Rahmawati Minhajat
Tutik Harjianti
Div. of Hematology & Medical Oncology
Dept. of Internal Medicine, Medical Faculty
Hasanuddin University
Sub Topics
Introduction of DIC.
Etiology of DIC.
Diagnosis of DIC.
Management of DIC.
Prognosis of DIC.
D.I.C :
Disseminated : widespread
Intravascular : inside the bloodline
Coagulation : blood clot production
Vasoconstriction
Fibrinolysis
Overstimulation of coagulation
DIC
1 Decreased of fibrinogen
1
2 Decreased of platelet
4 Exaggerated of fibrinolysis
1 TUMOR RELEASE OF
Tissue TRAUMA
Tissue NECROSIS
TISSUE FACTOR
INTO CIRCULATION
DIC
2 ENDOTOXIN ACTIVATION of COAG.
GRAM NEGATIVE BACT. CASCADE (F.XII)
DIC
EXPRESSION of TISSUE
FACTOR in MONOCYTE ACCELERATION of COAG RX
& ENDOTHELIAL cells
1. Abnormal coagulation
2. Bleeding (more often)
- can be found at any place
- spontaneous bleeding
- at the site of wound, cath etc.
Sub-acute DIC
Often found in cancer patients
Thrombosis in superficial & profundal veins
(DVT), commonly recurrent
Cryoprecipitate transfusion
(maintain the fibrinogen > 150.000 mg/dL)
Depends on :
1. Severity of coagulation reaction
2. Amount of bleeding
3. Etiology of DIC (malignancy etc)