP
Christopher Au, UROP
Bradley Mattix, UROP
Natasha Boghani, UROP
University of Colorado Boulder
Paige Fischer, Undergraduate researcher (U. of Wyoming)
Quinn Fleming, Graduate student
Dan McKinnon, Graduate student
Austin Healey, NSF-REU (U. of Pittsburgh)
Kristen Feaver, Senior thesis student
Lisa Sawicki, NSF-REU (U. of Florida)
Emily Maginnis, Undergraduate researcher
Donna Kuntzler, Undergraduate researcher
Bruce Han, Undergraduate researcher
Kayla Culver, NSF-REU (JHU)
Kiran Dyamenahalli, MSTP rotation student
Cara Rahon, Graduate student
Caroline Szczepanski, NSF REU (Lafayette College)

Fall 2015 - current

Winter 2015 - Summer 2015
Winter 2014 - Fall 2014
Winter 2014 - Spring 2015
Winter 2014 - current
Summer 2013 - Spring 2015
Summer 2013

Summer 2012 - Spring 2015

Spring 2011 - Fall 2012
Spring 2011 - Fall 2012
Summer 2011
Fall 2010 - Spring 2011
Summer 2010
Fall 2009 - Spring 2011
Fall 2009
Summer 2009 - Spring 2012
Summer 2009
Summer 2009
Spring 2009
Summer 2008

PROFESSIONAL SERVICE
NSF Biomaterials Workshop: Important Areas for Future Investment
- Attendee and contributing author to chapter on Cell-Material Interactions
Scientific Outreach and Academic Service:
- Lead Graduate Teaching Assistant, University of Colorado Boulder
- High School Honors Institute Mentor, University of Colorado Boulder
- Student Annual Research Symposium Organizing Committee, University of Colorado Boulder
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June 2012

2010 - 2012
2008 - 2011
2008 - 2010

Curriculum Vitae

Mark William Tibbitt, Ph.D.

- Science and Math Tutor, La Finca del Nino,

Trujillo, Honduras
- Engineers for a Sustainable World, Northwestern University
Professional membership: ACS (POLY and PMSE), AIChE, SFB.

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2007 - 2008
2007