PENGARUH EKSTRAK KENTAL DAGING JAMBU BIJI (Psidium

guajava) TERHADAP KADAR KOLESTEROL TOTAL DARAH

(Studi Eksperimental pada Tikus Jantan Galur Wistar yang Diinduksi Telur
Puyuh)

Karya Tulis Ilmiah

untuk memenuhi sebagian persyaratan

untuk mencapai gelar Sarjana Kedokteran

Oleh :
Lisa Ikha Herwiani
01.211.6435

FAKULTAS KEDOKTERAN
UNIVERSITAS ISLAM SULTAN AGUNG
SEMARANG
2015
 Karya Tulis Ilmiah

PENGARUH EKSTRAK RIMPANG LENGKUAS MERAH

(Alpinia purpurata (Vieill.) K. Schum) TERHADAP APOPTOSIS
SEL KANKER NASOFARING

Oleh :
Reny Dewi Fatmawati
01.209.5997

Telah disetujui oleh:

Pembimbing I

dr. Menik Sahariyani Tanggal

Pembimbing II

Siti Thomas Zulaikhah,SKM,M.Kes. Tanggal

 DAFTAR ISI

HALAMAN JUDUL ..........................................................................................

LEMBAR PENGESAHAN................................................................................

ii

DAFTAR ISI.......................................................................................................

iii

DAFTAR GAMBAR..........................................................................................

vi

DAFTAR TABEL................................................................................................

vii

DAFTAR LAMPIRAN.......................................................................................

viii

BAB I PENDAHULUAN.........................................................................

1 Latar Belakang......................................................................

2 Rumusan Masalah.................................................................

3 Tujuan Penelitian...................................................................

1 Tujuan Umum...........................................................

4
 2 Tujuan Khusus...........................................................

4 Manfaat Penelitian................................................................

1.4.1. Manfaat Praktis ........................................................

1.4.2. Manfaat teoritis.........................................................

BAB II TINJAUAN PUSTAKA .................................................................

2.1.........................................................Kolesterol

.......................................................................7
2.1.1 Definisi Kolesterol ...................................

7
2.1.2 Fungsi Kolesterol .....................................

8
2.1.3 Metabolisme Kolesterol............................

9
2.1.4 Mekanisme Transport Kolesterol dalam

Tubuh........................................................

10
2.1.5 Transport Kembali Kolesterol....................

11
2.1.6 Ekskresi Kolesterol....................................

11
2.1.7 Kadar Kolesterol Total...............................

12
 2.1.8 Pengukuran Kadar Kolesterol....................

13
2.1.9 Faktor-faktor yang Mempengaruhi Kadar

Kolesterol dalam Darah............................

14
2.2.............................................Jambu Biji Merah

.....................................................................16
2.2.1............................................Taksonomi

.............................................................16
2.2.2.............................................Morfologi

.............................................................16
2.2.3.....................Fungsi Daging Jambu Biji

.............................................................17
2.2.4...............Kandungan Daging Jambu Biji

.............................................................18
2.3.......................................Telur Burung Puyuh

.....................................................................21
2.4......................Tikus Putih Jantan Galur Wistar

.....................................................................21
2.5................Pengaruh Jambu Biji Terhadap Kadar

Kolesterol Total Darah ....................................

22
2.6..................................................Kerangka Teori

.....................................................................25
2.7...........................................Kerangka Konsep

.....................................................................26
2.8........................................................Hipotesis

.....................................................................26
BAB III METODE PENELITIAN...............................................................

27

1 Jenis dan Rancangan Penelitian ...........................................

27

2 Variabel Penelitian dan Definisi Operasional.......................

27

1 Variabel Penelitian....................................................

27

2 Definisi Operasional..................................................

27

3 Populasi dan Sampel.............................................................

29

4 Instrumen Penelitian..............................................................

30

5 Cara Penelitian......................................................................

21

6 Tempat dan waktu penelitian................................................

35

7 Alur Penelitian .....................................................................

36

8 Analisis Hasil .......................................................................

37
BAB IV HASIL PENELITIAN DAN PEMBAHASAN.............................

38

4.1Hasil Penelitian ....................................................................

38

4.2Pembahasan...........................................................................

41

BAB IV KESIMPULAN DAN SARAN.....................................................

46

5.1Kesimpulan...........................................................................

46

5.2Saran .....................................................................................

47

DAFTAR PUSTAKA .........................................................................................

48

LAMPIRAN .......................................................................................................

51
 DAFTAR GAMBAR

Gambar 2.1 Daun dan Buah Jambu Biji ...........................................................

16
 DAFTAR TABEL

Tabel 4.1 Diagram batang kadar kolesterol total antar kelompok perlakuan ..

39

Tabel 4.2 Hasil Uji Shapiro Wilk.....................................................................

39

Tabel 4.3 Hasil Uji Homogenitas Varian..........................................................

40

Tabel 4.4 Hasil Uji Mann Whitney..................................................................

41
 DAFTAR LAMPIRAN

Lampiran 1. Data Penelitian ............................................................................

51

Lampiran 2. Hasil Uji Statistik Deskriptif Data Kolesterol Total....................

52

Lampiran 3. Hasil Uji Normalitas dan Homogenitas Varian Data Kolesterol

Total.............................................................................................

53

Lampiran 4. Hasil Uji Kruskal Wallis Perbedaan Kolesterol Total Antar

Keenam Kelompok......................................................................

55

Lampiran 5. Hasil Uji Maan Whitney Perbedaan Kolesterol Total Antar Dua

Kelompok....................................................................................

56

Lampiran 6. Surat Keterangan Penelitian........................................................

64
Lampiran 7. Ethical Clearance.........................................................................

65