At the time flies Phlebotomus sucking the blood of patients with leishmaniasis, stage and in the
stomach sucked amastigot Phlebotomus, amastigot stage is transformed into a stage promastigot
which then migrate to the proboscis. Infection occurs by puncture Phlebotomus flies that enter
the stadium promastigot through probosisnya into the human body. Stadium promastigot,
multiply rapidly be split into many pairs of longitudinal and within 3-5 days.
Promastigot stage then migrate through the esophagus and pharynx to the hypopharynx channels
contained in the fly proboscis. Promastigot Stadium are the infective stage and can be
transmitted to humans when the fly sucks blood
When the flies bite humans and suck their blood, stage promastigot entry into
macrophages and transformed into amastigot stage, the next stage of this
amastigot breed again be split pairs of longitudinal and so live in the cells
(intracellular). Transmission can occur through direct contact flies bite wounds.
Parasites in the human body live intracellularly in the blood, which in the reticulo-
endothelial cells (RE) as the stadium amastigot called Leishmania donovan. These
parasites multiply split pairs and is approximately 2 microns. RE cells can be fully
charged by parasites, and cause the cell to rupture. Stadium amastigot while being
in peripheral blood circulation, and then enter or search for another RE cells, then
this stage can be found in RE cells liver, spleen, bone marrow and lymph visceral
limpe
Patologi Penyakit Kala Azar
Leishmania donovani is a protozoan that has one flagellum, 1 core and 1 kinetoplas.
Transmitted through the bite of blood-sucking flies.
prevention is done by:
a. all patients treated, to eliminate transmission
b. remove the rotting rubbish
c. eradicate wild dogs may be a reservoir leishmania donovani
v Leishmania tropica, in humans causes cutaneous leishmaniasis disease.
prevention is done by covering the skin lesions that are not exposed to flies to
prevent transmission to others and the eradication of insects with insecticide and
wild dogs.