Spleen
Capsulated
Secondary
Largest accumulation
of lymphoid tissue
Very vascular
(macrophage removing
effete RBC)
Circulation in the Spleen
*Feline Spleen. The Schweigger-Seidel sheath is hard to find in reality.
Sheathed arterioles
Schweigger-Seidel sheath
(sleeve-like sheath)
Penicillary artery
(a.k.a. Brush arterioles)
Branching out
Follicular artery
Through follicle
Central artery
Spleen
Spleen
Trabeculae
Germinal Center
Lymph follicle
B-cell outside ( Cortex)
T-cell inside ( Medullary)
Trabecular vessel
Spleen
Follicular (Central) artery
Casule -> Trabeculae
Trabecular vessel
Capsulated
Primary
Bilobed
@ mediastinum;
overlying the heart
Lobule
Cortico- Septa
medullary Continuation
junction of capsule
gives
division to
incomplete
lobules
C = Cortex
M = Medulla
CT = Connective tissue (Capsule)
Thymus, L-section
Lobules
Cortex
stained blue-violet
high cell density
Medulla
stained lighter and reddish
low cell density
THYMUS, x-section
Zoom,
cortex
Thymocytes/
Cortex maturing
stained blue-violet lymphocytes
high cell density
Medulla thymocyte/
stained lighter and reddish immature
low cell density lymphocytes
Zoom,
MIGRATION OF THYMOCYTES medulla
Zoom
Capsule
Cortex
Medulla Outer region
Inner region
Capsule
Capsule
Cortex
Medulla Outer region
Inner region
capillary
Hassals bodies
-concentric layers of the
reticulum cells Capsule
-
Zoom, medulla
Hassal corpuscle/ Hassals bodies/
Thymic corpuscle
Cortex Cortex Formed by
-higher cell
density = darker
concentric layers
of reticulum cells
Stain intensely
with eosin (pink)
Medulla
-lower cell Medulla
density = lighter
Credits to: http://www.bu.edu/histology/m/index.htm
A = Adipose tissue
L = Lymphoid tissue remnants
CT = connective tissue, also where
the capsule is.
Adipose
Lymphoid tissue
Residual
Cortex
tissue
Adipose
Adipose
Hassals body
Adipose
Lymp Node
Encapsulated
Secondary
Lymph Node in Theory
Cortex
B-cells predominate
Medulla
Efferent
Medullary sinus
lymphatic
Medullary cord vessel
T-cells predominate
Paracortex
Artery
High endothelial venule Vein
Afferent
lymphatic Blood capillaries
vessels around lymphatic
nodule
Paracortex
High-endothelial
venules
Entry point of
lymphocytes to
the circulation
Medulla
Medullary cords
Medullary sinus
Plasma cells
Lymphocytes
Zoom
Lymph Node
Cortex
Secondary follicle
Medullary cord
Medullary sinus
paracortex
Afferent Lymphatic vessels?
Primary follicle
Trabecular sinus/
cortical/marginal
sinus
Subcapsular sinus
Lymph Node
Primary Secondary
follicle follicle
Tonsils
Partly Encapsulated
Secondary
Part of MALT
According to location:
Palatine
Pharyngeal
Lingual
Palatine Tonsils
GC T-cell zone nasa
interfollicular
zone
E LN
C
E
LN
LN LN
GC
E CT CT
E E = Stratified Squamous Epithelium
C LN = Lymphoid nodules
GC = Germinal Centers
CT = Connective Tissue Capsule
C = Crypts
Tonsils Infiltration of lymphocytes in
the epithelium covering the
crypts
Salivary corpuscles C
Yung remnants na nasa crypts daw sabi
ni Doc.
Palatine Tonsils
CT
E = Stratified
GC Squamous Epithelium
GC LN = Lymphoid
C nodules
C GC = Germinal
Centers
E LN CT = Connective
Tissue Capsule
C = Crypts
C LN
Palatine Tonsils
Follicle cap (B-lymphocyte cap)
-ung nag surround sa nodule
Epithelial covering
Stratified squamous non-
keratinized epithelium
Capsular covering:
Connective tissue
Kaya siya partially encapsulated
Lingual Tonsils
Epithelium
Crypts
Lymphoreticular
tissue part of
Lamina propia
Mucus glands
of the Tongue
Crypts
Mucos Glands
Tongue Muscles
Pharyngeal Tonsils
multilayered ciliated epithelium Crypts
Goblet cells
Connective
Tissue
( Blue)
Lymphoreticular tissue
(Lymphocytes and reticular
fibers)
Intestine
NOT Encapsulated
Secondary
Still with MALT
GALT (Gut-associated
lymphoid tissue)
GALT
Peyers Patch (Plaques)
Intestinal Villi
Lymphoid Nodules
Germinal Center
Peyers Patches
Peyers Patches
Thymus MALT Lymph Nodes Spleen
Lymphoid nodules Absent Present Present (in cortex Present (in white pulp
only) only)
Unique features Hassall (thymic) Crypts lined by Thin paracortical Minor white pulp
corpuscles in surface mucosa in region between component, with
medulla; tonsils; epithelial M cortex and central arterioles;
epithelialreticular cells in mucosa medulla, with high major red pulp
cells in cortex and over Peyer endothelial venules component, with
medulla Patches (HEV); medullary many sinusoids
cords and sinuses