Mutao
Transverso
prica pirimdica
Transi
Transio
prica prica
pirimdica pirimdica
Tipos de muta
mutao
1. Substituio de bases
2. Frameshift (mudana do quadro de leitura):
2.1. Insero;
2.2. Deleo.
Muta
Mutao de ponto
quando apenas uma base substituda;
Tipos:
Muta
Mutao missense ou com sentido;
sentido
Muta
Mutao nonsense ou sem sentido;
sentido
Muta
Mutao silenciosa.
Muta
Mutao de ponto
quando apenas uma base substituda;
Tipos:
Muta
Mutao missense ou com sentido:
sentido pode causar alterao na
sequncia de aminocidos da protena codificada;
muta
mutao nonsense ou sem sentido:
sentido pode modificar um cdon
em cdon de parada;
Muta
Mutao missense (com sentido)
(+) 5
(-) 3
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
UGA
Asn
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao missense (com sentido)
(+) 5
(-) 3
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
UGA
Asn
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao missense (com sentido)
(+) 5
(-) 3
A T G A A A C A T C C G T GT A CG A T G T G A 3
T A C T T T G T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A A C A U C C G U GU
A CG
AUG
UGA
Lys
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao missense (com sentido)
Met
Asn
His
Pro
Cys
Thr
Met
COH Normal
Met
Lys
His
Pro
Cys
Thr
Met
COH Mutante
Muta
Mutao nonsense (sem sentido):
pode modificar um cdon em cdon de
parada
Muta
Mutao nonsense
(+) 5
(-) 3
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
UGA
Asn
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao nonsense
(+) 5
(-) 3
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
UGA
Asn
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao nonsense
(+) 5
(-) 3
A T G A A T C A T C C G T GA A CG A T G T G A 3
T A C T T A G T A G G C A CT T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GA
Asn
Met
His
Pro
A CG
AUG
UGA
COH
Muta
Mutao silenciosa:
pode no causar alterao de cdons devido
degenerao do cdigo gentico;
Muta
Mutao silenciosa
(+) 5
(-) 3
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
UGA
Asn
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao silenciosa
(+) 5
(-) 3
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
UGA
Asn
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao silenciosa
(+) 5
(-) 3
A T G A A T C A T C C T T GT A CG A T G T G A 3
T A C T T A G T A G G A A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C U U GU
A CG
AUG
UGA
Asn
Thr
Met
Met
His
Pro
Cys
COH
Muta
Mutao silenciosa
Met
Asn
His
Pro
Cys
Thr
Met
COH Normal
Met
Asn
His
Pro
Cys
Thr
Met
COH Mutante
Inser
Insero
(+) 5
(-) 3
A
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
Inser
Insero
(+) 5
(-) 3
A T G A A TC AA T C C G T GT A CG A T G T G A 3
T A C T T A GT T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
(+) 5 A U G
A A U C A A UC C
A CG
AUG
UGA
GU G UA C
GA U
G U G 3 Mutante
3 Normal
Inser
Insero
(+) 5
(-) 3
A T G A A TC AA T C C G T GT A CG A T G T G A 3
T A C T T A GT T A G G C A CA T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
(+) 5 A U G
A A U C A A UC C
A CG
AUG
UGA
GU G UA C
GA U
G U G 3 Mutante
Met
Asn
His
Pro
Cys
Thr
Met
Met
Asn
Gln
Ser
Val
Tyr
Asp
Val
3 Normal
COH Normal
COH Mutante
Dele
Deleo
(+) 5
(-) 3
A T G A A T C A T C C G T GT A CG A T G T G A 3
T A C T T A G T A G G C A CA T GC T A C A C T 3
Dele
Deleo
(+) 5
(-) 3
A T G A A T C A T C C G T T A CG A T G T G A 3
T A C T T A G T A G G C A A T GC T A C A C T 3
Dele
Deleo
(+) 5
(-) 3
A T G A A T C A T C C G T T A CG A T G T G A 3
T A C T T A G T A G G C A A T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
(+) 5 A U G
A A U C A U CCG
CGA
UGU
UUA
UGA
3 Normal
3 Mutante
Dele
Deleo
(+) 5
(-) 3
A T G A A T C A T C C G T T A CG A T G T G A 3
T A C T T A G T A G G C A A T GC T A C A C T 3
(+) 5 A U G
A A U C A U C C G U GU
A CG
AUG
(+) 5 A U G
A A U C A U CCG
CGA
UGU
UUA
Met
Asn
His
Pro
Cys
Thr
Met
Met
Asn
His
Pro
Leu
Arg
Cys
UGA
3 Normal
3 Mutante
COH Normal
COH Mutante
Agentes mutagnicos qu
qumicos:
Provocam leses como:
Agentes mutagnicos f
fsicos:
raios UV;
radiaes ionizantes (ionizam os compostos
qumicos celulares): alfa, beta, gama, raios X,
feixes de nutrons.
AGENTES QU
QUMICOS
Agentes qumicos
Desaminao:
Citosina
Uracila
Adenina
Hipoxantina
Agentes qumicos
Bases anlogas:
estrutura molecular semelhante s bases normais;
ex.1: 5-bromouracila (5-BU), anloga Timina:
Timina
Bases an
anlogas
2-aminopurina
Agentes qumicos
Depurinao
Depurinao
Agentes qumicos
Erros de incorporao
Erros de incorporao
Erros de incorporao
Erros de incorporao
AGENTES F
FSICOS
Radia
Radiao UltraUltra-violeta
C
D