Chapter 125 Myoglobinuria Jolin Vissing Introduction “Tesla iota Sictnpen tere iter eatin of myogltin Under tal ci ‘tens myogiin etre i inmate ‘Rive Gs th Bagel, Te rts bares vse then rexcode 1M-210}6/ m9 sd th corespone 1b the myegitun present in approxinaaly 50g of ce. The urine ten lakes onan appearance of dak fer or cach Col Nyopcbin ma sall roe (17D) {ha cans of 19 ino acids ard he gene encoding svoglbin cris kot vee ns Because oltesal Sire the molcaleatin poems myoglobin precedes leat ofthe forte ger rene Kee (CK) Soke ring mess: injury Mywglabin is compooed theghtoal sxpment and with hr single eme proup iether ebay hen tole in cular oxygen supp bu i isnot crea for Saye erable. Thus lt transgenic mice ck yoglbia expression have scemal le expecta and neers, de adaptive spores such as mend scalingy and everworesson of typonbondacble Utanscrpten facurs Rhabdeavolss Is ele sel etn with seta and dos he {© bow of mune proteins incading myoglobin othe ‘tmcller pace Tapia or Un inal Sebago secon aweling of afced munky, nynigi, and “Smmtimeswentnese Common fal shige of mp0 Ebina vt jy fo te swore fhe of freray supply 1 main seeclernnaltansport tase ‘on whe neal ea to arse in itracl Calg, This wil get mcle conacion ant ihe ee for re energy, ml celeune-dependent presen Tid plecphalilaee wl aslo cal down coca prtia sratuces of the mace, ard Iysonces wil {igetthe protin de Thus deroptin of seelemal ‘eiegay cov © Vieni Gece iy ed a dune func Causes af myoglobinuria Myogbdeus hs many inne as weil as aac caunes They are commonly divide wo geet apd apf causes. Table 1251 flees an overview of the han etcogien, nding the main nese respon sible and te sna common ata or ach mechan Indlstingpiting toteeen eng ed beelitry eno, hepa te low char» tao cl ngoylobeiar eur or finite incident Horeioy ctor tnd hs etent eliemte epieed mone EAI ear jie ney endo: ny aos coped ih pid ger Ingmeckensms, such generalized epleptsenaes ot Arig! alahol share. neuroma cinics theve ma nt arcssoeing patents wh have resurentepsoge= of myoplobinuta due ta genet dscrer but squad ests wih nyoglobinura Tus inasialy f 77 pats trah mopleinarie sean in a nonapetileed inky ‘ely all bad seu cacy seco beng the ot ‘oni sme flee in onder of equine, by Us Immobilenion vith compro, gener’ siete Ac aus andr tte Rreber lfc ony prod tiny Lew physical ies dens the duration ae inka Fiypatoiemin anc hypophosohtems prise spyogbiam, potas by capone he nase xetnlonally may prnace myeqlobinuria sone ab at poetiting com Horeditary causes Recarent myoghibiuria isthe hallmark of mebibhc Spopaliia Using pura prnget abla ned Insc nidae (FAD) 77 apne bape fe patina with nosy recement myopbiura aedied aw