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Mutation Data
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February 2016
2
RTECS
Sources
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Clusters
CASRNS
GOVREGS
HEALTH
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TOXICOLOGY
STN Database Clusters information (PDF).
Pricing
February 2016
3
RTECS
Display
Codes
Search Examples
S POISONOUS
S AROMATIC HYDROCARBON#
S ?TOXIC?
S C7H10
S 77772-15-7
Accession Number
Cancer Review (1)
/AN
/CREV
AN
CREV
/CELL
/CN
Class Identifier
/CI
Definitions (1)
Dose Information (includes dosage
amounts for IRR and MUT) (3,4)
/DEF
/DOSE
/DUR
S 10015/AN
S HUMAN?/CREV
S ANIMAL EVIDENCE/CREV
S BONE MARROW/CELL
S BMR/CELL
S 3-BUTEN-2-OL/CN
S "LEAD ARSENATE (DOT:OSHA)"/CN
S HORMONE/CI
S PRIMARY IRRITANT/CI
S FERMENT? PRODUCT#/DEF
S 82/DOSE
S 35-40/DOSE (P) MUT/FA
S DOSE<=50 (P) MG/IRR
S 10D/DUR
S 24H/DUR (P) IRR/FA
/EFF
S SHOCK/EFF
S H08/EFF
/Element
Symbol
/ASTA
S N>=5
S 2/P
S ASBESTOS/ASTA
S SECTION 8/ASTA
S CANCER REVIEW/FA
S 24H/DUR (P) IRR/FA
S NATURAL?/CI AND DEF/FNA
S 61.05/FW
Not displayed
S 47JMAE/ISN
S JOCEAH/ISN (P) TOX/FA
S NTIS?/ISN
/FA
/FNA
/FW
(or /MW)
/ISN
/IRR
S EYE#/IRR
S 500 MG/IRR
S EYES (P) HUMAN/IRR
MUT
CN
CI
DEF
IRR, MUT
ASTA
FA
Not displayed
FW
February 2016
4
RTECS
/JT
S TOXICOLOGY LETTERS/JT
Molecular Formula
/MF
/MUT
S C16H18N4/MF
S C16 H18 N4/MF
S C16H18N4O2S.2CLH/MF
S LUNG/MUT
S 50 MG L/MUT
/NREC
/NC
/ORGN
/SURV
Display
Codes
Search Examples
MUT
S 786/SURV
S TNF 33/SURV
S BENZYL CHLORIDE/NREC
S 4/NC
S MOUSE/ORGN
S MUS/ORGN (P) MUT/FA
SURV
/OMUL
S MUSCLE WEAKNESS/OMUL
OMUL
/PG
/REP
S A7/PG
S FETUS/REP
S 550 MG KG/REP
Not displayed
REP
/RTE
S SKIN/RTE
S ITT/RTE
/DATE
/RTN
/SO
S DATE>=20120700
S DA0184000/RTN
S NTIS/SO
S FAATDF 1997/SO
S NTP/SO (P) ASTA/FA
/SREG
/SYS
/TLV
/TOX
S AIR(1A)DUST/SREG
S DUST IN AIR/SREG
S DNA DAMAGE/SYS
S DND/SYS
S 300/TLV
S MG 2/TLV
S INHALATION/TOX
S FLUID# CHANG?/TOX
S (BRAIN (P) HMN)/TOX
S TOXICOLOGY REVIEW/TREV
S (CARCINOMA(P)RODENT)/TUM
S 17 G KG/TUM
DATE
RTN
ATSA, CREV, IRR,
MUT, OMUL,
NREC, REP,
SREG, TLV, TOX,
TREV, TUM
SREG
/TREV
/TUM
/WLN
S 10SW5SW10/WLN
NREC
Not displayed
IRR, MUT, OMUL,
REP, TOX, TUM
MUT
TLV
TOX
TREV
TUM
WLN
February 2016
5
RTECS
Default
Unit
Search
Code
mg/m**3
/LC50A
ppm
Search
Examples
Display
Codes
OMUL, TOX
/LC50V
S 11+-1/LC50A
S LC50A>20 g/m**3
S 175/LC50V
mg/m**3
/LCLOA
S 65-70/LCLOA
OMUL, TOX
ppm
/LCLOV
S 10<=LCLOV
OMUL, TOX
mg/kg
/LD50
OMUL, TOX
mg/kg
/LDLO
S 2E-03/LD50
S LD50<1 UG/G(P)TOX/FA
S 0.07+-1%/LDLO
mg/m**3
/TCLOA
S TCLOA>250
OMUL, REP,
TOX, TUM
ppm
/TCLOV
S 96+-2/TCLOV
OMUL, REP,
TOX, TUM
mg/kg
/TDLO
S 14/TDLO
OMUL, REP,
TOX, TUM
OMUL, TOX
OMUL, TOX
(1) Numeric search field that may be searched with numeric operators or ranges.
February 2016
6
RTECS
REP
RN
RTN
SREG
STF (2)
STR (3)
STS (2,3)
SURV
TLV
TOX
TREV
TUM
WLN
ALL
ASTAFULL
BIB
CREVFULL
EFFECTS
IDE
IRRFULL
LEGAL
MUTFULL
OMULFULL
QRD (4)
REPFULL
February 2016
Content
Examples
Accession Number
Federal Agency Status for EPA, NIOSH, NTP, and OSHA with source
information
Character Count
Class Identifier
Chemical Name
Cancer Review with source information
RTECS Entry/Update Date
Definitions
Field Availability
Formula Weight
Tabular display of irritation data (Route, Organism, Dose, Duration, Effect,
Source)
Molecular Formula
Tabular display of mutation data (System, Organism, Cell Type, Route, Dose,
Duration, and Source
NIOSH recommendations with source information
Tabular display of other multiple dose data
(Effect, Route, Organism, Dose, Duration,
Source)
Tabular display of reproductive effects data (Effect, Route, Organism, Dose,
Duration, Source)
CAS Registry Number
RTECS Number
Standards and regulations with source information
Flat Structure Diagram (no stereo bonds indicated)
Structure Diagram (includes stereo bonds and R/S/E/Z labels when available)
Stereo Structure (includes stereo bonds when available)
National Occupational Survey (NOHS, NOES) with source information
Threshold Limit Value with source information
Tabular display of toxicity data (Effect, Route, Organism, Dose, Duration,
Source)
Toxicology review with source information
Tabular display of tumorigenic data (Effect, Route, Organism, Dose, Duration,
Source)
Wiswesser Line Notation
D L4 1-4 AN
D L1 3 ASTA
AN, RN, RTN, MF, FW, CN, DEF, CI, WLN, DATE, CHC, STR, IRRFULL,
MUTFULL, REPFULL, TUMFULL, TOXFULL, OMULFULL, CREVFULL,
TREVFULL, TLVFULL, SREGFULL, NREC, SURV, ASTAFULL
ASTA with all titles listed under one header
CREV, TREV, TLV
CREV with all sources listed under one header and the complete cancer review
references cited in the sources
IRR, MUT, REP, TUM, TOX, OMUL
AN, RN, RTN, MF, FW, CN, DEF, CI, WLN, DATE, CHC, STR
IRR and complete irritation data references cited in the sources
SREG, NREC, SURV, ASTA
MUT and complete mutation data references cited in the sources
OMUL and the complete other multiple dose references cited in the sources
IDE and fields containing hit terms. When the hit terms occur in a table, only
the lines containing the hit terms are displayed. (QRD is the default)
REP and the complete reproductive effects references cited in the sources
D L3 2 ALL
D CHC 1,3-5
D CI 5-10
D 1-3,7,8 CN
D CREV
D DATE 1-5
D L1 DEF 3
D 1,3,6 FA L5
D FW
D IRR 2
D L8 MF 1-3
D MUT
D NREC
D OMUL
D REP
D RN 4
D RTN 3,4
D SREG
D STF
D 1-10 CN STR
D STS
D SURV 2
D L3 4 TLV
D TOX
D 5,3 TREV
D TUM
D L4 WLN 3
D ASTAFULL
D 1-3,5 BIB
D CREVFULL
D EFFECTS 1-10
D IDE
D IRRFULL 1,4
D LEGAL TOTAL
D MUTFULL
D OMULFULL
D L4 7 QRD
D REPFULL 1-4
7
RTECS
Content
Examples
SREG with all sources listed under one heading and the complete standards
and regulations references cited in the sources
TLV with all sources listed under one heading and the complete threshold limit
value references cited in the sources
TOX and the complete toxicity data references cited in the sources
TREV with sources listed under one heading and the complete toxicology
review references cited in the sources
TUM and complete tumorigenic data references cited in the sources
D SREGFULL 2 L4
Fields containing hit terms. When the hit term occurs in a table, only the line
containing the hit term is displayed.
Hit term with 20 words on either side (KeyWord-In-Context)
Number of occurrences of hit terms and fields in which they occur
D HIT
D L7 TLVFULL
D TOXFULL 1-3
D TREVFULL
D 3 TUMFULL
D KWIC NOH
D OCC 1-5
February 2016
8
RTECS
Field Code
ANALYZE/
SELECT (1)
AN
CREV
RN
CHEM
CELL
CN
NAME
CI
DEF
EFF
ASTA
FW
JT
MF
MW
SURV
NREC
OCC
ORGN
RTE
DATE
RTN
SO
SREG
SYS
TLV
TREV
WLN
Y
Y (2)
Y (3)
Y (3,4)
Y (2)
Y (5)
Y (3,5)
Y
Y (3)
Y (2)
Y (2)
Y
Y (2)
Y (default)
Y
Y (2)
Y (2)
N
Y (2)
Y (2)
Y
Y
Y (2,6)
Y (2)
Y (2)
Y (2)
Y (2)
Y
SORT
N
N
Y
N
N
Y
N
N
N
N
N
Y
N
N
Y
N
N
Y
N
N
Y
Y
N
N
N
N
N
Y
(1) HIT may be used to restrict terms extracted to terms that match the search expression used to create the answer set, e.g., SEL HIT
MF
(2) SELECT HIT and ANALYZE HIT are not valid with this field
(3) Appends /BI to the terms created by SELECT.
(4) SELECT HIT and ANALYZE HIT are valid only when search term is the first name in the CN field or is a CAS Registry Number.
(5) SELECT HIT and ANALYZE HIT are valid only when search term is the first name.
(6) Selects or analyzes the CODEN with /SO appended to the terms created by SELECT.
February 2016
9
RTECS
Sample Records
DISPLAY QRD (Default)
219959-86-1
RTECS
CY1204700
C17 H13 N3
259.31
Benzenamine, 4-(9H-pyrido(3,4-b)indol-9-yl)Tumorigen; Mutagen
Jul 2012
3684
DISPLAY ALL
219959-86-1
RTECS
CY1204700
C17 H13 N3
259.31
Benzenamine, 4-(9H-pyrido(3,4-b)indol-9-yl)-;
9-(4'-Aminophenyl)-9H-pyrido(3,4-b)indole;
Aminophenylnorharman
Tumorigen; Mutagen
Jul 2012
3684
10
RTECS
--------------+-----------+---------+-----+------+----+---------mutation in
|Salmonella |
|
|1
|
|MUREAV
microorganisms|typhimurium|
|
|mg/pla|
|577S,1,200
|
|
|
|te
|
|5
|
|
|
|(+S9) |
|
--------------+-----------+---------+-----+------+----+---------DNA damage
|Mouse
|
|oral |100.8 |12W |CRNGDP
|
|
|
|mg/kg |
|24,1985,20
|
|
|
|
|
|03
--------------+-----------+---------+-----+------+----+---------DNA damage
|Salmonella |
|
|0.1
|2H |MUTAEX
|typhimurium|
|
|umol/L|(+S9|21,411,200
|
|
|
|
|)
|6
--------------+-----------+---------+-----+------+----+---------DNA damage
|Salmonella |
|
|0.1
|3H |MUTAEX
|typhimurium|
|
|umol/L|
|21,411,200
|
|
|
|
|
|6
MUTATION DATA REFERENCES:
MUREAV Mutation Research
(Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964CRNGDP Carcinogenesis (London) (Oxford Univ. Press, Pinkhill House, Southfield
Road, Eynsham, Oxford OX8 1JJ, UK) V.11980MUTAEX Mutagenesis (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.11986-
February 2016
11
RTECS
TOXICITY DATA REFERENCES:
TXAPA9 Toxicology and Applied Pharmacology
St., Duluth, MN 55802) V.11959-
TOXICOLOGY
TOXICOLOGY
TOXICOLOGY
TOXICOLOGY
REVIEW (TREV):
REVIEW
MUREAV 562,19,2004
REVIEW
EMMUEG 45,150,2005
REVIEW
MUREAV 721,27,2011
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February 2016