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1. What number represents a normal hematocrit?

45

2. The following description applies to which blood cell type:


major job is to eat bacteria in the blood stream and/or exit the
blood stream through vessel walls and eat bacteria in connective
tissue areas.

neutrophil

3. The following description applies to which blood cell type: is


known to phagocytize antigen-antibody complexes and thereby
plays a role in the function of the immune system.

eosinophil

4.The following description applies to which blood cell type: exits


the blood stream and lives and functions in connective tissue
spaces where it is recognized and termed a histiocyte or tissue
macrophage.

monocyte

5. Which of the following cell types can differentiate into and


function as a plasma cell?

lymphocyte

9.006 The following description applies to which cell type:


terminally differentiated cell, clock-faced heterochromatin pattern
in nucleus, prominent Golgi apparatus, extensive amounts of
rough endoplasmic reticulum.

plasma cell

7. The following description best describes which formed element


of blood: microtubular system, canaliculi connecting to the
surface, dense granules containing serotonin.

platelet

8. If some red blood cells are placed in 0.9% sodium chloride what
will happen to them?

nothing

9. Which of the following blood cell types has had its peripheral
membrane proteins, which are on the P surface of its
plasmalemma, well studied?

RBC

10. In histological preparations what is the diameter of a RBC in


microns?

7.3

11. The plasmalemma of the RBC is like a bag containing proteins


and water. What percent of the total contents of a RBC is
hemoglobin?

35

12. In a patient with sickle cell anemia what fundamental change


has occurred in the hemoglobin?

valine substituted for glutamic acid

13 Antigen-IgE antibody coupling occurs on the surface of this cell


resulting in a degranulation and release of histamine and other
active substances. Identify the cell.

basophil

14. Myeloid tissue is the term used to describe which of the


following?

red bone marrow

15. Myeloid tissue is composed of parenchymal and stromal


elements. All of the following are nonparenchymal elements in red
bone marrow EXCEPT:

myeloblast
16 During hematopoiesis cells move from one type of cell kinetic
compartment into a different cell kinetic compartment (functional
not morphological compartments). Place the following cell kinetic
compartments in correct order with respect to hematopoiesis:
1=mature or near mature cells, 2=cells which continuously divide
but only some of which differentiate while others do not
differentiate, 3=cells which divide and differentiate.

2-3-1

17 Which cell in the granulocyte line of maturation has large


numbers of only uncommitted, azurophilic granules in its
cytoplasm?

promyelocyte

18 Which of the following bone marrow cells has the highest


concentration of free polysomes in its cytoplasm?

basophilic normoblast

19 Which of the following bone marrow cells normally has


repeated rounds of DNA synthesis without accompanying
cytokinesis or cell division?

megakaryoblast

20 A patient in your care has a peripheral blood workup with the


following facts: WBC count of 38,000/cubic mm and most of the
circulating WBCs are large cells with large nuclei containing 2-3
prominent nucleoli, the cytoplasm contains many azurophilic
granules. What is the diagnosis?

promyelocytic leukemia

21 A patient in your care has severe neutropenia. Treatment with


which of the following growth factors would be beneficial for this
person?

G-CSF

22 At which of the following steps does nuclear extrusion occur?


orthochromatophilic normoblast - reticulocyte

23 In a normal bone marrow smear, what is the ratio of the


number of cells in the myeloid line to those in the erythroid line?

3-1

24 In a normal bone marrow smear, what is the ratio of the


number of cells in the myeloid line to those in the erythroid line?

3-1

25 A patient in your care has a reticulocyte count of 13%. What


could be going on?

chronic, significant hemorrhage

26 In which of the following would you expect to see smooth


cytoplasm which is about 50/50 basophiliceosinophilic?

polychromatophilic normoblast or myelocyte

27 After nuclear extrusion during erythrocytopoiesis the anucleate


cell produced is very slightly basophilic. What causes this hint of
basophilia?

polysomes

28 Which of the following blood cells has 3-5 nuclear lobes and
two different sized cytoplasmic granules?

neutrophil

29 Which of the following has 2 nuclear lobes and large


cytoplasmic granules containing major basic protein?

eosinophil

30 Which of the following has a bean-shaped nucleus and


azurophilic cytoplasmic granules?

monocyte
31 Which of the following has 2 nuclear lobes and large granules
containing heparin and histamine?

basophil

32 Which of the following has a heterochromatinized nucleus and


a thin rim of cytoplasm?

lymphocyte

33 What is the average percentage of eosinophils in a normal


differential count?

3%

34 What is the average percentage of neutrophils in a normal


differential count?

70%

35 What is the average percentage of basophils in a normal


differential count?

1%

36 What is the average percentage of monocytes in a normal


differential count

6%

37 What is the average percentage of lymphocytes in a normal


differential count?

20K grams

38 What is the normal number of leukocytes in an aliquot of


peripheral blood?

7000/microliter

39 What is the normal number of platelets in an aliquot of


peripheral blood?

250,000/microliter
40 What is the normal number of erythrocytes in an aliquot of
peripheral blood?

5 million/microliter

41 A 16N megakaryocyte leads what kind of mitotic cell life?

differentiating intermitotic

42 The neutrophilic metamyelocyte leads what kind of mitotic cell


life?

Fixed postmitotic

43 The reticulocyte leads what kind of mitotic cell life?

fixed postmitotic

44 The reticulocyte leads what kind of mitotic cell life?

fixed postmitotic

45 The megakaryocytoblast leads what kind of mitotic cell life?

diferentiating intermitotic

46 The pronormoblast leads what kind of mitotic cell life?

differentiating intermitotic

47 The pluripotential cell found in bone marrow leads what kind of


mitotic cell life?

vegetative intermitotic

48 The promyelocyte leads which kind of mitotic cell life?

differentiating intermitotic

49 The orthochromatophilic normoblast leads which kind of


mitotic cell life?

fixed postmitotic
50 The polychromatophilic normoblast leads which kind of mitotic
cell life?

differentiating intermitotic

51 The neutrophilic myelocyte leads which kind of mitotic cell life?

differentiating intermitotic

52 The first clear indication of characteristic cytoplasmic granules


(neutrophilic, basophilic or eosinophilic) appears in which of the
following?

polychromatophilic normoblast or myelocyte

53 The cytoplasm of which of the following is loaded with "free"


polysomes?

basophilic normoblast or promyelocyte

54 Nuclear indentation first begins to be noticed in which of the


following?

orthochromatophilic normoblast or metamyelocyte

55 Nuclear extrusion occurs in which of the following?

orthochromatophilic normoblast or metamyelocyte

56 Nuclear extrusion occurs in which of the following?

orthochromatophilic normoblast or metamyelocyte

57 Immature, azurophilic granules fill cytoplasm in which of the


following?

basophilic normoblast or promyelocyte

58 For which of the following is about 1% is considered normal in


peripheral blood?

reticulocyte or band/stab form

59 In peripheral blood, 13% of which of the following would signal


septicemia (a bacterial infection in the blood stream)?

reticulocyte or band/stab form

60 Which of the following would contain a very delicate chromatin


pattern and prominent nucleoli?

pronormoblast or myeloblast