ISSN 2155-6113

Journal of AIDS & Clinical Research

Open Access
H-Factor: 9
Google Scholar h5 index: 14

Index Copernicus Value: 104.14

Acquired Immune Deficiency Syndrome (AIDS) is a disease caused due to HIV virus that affects
the human immune system tremendously eventually leading to death. HIV is considered as one
of the fatal cause of death in the present times. The global scenario of AIDS is alarming and
number of infected patients is regularly increasing. The rapid adaptation and evolution of the
virus is another important issue. Hybridization of various subtypes is posing challenge to the
global efforts for remedy. Extensive clinical contribution is necessary starting from detection to
therapy. Although, therapeutic procedures such as HAART is existing but constant challenge is
being faced due to the evolution of the virus.

Journal of AIDS & Clinical Research provides a global open access platform to put forth the
research and relevant discussions on this burning issue. This journal considers almost all
aspects of research and social issues related to HIV and AIDS encompassing clinical virology,
molecular biology and epidemiology, HIV anxiety disorder, virologic failure, multiple
comorbidities, HIV dementia scale, tertiary facility in relation to HIV, perceived susceptibility,
drug resistance, drug toxicity, clinical research with relation to HIV treatment regime etc.
Discussions on clinical aspects that determine the safety and effectiveness of medications,
devices, diagnostic products and treatment regimens associated with treatment of HIV and co-
infected patients are also welcome in this journal. Essential information on advances in the
diagnosis and treatment of HIV infections as well as on the development of therapeutics and
experimental vaccines are also welcome for publication. Novel contributions are expected to
maintain the quality of the journal and to achieve high impact factor.

This AIDS journal is a scholarly journal maintains high standards of scientific excellence and its
editorial board ensures a rapid peer review process with the help of the Editorial Manager
System. Manuscripts are accepted for publication only if at least two reviewers agree on the
scientific quality of a submitted manuscript.

Advances in HIV Tests

Many advanced HIV testing methodologies has been developed to reduce the risk of HIV
infection. HIV testing helps to improve the health outcomes for the people living with HIV.
Window period, ELISA, ELISA dongle, Western blot, Rapid or point-of-care tests, Interpreting
antibody tests, Accuracy of HIV testing are the Antibody tests. Some other methods for HIV
testing are Antigen tests, Nucleic acid-based tests, Screening, CD4 T-cell count, Oral
tests, AIDS denialism and fraudulent testing.
HIV Status
People who infected with the human immunodeficiency virus are called as HIV infected people
and they abbreviated as PLWHA (People Living With HIV/AIDS). According to the AIDS
epidemic update by UNAIDS in 2007, 33.2 million people are infected with HIV/AIDS and more
than 68% of infected HIV individuals are living in Sub-Saharan Africa. According to a UNAIDS
report, more than 4 million people were receiving antiretroviral therapy by the end of 2008 and
there is an increase of 1 million compared with the end of 2007.
Advances in Preventive Transmitted Disease
Accurate immune chromatographic assays to detect HIV, hepatitis C virus (HCV) and syphilis
antibodies have made home or supervised self-testing possible along with feasibility and
excellent test characteristics for HIV, HCV and syphilis POC tests. Several rapid oral HIV
tests are now available for purchase along with combined HIV and syphilis tests using a single
finger prick blood sample are evolving. Sexually transmitted infections (STIs) remain a major
global public health issue, with million incident bacterial infections each year.
Advances in HIV Treatment
Antiretroviral therapy has revolutionized HIV treatment in the past few decades. And newer
improvements such as one-pill-a-day drugs are making life with HIV person easier and safer.
ART works by combining drugs that attack the virus in different possible ways. ART doesn't cure
HIV still it stops it from reproducing itself and spreading it across. The goal of treatment is to get
the viral load so low that tests can't even detect the virus anymore.
Advances in HIV Medications
Over the past years, HIV/AIDS has gone from a death sentence to a chronic, manageable
disease, all thanks to large part to advances in biopharmaceutical research and development.
The 44 medicines and vaccines in the development pipeline include 25 antivirals,
16 vaccines and three cell/gene therapies. However, many multiple medical advancements
have taken place since 1981, when the CDC identified the first five cases of HIV/AIDS.
Since anti-retroviral treatments (ART) were approved in 1995, HIV/AIDS-related deaths in the
United States have dropped
Highly Active Antiretroviral Therapy
Antiretroviral therapy (ART) is treatment designed for people infected with human
immunodeficiency virus (HIV) using anti-HIV drugs. The treatment consists of a combination of
at least three drugs (often called highly active antiretroviral therapy or HAART) that
suppress HIV replication. Three drugs are used in order to reduce the survival of the virus
developing resistance. ART has the potential both to reduce mortality and morbidity rates
among HIV-infected people, and to improving their quality of life. A combination of three or
more antiretroviral medicines is more effective than using just one medicine to treat HIV.The
use of three or more antiretroviral medicinessometimes referred to as an anti-HIV "cocktail"
is currently the standard treatment for HIV infection.
Antiretroviral Treatment
Antiretroviral treatment are medications that treat HIV. The drugs do not kill or cure the virus.
However, when taken in combination they can prevent the growth of the virus. When the virus is
slowed down, so is HIV disease. Antiretroviral drugs are referred to as ARV. Combination ARV
therapy (cART) is referred to as highly active ART (HAART). Each type, or class, of ARV drugs
attacks HIV in a different way. The first class of anti-HIV drugs was the nucleoside reverse
transcriptase inhibitors (also called NRTIs or nukes.) These drugs block step 4, where the HIV
genetic material is used to create DNA from RNA.
Risk Behaviours of HIV/AIDS
In the United States, HIV is spread mainly through anal or vaginal sex or by sharing drug-use
equipment with an infected person. Substance use can contribute to these risks indirectly
because alcohol and other drugs can lower peoples inhibitions and make them less likely to use
condoms. This section provides information on the various risk behaviours and what you can do
to lower your risk.

You have an increased risk for getting HIV if you:

Are a man who has sex with other men.

Have multiple sex partners, especially partners who inject drugs.

Inject drugs or steroids, especially if you share needles, syringes, cookers, or other equipment
used to inject drugs.

Have high-risk partner(s) (a man or woman who has multiple sex partners or injects drugs, or a
man who has sex with men).

Have or have recently had a sexually transmitted infection, such as syphilis or genital herpes.
Drug Resistance of HIV
The ability of HIV to mutate and reproduce itself in the presence of antiretroviral drugs is
called HIV drug resistance (HIVDR). The consequences of HIVDR include treatment failure,
need to start more costly second- and third- line treatments, increased health costs associated
with these, spread of drug resistant HIV, and need to develop new anti-HIV drugs. WHO, and its
partner organizations and experts of HIV ResNet group have developed a Global strategy for
the surveillance and monitoring of HIV drug resistance. The strategy generates data on the
emergence and transmission of HIVDR and equips countries with information to select first and
second line antiretroviral therapy regimens. Highlights
 REACTION
Knowing about HIV/AIDS is not new to me for it is really rampant in the Philippines. I have
attended a symposium about the said topic when I was in high school and somewhat learned
about it today in college. Since I am in a medical course, its normal to talk about the dos and
donts and other things in line with HIV/AIDS. In order for us (student nurses) to enter a job
when we passed the board exam and all, we should be healthy. Medical examinations are
required, with this study, we would be able to distant ourselves from having HIV/AIDS.

The Human Immunodeficiency virus infection/Acquired immunodeficiency syndrome or simply

know as HIV/AIDS is a disease of the human immune system caused by infection with Human
immunodeficiency virus (HIV). HIV is a kind of disease that leaves a person vulnerable to life-
threatening infections by damaging your immune system. There are a lot of advances thats
happening in the field of science right now that actually helps in the early detection and
treatment of HIV/AIDS (not totally terminate the disease but helps in slowing down the
destruction of a persons body). The treatment consists of a combination of at least three drugs
(often called highly active antiretroviral therapy or HAART) that suppress HIV replication. In
the journal above, it shows the different precautions for you not to have HIV/AIDS and advices
on how to treat it if you have the disease. I do think that the content of the journal is very helpful
for it explains, gives idea, teaches and warns the readers about the topic.

Even though HIV is common nowadays, and its a bad thing, there are individuals who admit
that it is tough for them to cope with the social demands and more often degradation.
Employees that were diagnosed with HIV should be treated with all the help that they need and
not be disregarded.