Tobacco use remains the leading cause of preventable death in the United States, a
rank that it has held ever since deaths were first quantified by risk factors in the early
1990s.
In the United States, cigarette smoking and exposure to tobacco smoke account for
approximately one in five deaths (438,000 people) each year, as well as 5.5 million years of
potential life lost.
Although overweight runs a close second as a leading cause, tobacco use causes
more than twice as many deaths as alcohol consumption, motor vehicle accidents, firearm
use, unsafe sexual behavior, and illicit drug use combined.
In addition to this staggering loss of life, as of 2001 tobacco use cost society more
than $167 billion per year through smoking-attributable health care expenditures ($76
billion) and adult productivity losses ($92 billion).
Smoking harms nearly every organ of the body, has been causally linked to
dozens of adverse health effects, and reduces overall health status. Cigarette smoking
alone is responsible for more than 30% of U.S. cancer deaths. Smokeless tobacco use
causes oral cancer and other oral lesions. Environmental tobacco smoke, a known
human carcinogen, causes premature death and disease in children and in adults who do
not smoke;
The highest levels of smoking were among people aged 2544 years (23.8%);
American Indians and Alaskan Natives (33.4%); people who had earned a General
Educational Development (GED) but not a standard high-school diploma (39.6%); and
people living below the poverty threshold (29.1%).
1
Although the national smoking rate is slowly declining, it is still well above the
national goals set in Healthy People 2010: less than 12% for adults and 16% for
adolescents.
Although one option for clinicians is to deliver intensive counseling as the primary
focus of a series of clinic visits, an alternative is to offer simple advice to quit coupled with
referral to a quit line, a 30-second option that many clinicians may find easier to incorporate
into their daily practice.
Background
Many clinicians recognize smoking as a major threat to a patient's health but do not
feel confident in their ability to intervene effectively. Most clinicians have not experienced
success in helping patients to stop smoking.
Most have treated patients with significant tobacco-related diseases who have been
unable to stop despite multiple attempts, even as they became sicker. Repeated failures to
help patients stop smoking frequently cause clinicians to become discouraged and
reinforce the belief that nothing can be done about smoking
Another barrier preventing clinicians from trying to help patients quit smoking
includes a lack of formal training in tested cessation techniques. Perhaps most important,
many office practices are not organized to support the delivery of smoking cessation
interventions.
However, the evidence is clear: advice from clinicians helps smokers quit. Even
providing brief, simple advice increases the likelihood that a smoker will successfully quit
and remain abstinent 12 months later. The methods outlined here show how best to use
the limited time available to impact smoking
behavior among patients.
Methods
Treating Tobacco Use and Dependence, which is available online in its entirety and
in a summary for clinicians, details the PHS clinical practice guidelines for promoting
smoking cessation among patients.
Clinician Intervention
The clinician intervention recommended in the PHS guideline comprises five
activities, each beginning with the letter A:
Ask all patients about smoking
Advise smokers to stop
2
Assess if the smoker is willing to make a quit attempt
Assist their efforts with self-help materials, a quit date, and possibly cessation
medication
Arrange follow-up
This intervention plan describes a general approach to patients who smoke and can
be used in almost any outpatient encounter, whether the clinician and patient have 30
seconds or 30 minutes for the discussion.
Ask about smoking at every opportunity. For example, a nurse or other staff
member should routinely ask patients Do you smoke? or Are you still smoking? at each
visit, usually while measuring vital signs.
Advise all smokers to stop. A clear statement of advice (e.g., As your physician, I
must advise you to stop smoking now) is essential. Many patients do not recall receiving
this advice from their clinician. Therefore, the statement must be short, clear, and
memorable.
Assess if the smoker is willing to make a quit attempt. Patients' level of interest in
stopping smoking is usually evident in discussions with the clinician. If it is not, ask patients
if they want to stop.
3
Roadblocksask the patient to identify barriers or impediments to quitting
Repetitionrepeat motivational intervention at every clinic visit
Assist the patient in stopping. For those patients who express a sincere desire to
stop smoking, the clinician should help them set a specific date for the next attempt. There
is evidence that patients who set a quit date are more likely to make a serious attempt to
stop than those who do not.
This date should be in the near future (generally within 4 weeks), but not immediate,
giving the patient the necessary time to prepare to stop. Patients should be encouraged to
announce their quit date to family, friends, and coworkers.
Once a patient has selected a specific date to stop, information must be provided so
that he or she can prepare for that date. For patients who can read, this is easily
accomplished by providing them with a self-help brochure.
Effective brochures provide the patient with necessary information about smoking
cessation (e.g., symptoms and time course of withdrawal, cessation tips, reasons to quit,
answers to common questions).
Patients who cannot read need to acquire this information from other sources, such
as audiotapes, video materials, or counseling by a clinician or health educator.
Arrange follow-up visits. When patients know that their progress will be reviewed,
their chances of successfully stopping improve. This monitoring may include a letter or
telephone call from the office staff just before the quit date, reinforcing the decision to stop.
Most relapses occur in the first weeks after cessation. A person who comes to the
office after being a nonsmoker for 12 weeks has a much improved chance of remaining
abstinent than those without follow-up.
For this reason, it is critical that patients be contacted during their first 2 weeks of
abstinence to reinforce their decision to stop. Nurses or other clinicians as well as the
physician may conduct this follow-up in the office or by telephone.
Although follow-up visits are critical during the first 2 weeks after cessation, clinic
staff should remain in contact with the patient and schedule a formal follow-up visit in 12
months
For patients who cannot return for an appointment, contact by telephone or by mail
may be helpful. Many patients can benefit from the social support and information offered
through quit lines, Internet discussion sites, and local support group sessions offered by
the American Cancer Society, the American Lung Association, or local churches or
community organizations.
4
While only a small proportion of patients referred to such programs actually
participate, these programs have the potential for large public health impact. However, for
individual patients, clinicians should consider these referrals as augmenting, not replacing,
a clinician's care.
Patients may also express interest in techniques such as hypnosis and acupuncture.
These have not been proved to be effective through randomized, controlled trials but are
probably not harmful.
Informed patients who wish to try these techniques should not be discouraged from
doing so.
Pharmacologic Agents
All forms of nicotine replacement therapy can help patients stop smoking, almost
doubling long-term success rates, with similar efficacy to prescription medication.
The long-term use of nicotine replacement therapies does not pose a known health
risk and may be helpful with smokers who report persistent withdrawal symptoms.
However, use of any nicotine replacement therapy should be avoided for 1 month following
myocardial infarction, serious arrhythmia, or unstable angina.
Clinical trial data suggest that bupropion and varenicline tartrate are effective aids to
smoking cessation. Bupropion can be paired safely with nicotine replacement therapy,
although blood pressure may need more careful monitoring.
Even when used alone, bupropion use leads to quit rates about double those
achieved with the nicotine patch. The effects of bupropion go beyond antidepressant
activity, but its mechanism of action in smoking cessation remains unknown Additionally,
the FDA has approved the use of bupropion sustained release for long-term maintenance.
5
The more recently approved varenicline tartrate appears to be even more effective
than bupropion. Nortriptyline and clonidine have smoking cessation efficacy, and while
these may produce a number of unpleasant side effects, they should be considered when
FDA-approved medications are not available to patients due to cost issues.
Quit Lines
The use of telephone-based tobacco cessation services, commonly known as quit
lines, has been shown to improve smoking cessation rates. Their effectiveness with
smokers who use them is well established. In many states with comprehensive tobacco
control programs, quit lines play an important role in media-based efforts to encourage
smoking cessation.
Depending on the state, and sometimes by insurance status within states, quit lines
offer either reactive counseling (smokers can call as needed during their quit attempt) or
the more effective proactive counseling (a series of counseling calls initiated by quit line
personnel timed around a quit attempt).
Quit lines are accessible and eliminate many barriers associated with traditional
smoking cessation classes or support groups. These include having to wait for sessions to
be offered, needing to arrange transportation and/or childcare, and discomfort with
participating in a group discussion.
Every quit line serves thousands of tobacco users each year, a volume rarely
achieved by other behavioral services, yet they currently reach only 15% of the tobacco
users in their states each year.
This can be done in 30 seconds. When incorporating all the 5As into busy office
visits is not feasible, this Ask, Advise, and Refer strategy is a very reasonable shortcut
and far better than not addressing tobacco use at all.
In some states clinicians can send referrals directly to the quit line, whose
counselors will then contact the patient directly (proactive telephone counseling). Proactive
counseling, which eliminates the need for the patient to place the call and has been proved
to be more effective than reactive counseling, is usually arranged by completing a referral
form (often signed by both patient and clinician), which is then faxed to the service.
6
Most state quit lines offer proactive counseling only to smokers ready to make a quit
attempt in the next 30 days and practices may therefore need to screen potential quit line
referrals to verify their stage of readiness to change.
For smokers not yet ready to quit, providing the telephone number for them to call is
more appropriate. In either case, clinicians should be prepared to respond to calls from
patients who are referred to quit lines and want prescription-only cessation medication
options that were not discussed and arranged before their referral.
Weight Gain
The issue of potential weight gain is important for many patients who try to stop
smoking. Some patients cite weight gain as the reason for relapse after previous attempts
to stop. The average amount of weight gained after cessation is approximately 5 lb. Some
patients gain no weight after cessation, but a small proportion of people gain large amounts
of weight.
Recommendations for more frequent physical activity (even in short bouts) may both
help prevent weight gain and support smoke-free behavior.
Many smokers, especially adults older than 40 years, have made several serious
attempts to stop smoking but have always relapsed.
Multiple Relapses
Nicotine is a powerfully addictive drug. These patients have frequently tried various
smoking cessation products and programs, all without success. Such patients are often
discouraged by their failed attempts to stop and are therefore less willing to try again.
These patients (and their clinicians) need to be aware that relapse is a typical part of
the cessation process. Most smokers require several attempts to achieve permanent
abstinence, and knowing this may bring encouragement to relapsing smokers. Even in a
relatively short clinic visit, a clinician can help a patient benefit from past relapses rather
than view them as a personal failure and a reason to avoid future quit attempts.
During the visit, the clinician can help the patient to identify the circumstances that
led to past relapses and to develop strategies for use in either avoiding those
circumstances or responding to them in a different manner.
7
A simple question from the cliniciansuch as When you resumed smoking, where
did your first cigarette come from?or what was going on in your life when you started
up again?will start the discussion of the reason(s) for relapse. There are several
common reasons offered for relapse, including withdrawal symptoms, weight gain, stress
at work or home, alcohol intoxication, or social pressure.
Once the patient has described the circumstances of the relapse, the clinician can
ask, How do you think you would deal with that situation if it happened again? or How do
you think you could avoid that situation in the future? The clinician can offer advice about
some situations and help with withdrawal symptoms, but the patient must develop a
personalized plan for responding to circumstances that have caused past relapses.
Patients commonly say that they had a relapse due to stress at their job or at home.
Marital difficulties, problems with other family members, loss of a job, or increased work
responsibilities are often given as reasons for relapse.
Patients, with the help of their clinician, need to anticipate the difficult times that may
occur while they are attempting to quit and be prepared with a response other than taking
up smoking again.
Various social factors are frequently implicated in relapse, particularly when the
patient is confronted by situations or friends who provide strong cues or prompts for
smoking. Parties and other social gatherings are common sites of relapses, especially
among patients who consume alcohol at these events.
During the time available in a brief office visit, it will not be possible for the clinician
to help patients make major changes in their social skills or in their support system for
behavior change. However, all patients should be encouraged to tell their family, friends,
and coworkers of their decision to stop smoking in advance of their quit date and to seek
their support and encouragement.
Patients with little support for stopping can be referred to group cessation programs.
Referral to a counselor or other health professional may also be useful.
It is often difficult for a patient to stop if his or her spouse or partner also smokes and
is unwilling to stop. The unwilling spouse/partner should be encouraged to join in the quit
attempt. If this is unsuccessful, that person should at least be encouraged to smoke only
outside the home.
8
Special Populations
As discussed earlier, the advice and assistance a clinician provides should reflect an
understanding of the patient's medical, social, and cultural background. By asking the
patient about anticipated problems with smoking cessation and potential solutions to these
problems, the clinician can help patients construct solutions that are relevant to their social
and cultural setting.
Clinicians also need to recognize that smoking and tobacco use are viewed in
different ways by different cultural groups, and that these views may influence how and
why a patient stops. Self-help materials designed for special population groups are
becoming more widely available.
Young people comprise another group that can benefit from the advice and
assistance of clinicians. Because most adult smokers first become addicted to nicotine
during childhood and adolescence, advice from clinicians during these life stages is critical.
Although any adolescent is a potential smoker, those at highest risk
Adolescents who are already regular smokers should be advised and assisted in the
same manner as an adult patient. However, adolescents are often much more concerned
with the immediate effects of smoking, such as smokers' breath and smell and diminished
athletic performance, and are often not influenced by information about long-term risks
such as cancer and other tobacco-related diseases.
Finally, clinicians should routinely ask about vulnerable household members who
might be exposed to secondhand smoke. Children of any age should be protected from
exposure to environmental tobacco smoke. Parents who smoke should be advised to stop
and to keep their children in smoke-free environments at home, at day care, and in other
9
settings. Similar precautions must be taken when older adults are receiving care in the
home.
Even brief exposure to secondhand smoke could pose significant acute risks to ill
older adults or to anyone at high risk for cardiovascular or respiratory disease. Those
caring for relatives with heart or lung disease should be advised not to smoke in the
presence of the sick relative. Some clinicians systematically identify passive smokers
(including children) in their practices and routinely provide recommendations to reduce
their exposure.
The goal is to ensure that all patients who smoke are routinely and efficiently
identified, consistently monitored, and appropriately treated. Evidence-based office
practices shown to reduce tobacco use among patients include the following:
To act as a coordinated team, all office staff members must understand that smoking
cessation is an important task for the practice, and they must know their roles. The team
approach is facilitated by naming a smoking cessation coordinator, usually a nurse.
With the help of the other staff members, the coordinator will incorporate the various
components of the planned intervention program into the day-to-day activities of the
practice. The smoking cessation coordinator also helps maintain the staff members'
commitment to the program and ensures that the system is operating smoothly.
Both the system itself and staff fulfillment of their roles should be reviewed
periodically and adjustments made as necessary.
The team approach emphasizes staff identification of each patient who uses
tobacco. When patients are identified as smokers, their charts should be marked in a
prominent manner.
The typical identifier is a brightly colored permanent sticker or stamp, but it can also
be a removable sticker that is put on the chart at each visit. Practices with paper records
can revise their forms to include tobacco use as a vital sign, and those with electronic
10
health records can go one step further and display screen prompts to staff to obtain this
information.
The regular use of these chart reminders, which facilitates the provision of brief
cessation advice as a routine part of every office visit for patients who smoke, has been
shown to significantly increase cessation rates in office practices. It is important that all
staff members understand and use this kind of charting system.
There should be a specific staff member assigned to scheduling the follow-up visits
and making contact with the patient just before the planned quit date, working closely with
the staff person who conducts the follow-up visits. Staff members can also review with
patients their self-help materials and instructions for use of any recommended or
prescribed cessation medications.
Steps for making an office or clinic itself tobacco-free include posting no-smoking
signs, removing ashtrays, displaying tobacco cessation and prevention information
prominently, and eliminating tobacco advertising from the office, either by subscribing to
magazines that do not carry such advertising or by crossing out the tobacco
advertisements with bright markers.
Conclusion
Clinician assistance for individual smokers can have an enormous public health
impact as well as benefiting each individual patient who quits. Even with very modest
expectations of cessation rates, 100,000 clinicians using effective intervention strategies
could potentially assist more than 3 million smokers to quit each year.
Substance Use
In 2004, an estimated 22.5 million Americans aged 12 years or older met criteria for
either substance abuse or dependence. In 2003, there were more than 620,000 emergency
department visits related to drug or alcohol use.
Substance use disorders (SUDs) result in significant health care and criminal justice
costs as well as lost productivity. Estimates of total annual costs of these disorders
exceeded $420 billion in 1995, representing an almost twofold increase from estimates 3
years earlier ($240 billion in 1992).
Substance use spans a continuum starting with abstinence and continuing through
at-risk use, to abuse and dependence. Individuals with at-risk use do not meet Diagnostic
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and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for substance
abuse or dependence, but they use alcohol and/or other drugs in a pattern that places
them at risk for physical, psychosocial, occupational, or legal harms.
The primary care clinician can play a critical role in the assessment and treatment of
substance-related disorders and, hence, in the prevention of the individual and societal
sequelae of SUDs. For most substance abusing or dependent individuals, primary care
clinicians are their first point of contact with the health care system
Therefore, primary care clinicians are ideally situated to provide initial assessment,
brief counseling, pharmacotherapy, and referrals to appropriate specialists and
psychosocial rehabilitation. This chapter serves as a review of the risk factors, screening
instruments, assessment, diagnosis, and treatment of SUDs in the primary care setting.
The U.S. Preventive Services Task Force, the Institute of Medicine, the American
Academy of Family Physicians, and the National Institute on Alcohol Abuse and Alcoholism
recommend routine screening of adults, including pregnant women, for alcohol use
disorders. Screening of adolescents is also encouraged.
Screening for illicit drug use and drug-related problems in PHEs is recommended by
the American Academy of Pediatrics and the American Medical Association. Illicit drugs
are virtually all of the psychoactive drugs that are illegal to sell, possess, or use (e.g.,
marijuana, heroin, and cocaine) and include prescription pharmaceuticals that are used on
a nonprescription basis.
Screening Instruments
Screening instruments for at-risk alcohol use and alcohol use disorders are much
more varied and well studied than instruments for illicit drug use. Similar to screens for
other clinical conditions, the clinician should keep in mind that these instruments are not
diagnostic for substance abuse or dependence. A positive finding upon screening
mandates further evaluation through detailed interviews and/or specialist consultation.
12
Several instruments have been developed and studied as screens for at-risk alcohol
use and/or alcohol use disorders. Each has its advantages and disadvantages in terms of
testing characteristics and convenience of administration.
This section of the chapter focuses on those screens found to be most practical for
use in the primary care setting. Such sophisticated screening instruments as the Michigan
Alcoholism Screening Test (MAST) or the Substance Abuse Subtle Screening Inventory
(SASSI) are very detailed and therefore impractical for use in a busy primary care setting.
It should be noted that the CAGE questions are time insensitive; therefore, they do
not distinguish a past from a current problem. Two positive responses are most generally
considered criteria for a positive screen. Reducing the cutoff for a positive screen to one
positive response improves test sensitivity (from approximately 76% to 88%) but reduces
test specificity (from approximately 86% to 74%).
A more detailed screening instrument, the Alcohol Use Disorders Identification Test
(AUDIT), was developed by the World Health Organization as a screen for current at-risk
drinking and alcohol use disorders. The AUDIT consists of ten questions each scored on a
five-point Likert scale (04) yielding a possible range of 040. A score of 8 or greater
indicates the need for further evaluation. In the outpatient clinic population, the AUDIT
exhibits improved specificity (9596%) over the CAGE at traditional cutoffs, but at the
expense of sensitivity (3863%).
A single quantity question (e.g., On any single occasion during the last 3 months,
have you had more than five drinks containing alcohol?) has also been evaluated as a
screen for at-risk drinking and alcohol use disorders in the outpatient clinical setting and for
binge drinking. Its performance compares favorably to that of the other short screening
instruments for problematic alcohol use.
The application and utility of the widely used screening instruments, such as CAGE,
AUDIT, and variations of the MAST, have primarily been studied among men, using cutoff
values and diagnostic criteria more appropriate for men. Therefore, test characteristics and
the goals for alcohol screening tools may differ significantly when applied to groups other
than adult males.
13
Among pregnant women, for instance, dependent drinking is less common than in
men and cutoffs for potentially harmful drinking patterns are lower than that for men.
Studies also indicate that traditional screening instruments may not provide accurate
results in the general female population and among adolescents. Screening should be
modified accordingly to detect use patterns of risk in special populations.
Pregnancy
The CAGE has been modified to yield screening questionnaires more appropriate
for pregnant women. Screening in the population of pregnant women is designed to detect
at-risk drinking and more severe alcohol-related behaviors. At-risk drinking for a pregnant
woman has been defined as consuming 1 oz or more of alcohol daily
Screening instruments are therefore designed for the detection of this lower volume
of consumption. Epidemiologic studies, however, indicate that fetal harm may be
associated with even lower levels of consumption: three drinks per week or 0.5 oz of
alcohol daily. Due in part to this lack of clarity in the literature, women should be counseled
that no level of alcohol consumption is known to be safe during pregnancy.
Far fewer instruments have been investigated for screening of SUDs other than
alcohol-related disorders. The evaluation of screens for which there are published results
has focused on conjoint screening, or screening simultaneously for alcohol and other drug
use disorders. Two such instruments are the CAGE-AID and the two-item conjoint screen
(TICS). The two-item conjoint screen asks the following two questions:
In the last year, have you ever drunk or used drugs more than you meant to?
Have you felt that you wanted or needed to cut down on your drinking or drug use in
the last year?
Adolescence
Risk Factors
Knowledge of the factors associated with the development of SUDs may help the
clinician overcome some of the shortcomings of traditional screening tests. SUDs are
14
multifactorial in their etiology. For any individual, risk is determined by an array of
biological, behavioral, and environmental factors, such as family history, sex, age, ethnicity,
employment status, education, and psychiatric history.
Family history is the most powerful and consistent risk factor for the development of
SUDs. Alcohol and drug use disorders are generally more common among men than
women. However, among those who consume drugs, the likelihood of developing a SUD is
similar for men and women. The prevalence of alcoholism declines with age.
The prevalence of the SUDs associated with the use of drugs (other than
prescription drugs used on a nonprescription basis) peaks in adolescence and young
adulthood (age 2135 years) and declines thereafter.
Unemployment has been linked to alcohol use disorders. Longer work hours and
dropping out of high school are each associated with a greater risk of drug and alcohol use
among adolescents, although of course excessive alcohol use can be a cause of these
circumstances as well as a consequence.
The prevalence of alcohol and drug disorders has been estimated to be 2050%
respectively among individuals reporting a history of a psychiatric disorder.The nature of
the link between specific psychiatric syndromes and SUDs is complex and beyond the
scope of this chapter.
Treatment
There are a number of evidence-based methods available to treat alcohol and drug
use disorders. These include brief primary care office-based interventions, motivational
interviewing therapy, pharmacotherapy, cognitive behavioral therapy (CBT), Alcoholics
Anonymous (AA)-based self-help groups, and traditional alcohol and drug group therapy.
There is sufficient evidence to recommend each of these methods for the treatment
of alcohol and drug use disorders. Other methods such as acupuncture, herbal medication,
and massage therapy have insufficient evidence to recommend implementation and
therefore will not be reviewed in this chapter.
There are six basic steps in the brief intervention. The first step is for the clinician
to express concern that the patient is drinking above recommended levels, or concern
15
about the patient's drug use. The second step is to connect the patient's drinking or drug
use to health, social, or family concerns of importance to that patient.
The fourth step is to make a specific recommendation for the patient to reduce use
or become abstinent in an effort to reduce the potential for drug-related harm. The fifth step
is to negotiate with the patient a realistic change in alcohol or drug use in the next 30 days.
Client-Centered Counseling
MET is a technique easily learned by primary care clinicians to help patients move
along in the readiness-to-change paradigm (see pages 133134). Techniques utilized in
MET include rolling with patient resistance, dealing with patient ambivalence, setting up
cognitive dissonance, and using behavioral change contracts. This technique can move
patients from contemplating reducing their drinking or drug use to actual behavior change.
CBT provides patients with specific skills designed to deal with triggers, craving, and
high-risk situations. Relapse prevention programs are based on CBT counseling strategies,
which are primarily used by counselors in 1-hour sessions lasting 1016 weeks. Clinicians
can use CBT to role-play with patients on how to deal with high-risk social situations that
often lead to relapse.
CBT therapy is used to change a variety of behaviors and/or their results including
tobacco use disorders, alcohol use problems, and obesity.
16
focuses on recording how alcohol and/or drugs have damaged patients' lives and those
around them. Step 5 involves sharing these events with another person. Clinicians can ask
patients to complete step 4 on their own and then use a regular clinician visit to go over the
items.
Self-help peer groups remain the main source of help for patients trying to deal with
their alcohol and drug use. As part of the information on community resources that
practices should keep on hand for patients, clinicians may want to have a list of local AA
chapters and Al-Anon meetings available in the waiting room or as a handout. This list can
be obtained from the local AA chapter, which is often listed in telephone directories or on
websites.
AA meetings remain one of the most widely used options for the treatment of alcohol
and drug dependence throughout the world. Unlike a patient's primary care clinician, AA is
free and available after 5 PM, on weekends, and during the holidays.
Alcohol use is a major cause of motor vehicle crashes. When counseling patients
regarding drinking and driving and the risk for motor vehicle accidents and injury, it should
be emphasized that, although legal blood alcohol limits promote safety to some degree,
evidence indicates that impairment occurs within legal blood alcohol concentration limits.
In addition to increasing the risk of injury, recent alcohol consumption also increases
the probability of sustaining more severe injury with poorer clinical outcome. Patients
should be made aware of local safe ride programs (transportation alternatives for
intoxicated drivers) as a preventive measure.
Alcohol Dependence
There are two groups of medications that can be helpful in the primary treatment of
alcohol dependence: aversive agents and anticraving agents. These medications are not
recommended for the treatment of patients engaged in at-risk or problem drinking,
pregnant women, or patients younger than 16 years.
The first class consists of aversive agents such as disulfiram and metronidazole.
Patients who take the medication at least 5 days a week are likely to remain sober.
Supervised medication dosing by a partner or close personal contact may facilitate
compliance. Liver function tests should be monitored at baseline, 2 months after initiation,
and every 6 months thereafter.
17
The second class of medications is the anticraving drugs. Two are currently
approved by the U.S. Food and Drug Administration (FDA): naltrexone and acamprosate.
An injectable formulation of naltrexone has received FDA approval for monthly
administration for alcohol dependence. Acamprosate has been widely used in Europe for
some years.
Anticraving drugs are most effective when administered for 312 months. They are
meant to be used in patients who are trying to become abstinent, and they are therefore
less effective in patients who continue to drink intermittently while taking the medication.
Liver and renal function should be checked at baseline and 2 months after initiation.
Drug Dependence
Methadone and buprenorphine are the primary treatments for opioid dependence
and are currently approved by the FDA. These medications reduce craving, prevent
withdrawal, and often lead to abstinence from opioids and other illicit drugs, thereby
preventing related complications, such as blood-borne virus transmission and cutaneous
infections
18
Comorbidity is a common problem seen in patients with alcohol and drug use
disorders. Many patients with SUDs often have mental health disorders such as unipolar
depression, anxiety, panic attacks, bipolar disorders, and post-traumatic stress disorder
(PTSD). Primary care clinicians need to identify these comorbidities before developing a
SUD treatment plan.
Tobacco and marijuana use are the cause of the two most common SUDs in the
United States and throughout the world. The number of persons using these two
substances on a regular basis far exceeds those using alcohol and all other illicit drugs
combined. Continued use of these substances not only has adverse health and societal
effects but these substances also interact with treatments for alcohol and other drug
problems.
Tobacco use is the leading cause of death in the United States and deserves special
emphasis. In general clinicians should recommend cessation of all mood-altering drugs
and then negotiate with patients as to how to proceed. Some patients will agree to try
cessation of multiple drugs.
Other patients prefer to start with one at a time. The key is to develop a partnership
with the patient to successfully address these very challenging problems.
19
Pseudoaddiction is defined as the seeking of additional medications, appropriately
or inappropriately, due to undertreatment of pain. When the pain is adequately treated, the
aberrant behaviors cease.
Clinicians treating chronic pain should assess and monitor for signs and symptoms
of substance dependence, such as aberrant behaviors surrounding medication use that
might indicate a loss of control over opioid use. Clinicians should monitor the manner in
which the patient is taking the medication and whether the patient complies with the
recommendations of the prescribing provider.
Clinicians should also determine whether the patient is taking opioid analgesics for
reasons other than pain relief, such as craving, anxiety relief, insomnia, or depression.
This can be accomplished by asking all new patients to complete a short set of
questions on alcohol and drug use. Computer prompts can be set to remind clinicians and
nurses to query all patients at some predetermined frequency and to be sure to target high-
risk patients: pregnant women, patients with uncontrolled hypertension, and tobacco users.
Some clinics assess alcohol use as a vital sign.
Toxicology screens are helpful in high-risk patients such as those receiving pain
medication or sedative drugs. For further details on how to organize practices to improve
the delivery of preventive services, see
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