SUPPLEMENTARY DATA

Supplementary Figure 1. Agreement Between Recalled Weights and Confirmed Weights.

Supplementary Figure 2. Distribution of Body Weight (A) and Age (B) According to The Quartiles of
Rate max_wt . Abbreviations: Wt 20y , weight at age 20 years; Wt max , weight at maximum weight; Wt T2D ,
weight at T2D diagnosis; Age max_wt , age at maximum weight; Age T2D , age at T2D diagnosis.

2014 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc13-2365/-/DC1

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Supplementary Figure 3. Prevalence of Three Types of Plaque According to The Quartiles of

Rate max_wt . The prevalence of mixed and noncalcified plaques increased with the Rate max_wt , whereas
there was no relationship between the Rate max_wt and the presence of calcified plaques.

2014 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc13-2365/-/DC1

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Supplementary Table 1. Multivariable Logistic Regression Models for Variables Including Weight Change from Age 20 years to Maximum
Weight associated with Coronary Artery Lesions.

Significant stenosis Multivessel involvement Atherosclerotic coronary

High CACS (100)
(50%) (2 vessels) segments (any plaque)
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
Age (years) 1.02 (1.01-1.04)* 1.01 (0.99-1.02) 1.01 (1.00-1.02) 1.01 (0.99-1.02)
Sex (men vs women) 1.10 (0.74-1.59) 1.26 (0.92-1.74) 1.31 (0.96-1.78)* 1.23 (0.80-1.62)
2
BMI 20y (kg/m ) 1.06 (1.00-1.12)* 1.04 (0.99-1.09) 1.01 (0.97-1.06) 1.05 (0.99-1.10)
BMI T2D (kg/m2) 0.99 (0.95-1.05) 0.99 (0.95-1.04) 0.97 (0.93-1.01) 0.98 (0.93-1.11)
SBP 140 mmHg or taking
1.60 (1.17-2.20) 1.35 (1.03-1.75)* 1.63 (1.26-2.09) 1.49 (1.11-1.99)
antihypertensive medication
Smoking (pack-years) 1.02 (1.01-1.03) 1.01 (1.01-1.02)* 1.02 (1.01-1.02) 1.01 (1.00-1.02)*
Alcohol (current vs. none) 0.67 (0.42-1.08) 0.72 (0.48-1.07) 0.90 (0.62-1.31) 1.21 (0.81-1.82)
Exercise (irregular vs regular) 1.34 (0.94-1.92) 1.02 (0.76-1.37) 1.10 (0.83-1.46) 1.03 (0.75-1.43)
Fhx of CAD (yes vs no) 1.95 (1.38-2.77) 1.58 (1.16-2.14) 2.18 (1.65-2.90) 1.62 (1.16-2.27)
A1C (%) 1.16 (1.04-1.28) 1.11 (1.01-1.21)* 1.11 (1.02-1.20)* 1.04 (0.94-1.15)
LDL-cholesterol 130 mg/dl or
1.96 (1.43-2.69) 2.30 (1.77-3.00) 2.08 (1.61-2.68) 2.39 (1.78-3.21)
taking statin medication
Log-triglyceride (mg/dl) 0.99 (0.71-1.39) 1.12 (0.84-1.49) 0.81 (0.62-1.06) 0.87 (0.64-1.19)
HDL-cholesterol (mg/dl) 1.00 (0.99-1.02) 1.00 (0.99-1.02) 0.99 (0.98-1.00) 0.99 (0.98-1.01)
Quartiles of Wt
1 (lowest) 1 - 1 - 1 - 1 -
2 1.10 (0.66-1.84) 0.99 (0.66-1.50) 1.10 (0.74-1.64) 1.12 (0.71-1.76)
3 1.21 (0.86-1.98) 1.14 (0.75-1.75) 1.16 (0.77-1.75) 0.96 (0.58-1.52)
4 (highest) 1.62 (1.01-2.32)* 1.45 (0.98-1.90) 1.52 (0.99-2.01) 1.34 (0.91-1.71)
Adjusted for age, sex, BMI 20y , SBP 140 mmHg or taking antihypertensive medication, smoking, alcohol intake, exercise habits, family
history of CAD, A1C level, and LDL-cholesterol level 130 mg/dl or taking statin medication, *P < .05, P < .01.

2014 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc13-2365/-/DC1

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Abbreviations: CACS, coronary artery calcium score; CAD, coronary artery disease; CI, confidence interval; BMI, body mass index;
Fhx, family history; OR, odds ratio; Wt (kg), Wt max Wt 20y ; SBP, systolic blood pressure.

Supplementary Table 2. Multivariable Logistic Regression Models for Variables Including Weight Change from Age 20 years to Maximum
Weight Associated with Plaque Types.

Calcified plaque Mixed plaque Noncalcified plaque

95% CI 95% CI 95% CI
OR OR OR
(lower, upper) (lower, upper) (lower, upper)
Age (years) 1.00 0.98 1.02 1.00 0.98 1.02 1.01 0.99 1.03
Sex (men vs women) 1.11 0.67 1.86 1.07 0.66 1.73 1.36 0.83 2.24
2 1.04 0.95 1.13 1.02 0.94 1.10 1.07 0.99 1.16
BMI 20y (kg/m )
BMI T2D (kg/m2) 0.96 0.89 1.02 1.01 0.95 1.08 0.97 0.91 1.04
SBP 140 mmHg or taking 1.50 0.98 2.30 1.78 1.20 2.64 1.62* 1.07 2.45
antihypertensive medication
Smoking (pack-years) 1.02* 1.00 1.03 1.01* 1.00 1.02 1.01* 1.00 1.03
Alcohol (current vs none) 0.86 0.45 1.63 1.34 0.79 2.25 0.83 0.44 1.58
Exercise (irregular vs regular) 1.10 0.69 1.75 1.18 0.76 1.86 0.92 0.59 1.44
Fhx of CAD (yes vs no)* 1.84* 1.15 2.95 1.62* 1.05 2.50 2.43 1.57 3.77
A1C (%) 1.04 0.90 1.20 1.11 0.98 1.26 1.03 0.89 1.18
LDL-cholesterol 130 mg/dl or 1.68* 1.09 2.58 1.82 1.23 2.71 1.55* 1.02 2.35
taking statin medication
Log-triglyceride (mg/dl) 0.69 0.44 1.08 0.93 0.62 1.39 0.85 0.55 1.30
HDL-cholesterol (mg/dl) 1.00 0.98 1.02 0.98 0.97 1.00 1.00 0.99 1.02
Quartiles of Wt
1st (lowest) quartile 1 - - 1 - - 1 - -
nd 1.14 0.60 2.18 1.51 0.75 3.03 1.35 0.70 2.60
2
3rd 0.85 0.40 1.79 1.87 0.91 3.84 1.30 0.63 2.66
th 1.93 0.91 4.08 2.26* 1.04 4.91 2.29* 1.08 4.87
4 (highest)

2014 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc13-2365/-/DC1

SUPPLEMENTARY DATA

Abbreviations: BMI, body mass index; CI, confidence interval; Fhx, family history; OR, odds ratio; Wt (kg), Wt max Wt 20y ; SBP, systolic
blood pressure, *P < .05, P < .01.

2014 American Diabetes Association. Published online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc13-2365/-/DC1