Material Safety Data Sheet

Nicotinamide

MSDS# 02889
Section 1 - Chemical Product and Company Identification
MSDS Name: Nicotinamide
Catalog Numbers: AC128270000, AC128271000, AC128275000, AC220000000, AC220000500, BP876-500
Synonyms: 3-Pyridinecarboxamide; Niacinamide.
Acros Organics BVBA
Company Identification: Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium
Acros Organics
Company Identification: (USA) One Reagent Lane
Fair Lawn, NJ 07410
For information in the US, call: 800-ACROS-01
For information in Europe, call: +32 14 57 52 11
Emergency Number, Europe: +32 14 57 52 99
Emergency Number US: 201-796-7100
CHEMTREC Phone Number, US: 800-424-9300
CHEMTREC Phone Number, Europe: 703-527-3887
Section 2 - Composition, Information on Ingredients
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CAS#: 98-92-0
Chemical Name: Nicotinamide
%: 98+
EINECS#: 202-713-4
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Hazard Symbols: XI


Risk Phrases: 36
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Warning! Causes eye irritation. May cause skin and respiratory tract irritation. Target Organs: Blood, liver, eyes.
Potential Health Effects
Eye: Causes eye irritation.
Skin: May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation: May cause respiratory tract irritation. May be harmful if inhaled.
Chronic exposure may cause liver damage. Laboratory experiments have resulted in mutagenic effects. Chronic
Chronic:
exposure may cause blood effects.
Section 4 - First Aid Measures
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
Eyes:
eyelids. Get medical aid.
 Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and
Skin:
shoes. Get medical aid if irritation develops or persists.
Ingestion: Do not induce vomiting. Get medical aid.
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If
Inhalation:
breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to
Physician:
Section 5 - Fire Fighting Measures
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH
General
(approved or equivalent), and full protective gear. This material in sufficient quantity and reduced particle
Information:
size is capable of creating a dust explosion.
Extinguishing
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Media:
Autoignition
480 deg C ( 896.00 deg F)
Temperature:
Flash Point: Not applicable.
Explosion Limits:
Not available
Lower:
Explosion Limits:
Not available
Upper:
NFPA Rating: health: 2; flammability: 1; instability: 0;
Section 6 - Accidental Release Measures
General
Use proper personal protective equipment as indicated in Section 8.
Information:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty
Spills/Leaks:
conditions. Provide ventilation. Do not let this chemical enter the environment.
Section 7 - Handling and Storage
Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on
Handling:
clothing. Do not ingest or inhale.
Storage: Store in a cool, dry place. Store in a tightly closed container.
Section 8 - Exposure Controls, Personal Protection
+-------------------- +------------------- +------------------- +----------------- +
| Chemical Name | ACGIH | NIOSH |OSHA - Final PELs|
|-------------------- |------------------- |------------------- |----------------- |
| Nicotinamide |none listed |none listed |none listed |
+-------------------- +------------------- +------------------- +----------------- +

OSHA Vacated PELs: Nicotinamide: None listed

Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use
adequate ventilation to keep airborne concentrations low.
Exposure Limits
Personal Protective Equipment
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face
Eyes:
protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or
Respirators:
European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
Physical State: Crystalline powder
Color: white
Odor: odorless
 pH: 6-7.5 (5% aq soln)
Vapor Pressure: Not available
Vapor Density: Not available
Evaporation Rate: Not available
Viscosity: Not available
Boiling Point: 150 - 160 deg C @ 760 mmHg
Freezing/Melting Point: 128 -131 deg C
Decomposition Temperature:
Solubility in water: Soluble
Specific Gravity/Density: Not available.
Molecular Formula: C6H6N2O
Molecular Weight: 122.13
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials Strong oxidizing agents.
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization Will not occur.
Section 11 - Toxicological Information
RTECS#: CAS# 98-92-0: QS3675000
RTECS:
CAS# 98-92-0: Oral, mouse: LD50 = 2500 mg/kg;
LD50/LC50:
Oral, rat: LD50 = 3500 mg/kg;
.
Carcinogenicity: Nicotinamide - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
The toxicological properties have not been fully investigated. See actual entry in RTECS for complete
Other:
information.
Section 12 - Ecological Information
Other: Do not empty into drains.
Section 13 - Disposal Considerations
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - Transport Information
US DOT
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
Canada TDG
Shipping Name: Not regulated as a hazardous material
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36 Irritating to eyes.
Safety Phrases:
 S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face protection.
WGK (Water Danger/Protection)
CAS# 98-92-0: 0
Canada
CAS# 98-92-0 is listed on Canada's DSL List
Canadian WHMIS Classifications: D2B
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations
and the MSDS contains all of the information required by those regulations.
CAS# 98-92-0 is not listed on Canada's Ingredient Disclosure List.
US Federal
TSCA
CAS# 98-92-0 is listed on the TSCA
Inventory.
Section 16 - Other Information
MSDS Creation Date: 9/02/1997
Revision #7 Date 7/20/2009

The information above is believed to be accurate and represents the best information currently available
to us. However, we make no warranty of merchantibility or any other warranty, express or implied,
with respect to such information, and we assume no liability resulting from its use. Users should make
their own investigations to determine the suitability of the information for their particular purposes. In no
event shall the company be liable for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential, or exemplary damages howsoever arising, even if the
company has been advised of the possibility of such damages.
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