Important Information about Low Dose Naltrexone

by Diana Gale

Read this entire document first ... it may just change

your life!

Low Dose Naltrexone is neither an immune "suppressant", nor an immune "booster".

LDN orchestrates the immune system and works to restore homeostasis (balance) in
whatever way you need. Some of the things we now know that LDN does in the body:
it enhances immune function by increasing endogenous endorphin production, reduces
inflammation, promotes DNA synthesis, and facilitates motility and healing in the gut.

Low Dose Naltrexone is an exception to the saying 'if something sounds too good to be
true, it probably is'.

When you talk to your doctor, explain CLEARLY that this is "Low Dose" Naltrexone-
only 2 to 4.5 mg! Give your doctor document # 12 "LDN information for physicians".

I believe that if you decide to give LDN a good try (6 months to 1 year), you'll probably
look at your life like this: "Before LDN" and "After LDN" - Diana Gale

PLEASE READ THIS ENTIRE DOCUMENT *BEFORE* STARTING

LDN!

Avoid the mistakes many people make with dosage and timing...
Feel free to forward this to anyone

NEW information comes to light as the LDN community grows and ages.

2009 DIANA GALE

 How Does LDN Work?

The video at http://www.ldnscience.org/ explains the action of LDN. Endorphins are opiate-like molecules produced
naturally in the body. The term endorphin' comes from endogenous morphine', meaning that it is created within the
body, differentiating it from opioids that are administered from external sources. Endorphins are produced in most cells
in the body, and are important regulators of cell growth and, therefore, the immune system. Disorders of the immune
system can occur with unusually low levels of endorphins. The particular endorphin that has been found to influence
cell growth and immunity is called Opioid Growth Factor (OGF) or Metenkephalin.

For an endorphin such as OGF to exert its beneficial effects, it must interact with the body's cells. It does this by
binding to a receptor on the surface of the cells. The receptor to which OGF binds is the Opioid Growth Factor
Receptor' (OGFr) previously known as the Zeta () receptor. For the endorphin system to be fully functional, two
elements are required: opioid production and cell interaction.

Naltrexone is an externally administered drug that binds to opioid receptors. In doing so, it displaces the endorphins
which were previously bound to the receptors. Specifically, by binding to the OGF receptor, it displaces the body's
naturally-produced OGF. As a consequence of this displacement, the affected cells become deficient in OGF and three
things happen:

1. Receptor production is increased in order to try to capture more OGF.

2. Receptor sensitivity is increased, also to capture more OGF.
3. Production of OGF is increased in order to compensate for the perceived shortage of OGF.

Since LDN blocks OGF receptors only for a few hours before it is naturally excreted, what results is a rebound effect in
which both the production and utilization of OGF is greatly increased. Once the LDN has been metabolized, the
elevated endorphins produced as a result of the rebound effect interact with the more-sensitive and more-plentiful
receptors - all to assist in regulating cell growth and immunity.

The duration of the rebound effect varies from individual to individual, but generally persists for about one day. The
benefits of the rebound effect can only be utilized by taking a low dose of regular Naltrexone. Taking a high dose of
Naltrexone, or using a timed-release formulation, will result in continuous blockade of OGF receptors, and there will be
no rebound effect.

The use of regular-dose Naltrexone results in continuous opioid receptor blockade', whilst the use of low-dose
Naltrexone results in temporary opioid receptor blockade'. In order to benefit from the rebound effect and achieve the
therapeutic benefit of LDN, it is essential to avoid full-dose and timed-release versions of the drug.

Individual metabolism varies, and this results in a variation of the speed at which LDN is eliminated from the body, as
well as the length of the endorphin rebound effect. A single daily dose (between 3.0 mg and 5.0 mg) is suitable for most
people; however, modification of the dosage is sometimes needed. Many people find the right dosage with trial and
error. Recently in the history of LDN use, individuals have reported a response to double-dosing -- LDN is taken
morning and evening -- for example: 2.0 mg to 5.0 mg at night and 2.0 mg to 5.0 mg in the morning. It has also been
reported within the last few years that the need for LDN MAY be reduced after 3 to 5 years at 4.5 mg (3.0 for M.S.).
Experts now understand that each person must experiment to find the right dosage, and that the right dosage MAY
change as the body heals. Also, over time, you may no longer be clearing the dose in the 4-6 hours required to give
sufficient time for the OGF to interact with its receptor to control cell proliferation.

The beneficial effects of Low Dose Naltrexone were first discovered by Dr. Bernard Bihari, M.D., a physician in New
York City treating addicts, some of whom also had Multiple Sclerosis. He discovered that a small dose stimulates the
body to greatly increase production of endorphins, enkephalin and metenkephalin, which orchestrate the immune
system. Although Dr. Bihari did much of the early clinical work, Dr. M. Zagon did groundwork with animal research
studies at Pennsylvania State University. Multiple Studies have been done that prove the efficacy of LDN for multiple
conditions.

2009 DIANA GALE

Many people with ONE immune/autoimmune condition will go on to get more. This is called a "constellation". For
example, people often have EBV, Hashimoto's & Interstitial Cystitis together. A constellation may appear over a period
of years. So ... should you have only one condition, this is an extremely good and urgent reason to begin LDN as soon
as possible to prevent the piling on of other conditions now that your immune system is reactive.

"...To the best of my knowledge... there has never been a drug that could help so many different conditions at such a
low cost and with so few side effects. To me, that is a wonder!" --Dudley Delany, LDN advocate.

Some New Information about the Secondary way that LDN Works!

LDN blocks toll-like receptors (TLR4) on microglia, which are a part of the immune system
that cleans up damaged cells by destroying them. This inflammatory response is triggered by
lipo-polysaccharides (LPS), which attach to TLR4 receptors on microglia, stimulating a destructive
response via cytokines, thereby damaging healthy cells in the vicinity, which then produce more
LPS, stimulating even more of an inflammatory response from microglia ... a vicious cycle.

By blocking the TLR4 receptors for just a few hours after each small dose is taken, LDN
interrupts the feedback loop, calming the immune response and allowing the damaged tissue
to heal.

IMPORTANT INFORMATION ABOUT LDN & CANDIDA ISSUES

LDN users who stop taking LDN treatment for a few weeks or months have reported issues with Candida Albicans in
the gut and on the skin. As well, a few LDN users who did not pause treatment have reported Candida issues.
Information about why this happens does not appear to be forthcoming; however, there is a very good treatment
available. People using HOMEOPATIC "Candida Albicans" report that it has done a great job of controlling their
Candida issues. If you have a Naturopath who can prescribe a proper dosage, go with that. If you have to self-treat -
there are reports that the 30C strength 2 to 3 times a day has been very, very good at controlling Candida. Side-effects
or harm from homeopathic Candida pellets has not been reported. This is a recommended link to purchase a quality
homeopathic at a very good cost: http://www.elixirs.com//products.cfm?productcode=S11

FAQS with a Physician & an LDN Expert

Q: I am on long-term Opiate pain medication. Can I take LDN now?

A: NO. Long-term opiates, taken regularly several times per day, cannot be used for at least 2-3 WEEKS, if not longer,
prior to starting LDN. If you are on long-term opiates, work with a medical professional as you make the change to
LDN. To simplify, LDN will rip the opiates from the endorphin receptors in your body, causing withdrawal symptoms.
If the use of opiates is intermittent or 'as needed' and not taken daily/several times per day, LDN can be started
cautiously at a lowered dose (.50 mg) as a test. If there is a withdrawal reaction that is unbearable, stop LDN and wean
off the opiates for a week or two; then try again. Once on LDN for good, a single dose of an opiate 12 hours after the
dose of LDN can be attempted only as needed; however, Tramadol is the only recommended opiate for this type of
temporary use. Again, if there is a reaction, change to a non-opiate pain medication.

Low-Dose Naltrexone can be made by the individual, or compounded at various pharmacies. LDN is not a radical
treatment. Tell your physician that you wish to try a well-known FDA approved drug at 10 times a smaller dose than
usually taken, and that you can do it under his supervision, which you would very much appreciate, or you can do it on
your own. Often doctors will respond to this way of looking at the topic in a positive way. Try rating your pain and
symptoms on a scale of 1 to 10 and sharing your (hopefully vast) improvement with the doctor as you titrate LDN from
.50 or 1.0 mg, to whatever dosage you eventually settle upon.

2009 DIANA GALE

Many LDN users report no need for prescription pain medication of any kind as long as they are on LDN. LDN will
make all opiates work better, due to the great increase of endorphin receptors, so use caution and take a lower dose.
PLEASE READ "Drugs that may interact with LDN" and "Drugs not to take with LDN", found in this packet.

Q: I heard that LDN works because of the placebo effect. Is this true?
A: NO. Some naysayers claim that the reason LDN works for millions of human beings is because of the placebo effect.
Research with animals shows marked and measurable improvements in their diseases. Animals do not read and cannot
grasp what a placebo is, so their improvement cannot be attributed to the placebo effect. LDN does nothing except shut
down your body's endorphin production and cell receptors for a short period, and this brief switch-off basically tricks
production of endorphin, enkephalin and metenkephalin into high gear.

Q: I heard someone say they take LDN, but they are not sick.
A: Many healthy medical practitioners take LDN and prescribe it to the entire family--children and pregnant/nursing
women included--as a preventative for cold, flu and virus, and to prevent infection with many chronic and autoimmune
diseases. It is the experience of many LDN users that as long as they are on it they rarely experience colds, flu, viruses,
depression or anxiety and if they do get a cold/flu, they are able to fight the infection off more quickly than usual and
get far fewer secondary infections.

Q: Can I take LDN if I am trying to get pregnant?

A: LDN is said to be safe during pregnancy. Dr. Phil Boyle, a specialist in fertility says: "I am confident that LDN is
perfectly safe in pregnancy and in certain cases will actually reduce the risk of miscarriage. I have been prescribing
LDN regularly during pregnancy... and the results have been excellent. Clinical experience has proven to me that it is
safe. We've had over 50 babies whose moms have been on LDN throughout their pregnancies and those babies, if
anything, have been even healthier than those whose moms haven't been on [low dose] Naltrexone."

A Letter to give to your medical professional (slightly edited)

"LDN is a major breakthrough, but like other innovative therapies, it's virtually ignored by conventional physicians. It's
the same old song and dance: 'If it were any good, I'd know about it.' Yet this safe, economical drug stands to benefit
millions - not only those with cancer and MS, but also people dealing with autism, Parkinson's, fibromyalgia, chronic
fatigue syndrome, and other autoimmune diseases.

Cancer in Remission http://www.ldnnow.co.uk/8601.html?entryId=a2adaa85d14f99c2ce4d0f9c77741fdc

Autoimmune Disorders Respond Well A recent pilot study found that LDN improves mood, cognition, and pain
scores in patients with progressive multiple sclerosis. And researchers from Pennsylvania State University College of
Medicine demonstrated that 67 percent of patients with Crohn's disease who were treated with 4.5 mg of LDN for 12
weeks went into remission. The buzz from patients is even better than the studies. Vicki Finlayson had suffered with
debilitating multiple sclerosis. After 10 years of unbearable pain, horrible fatigue, growing depression, and dependence
on Vicodin and morphine to control her pain, Vicki learned about LDN. Once she started taking it - after her doctor
initially refused to prescribe it and she had to wean herself off opioid painkillers - she got her life back. She's been back
at work a year and a half now, she's off all other drugs, and she's feeling great.

Recommendations In addition to the conditions discussed above, LDN is an excellent therapy for general health
enhancement and disease prevention. The only contraindication is narcotic drugs. LDN blocks their effects and could
cause withdrawal symptoms, so it should be started only after those drugs are completely out of your system. LDN is
safe and well tolerated. Some people report vivid dreams at first, but in my clinical experience, sleep disturbances are
rare. To avoid this, you may want to start with a [low] dose... and build up slowly over two months. To learn more

2009 DIANA GALE

about LDN, visit lowdosenaltrexone.org or simply surf the Internet. This will give you a feel for patient enthusiasm for
LDN. ~ Julian Whitaker, MD."

Purchasing Naltrexone

LDN from the NHS

Hundreds of GP's are prescribing LDN on the NHS in Britain, but they will only prescribe if you are a patient and live
within their catchment area, so go ahead and provide this LDN Packet to your own GP first. If they refuse to prescribe,
contact the practice manager of other GP surgeries in your area and ask if any of their doctors will prescribe LDN for
you if you become a patient. Many people have done this with success.

Crystal Nason Ferguson keeps a list of legally prescribing doctors from all over the world. Please email her at:
angelindisguiseldn@yahoo.com. Crystal's website: http://crystalangel6267.webs.com/mystory.htm

Dr. Tom Gilhooly of Scotland prescribes LDN for many of his patients: http://www.ldnresearchtrust.org/ldn-
information/58-dr-tom-gilhooly-mbchb-mrcgp.asp

Websites that sell LDN & Naltrexone

This information is provided for an International audience. You take full responsibility for your actions
under the laws of the country in which you live.

http://www.webspawner.com/users/howtoobtainldn/index.html http://www.ldnaware.org/ldn-info/101-pharmacies-and-chemists-
usa.asp

International Pharmacy Websites

Prices & websites change! Please let me know if you find a website that is no longer working, or you
find new ones I can add! <jdothermail@gmail.com>

Pharmacies cannot accept PayPal for Rx purchases for legal reasons. It can be safer to use a Prepaid Visa
(walmart.com sells the cards)

CHEAPEST w/o a Script:

All Day Chemist 50 mg -- 10 pills=$20.35, 30 pills=$58.87, 60 pills=$11.37 + shipping
https://www.alldaychemist.com/search.php?search_query=Naltima

Euro Drugs
50 mg -- 30 pills=$133, 60 pills=$254, 90 pills=$364 + shipping
http://www.eurodrugstore.eu/alcohol-drug-treatment__50__en/naltrexone__2994.html

Anti-Aging, U.K.
30 pills of 4.5 mg=$59.99 + shipping
http://www.antiaging-systems.com/113-naltrexone

River Pharmacy, Canada Complaints have been made about the consistency of their pills. Buy at your own risk!
IF you do end up using these pills, it is recommended to make a 3-pill refrigerated solution with distilled water to

2009 DIANA GALE

help even out the consistency of each dose
50 mg web order prices -- 10 pills=$49.72, 30 pills=$133.50, 60 pills=$177.00, 90 pills=$198.00, 120 pills=$238.14
https://www.riverpharmacy.ca/drug/revia

Trinova Health Compounding Pharmacy

fill out our confidential contact form, or call the pharmacy at 844-219-2139. Trinova Health works with many
physicians and can easily help you locate one in your area. Some patients may even be able to have their visit from the
comfort of their home via telehealth
http://www.trinovahealth.com/

United Pharmacies, India. Complaints have been made about the strength of their pills. There are also recent reports of
fraudulent use of credit cards used there. It is recommended that you use an International cash card in the exact amount
required to make purchases from this site. Trust the quality and use your personal credit/debit card at your own risk! IF
you do end up using these pills, it is recommended to make a 3-pill LDN refrigerated solution with distilled water to
help even out the consistency of each dose.
https://secure.unitedpharmacies.com/customer/search.php?substring=Nodict

Pharmacies known to be reliable compounders of LDN

(see SEE NOTES about issues with compounding pharmacies here:
http://www.lowdosenaltrexone.org/comp_pharm.htm)

IMPORTANT: Be sure to specify that you do NOT want a slow-release form!

Pharmacy Phone Fax

(212) 685-0500
Irmat Pharmacy, New York, NY (212) 532-6596
(800) 975-2809

Gideon's Drugs, New York, NY (212) 575-6868 (212) 575-6334

Belmar Pharmacy, Lakewood, CO (800) 525-9473 (866) 415-2923

(630) 859-0333
The Compounder Pharmacy, Aurora, IL (630) 859-0114
(800) 679-4667

The Pharmacy Shop and (585) 396-9970

(585) 396-7264
Compounding Center, Canandaigua, NY (800) 396-9970

McGuff Compounding Pharmacy, (714) 438-0536

(877) 444-1155
Santa Ana, CA (877) 444-1133

2009 DIANA GALE

 (416) 488-2600
Smith's Pharmacy, Toronto, Canada (416) 484-8855
(800) 361-6624

+44-141-647-8032
Dickson Chemist, Glasgow, Scotland +44-141-647-8032
+44-800-027-0673

PLEASE send me contact info for any trusted pharmacy not in the list!

How to Make Oral LDN Solution with a 50 mg prescription Naltrexone pill

A video showing how to do this: http://www.youtube.com/watch?v=bOekLFIvR7I&feature=related

Each 50 mg pill is mixed in 50 ml of distilled bottled water. 1 ml of the mixture = 1 mg of LDN.

1) Use a needle-less syringe and a container with a wide opening (get a free syringe and orange prescription bottle with
a pop-top from the pharmacy).

2) To fill, draw water up to the 5 ml line on the syringe TEN times and squirt it into the container for a total of 50 ml.
(If using a 10 ml syringe, draw up 10 ml FIVE times). Use a permanent marker to make a line on the outside of the
container at the top of the water line and cover that with clear tape so it won't rub off. View the liquid level by placing
the container on a flat surface to make sure it is always consistent.

3) Now fill the container to the line, throw in a pill and let it sit for an hour or so to dissolve. It is not necessary to crush
the pill.

4) Shake the mixture very well once the pill is dissolved. Once the liquid has been used up, wash, rinse and dry before
making another batch. Store it in the refrigerator in very warm weather, but this is not necessary if you plan to use it up
within a few days.

5) The blood plasma half-life of LDN is about 4-5 hours. Since I want the LDN out of my system by the time
endorphin levels peak (generally between 2-4 a.m.), I take my dose each night at 10 PM during Daylight Savings.
During winter months I take it at 9 p.m.

Topical LDN can be compounded at the special pharmacies listed above.

Titration

Dr. Jaquelyn McCandless states that one should never skip a dose of LDN for the first six months of use, as this can
cause confusion in immune response. After 6 months or so, if a dose is accidentally skipped, this is not so severe, but
she recommends never skipping a dose on purpose unless it is unavoidable.

2009 DIANA GALE

 Dosage
Dosage is often determined by trial and error. Most educated users start with .50 mg for 3 weeks and only experience
mild side-effects. If your liver is ever seriously compromised, a lower dose may be needed. Those with Hashimoto's and
Adrenal Fatigue usually start out very slowly and carefully - LDN can activate issues before addressing them, and going
up too quickly can cause unneeded stress.

ONE FULL YEAR is the recommended period to trial LDN to know for certain whether it will work for a health
issue. LDN can greatly help with adrenal fatigue, but it happens in a roundabout, indirect manner over time. It can be a
year or more before one might notice changes in adrenal function.

9-2013 UPDATE: Dr. Zagon, LDN expert, is recommending that if symptoms begin to return after some time at 4.5
mg, try taking LDN every other night, or even every 3rd night. He also suggests that less than 4.5 mg may be a better
dose for many users -- many people are reporting that after a few years, they can lower the dosage.

PLEASE study LDN news online to keep up with the latest information!

Side-Effects
Lasting clinical side-effects have not been reported for Low Dose Naltrexone, and very few lasting, adverse reactions
have ever been reported. Many LDN users report that even if they experience mild sleep issues, they do not wake up
exhausted, or struggle with fatigue the following day.

Herxheimer Reaction http://www.lauricidin.com/herxheimer_reaction.asp

Rapid killing-off of large amounts of fungus, bacteria and/or viruses in the body can make one feel very ill, and may
occur when LDN is first started if the initial dose is too high. This is one good reason it is recommended to raise dosage
slowly over a period of weeks, and use whatever other supplements or medications are needed to combat infection,
fungus or viruses.

More LDN Facts

LDN is mainly excreted in the urine with 60% of an orally administered dose recovered over a 48-hour period and only
23% excreted through the bowel. LDN has a half-life of about 10 hours and is approximately 20% bound to protein.

LDN induces a sharp increase in pituitary and adrenal production of beta-endorphin and metenkephalin (OGF) in the
pre-dawn hours between 2 am and 4 am, when 90% of the manufacturing of those hormones occurs. Most studies have
shown that Low Dose Naltrexone induces a two- to three-fold increase in the production of metenkephalin overnight.
LDN only stays in the system 4 to 5 hours, so if it is taken it too early or late in the evening, the peak endorphin
production time is missed. Taken at other times of day, the endorphin boost may not be enough to halt disease
progression if disease is chronic and progressive. LDN not only increases endorphin production; over time it also
increases the number of important immune cell receptors that use endorphins.

OFF-LABEL USE. While it is illegal for a pharmaceutical company to market or promote a drug for a use other than
that approved by the FDA, it is NOT illegal for a physician to prescribe an FDA-approved drug for a non-FDA-
approved use. This is called an "off-label" prescription, and physicians do it every day. Neurontin was approved by the
FDA in 1993 for the treatment of epilepsy; yet it is routinely prescribed off-label for the treatment of MS. All
physicians understand that the responsible off-label use of an FDA-approved medication such as Naltrexone is perfectly
ethical and legal.

2009 DIANA GALE

 A Talk by Dr. Tom Gilhooly (edited slightly)

"The 2nd European LDN conference in Glasgow this year saw the first presentation of a remarkable study into LDN for
the treatment of fibromyalgia by Dr Jarred Younger of Stanford University. This is the sort of top quality research that
we have been crying out for, and perhaps even more remarkable than the results of the study was Dr Younger's clarity
on how LDN works. The vacuum that has existed in LDN research has been filled by lots of myths and legends, such as
timing of administration and dosage of the drug. Dr Younger explained that LDN is a "racemic mix" of mirror image
right- and left-handed molecules. This is common in chemistry, and most drugs consist of such a natural mix. It is usual
for only one of the sides to be biologically active, but in the case of LDN, both sides are active. The right handed
molecule blocks the opiate receptors, which confer the action the drug is licensed for i.e., blocking the action of heroin
and other illicit opiates. The more interesting part regards the left-handed molecule, which acts on the Toll-like 4
receptors on the surface of immune cells and acts as an immune modulator. Dr Younger studied the effect on microglial
cells, a type of immune cell important to the neurological system, which becomes active when the immune system is
activated. These cells are important in fibromyalgia, but also in MS, Parkinson's, and other neurological conditions. The
left-handed Naltrexone binds to these receptors and reduces the inflammatory chemicals that are pouring out of these
cells. This idea makes great sense and fits very well with our findings in the clinic. If this is the mode of action, it fits
with the hypothesis of Dr Agrawal and others... This is a big discovery... This would suggest that the opiate-blocking
effect of LDN is actually the limiting factor on dose and we should aim to get the highest dose possible that the patient
can tolerate, to produce the greatest effect on the immune system. It also puts paid to the idea that LDN is an 'immune
booster' that should not be used with other immune modulators: In fact, it is likely that LDN will be synergistic with
these drugs. As if this were not enough ... along comes the much-anticipated double-blind study on Crohn's Disease by
Prof Jill Smith and Ian Zagon from Penn State. This shows a remarkable 83% improvement in the LDN group, with
almost half going into remission... In Crohn's disease and other inflammatory bowel diseases including Celiac, there is
an increase in Toll Like 4 Receptor numbers on the bowel mucosa. This could explain the rapid and dramatic response
to LDN of many patients with these conditions."

Cautionary Warnings! http://www.webspawner.com/users/avoidthesedrugsonldn/index.html

OPIATES. Because LDN blocks opioid receptors throughout the body for three to four hours, users cannot take a long-
term narcotic like Hydrocodone, Morphine, Percocet, or codeine-containing medication. Patients who have become
dependent on daily use of narcotic-containing pain medication may require 10 days to 2 weeks to wean off of it
completely before starting LDN, but it is well worth the effort! Substitute one of these non-narcotic painkillers
approved for use with LDN when weaning off narcotics: Moxxor, Aspirin, Tylenol, Advil, Motrin, Aleve, Naprosyn,
Ansaid, Dolobid, Orudis, Voltaren, Feldene, or Mobic. The food supplement DL-Phenylalanine (DLPA) is said to
enhance the effectiveness of LDN and can be taken twice a day on an empty stomach in doses of 500 mg.

MS DRUGS. Some MS drugs are not indicated for use with LDN. If there is any doubt, please submit to your doctor a
full list of the drugs you are presently taking so that their compatibility may be assessed. Dr. M.R. Lawrence talks about
LDN for MS: http://www.webspawner.com/users/sideeffectsofldn/index.html, http://tinyurl.com/treating-ms-relapses

STEROIDS. In the past it was believed one should not take them with LDN, but currently many use oral steroids like
Prednisone (up to 10) and Hydrocortisone (up to 40) while taking LDN.

PLAQUENIL (Hydroxychloroquine). LDN and Plaquenil can be taken together. The LDN Research Trust group on
Facebook has members who take both successfully.

CHEMOTHERAPY There is no known problem combining LDN with chemotherapy, and in theory (based on work
done with animals), LDN could enable the chemo to work more effectively. This is because LDN raises OGF levels that
act to slow down cell division, enabling the chemo to achieve a greater effect than if taken alone. However, if any
opiate pain killers are being taken with the chemotherapy, LDN would neutralize the effect of the painkillers for several

2009 DIANA GALE

hours.

FILLERS http://www.lowdosenaltrexone.org/gazorpa/LDNFillers.html

Calcium Carbonate. Some pharmacies and manufacturers use a substance called Calcium Carbonate as filler when
compounding or making pills, which makes the medication time-release or slow-release in the body. LDN stimulates
the body to create high endorphins at a specific time. It is this endorphin boost that triggers the immune system to
modulate. Basically one wants as many endorphins as possible to jump-start the immune system. If the Naltrexone pill
has CC as the filler, the drug will be slow-release and the body will never achieve that high level of endorphins. This
basically shoots down any chance of getting the maximum potential for the immune system. This is an even bigger
concern for cancer patients who need immediate results from LDN.

Some users who switched brands of LDN had a return of their symptoms. The brands they switched to had Calcium
Carbonate as filler. Dr. Bihari confirmed this in an interview, saying that anyone on LDN, particularly a cancer patient,
should avoid Calcium Carbonate at all times. Check the ingredients of every supplement and medication for Calcium
Carbonate, especially Alpha Lopioc Acid and B-Complex vitamin pills. Common fillers that seem to have no adverse
effect on LDN uptake are Lactose, Acidophilus and Avicel (which is a fast-releaser). Dr. Bihari has been quoted as
saying Lactose is his preference. Ask the pharmacist and avoid Calcium Carbonate to get the most out of each LDN
dose.

LDN has the top-rated ability to raise endorphin counts. Dr. Bihari said that about 65% of his patients experienced a
complete stop of disease progression. Of those, 30% went into full remission. If success is reliant on endorphin
production; then perhaps we should be focusing on doing other things to stimulate that. Some natural ways to do this
are aerobic exercise and acupuncture. Chocolate has a substance called Phenylalanine, which slows the breakdown of
endorphins in the body.

Books
Google LDN by Joseph Wouk (e-book no longer free) http://video.google.com/videoplay?docid=4440379733824898139

201 Reasons for LDN by the LDN Research Trust for International LDN Awareness Week 18-24 October 2010. (free e-
book attached with this email). Download http://www.ldnresearchtrustfiles.co.uk/docs/eBook.pdf

The Faces of Low Dose Naltrexone created for the First International Low Dose Naltrexone Awareness Week. (free e-
book attached with this email) Download http://ebookbrowse.com/ebook-sept-14-09-the-faces-of-low-dose-naltrexone-pdf-d85722067

Those Who Suffer Much Know Much - Low Dose Naltrexone (LDN) Why Weren't You Told? 51 case studies compiled
by Cris Kerr of Case Health, fifth revised. (free e-book attached with this email) Download
http://www.keephopealive.org/naltrexonecasereports.pdf

The Promise of Low Dose Naltrexone Therapy: Potential Benefits in Cancer, Autoimmune, Neurological and Infectious
Disorders by Elaine Moore, McFarland Publishing. Up the Creek with a Paddle: Beat MS and All Autoimmune
Disorders with LDN, by Mary Bradley.

Websites, Groups & LINKS

A List of Clinical Trials: http://www.lowdosenaltrexone.org/ldn_trials.htm

Ulcerative Colitis/Crohn's/Celiac/IBS Info with Studies:

http://wp.rxisk.org/low-dose-naltrexone/

2009 DIANA GALE

http://drhoffman.com/article/one-patients-uc-success-story-2/
Other:
www.lowdosenaltrexone.org/ldn_trials.htm
www.healingwell.com/community/default.aspx?f=17&m=2119242
http://www.crohnsforum.com/showthread.php?t=31142
http://curetogether.com/blog/2011/09/20/crohns-study-results-29-treatments-rated-by-patients/
www.drdach.com/Crohn_s_LDN.html
www.posterwall.com/blog_attachment.php?attachmentid=2477&d=1300033072
www.ncbi.nlm.nih.gov/pubmed/17222320
http://api.ning.com/files/8gos8*N7Z7vvpKWIW*mQnFAbzT7tktUr-Rz0p40C-SrjURj0O4WkkOW2TqwCyx3gj4v-
BdMqQHUEVohnIgYoW8B0LF4P7yJS/Crohns2011.pdf.

MS Trials:
www.ncbi.nlm.nih.gov/pubmed/18728058?ordinalpos=&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.
SmartSearch&linkpos=1&log$=citationsensor

http://onlinelibrary.wiley.com/doi/10.1002/ana.22006/abstract

Glioma Trial: Katherine B Peters, MD, PhD, a neuro-oncologist at Duke University, is the principal investigator. The
placebo-controlled, randomized clinical trial involves patients with high-grade malignant Glioma. They receive, in
addition to standard chemo-radiation, either placebo or LDN. http://clinicaltrials.gov/ct2/show/NCT01303835

Cancer Studies:
www.ncbi.nlm.nih.gov/pubmed/16484716?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RV
DocSum&ordinalpos=6

Fibromyalgia Studies: www.ncbi.nlm.nih.gov/pmc/articles/PMC2891387,

http://curetogether.com/blog/2011/10/05/stanford-fibromyalgia-study-on-ldn-replicated-at-curetogether

Many healthy people take LDN for anti-aging and to increase stamina, such as Dr. Berkson, the ALA guru:
www.honestmedicine.com/2009/03/burt-berkson-md-phd-talks-with-honest-medicine-about-his-work-and-our-medical-
system-the-interview-t.html

Read Francie's post: http://ldn.proboards.com/index.cgi?board=personal&action=display&thread=2496

Facebook

www.facebook.com/groups/LDNRT/?ref=ts&fref=ts LDN Research Trust Group.

Other Links

www.rsds.org/2/library/article_archive/pop/Younger_LowDoseNaltrexone.pdf Fibromyalgia Study.

www.googleldn.com/ Joseph Wouk's website.

www.curetogether.com A consumer driven Health 2.0 - A company that brings patients with hundreds of conditions
together in overlapping data communities, to share and learn from each other privately.

www.lowdosenaltrexone.org Dr. Bihari's 20 years of clinical experience with LDN for MS, cancer, HIV

2009 DIANA GALE

www.inspire.com/groups/.../success-with-ldn-treatment Scleroderma Foundation LDN discussions.

www.ldners.org/resources.htm UK LDN Research Petition Drive and Interview.

www.lowdosenaltrexone.org/gazorpa/PatientGuide.html How To Talk to Your Doctor about LDN.

www.youtube.com/watch?v=mDIuzw6LyiI http://www.youtube.com/watch?v=1fzqY42rvTY LDN Q & A Video

Parts 1 & 2

www.ldndatabase.com/ LDN World Database. Not just anecdotes -- this is Patient Based Evidence! Post your results!

www.lowdosenaltrexone.org/ldn_latest_news.htm Project LDN: Funding Clinical Trials - and organizer of the USA
LDN Conferences.

www.patientslikeme.com/ Resource for tracking diseases and many patients using LDN.

www.thisisms.com/forum/low-dose-naltrexone-f10/ LDN & MS, with a Forum.

crystalangel6267.webs.com/ Crystal's LDN Website.

www.ldnresearchtrust.org/ Fund raising for a clinical trial of LDN against MS.

www.ldn.org.pl/ Polish Language LDN Site.

groups.yahoo.com/group/Autism_LDN Autism LDN Yahoo Group - information from Dr. Jaquelyn McCandless.
Check the Files section.

www.ldn-for-fibro.com/ Discussion group.

www.ldn4cancer.com Dee's story, including published papers on treating cancer w/ LDN.

ldn.proboards.com/index.cgi Dr. McCandless Autism discussion board

www.ldnafricaaids.org/ Mali HIV + AIDS LDN Initiative Dr. McCandless.

www.lowdosenaltrexone.org/ LDN Org.

hwww.ldnscience.org/users-stories User's Stories.

www.ldnresearchtrust.org/ LDN Research Trust.

http://articles.mercola.com/sites/articles/archive/2011/09/19/one-of-the-rare-drugs-that-actually-helps-your-body-to-
heal-itself.aspx Doctor Mercola supports LDN use.

http://thecompounder.blogspot.com/2012/06/relieve-itching-with-naltrexone-cream.html Article on topical LDN cream.

Pets & LDN

www.ldndatabase.com/pets.html Database for pets on LDN

2009 DIANA GALE

www.skipspharmacy.com Dr. Skip Lenz knows quite a bit about LDN for pets.

http://health.groups.yahoo.com/group/LDN_4_Pets/ a Yahoo group.

www.lowdosenaltrexone.org/ldn_trials.htm#Animal Clinical trials.

A Working List of Conditions & Diseases for which LDN is used

Look up your condition in this list by medical or common name

Hint: you can also google "LDN+your condition" for the most up-to-date
information and Youtube videos
Acne/Cystic Acne
Acute Brachial Neuropathy (Parsonage-Aldren-Turner Syndrome, aka neuralgic amyotrophy, brachial neuritis, brachial plexus
neuropathy, brachial plexitis)
Acute Disseminated Encephalomyelitis
Acute Febrile Neutrophilic Dermatosis (Sweets Syndrome)
Acute Febrile Vasculitic Syndrome (Kawasaki's Disease)
Acute Hemorrhagic Leukoencephalitis
Addiction
ADHD/ADD
Adiposis Dolorosa (Dercum's Disease)
Adrenal Fatigue
Agammaglobulinemia
Allergies
Alopecia Areata
Alzheimer's
Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's Disease)
Ankylosing Spondylitis
Anorexia Nervosa
Anti-Aging
Anti-GBM/TBM Nephritis
Antiglomerular Basement Antibody Disease (Goodpasture's Syndrome)
Antiphospholipid syndrome
Antisynthetase syndrome
Aphasia/Dysphasia/Dysnomia
Asperger's Syndrome
Asthma (autoimmune mast cell and other types)
Atopic allergy
Atopic Dermatitis
Autism Spectrum Disorders
Autoimmune Aplastic Anemia
Autoimmune Cardiomyopathy
Autoimmune Enteropathy

2009 DIANA GALE

Autoimmune Hemolytic Anemia
Autoimmune Hepatitis
Autoimmune Inner Ear Disease (AIED)
Autoimmune Lymphoproliferative Syndrome
Autoimmune Pancreatitis
Autoimmune Peripheral Neuropathy
Autoimmune Polyendocrine Syndrome (Schmidt Syndrome)
Autoimmune Polyendocrinopathy Candidiasis-Ectodermal Dystrophy (APECED)
Autoimmune Progesterone Dermatitis
Autoimmune Thrombocytopenic Purpura
Autoimmune Urticaria
Autoimmune Uveitis
Balo Concentric Sclerosis (Balo Disease)
Becker's Muscular Dystrophy
Behcet's Syndrome/Disease
Bickerstaff's Encephalitis
Bipolar Disorder https://www.ldnscience.org/resources/interviews-patients/lisa-nilsen-bipolar-
disorder?utm_source=fb&utm_campaign=bipolar-lisa-feb20&utm_medium=post
Bladder Cancer
Blau Syndrome (heterozygous mutation in the NOD2/CARD15 gene)
Brain Fog/Memory issues
Breast Cancer
Bulimia
Bullous Pemphigoid
Cancer: http://www.lowdosenaltrexone.org/ldn_and_cancer.htm
Carcinoid
Celiac Disease
Chronic Fatigue Syndrome (CFS)
Chronic Inflammatory Demyelinating Polyneuropathy
Chronic Obstructive Pulmonary Disease (COPD)
Chronic Recurrent Multifocal Osteomyelitis (Majeed Syndrome)
Cicatricial Pemphigoid
Cogan Syndrome
Cold Agglutinin Disease
Colon & Rectal Cancer
Common Cold/Flu/Pneumonia
Complement Component 2 Deficiency
Complex Regional Pain Syndrome (CRPS) http://www.lowdosenaltrexone.org/others.htm#Journal
Coombs' Positive Hemolytic Anemia
Cranial Arteritis
CREST Syndrome (Calcinosis, Raynaud phenomenon, Esophageal Dysmotility, Sclerodactyly, and Telangiectasia)
Crohn's Disease www.posterwall.com/blog_attachment.php?attachmentid=2477&d=1300033072 AND
http://www.drdach.com/Crohn_s_LDN.html
Hypercortisolism/Hyperadrenocorticism (Cushing's Syndrome/Disease, Itsenko-Cushing Syndrome)
Cutaneous LeukocytoclasticAngiitis
Dementia
Depressed Immune Function
Depression/Social Withdrawal http://davidnixon.posterous.com/the-beneficial-by-products-of-low-dose-naltre
Dermatitis Herpetiformis
Diabetes, Type II and Mellitus Type 1

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Diffuse Cutaneous Systemic Sclerosis
Discoid Lupus Erythematosus
Dressler's Syndrome (secondary form of Pericarditis)
Eczema
Emphysema (COPD)
Endometriosis
Endorphin/Dopamine Deficiency Syndrome https://www.facebook.com/note.php?note_id=423708181450
Enthesitis-related Arthritis
Eosinophilic Fasciitis
Eosinophilic Gastroenteritis
Eosinophilic Granulomatosis (Churg-Strauss Syndrome)
Epidermolysis Bullosa Acquisita
Epstein-Barr Virus (EBV/CEBV)
Erythema Nodosum (EN)
Essential Mixed Cryoglobulinemia
Esophageal Spasm
Evan's Syndrome
Fibrodysplasia Ossificans Progressiva
Fibromyalgia (Myalgic Encephalopathy/Myalgic Encephalomyelitis, post-viral illness) http://www.webspawner.com/users/ldnforfms/
new! https://www.ldnscience.org/research/a-novel-glial-cell-inhibitor-low-dose-naltrexone-reduces-pain-and-depression-and-improves-function-
in-chronic-pain-a-choir-study
Fibrosing Aveolitis
Food Sensitivities
Gastritis
Gastrointestinal Pemphigoid
Giant Lymph Node Hyperplasia / Angiofollicular Lymph Node Hyperplasia (Castleman's Disease)
Gingivitis
Glioblastoma
Glioma
Glomerulonephritis
Grave's Thyroid Disease
Guillain-Barre syndrome (GBS)
Hemolytic Anemia
Hashimoto's Encephalitis
Hashimoto's Thyroiditis
Heat Stroke http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1997.tb51745.x/abstract,
http://www.jstage.jst.go.jp/article/jphs/97/4/97_519/_article
Henoch-Schonlein Purpura
Herpes Gestationis
Herpes Simplex Virus (HSV)
Hidradenitis Suppurativa
HIV/AIDS http://www.academicjournals.org/jahr/PDF/Pdf2011/October/Traore%20et%20al%20%281%29.pdf
Hypoglycemia/Severe Reactive (postprandial) Hypoglycemia
Hypothermia http://www.jstage.jst.go.jp/article/jphs/97/4/97_519/_article
Idiopathic Inflammatory Bowel Disease (IBD)
Idiopathic Inflammatory Demyelinating Diseases
Idiopathic Pulmonary Fibrosis
IgA Nephropathy (Berger's Disease)
Inclusion Body Myositis
Infertility

2009 DIANA GALE

Inflammatory Demyelinating Polyneuopathy
Insulin Resistance
Interstitial Cystitis (IC)
Irritable Bowel Syndrome (IBS) https://www.ldnscience.org/research/low-dose-naltrexone-reduces-in-vitro-endoplasmic-reticulum-stress-
and-stimulates-wound-healing-in-intestinal-epithelial-cells new!
Juvenile Idiopathic Arthritis
Juvenile Rheumatoid Arthritis
Lambert-Eaton Myasthenic Syndrome
Leukocytoclastic Vasculitis
Lichen Planus
Lichen Sclerosus
Linear IgA Disease (LAD)
Liver Cancer
Lung Cancer (Non-Small Cell)
Lupoid Hepatitis
Lupus Erythematosus
Lyme Disease
Lymphocytic Leukemia (chronic)
Lymphoma (Hodgkin's and Non-Hodgkin's)
Malignant Atrophic Papulosis (Dego's Disease)
Malignant Melanoma
Meniere's Disease
Microscopic Polyangiitis
Miller-Fisher Syndrome (variant of Guillain-Barre)
Migraine
Mixed Connective Tissue Disease
Morphea (localized Scleroderma)
Multiple Autoimmune Syndrome (MAS)
Multiple Chemical Sensitivity (MCS)
Multiple Myeloma
Multiple Sclerosis (MS)
Murine Inflammatory Bowel Disease
Myalgic Encephalopathy/Myalgic Encephalomyelitis ('fibromyalgia', ME, post viral illness)
Myasthenia Gravis
Myositis (Dermatomyositis, Inclusion-Body, Juvenile, and Polymyositis)
Neuroblastoma
Neuromyelitis Optica (Devic's Disease)
Neuromyotonia
Neuropathy https://www.conquerchiari.org/subs%20only/Volume%202/Issue%202%285%29/New%20Neuropathic%20Drug%202%285%29.html
Neuropsychiatric Disorders associated with streptococcal-A (GABHS) (PANS / PANDAS, Pediatric Autoimmune
Neuropsychiatric Disorder)
Nonpruritic Urticaria (Schnitzler syndrome)
Obsessive Compulsive Disorder (OCD)
Occular Cicatricial Pemphigoid
Ocular Rosacea
Opsoclonus Myoclonus Syndrome
Ophthalmoplegia (Tolosa-Hunt syndrome)
Ord's Thyroiditis
Ovarian Cancer http://www.ncbi.nlm.nih.gov/pubmed/21531450, http://www.sciencedirect.com/science/article/pii/S0090825811008663

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PAIN caused by many, many things
Palindromic Rheumatism
Pancreatic Cancer http://www.ncbi.nlm.nih.gov/pubmed/20890374
Paraneoplastic Cerebellar Degeneration
Parkinson's Disease (Ataxia, Dystonia, Essential Tremor, Atypical Parkinsonism)
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Pars Planitis
Pemphigoid Gestationis (mucus membrane)
Pemphigus (types: Herpetiformis, Foliaceus, Vulgaris)
Perivenous Encephalomyelitis
Pernicious Anemia
Pityriasis Lichenoides et Varioliformis aAcuta (PLEVA, Mucha-Habermann Disease)
Plasma-cell Proliferative Disorder (POEMS / Crow-Fukase Syndrome / Takatsuki Disease / PEP Syndrome)
Poliomyelitis (Polio symptoms)
Polyarteritis Nodosa
Polycystic Ovarian Disease (PCOD) or Syndrome (PCOS) 3 links: http://www.medhelp.org/posts/Fertility---Infertility---IVF/For-
women-with-PCOS--PMS--anxiety--autoimmune-disorders--persistent-fatigue-or-brown-menstrual-bleeding/show/507446 ...
http://ldn.proboards.com/thread/1845/daughters-on-ldn-ms-pcos ... http://www.ovarian-cysts-pcos.com/
Polymyalgia Rheumatica (PMR)
Post-Exertional Neuroimmune Exhaustion (PENE)
Post-Herpetic Neuralgia
Premenstrual Syndrome (PMS)
Primary Adrenal Insufficiency (Addison's Disease)
Primary Biliary Cirrhosis
Primary Lateral Sclerosis (PLS)
Primary Sclerosing Cholangitis
Progressive Hemifacial Atrophy (Parry Romberg Syndrome)
Progressive Inflammatory Neuropathy
Prostate Cancer
Psoriasis
Psoriatic Arthritis
Pure Red Cell Aplasia
Pyoderma Gangrenosum
Rasmussen's Encephalitis
Reactive Arthritis (Reiter's Syndrome)
Reflex Sympathetic Dystrophy (RSD)
Relapsing Polychondritis
Renal Cell Carcinoma
Restless Leg Syndrome (RLS)
Retinocochleocerebral Vasculopathy (Susac's Syndrome)
Retroperitoneal Fibrosis
Reynaud Phenomenon/Syndrome
Rheumatioid Arthritis (RA)
Rheumatoid Fever
Rosacea
Sacoidosis
Schizophrenia
Scleritis
Scleroderma (Diffuse, Stiff Person Syndrome-SPS)
Seizures

2009 DIANA GALE

Self-Injury, Self Harm
Sensitivity to heat and cold http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1997.tb51745.x/abstract,
http://www.jstage.jst.go.jp/article/jphs/97/4/97_519/_article
Shingles
Still's Disease
Sjogren's Syndrome
Sleep Disorders
Spinal Stenosis
Spondyloarthropathy
Subacute Bacterial Endocarditis (SBE)
Suicidal Ideation https://www.ldnscience.org/resources/interviews-patients/lisa-nilsen-bipolar-
disorder?utm_source=fb&utm_campaign=bipolar-lisa-feb20&utm_medium=post
Sydenham Chorea
Sympathetic Ophthalmia
Systemic Lupus Erythematosis (SLE)
Takayasus Arteritis (TAK)
Temporal arteritis (Giant Cell Arteritis)
Throat Cancer
Tick Borne Illnesses other than Lyme
Torticollis
Transverse Myelitis
Ulcerative Colitis http://wp.rxisk.org/low-dose-naltrexone/ AND http://drhoffman.com/article/one-patients-uc-success-story-2/
Undifferentiated Connective Tissue Disease
Undifferentiated Spondyloarthropathy
Uterine Cancer
Vasculitis
Viral & Post-Viral Syndromes
Vitiligo
Wegener's Granulomatosis
Wounds http://ebm.rsmjournals.com/content/early/2011/09/13/ebm.2011.011163.short

Other Cancer Links

http://www.ldnnow.co.uk/8601.html - new info!

http://www.ncbi.nlm.nih.gov/pubmed/21584896
http://www.lowdosenaltrexone.org/ldn_and_cancer.htm
http://ldn.proboards.com/index.cgi?board=personal&action=display&thread=816
http://www.mbschachter.com/protocol_for_low.htm
http://www.webspawner.com/users/ldnforcancer/index.html
http://jeffreydach.com/2007/08/01/low-dose-nalotrexone-ldn-by-jeffrey-dach-md.aspx

COPYRIGHT 2009 Diana Gale

2/19/2017 UPDATE

2009 DIANA GALE