KETONE RETROSYNTHESIS SECTION 3-EXAMPLES

Next example targeted

molecule 8 or TM8 .

CH2 O we are using two processes

CH3 O
here:
+
CH2
CH3
+H2C- CH3
a) interconversion of
functional group and
discconection at the
selected place
O O

we can use
H3C CH3
this molecule

CH3 TM8b

Br

TM8a
and again we have
Interconversion of functional
H3C group or IFG process

OH
After this its easy to make a
reaction suggestion.
Synthesis suggestion:
O H3C O
CH3

H
cat/H2 OH
O

triple bond reduced H3C

CH3
CH3
NaBH4 /LiAlH 4 HBr/AcOH + O O
OH Br

CH3