aneoi7 ‘Aphthous Stomaits Differential Diagnoses This site is intended for healthcare professionals Medscape Aphthous Stomatitis Differential Diagnoses Updated: Feb 09, 2016 Author: Ginat W Mirowski, MD, DMD; Chief Editor: William D James, MD more... DDX Diagnostic Considerations Also consider the following: * Local, traumatic ulceration + Environmental triggers: Food (eg, figs, cheese, tomato, tomato sauce, vinegar, lemon, pineapple, milk, wheat flour) '®2] ; sodium lauryl sulfate, a detergent used as an emulsifier and surface cleanser and found in many toothpastes and oral rinses !63. 641 * Drugs (eg, nonsteroidal anti-inflammatory drugs [NSAIDs], '®5 chemotherapies and cytotoxic drugs, Nicorandil, gold) [6] + Hematinic deficiencies (up to 20%) (iron, folic acid, vitamin B12; rarely vitamin B-1 and B-6) (16) + Deep fungal disease (major aphthae) [7] + Rheumatologic diseases, including systemic lupus erythematous and reactive arthritis [681 * Gl diseases (3%) (eg, Crohn disease, ulcerative colitis, celiac disease or gluten sensitive enteropathy [HLA -DRW 10 and DQW1], malabsorption, pernicious anemia) [91 * Sweet syndrome [7] + Causes of systemic neutropenia, including cyclic neutropenia and benign familial neutropenia 7 * PFAPA syndrome (periodic fever, pharyngitis, adenitis, and oral ulceration) [72 731 * MAGIC (mouth and genital ulcers with inflamed cartilage) [741 * Primary and secondary immunodeficiencies, including HIV infection 751 * Trisomy 8, myelodysplasia |761 + Behcet disease !77: 78] (For information on diagnostic criteria for Behget disease, see the Medscape article Behget disease.) Differential Diagnoses Acute Cutaneous Lupus Erythematosus (ACLE) Allergic Contact Dermatitis Cancers of the Oral Mucosa Cicatricial Pemphigoid Contact Stomatitis + Dermatologic Aspects of Behcet Disease itpilemecicine,medscape.comlartcla107S570-difererdal 12aneoi7 ‘Aphthous Stomaits Differential Diagnoses Dermatologic Manifestations of Gastrointestinal Disease Dermatologic Manifestations of Hand-Foot-and-Mouth Disease Dermatologic Manifestations of Hematologic Disease Dermatologic Manifestations of Herpes Simplex Drug-Induced Bullous Disorders Drug-Induced Lupus Erythematosus Drug-Induced Pemphigus Erythema Multiforme IgA Pemphigus Irritant Contact Dermatitis Langerhans Cell Histiocytosis Lichen Planus Linear IgA Dermatosis Paraneoplastic Pemphigus Pediatric Syphilis Pemphigus Vulgaris Reactive Arthritis Workup, Iitpilemecicine,medscape.comlartcla107S570-difererdal 22