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Table of contents
1. Radiological analysis of hyaline membrane disease after exogenous surfactant treatment........................ 1

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Document 1 of 1

Radiological analysis of hyaline membrane disease after exogenous surfactant treatment

Author: Slama, Malika; Andr, C; Huon, Catherine; Antoun, Hanane; Adamsbaum, Catherine
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Abstract:

Background. Exogenous surfactant treatment of hyaline membrane disease is known to modify the pattern of
radiological changes on the chest radiograph. Objectives. To analyse and attempt to explain the radiological
changes observed after exogenous surfactant treatment. Materials and methods. Thirty-nine premature infants
with typical hyaline membrane disease. Results. Transient asymmetrical clearing with better aeration of the right
lung in the absence of malposition of the tip of the endotracheal tube was observed in nine cases (23 %). This
asymmetry was patchy in one case. It was due to a complication of mechanical ventilation in three cases
[pneumothorax ( n = 2) and pneumomediastinum (n = 1)]. In the other six cases, asymmetrical clearing could be
related to the anatomical position of the right main bronchus, which facilitates distribution of surfactant to the
right lung. However, the course of these premature infants was similar to that of infants with symmetrical chest
radiological findings after treatment. Conclusions. Asymmetrical clearing of chest radiographs, sometimes
patchy, after surfactant treatment requires exclusion of pneumothorax or infection but has no influence on
clinical outcome. [PUBLICATION ABSTRACT]
MeSH: Female, Follow-Up Studies, Gestational Age, Humans, Hyaline Membrane Disease -- drug therapy,
Infant, Newborn, Instillation, Drug, Male, Pulmonary Surfactants -- administration & dosage, Radiography,
Thoracic, Retrospective Studies, Treatment Outcome, Biological Agents (major), Hyaline Membrane Disease -radiography (major), Phospholipids (major), Pulmonary Surfactants -- therapeutic use (major)
Substance: Biological Agents; Phospholipids; Pulmonary Surfactants; poractant alfa;
Publication title: Pediatric Radiology; Heidelberg
Volume: 29
Issue: 1
Pages: 56-60
Number of pages: 5
Publication year: 1999
Publication date: Jan 1999
Year: 1999
Publisher: Springer Science & Business Media
Place of publication: Heidelberg
Country of publication: Netherlands
Publication subject: Medical Sciences--Radiology And Nuclear Medicine, Medical Sciences--Pediatrics
ISSN: 03010449
Source type: Scholarly Journals
Language of publication: English

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Document type: Comparative Study

DOI: http://dx.doi.org/10.1007/s002470050535
Accession number: 9880619
ProQuest document ID: 222700642
Document URL: https://search.proquest.com/docview/222700642?accountid=25704
Copyright: Springer-Verlag Berlin Heidelberg 1999
Last updated: 2013-06-04
Database: Family Health Database

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