PERIPHERAL NERVE DISEASE 2.

Chronic inflammatory demyelinating polyneuropathy (CIDP)

3. Paraproteinemias
4. Uremia (occasionally subacute)
The principal neuropathic syndromes and their causes 5. Beriberi (usually subacute)
I. Syndrome of acute motor paralysis with variable disturbance of sensory and autonomic 6. Diabetes
function 7. Connective tissue diseases
A. Guillain-Barre syndrome (GBS; acute inflammatory polyneuropathy; acute 8. Amyloidosis
autoimmune neuropathy) 9. Leprosy
B. Acute axonal form of GBS 10. Hypothyroidism
C. Acute sensory neuropathy and neuronopathy syndrome 11. Benign sensory form in the elderly
D. Diphtheritic polyneuropathy B. Syndrome of more chronic polyneuropathy, genetically determined forms
E. Porphyric polyneuropathy 1. Inherited polyneuropathies of predominantly sensory type
F. Certain toxic polyneuropathies (thallium, triorthocresyl phosphate) a. Dominant mutilating sensory neuropathy in adults
G. Rarely, paraneoplastic b. Recessive mutilating sensory neuropathy of childhood
H. Acute pandysautonomic neuropathy c. Congenital insensitivity to pain
I. Tick paralysis d. Other inherited sensory neuropathies, including those associated with
J. Critical illness polyneuropathy spinocerebellar degenerations, Riley-Day syndrome,
II. Syndrome of subacute sensorimotor paralysis and the universal anesthesia syndrome
A. Symmetrical polyneuropathies C. Inherited polyneuropathies of mixed sensorimotor types
1. Deficiency states: alcoholism (beriberi), pellagra, vitamin B12 deficiency, 1. Idiopathic group
chronic gastrointestinal disease a. Peroneal muscular atrophy [Charcot-Marie-Tooth; CMT types I
2. Poisoning with heavy metals and solvents: arsenic, lead, mercury, thallium, (demyelinating) and II (axonal) and CMTX]
methyl n-butyl ketone, n-hexane, methyl bromide, b. Hypertrophic polyneuropathy of Dejerine-Sottas, adult and childhood
ethylene oxide, organophosphates (TOCP etc.), acrylamide forms (CMT3)
3. Drug toxicity: isoniazid, ethionamide, hydralazine, nitrofurantoin and related c. Roussy-Levy polyneuropathy (CMT3)
nitrofurazones, disulfiram, carbon disulfide, d. Polyneuropathy with optic atrophy, spastic paraplegia,
vincristine, cisplatin, paclitaxel, chloramphenicol, phenytoin, pyridoxine, spinocerebellar degeneration, mental retardation, and dementia
amitriptyline, dapsone, stilbamidine, trichlorethylene, e. Hereditary liability to pressure palsy (HNPP)
thalidomide, clioquinol, amiodirione, adulterated agents such as L-tryptophan 2. Inherited polyneuropathies with a recognized metabolic
4. Uremic polyneuropathy a. Refsum disease
5. Subacute inflammatory polyneuropathy b. Metachromatic leukodystrophy
B. Asymmetrical neuropathies (mononeuropathy multiplex) c. Globoid-body leukodystrophy (Krabbe disease)
1. Diabetes d. Adrenoleukodystrophy
2. Polyarteritis nodosa and other inflammatory angiopathic neuropathies e. Amyloid polyneuropathy
(Churg-Strauss, hypereosinophilic, rheumatoid, lupus, f. Porphyric polyneuropathy
Wegener granulomatosis, isolated peripheral nervous system vasculitis g. Anderson-Fabry disease
3. Mixed cryoglobulinemia h. Abetalipoproteinemia and Tangier disease
4. Sjogren-sicca syndrome IV. Neuropathy associated with mitochondrial diseases
5. Sarcoidosis V. Syndrome of recurrent or relapsing polyneuropathy
6. Ischemic neuropathy with peripheral vascular disease A. Guillain-Barre syndrome
7. Lyme disease B. Porphyria
C. Unusual sensory neuropathies C. Chronic inflammatory demyelinating polyneuropathy
1. Wartenberg migrant sensory neuropathy D. Certain forms of mononeuritis multiplex
2. Sensory perineuritis E. Beriberi or intoxications
D. Meningeal based nerve root disease (polyradiculopathy) F. Refsum disease, Tangier disease
1. Neoplastic infiltration VI. Syndrome of mononeuropathy or plexopathy
2. Granulomatous and infectious infiltration: Lyme, sarcoid A. Brachial plexus neuropathies
3. Spinal diseases: osteoarthritic spondylitis B. Brachial mononeuropathies
4. Idiopathic polyradiculopathy C. Causalgia
III. Syndrome of chronic sensorimotor polyneuropathy D. Lumbosacral plexopathies
A. Less chronic acquired forms E. Crural mononeuropathies
1. Paraneoplastic: carcinoma, lymphoma, myeloma, and other malignancies F. Migrant sensory neuropathy
G. Entrapment neuropathies