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Welcome to



The human body is truly an amazing thing. Capable of awe-inspiring feats of
speed and agility, while being mind-blowing in complexity, our bodies are
unmatched by any other species on Earth. In this new edition of the Book
of the Human Body, we explore our amazing anatomy in fine detail before
delving into the intricacies of the complex processes, functions and systems
that keep us going. For instance, did you know you really have 16 senses?
We also explain the weirdest and most wonderful bodily phenomena, from
blushing to hiccuping, cramps to blisters. We will tour the human body
from head to toe, using anatomical illustrations, amazing photography
and authoritative explanations to teach you more. This book will help you
understand the wonder that is the human body and in no time you will begin
to see yourself in a whole new light!

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How It Works Book of the Human Body Seventh Edition 2016 Imagine Publishing Ltd

Part of the

bookazine series
Human anatomy Urinary
010 50 amazing body facts explained
018 Human cells
020 Inside a nucleus
021 What are stem cells?
022 Brain power
026 Vision and eyesight
028 How ears work
030 The tonsils
031 Vocal cords
032 All about teeth
034 Anatomy of the neck The power of
your brain
036 The human skeleton 092
How do we
038 The spine breathe?
040 How the body moves
042 How muscles work
044 Skin colour / Skin grafts
045 Under the skin
046 Heart attacks
047 Heart bypasses
048 The human kidneys
050 Kidney transplants
052 Vestigial organs
053 How the spleen works
054 How the liver works The body at work
056 The small intestine 076 The science of sleep
058 The human ribcage 084 The blood-brain barrier
060 How the pancreas works 085 Pituitary gland up close
062 How your bladder works 086 Human digestion explained
064 The urinary system 088 Altitude sickness / Synapses
066 Inside the human stomach 089 Eat too much / Adrenaline
068 The human hand 090 Human respiration
070 Finger nails / Achilles tendon 092 Dehydration / Sweating
071 Inside the knee 093 Scar types
072 How your feet work 094 The immune system

157 Correcting heart rhythms /
Curious questions Salt / Adams apple

142 Left or right brained? 158 Seasickness / Rumbling

144 Brain freeze
159 Cravings
145 Runny nose / Comas
160 Feet smell / Knee-jerk
146 Sore throat / Ears pop / reaction
161 Blisters / Bruises
147 Memory / Toothpaste /
Epidurals 162 Brain control / Laughing
148 Know your nerve cells 163 Dandruff / Eye adjustment /
Distance the eye can see
149 What is Tinnitus? / When does
the brain stop growing? 164 Allergies / Eczema
150 What is keratin /
Hair in the sun 165 Growing pains / Squinting

151 What powers cells? 166 What are twins?

152 Can we see thoughts? 168 Alveoli

046 169 Migraines / Eyedrops
How do heart 154 How anaesthesia works
attacks happen? 155 Stomach ulcers / Mouth ulcers 170 Paper cuts / Pins and
needles / Funny bones
156 Enzymes / Love
171 Aching muscles / Fat hormone
98 Bone fracture healing
99 Making protein 172 Raw meat / Inoculations /
Upper arm and leg
100 The cell cycle
173 What causes insomnia?
102 Human pregnancy
174 Hair growth / Blonde hair
104 Embryo development appearance
106 Altitude sickness / Synapses 175 Why do we get angry?
107 The biology of hunger
108 Neurotransmitters and Why is it called
your feelings a funny bone?
109 Short term memory
110 White blood cells
112 The science of genetics
117 What is anxiety?
118 Circulatory system
120 How your blood works
124 Blood vessels /
125 Tracheotomy surgery
126 Hormones
128 Exploring the sensory system
132 Chickenpox
133 Why we cry 100
Healing bone
134 The other senses fractures

Inside the eye

024 50 fantastic
How facts about
we think the body


Stem cells
The human

010 50 amazing body facts 040 How the body moves

From head to toe The types of joints explained
018 Human cells 042 How muscles work
How are they structured? Muscle power revealed
020 Inside a nucleus 044 Skin colour / Skin grafts
Dissecting a cells control centre Skin facts explained
021 What are stem cells? 031 Vocal cords 045 Under the skin
Building block bring new life See how they help us talk Anatomy of our largest organ
022 Brain power 032 All about teeth 046 Heart attacks
About our most complex organ Dental anatomy and more Why do they happen?
026 The science of vision 034 Anatomy of the neck 047 Heart bypasses
Inside the eye Impressive anatomical design How are blockages bypassed?
028 How ears work 036 The human skeleton 048 Human kidneys
Sound and balance explained A bounty of boney facts How do your kidneys function?
030 The tonsils 038 The human spine 050 Kidney transplants
What are these fleshy lumps? 33 vertebrae explained The bodys natural filters

the nerves

How do
we smell?

How do our
feet work?

Inside the heart

Cell structure

052 Vestigial organs

Are they really useless?
053 How the spleen works
Learn how it staves off infections
054 How the liver works
The ultimate multitasker
056 The small intestine 066 Inside the human stomach
How does this organ work? How does this organ digest food?
058 The human ribcage 068 The human hand
The protective function of the ribs Our most versatile body part
060 How the pancreas works 070 Finger nails / Achilles tendon
The bodys digestive workhorse A look at fingernails and more
062 How your bladder works 071 Inside the knee
Waste removal facts See how it allows us to walk
064 The urinary system 072 How your feet work
How we process waste Feet facts and stats


Amazing facts
about the
There are lots of medical
questions everybody wants
to ask but we just never
get the chance until now!

he human body is the most complex
organism we know and if humans
tried to build one artificially, wed
fail abysmally. Theres more we dont
know about the body than we do know.
This includes many of the quirks and
seemingly useless traits that our
species carry. However, not all of
these traits are as bizarre as they
may seem, and many have an
evolutionary tale behind them.
Asking these questions is only
natural but most of us are too
embarrassed or never get the
opportunity so heres a
chance to clear up all those
niggling queries. Well take a
head-to-toe tour of the
quirks of human biology,
looking at everything
from tongue rolling and
why we are ticklish
through to pulled
and why
we dream.

DID YOU KNOW? Useless body parts include the appendix, the coccyx and wisdom teeth

Pre-motor cortex

1 How do
we think?
What are thoughts? This question will
keep scientists, doctors and
Frontal lobe
The frontal lobe is where your
personality is, and where your
thoughts and emotions form.
Removing this or damaging it can
The pre-motor cortex is where
some of your movements are
Primary motor cortex
The primary motor cortex and the primary
somatosensory cortex are the areas which
receive sensory innervations and then
co-ordinate your whole range of movements.
alter your persona.
philosophers busy for decades to
come. It all depends how you want to
Parietal lobe
The parietal lobe is responsible for
define the term thoughts. Scientists your complex sensory system.
may talk about synapse formation,
pattern recognition and cerebral
activation in response to a stimulus
(seeing an apple and recognising it). Brocas Primary auditory
Philosophers, and also many area complex
scientists, will argue that a network of Brocas area is The primary auditory
neurons cannot possibly explain the where you form complex is right next to
complex words the ear and is where you
many thousands of thoughts and
and speech interpret sound waves
emotions that we must deal with. A
patterns. into meaningful
sports doctor might state that when
you choose to run, you activate a series
of well-trodden pathways that lead
from your brain to your muscles in less Temporal lobe SPL
than just a second.
The temporal lobe decides what to Occipital lobe
do with sound information and also The occipital lobe is all
There are some specifics we do combines it with visual data. the way at the back, but
know though such as which areas of Wernickes area
it interprets the light
Wernickes area is where you interpret
your brain are responsible for various signals in your eyes into
the language you hear, and then you
types of thoughts and decisions. will form a response via Brocas area.
shapes and patterns.

5 Why can
some people
roll their
tongues but
others cant?
Although were often taught in school that
tongue rolling is due to genes, the truth is 6 What is
a pulse?
3 Do eyeballs likely to be more complex. There is likely When you feel your
to be an overlap of genetic factors and
own pulse, youre
grow like the environmental influence. Studies on
actually feeling the
rest of the body? families and twins have shown that it
simply cannot be a case of just genetic direct transmission
Dora Pete

Only a small amount inheritance. Ask around the fact that of your heartbeat
some people can learn to do it suggests down your artery.
this is actually why that in at least some people its You can only feel a
babies appear to be so environmental (ie a learned behaviour)
pulse where you

2 In the
do we wake up
beautiful, as their eyes
are out of proportion
and so appear bigger.
rather than genetic (inborn).
can compress an
artery against a
bone, eg the radial
arteryat the wrist.
or open our The carotid artery
can be felt against
eyes first? 4 Why do we fiddle
subconsciously? the vertebral body,
Sleep is a gift from nature, which is but beware, if press
more complex than you think. There Im constantly
are five stages of sleep which represent playing with my hair too hard and you
the increasing depths of sleep when This is a behavioural response
can actually faint,
youre suddenly wide awake and your some people play with their hair press both at the
eyes spring open, its often a natural when theyre nervous or bored. For same time and
awakening and youre coming out of the vast majority of people such youll cut off the
rapid eye movement (REM) sleep; you traits are perfectly normal. If they bloodto your brain
may well remember your dreams. If begin to interfere with your life,
youre coming out of a different phase,
and,as a protective
behavioural psychologists can help
eg when your alarm clock goes off, it but its extremely rare that youll
mechanism, youll
will take longer and you might not end up there. definitely faint!
want to open your eyes straight away!


2D field
The areas from 120 to 180
degrees are seen as 2D as
only one eye contributes, but
we dont really notice.
7 Whats my
field of vision
in degrees?
12 Why do
we burp?
A burp is the bodies
The human field of vision is just about 180
way of releasing gas
degrees. The central portion of this naturally from your
3D field
(approximately 120 degrees) is binocular or stomach. This gas has
stereoscopic ie both eyes contribute,
The central 120-degree either been swallowed

Matt Willman
allowing depth perception so that we can
portion is the 3D part of
our vision as both eyes see in 3D. The peripheral edges are or is the result of
contribute this is the part monocular, meaning that there is no something that you
we use the most. overlap from the other eye so we see in 2D. have ingested such
as a sparkling drink.
The sound is

8 What is
the point
of tonsils?
11 How fast does
blood travel round
the human body?
vibrations which are
taking place in the
The tonsils are collections
sphincter, the

of lymphatic tissues which
Your total circulating volume is about five litres. Each narrowest part of the
red blood cell within this has to go from your heart,
are thought to help fight off
down the motorway-like arteries, through the
gastrointestinal tract.
pathogens from the upper
back-road capillary system, and then back through the
respiratory tract. However,
rush-hour veins to get back to your heart. The process
the tonsils themselves can
typically takes about a minute. When youre in a rush
sometimes even become
and your heart rate shoots up, the time reduces as the
infected leading to
blood diverts from the less-important structures (eg
tonsillitis. The ones you
large bowel) to the more essential (eg muscles).
can see at the back of your
throat are just part of the
ring of tonsils. You wont 1. The most
miss them if theyre taken important organ
The brain has its own
out for recurrent infections special blood supply 2. Under pressure

as the rest of your immune arranged in a circle. Blood is moving fastest

system will compensate. and under the highest
pressure as it leaves the
heart and enters the
elastic aorta.

9 What are
lips for?
Lips are predominantly used as a tactile sensory organ,
typically for eating, but also for pleasure when kissing. They
are also used to help fine-tune our voices when we speak.

10 Why does it feel so weird when

you hit your funny bone?
13 How many
inches of
hair does the
Youre actually hitting the ulnar nerve as it wraps around the 4. The inferior
vena cava
average person
bony prominence of the humerus bone, leading to a funny
sensation. Although not so funny as the brain interprets this This massive vein sits grow from their
sudden trauma as pain to your forearm and fingers!
behind the aorta but is
no poor relation
5. The
furthest point
head each year?
without it, blood These arteries and Its different for everybody your
wouldnt get back

ULNAR NERVE veins are the furthest age, nutrition, health status, genes

to your heart. away from your and gender all play a role. In terms
heart, and blood flow
of length, anywhere between
here is slow. As you
3. The kidneys grow older, these 0.5-1 inch (1.2-2.5cm) a month
These demand a massive vessels are often the might tends to be considered
25 per cent of the blood first to get blocked by average,but dont be surprised if
from each heart beat! fatty plaques. youre outside this range.

DID YOU KNOW? The average person breaks wind between 8-16 times per day

Why are
14 everyones
Men and women are built from
the same template, and these
different? are just a remnant of a mans
early development.
Your fingerprints are fine ridges of
skin in the tips of your fingers and WHATS THE
toes. They are useful for improving
the detection of small vibrations
and to add friction for better grip. Biologically, eyebrows can
No two fingerprints are the same help to keep sweat and
Why do we all
either on your hands or between
two people and thats down to
your unique set of genes.
17 have different
coloured hair?
rainwater from falling into
your eyes. More importantly in
humans, they are key aids to
non-verbal communication.
Most of it is down to the genes that result

15 Why do
we only
from when your parents come together to
make you. Some hair colours win out
(typically the dark ones) whereas some (eg
blonde) are less strong in the genetic race.
The umbilicus is where a
babys blood flows through to
get to the placenta to exchange
some dreams? Is it possible to
Dreams have fascinated humans
for thousands of years. Some
18 keep your eyes
open when you sneeze?
oxygen and nutrients with the
mothers blood. Once out, the
umbilical cord is clamped
several centimetres away from
people think they are harmless Your eyes remain shut as a the baby and left to fall off. No
while others think they are vital to defence mechanism to prevent one quite knows why youll get
our emotional wellbeing. Most the spray and nasal bacteria an innie or an outie its

people have four to eight dreams entering and infecting your probably all just luck.
per night which are influenced by eyes. The urban myth that
stress, anxiety and desires, but
they remember very few of them.
There is research to prove that if
your eyes will pop out if you
keep them open is unlikely
to happen but keeping
you awake from the rapid eye them shut will provide THAN TOENAILS?
movement (REM) part of your sleep some protection against
cycle, youre likely to remember nasty bugs and viruses.
your dreams more clearly.

Why, as we
16 get older,
does hair growth
become so erratic?
Hair follicles in different parts of your
The longer the bone at the end
body are actually programmed by your
of a digit, the faster the growth
genes to do different things, eg the
rate of the nail. However there
follicles on your arm produce hair much
are many other influences too
slower than those on your head. Men
nutrition, sun exposure,
can go bald due to a combination of
activity, blood supply and
genes and hormonal changes, which
thats just to name a few.
may not happen in other areas (eg nasal
hair).Its different for everybody! WHY DOES MY
What gives me
19 my personality?
Researchers have spent their whole lives trying to
This happens because youre
compressing a nerve as youre
lying on your arm. There are
several nerves supplying the
answer this one. Your personality forms in the front
lobes of your brain, and there are clear personality skin of your arm and three
types. Most of it is your environment that is, your supplying your hand (the
upbringing, education, surroundings. However some radial, median and ulnar
of it is genetic, although its unclear how much. The nerves), so depending on
strongest research in this comes from studying twins which part of your arm you lie
what influences one set of twins to grow up and be on, you might tingle in your
best friends, yet in another pair, one might become a forearm, hand or fingers.
professor and the other a murderer.


25 What makes some blood

groups incompatible while
others are universal?
Your blood type is determined by protein markers known as antigens on the surface of your
26 What is a pulled
The hamstrings
red blood cells. You can have A antigens, B antigens, or none in which case youre blood type These are a group of
O. However, if you dont have the antigen, your antibodies will attack foreign blood. If youre A pulled muscle, or
three main muscles
type A and youre given B, your antibodies attack the B antigens. However, if youre blood type strain, is a tear in a group
which flex the knee.
of muscle fibres as a
AB, you can safely receive any type. Those who are blood group O have no antigens so can give
result of overstretching.
blood to anyone, but they have antibodies to A and B so can only receive O back!
You have A antigens and B
antibodies. You can receive blood
groups A and O, but cant receive B.
You can donate to A and AB.

You have B antigens and A
antibodies. You can receive blood
groups B and O, but cant receive
A. You can donate to B and AB.

You have A and B antigens and no
antibodies. You can receive blood
groups A, B, AB and O (universal
recipient), and can donate to AB.

You have no antigens but have A and B Though warming up can help prevent
antibodies. You can receive blood group sprains, they can happen to anyone,
O, but cant receive A, B or AB and can from walkers to marathon runners.
donate to all: A, B, AB and O.

Pulled muscles are treated with RICE:

rest, ice, compression and elevation

28 What is the
appendix? Ive
heard it has no use
29 Why does
but can kill you
skin turn yellow
The appendix is useful in cows for
if they contract
digesting grass and koala bears for liver disease?
digesting eucalyptus koalas can have This yellow discolouration of the skin
a 4m (13ft)-long appendix! In humans, or the whites of the eyes is called
however, the appendix has no useful jaundice. It is actually due to a buildup
function and is actually a remnant of of bilirubin within your body, when
our development. It typically measures normally this is excreted in the urine
5-10cm (1.9-3.9in), but if it gets blocked it (hence why urine has a yellow tint).
can get inflamed. If it isnt quickly Diseases such as hepatitis and
removed, the appendix can burst and gallstones can lead to a buildup of
lead to widespread infection which can bilirubin due to altered physiological

27 Which be lethal. processes, but there are other causes.


uses up the
most oxygen?
The heart is the most
efficient it extracts
30 What
is the
gag reflex?
3. Vagus nerve
The vagus nerve is stimulated,
leading to forceful contraction
of the stomach and diaphragm
80 per cent of the to expel the object forwards.
1. Foreign bodies
oxygen from blood. This is a protective mechanism to prevent
But the liver gets the food or foreign bodies entering the back of
most blood 40 per the throat at times other than swallowing.

cent of the cardiac 4. The gag

output compared to 2. Soft palate This forceful expulsion
The soft palate (the fleshy part of the
the kidneys, which mouth roof) is stimulated, sending signals
leads to gagging, which
can develop into retching
get 25 per cent, and down the glossopharyngeal nerve. and vomiting.
heart, which only
receives 5 per cent.

DID YOU KNOW? Your brain interprets pain from the rest of the body, but doesnt have any pain receptors itself

Why dont eyelashes

32 keep growing?
Your eyelashes are formed from hair follicles, just like those on your
head, arms and body. Each follicle is genetically programmed to
function differently. Your eyelashes are programmed to grow to a
certain length and even re-grow if they fall out, but they wont grow
beyond a certain length, which is handy for seeing!

shlomit g

Freckles are concentrations
of the dark skin pigment
melanin in the skin. They
typically occur on the face
and shoulders, and are more
common in light-skinned
people. They are also a
well-recognised genetic trait
33 What
makes us
34 we
survive on
and become more dominant
during sun-exposure.

left-handed? vitamins
Why are we
31 ticklish?
One side of the brain is more
dominant over the other. Since
each hemisphere of the brain
No, your body needs

Klaus D. Peter, Wiehl, Germany

Light touches, by feathers, spiders, insects or other controls the opposite side of a diet balanced with
humans, can stimulate fine nerve-endings in the skin your body, meaning the left
which send impulses to the somatosensory cortex in controls the right side of your
vitamins, protein,
the brain. Certain areas are more ticklish such as the body. This is why right-handed minerals
feet which may indicate that it is a defence people have stronger left brain carbohydrates, and
mechanism against unexpected predators. It is the hemispheres. However you can fat to survive. You
unexpected nature of this stimulus that means you can find an ambidextrous person,
be tickled. Although you can give yourself goosebumps where hemispheres are cant cut one of these
through light tickling, you cant make yourself laugh. co-dominant, and these people
are equally capable with both
and expect your
body to stay healthy. 37 WHAT IS
right and left hands! Warts are small, rough,
It is the proportions round growths of the skin
of these which keep caused by the human
us healthy and fit. papilloma virus. There are
You can get these different types which can
occur in different parts of the
from the five major body, and they can be
food groups. Food contagious. They commonly
charts can help with
Jeinny Solis

occur on the hands, but can

this balancing act. also come up anywhere from
the genitals to the feet!

Why do we get a

35 high temperature
when were ill?
This is known in the medical
world as a myoclonic twitch.
Although some researchers
say these twitches are
The immune response leads to inflammation and the release of associated with stress or
inflammatory factors into your blood stream. These lead to an increased caffeine use, they are likely
heart rate and blood flow, which increases your core body temperature to be a natural part of the
as if your body is doing exercise. This can lead to increased heat sleep process. If it happens to
production and thus dehydration; for this reason, its important to you, its perfectly normal.
drink plenty of clear fluids when youre feeling unwell.


39 What triggers

3x SPL
the heart and
keeps it beating?
The heart keeps itself beating. The
sinoatrial node (SAN) is in the wall of the
right atrium of the heart, and is where the
heartbeat starts. These beats occur due to
changes in electrical currents as calcium,
sodium and potassium move across
membranes. The heart can beat at a rate of
60 beats per minute constantly if left alone.
However we often need it to go faster. The
sympathetic nervous system sends rapid
signals from the brain to stimulate the
heart to beat faster when we need it to in
fight or flight scenarios. If the SAN fails, a
pacemaker can send artificial electrical
signals to keep the heart going.

1. Atrial systole Systole = contraction
2. Ventricular systole 3. Ventricular diastole Diastole = relaxation
The atria are the
low-pressure upper The ventricles contract next, The heart is now relaxed and can
chambers, and are the and they send high-pressure refill, ready for the next beat.
first to contract, emptying blood out into the aorta to
blood into the ventricles. supply the body.

40 Why do bruises go
41 Why

Lali Masriera
purple or yellow? does
A bruise forms when capillaries under the skin leak and allow
blood to settle in the surrounding tissues. The haemoglobin in
red blood cells is broken down, and these by-products give a onions make
dark yellow, brown or purple discolouration depending on the
volume of blood and colour of the overlying skin. Despite
us cry?
popular belief, you cannot age a bruise different peoples Onions make your eyes water due to their expulsion of
bruises change colour at different rates. an irritant gas once cut. This occurs as when an onion
is cut with a knife, many of its internal cells are broken

1. Damage to the
blood vessels
After trauma such as a fall,
3. Discolouration
Haemoglobin is then
broken down into its
smaller components, which
down, allowing enzymes to break down amino acid
sulphoxides and generate sulphenic acids. These
sulphenic acids are then rearranged by another
enzyme and, as a direct consequence, syn-
propanethial-S-oxide gas is produced, which is volatile.
44 Why do
men go bald
the small capillaries are
torn and burst.
are what give the dark
discolouration of a bruise.
This volatile gas then diffuses in the air surrounding
the onion, eventually reaching the eyes of the cutter,
than women?
where it proceeds to activate sensory neurons and Simple male pattern baldness is due
2. Blood leaks create a stinging sensation. As such, the eyes then to a combination of genetic factors
into the skin follow protocol and generate tears from their tear and hormones. The most implicated
Blood settles into the glands in order to dilute and remove the irritant. hormone is testosterone, which men
tissues surrounding the Interestingly, the volatile gas generated by cutting have high levels of but women have
vessel. The pressure onions can be largely mitigated by submerging the low levels of, so they win (or lose?) in
from the bruise then onion in water prior to or midway through cutting, this particular hormone contest!
helps stem the bleeding.
with the liquid absorbing much of the irritant.

42 What is
the little
triangle shape
on the side of
43 When were
tired, why do
we get bags under
the ear?
This is the tragus. It serves our eyes?
no major function that we Blood doesnt circulate around your body as
know of, but it may help to efficiently when youre asleep so excess water can
reflect sounds into the ear pool under the eyes, making them puffy. Fatigue,
David Benbennick to improve hearing. nutrition, age and genes also cause bags.

DID YOU KNOW? There are many home remedies for baggy eyes, including tea bags, potatoes and cold spoons

47 Why do we
get itchy?
Itching is caused by the release of a
48 Why do some
conditions skip a
transmitter called histamine from
mast cells which circulate in your body. generation?
These cells are often released in
response to a stimulus, such as a bee
Genes work in pairs. Some genes are
sting or an allergic reaction. They lead recessive and if paired with a
to inflammation and swelling, and dominant half, they wont shine
send impulses to the brain via nerves through. However, if two recessive
which causes the desire to itch.
genes combine (one from your
mother and one from your father),
the recessive trait will show through.

49 Why do amputees
sometimes still
45 Why do
we blink?
Blinking helps keep your eyes clean and moist. Blinking
spreads secretions from the tear glands (lacrimal fluids)
feel pain in their
amputated limbs?
This is phantom limb pain and can range from a mild
over the surface of the eyeball, keeping it moist and also annoyance to a debilitating pain. The brain can
sweeping away small particles such as dust. sometimes struggle to adjust to the loss of a limb, and
it can still interpret the limb as being there. Since the
nerves have been cut, it interprets these new signals
as pain. There isnt a surgical cure as yet, though time
and special medications can help lessen the pain.

50 Which muscle produces the

most powerful contraction
relative to its size?
The gluteus maximus is the largest muscle and forms the bulk of your buttock. The heart (cardiac
muscle) is the hardest-working muscle, as it is constantly beating and clearly can never take a break!
However the strongest muscle based on weight is the masseter. This is the muscle that clenches the
jaw shut put a finger over the lowest, outer part of your jaw and clench your teeth and youll feel it.

Myosin head Actin filament

Actin filament
is pulled

1. Taking the first step 2. Preparation

Muscle contraction starts with an impulse received from the The calcium binds to troponin which is a receptor on
nerves supplying the muscle an action potential. This the actin protein. This binding changes the shape of
action potential causes calcium ions to flood across the tropomyosin, another protein which is bound to actin.
protein muscle fibres. The muscle fibres are formed from two These shape changes lead to the opening of a series of
key proteins: actin and myosin. binding sites on the actin protein.

46 How come most

people have one foot
larger than the other?
Cross bridge
Energised myosin

Most peoples feet are different sizes in fact the two 3. Binding
halves of most peoples bodies are different! We all start
4. Unbinding
Now the binding sites are free on actin, the myosin heads When the energy runs out, the proteins lose their
from one cell, but as the cells multiply, genes give them forge strong bonds in these points. This leads to the strong bonds and disengage, and from there they
varying characteristics. contraction of the newly formed protein complex; when all return to their original resting state.
of the proteins contract, the muscle bulk contracts.


Cell structure Cell membrane

Surrounding and supporting

each cell is a plasma membrane
that controls everything that
enters and exits.

The human body has over 75 Nucleus

The nucleus is the cells brain
trillion cells, but what are they and or control centre. Inside the
nucleus is DNA information,
how do they work? which explains how to make
the essential proteins needed
to run the cell.

ells are life and cells are alive.
You are here because every cell
inside your body has a specific
function and a very specialised job to Ribosomes
do. There are many different types of These tiny structures make proteins and
cell, each one working to keep the can be found either floating in the
cytoplasm or attached like studs to the
bodys various systems operating. A
endoplasmic reticulum, which is a conveyor
single cell is the smallest unit of living belt-like membrane that transports proteins
material in the body capable of life. around the cell.
When grouped together in layers or
clusters, however, cells with similar
jobs to do form tissue, such as skin or
muscle. To keep these cells working,
there are thousands of chemical
reactions going on all the time.
All animal cells contain a nucleus, Endoplasmic reticulum
The groups of folded membranes (canals)
which acts like a control hub telling the
connecting the nucleus to the cytoplasm are
cell what to do and contains the cells called the endoplasmic reticulum (ER). If
genetic information (DNA). Most of the studded with ribosomes the ER is referred to
material within a cell is a watery, as rough ER; if not it is known as smooth
jelly-like substance called cytoplasm ER. Both help transport materials around the
(cyto means cell), which circulates cell but also have differing functions.
around the cell and is held in by a thin
external membrane, which consists of
two layers. Within the cytoplasm is a
variety of structures called organelles,
which all have different tasks, such as
manufacturing proteins the cells key
chemicals. One vital example of an
organelle is a ribosome; these numerous
structures can be found either floating
around in the cytoplasm or attached to
internal membranes. Ribosomes are
crucial in the production of proteins
from amino acids.
In turn, proteins are essential to Rough endoplasmic
building your cells and carrying out the reticulum (studded
biochemical reactions the body needs in with ribosomes)
order to grow and develop and also to
repair itself and heal.

Golgi body
Mitochondria Another organelle, the Golgi body is one
These organelles supply cells with the energy that processes and packages proteins,
necessary for them to carry out their functions. including hormones and enzymes, for
The amount of energy used by a cell is measured transportation either in and around the
in molecules of adenosine triphosphate (ATP). cell or out towards the membrane for
Mitochondria use the products of glucose secretion outside the cell where it can
metabolism as fuel to produce the ATP. enter the bloodstream.

DID YOU KNOW? Bacteria are the simplest living cells and the most widespread life form on Earth

Cell anatomy
Types of human cell
This is the jelly-like So far around 200 different varieties of cell have been
substance made of
water, amino acids and
identified, and they all have a very specific function to
enzymes found inside perform. Discover the main types and what they do
the cell membrane.
Within the cytoplasm are they are voluntary. Cardiac muscles, meanwhile,
organelles such as the
The cells that make up the nervous are involuntary, which is fortunate because
nucleus, mitochondria they are used to keep your heart beating.
system and the brain are nerve cells
and ribosomes, each Found in the walls of the heart, these muscles
or neurons. Electrical messages
of which performs a pass between nerve cells along create their own stimuli to contract without
specific role, causing long filaments called axons. To input from the brain. Smooth muscles,
chemical reactions in cross the gaps between nerve which are pretty slow and also involuntary,
the cytoplasm. cells (the synapse) that electrical make up the linings of hollow structures
signal is converted into a chemical such as blood vessels and your digestive
signal. These cells enable us to feel tract. Their wave-like contraction aids the
sensations, such as pain, and they transport of blood around the body and the
Pore also enable us to move. digestion of food.


The cells that make up bone matrix the hard These cells also known as
structure that makes bones strong consist of three adipocytes or lipocytes make
main types. Your bone mass is constantly changing up your adipose tissue, or
and reforming and each of the three bone cells plays body fat, which can
its part in this process. First the osteoblasts, which cushion, insulate and
come from bone marrow, build up bone mass and protect the body. This
structure. These cells then become buried in the tissue is found beneath
matrix at which point they become your skin and also
known as osteocytes. Osteocytes surrounding your other
make up around 90 per cent of organs. The size of a fat
the cells in your skeleton and cell can increase or
decrease depending on the

are responsible for

maintaining the bone amount of energy it stores. If we
material. Finally, while the gain weight the cells fill with more
osteoblasts add to bone mass, watery fat, and eventually the number of fat cells will
osteoclasts are the cells begin to increase. There are two types of adipose
capable of dissolving bone and tissue: white and brown. The white adipose tissue
changing its mass. stores energy and insulates the body by maintaining
body heat. The brown adipose tissue, on the other
PHOTORECEPTOR CELLS hand, can actually create heat and isnt burned for
The cones and rods on the retina at the back of the energy this is why animals are able to hibernate for
eye are known as photoreceptor months on end without food.
Science Photo Library

cells. These contain light-

sensitive pigments that EPITHELIAL CELLS
convert the image that Epithelial cells make up the epithelial tissue that
enters the eye into nerve lines and protects your organs and
signals, which the brain constitute the primary

interprets as pictures. The material of your skin.

rods enable you to perceive These tissues form a
light, dark and movement, barrier between the
while the cones bring colour precious organs and

to your world. unwanted pathogens or

other fluids. As well as
LIVER CELLS covering your skin, youll
The cells in your liver are responsible for regulating the find epithelial cells inside
composition of your blood. These cells your nose, around your lungs
filter out toxins as well as controlling and in your mouth.
fat, sugar and amino acid levels.
Around 80 per cent of the livers RED BLOOD CELLS

mass consists of hepatocytes, Unlike all the other cells in your

which are the livers body, your red blood cells (also
specialised cells that are known as erythrocytes) do
involved with the production of not contain a nucleus. You
proteins and bile. are topped up with
around 25 trillion red
MUSCLE CELLS blood cells thats a third
There are three types of muscle of all your cells, making
cell skeletal, cardiac and smooth and them the most
each differs depending on the function common cell in
it performs and its location in the your body. Formed
Lysosomes body. Skeletal muscles contain long in the bone marrow,
This digestive enzyme breaks down fibres that attach to bone. When these cells are
unwanted substances and worn-out triggered by a nerve signal, the important because they carry oxygen to all
organelles that could harm the cell by muscle contracts and pulls the bone the tissues in your body. Oxygen is carried
digesting the product and then with it, making you move. We can in haemoglobin, a pigmented protein that
ejecting it outside the cell. control skeletal muscles because gives blood cells their red colour.


Inside a nucleus Central command

Dissecting the control centre of a cell
Take a peek at whats happening inside

urrounded by cytoplasm, the nucleus responsible for making proteins out of amino the brain of a eukaryotic cell
contains a cells DNA and controls all acids which take care of growth and repair. 1 Nuclear pore
of its functions and processes such as The nucleus is the most protected part of These channels control the movement of molecules
movement and reproduction. the cell. In animal cells it is located near its between the nucleus and cytoplasm.
There are two main types of cell: centre and away from the membrane for 2 Nuclear envelope
eukaryotic and prokaryotic. Eukaryotic cells maximum cushioning. As well as the Acts as a wall to protect the DNA within the nucleus
contain a nucleus while prokaryotic do not. jelly-like cytoplasm around it, the nucleus is and regulates cytoplasm access.
Some eukaryotic cells have more than one filled with nucleoplasm, a viscous liquid 3 Nucleolus
nucleus called multinucleate cells which maintains its structural integrity. Made up of protein and RNA, this is the heart of the
occurring when fusion or division creates Conversely, in plant cells, the nucleus is nucleus which manufactures ribosomes.
two or more nuclei. more sporadically placed. This is due to the 4 Nucleoplasm
At the heart of a nucleus youll find the fact that a plant cell has a larger vacuole and This semi-liquid, semi-jelly material surrounds the
nucleolus; this particular area is essential in there is added protection which is granted by nucleolus and keeps the organelles structure.
the formation of ribosomes. Ribosomes are a cell wall. 5 Chromatin
Produces chromosomes and aids cell division by
condensing DNA molecules.
Nucleus in context
Explore the larger body that a
nucleus rules over and meet
its cellmates


How do cells
survive without
Mitochondrion a nucleus?
Ribosomes Double membraned, Prokaryotic cells are actually much more basic
Made up of two separate this produces energy for
entities, ribosomes make than their eukaryotic counterparts. Not only
the cell by breaking
proteins to be used both down nutrients via are they up to 100 times smaller but they also
inside and outside the cell. cellular respiration. are mainly a comprising species of bacteria,
prokaryotic cells have fewer functions than
other cells, so they do not require a nucleus to
act as the control centre for the organism.
Golgi apparatus Instead, these cells have their DNA moving
Named after the Italian
around the cell rather than being housed in a
biologist Camillo Golgi,
they create lysosomes Lysosome nucleus. They have no chloroplasts, no
and also organise the Small and spherical, membrane-bound organelles and they dont
proteins for secretion. this organelle contains undertake cell division in the form of mitosis or
digestive enzymes that meiosis like eukaryotic cells do.
attack invading bacteria.
Prokaryotic cells divide asexually with DNA
molecules replicating themselves in a process

that is known as binary fission.

DID YOU KNOW? Stem cells have the ability to self-renew

A stem cell surrounded by

red blood cells. Soon it
could become one of them

What are stem cells?

Understand how these building blocks bring new life

tem cells are incredibly proliferation while others such
special because they have
the potential to become
as nerve cells dont divide at all.
There are two stem cell types, Cloning cells
any kind of cell in the body, from as Professor Paul Fairchild, Scientists can reprogram cells to
red blood cells to brain cells. They co-director of the Oxford Stem Cell forget their current role and
are essential to life and growth, as Institute at Oxford Martin School become pluripotent cells
they repair tissues and replace explains: Adult stem cells are indistinguishable from early
dead cells. Skin, for example, is multipotent, which means they embryonic stem cells. Induced
pluripotent stem cells (IPSCs) can be
constantly replenished by skin are able to produce numerous
used to take on the characteristics of
stem cells. cells that are loosely related, such nearby cells.
Stem cells begin their life cycle as stem cells in the bone marrow IPSCs are more reliable than stem
as generic, featureless cells that can generate cells that make up cells grown from a donated embryo
dont contain tissue-specific the blood, he says. In contrast, because the body is more likely to
structures, such as the ability to pluripotent stem cells, found accept self-generated cells. IPSCs can
treat degenerative conditions such as
carry oxygen. Stem cells become within developing embryos, are
Parkinsons disease and baldness,
specialised through a process able to make any one of the which are caused by cells dying
called differentiation. This is estimated 210 cell types that make without being replaced. The IPSCs fill
triggered by signals inside and up the human body. those gaps in order to restore the
outside the cell. Internal signals This fascinating ability to bodys systems.
come from strands of DNA that transform and divide has made Professor Fairchild explains, by
deriving these cells from individuals
carry information for all cellular stem cells a rich source for
with rare conditions, we are able to
structures, while external signals medical research. Once their true model the condition in the laboratory
include chemicals from nearby potential has been harnessed, and investigate the effects of new
cells. Stem cells can replicate they could be used to treat a huge drugs on that disease.
many times known as range of diseases and disabilities.


The human brain is the most
mysterious and complex entity
in the known universe
ts a computer, a thinking machine, a pink organ, and a vast

I collection of neurons but how does it work? The human brain is

amazingly complex in fact, more complex than anything in the
known universe. The brain effortlessly consumes power, stores
memories, processes thoughts, and reacts to danger.
In some ways, the human brain is like a car engine. The fuel which
could be the sandwich you had for lunch or a sugar doughnut for
breakfast causes neurons to fire in a logical sequence and to bond
with other neurons. This combination of neurons occurs incredibly
fast, but the chain reaction might help you compose a symphony or Basal ganglia (unseen)
recall entire passages of a book, help you pedal a bike or write an Regulates involuntary movements
email to a friend. such as posture and gait when we
Scientists are just beginning to understand how these brain walk, and also regulates tremors and
neurons work they have not figured out how they trigger a other irregularities. This is the
reaction when you touch a hot stove, for example, or why you section of the brain where
Parkinsons Disease can develop.
can re-generate brain cells when you work out at the gym.
The connections inside a brain are very similar to the internet
the connections are constantly exchanging information. Yet,
even the internet is rather simplistic when compared to neurons. Hypothalamus
Controls metabolic functions such as
There are ten to 100 neurons, and each one makes thousands of
body temperature, digestion,
connections. This is how the brain processes information, or breathing, blood pressure, thirst,
determines how to move an arm and grip a surface. These calculations, hunger, sexual drive, pain relays, and
perceptions, memories, and reactions occur almost instantaneously, also regulates some hormones.
and not just a few times per minute, but millions. According to Jim Olds,
research director with George Mason University, if the internet were as
complex as our solar system, then the brain would be as complex as
our galaxy. In other words, we have a lot to learn. Science has not given
up trying, and has made recent discoveries about how we adapt, learn
new information, and can actually increase brain capability.
Parts of
In the most basic sense, our brain is the centre of all input and
outputs in the human body. Dr Paula Tallal, a co-director of
the brain
So what are the parts of the brain? According
neuroscience at Rutgers University, says the brain is constantly to Olds, there are almost too many to count
processing sensory information even from infancy. Its easiest to perhaps a hundred or more, depending on
think of the brain in terms of inputs and outputs, says Tallal. Inputs who you ask. However, there are some key
are sensory information, outputs are how our brain organises that areas that control certain functions and store
information and controls our motor systems. thoughts and memories.
Tallal says one of the primary functions of the brain is in learning to
predict what comes next. In her research for Scientific Learning, she
has found that young children enjoy having the same book read to
them again and again because that is how the brain registers acoustic
cues that form into phonemes (sounds) to become spoken words.
We learn to put things together so that they become smooth
sequences, she says. These smooth sequences are observable in the
brain, interpreting the outside world and making sense of it. The brain
is actually a series of interconnected superhighways or pathways

DID YOU KNOW? The average human brain is 140mm wide x 167mm long x 93mm high

Cerebral cortex
The grey matter of the brain controls
cognition, motor activity, sensation, and
other higher level functions. Includes Functions of the
cerebral cortex
the association areas which help
process information. These
association areas are what
distinguishes the human
brain from other brains.
The cerebral cortex is the wrinkling part
of our brain that shows up when you see
Frontal lobe
pictures of the brain
Primarily controls senses
such as taste, hearing, and
smell. Association areas
might help us determine
language and the tone of movements
someones voice. Skeletal movement Parietal lobe
Where the brain senses
touch and anything that
Problem interacts with the surface
solving of the skin, makes us
aware of the feelings
of our body and
where we are
in space.

Touch and skin



from eyes

Speech Analysis of
signal from eyes


Prefrontal cortex S
PL Temporal lobe
Executive functions such as complex What distinguishes the human
planning, memorising, social and verbal brain the ability to process
skills, and anything that requires and interpret what other parts
advanced thinking and interactions. In Analysis of of the brain are hearing,
sounds sensing, or tasting and
adults, helps us determine whether an
action makes sense or is dangerous. determine a response.

Cerebellum In a sense, the main function of

Consists of two cerebral
hemispheres that controls motor the brain is in ordering information
activity, the planning of
movements, co-ordination, and interpreting the outside world and
other body functions. This section
of the brain weighs about 200
grams (compared to 1,300 grams
making sense of it
for the main cortex).
that move data from one part of the body to some cases). This means that when you reach
another. out to open a door, your brain has already
Limbic system Tallal says another way to think about the predetermined how to move your elbow and
The part of the brain that brain is by lower and upper areas. The spinal clasp your hand around the door handle
controls intuitive thinking, cord moves information up to the brain stem, maybe even simulated this movement more
emotional response,
then up into the cerebral cortex which than once, before you even actually perform
sense of smell and taste.
controls thoughts and memories. the action.
Interestingly, the brain really does work like a Another interesting aspect is that not only
powerful computer in determining not only are there are some voluntary movements but
movements but registering memories that can there are also some involuntary movements.
be quickly recalled. Some sections of the brain might control a
According to Dr Robert Melillo, a neurologist voluntary movement such as patting your
and the founder of the Brain Balance Centers knee to a beat. Another section controls
(, the brain involuntary movements, such as the gait of your
will then actually predetermine actions and walk which is passed down from your parents.
calculate the results about a half-second Reflexes, long-term memories, the pain reflex
before performing them (or even faster in these are all controlled by sections in the brain.


A neuron is a nerve cell in
the brain that can be
activated (usually by
glucose) to connect with
other neurons and form a
bond that triggers an
action in the brain.
Neurotransmitter Neurons fire like electrical circuits
A neurotransmitter is the
electro-chemical circuit
Neurons are a kind of cell that are in the brain (humans
that carries the signal from have many cells in the body, including fat cells, kidney
one neuron to another cells, and gland cells). A neuron is essentially like a hub that
along the axon. works with nearby neurons to generate both an electrical
and chemical charge. Dr Likosky of the Swedish Medical
A thin synapse Institute says another way of thinking about neurons is
A thin synapse
(measuring just a few
that they are like a basketball and the connections (called
nanometres) between axons) are like electrical wires that connect to other
the neurotransmitter, neurons. This creates a kind of circuit in the human body.
carried along the axon in Tallal explained that input from the five senses in the body
the brain, forms the cause neurons to fire.
electro-chemical The more often a collection of neurons are stimulated
connection. together in time, the more likely they are to bind together
and the easier it becomes for that pattern of neurons to fire
in synchrony as well as sequentially, says Tallal.

Brain maps
TrackVis generates unique maps of the brain
TrackVis is a free program used by neurologists to see a map of the brain
that shows the fibre connections. On every brain, these neural
DK Images

pathways help connect one part of the brain to another so that a feeling
you experience in one part of the brain can be transmitted and
processed by another part of the brain (one that may decide the touch is
The brain - a fragile harmful or pleasant). TrackVis uses fMRI readings on actual patients to
generate the colourful and eye-catching images. To construct the maps,
organ that weighs the program can take several hours to determine exactly how the fibres
are positioning in the brain.
about 1,500 grams

What is my
brain like?
If you could hold it in your hand
In pictures that we are all accustomed to seeing, the human
brain often looks pink and spongy, with a sheen of slime. The computers used to
According to Dr William Likosky, a neurologist at the Swedish generate the TrackVis
maps might use up to
Medical Institute (, the brain is actually
1,000 graphics processors
quite different from what most people would immediately that work in tandem to
think it is. process the data.
Likosky described the brain as being not unlike feta cheese
in appearance a fragile organ that weighs about 1,500 grams
and sags almost like a bag filled with water.
In the skull, the brain is highly protected and has hard
tissue, but most of the fatty tissue in the brain which helps
pass chemicals and other substances through membranes
is considerably more delicate.

DID YOU KNOW? The adult human brain weighs about 1.4kg (or three pounds)

Nerve transmissions Nerve triggers

How do Some nerve transmissions travel great

distances through the human body,
others travel short distances both use
When many neurons are activated together
at the same time, the nerve is excited this
is when we might feel the sensation of

a de-polarisation to create the circuit. touch or a distinct smell.
De-polarisation is like a wound-up
spring that releases stored energy once
it is triggered.

work? Myelinated and

Nerves carry signals throughout the Some nerves are myelinated
body a chemical superhighway (or insulated) with fatty tissue
that appears white and forms a
Nerves are the transmission cables that carry brain waves in the slower connection over a
human body, says Sol Diamond, an assistant professor at the Thayer longer distance. Others are

DK Images
School of Engineering at Dartmouth. According to Diamond, nerves un-myelinated and are
communicate these signals from one point to another, whether from un-insulated. These nerves
travel shorter distances.
your toenail up to your brain or from the side of your head.

What does the

spinal cord do? Spinal cord core
In the core of the spinal cord, grey matter
like the kind in the outer layer of the

The spinal cord actually brain is for processing nerve cells such
as touch, pain and movement.
is part of the brain and
plays a major role
Scientists have known for
the past 100 years or so Neuronal fibre
that the spinal cord is
actually part of the brain.
According to Melillo,
while the brain has grey
matter on the outside
(protected by the skull)
and protected white
matter on the inside, the Nerve root
spinal cord is the reverse: Spinal nerve
the grey matter is inside
the spinal cord and the
white matter is outside.
Grey matter cells According to Tallal, by repeating brain
Grey matter cells in the spinal cord activities such as memorisation and
cannot regenerate, which is why pattern recognition, you can grow new
people with a serious spinal cord injury brain cells in the spinal cord and brain.
cannot recover over a period of time.
White matter cells can re-generate.

White matter cells

White matter cells in the spinal cord
carry the electro-chemical pulses up to
the brain. For example, when you are Neuroplasticity
kicked in the shin, you feel the pain in In the spinal cord and in the brain, cells
the shin and your brain then tells you can rejuvenate over time when you
to move your hand to cover that area. exercise and become strengthened. This
process is called neuroplasticity.


Inside the
human eye
Uncovering one of the most complex constructs in the natural world
he structure of the human eye is so similar way to a camera, with an opening structure bends the light, focusing it down to a

T incredibly complex that its actually

hard to believe that its not the product
of intelligent design. But by looking at and
through which the light enters, a lens for
focusing and a light-sensitive membrane.
The amount of light that enters the eye is
point on the retina, at the back of the eye.
The retina is covered in millions of light-
sensitive receptors known as rods and cones.
studying the eyes of various other animals, controlled by the circular and radial muscles Each receptor contains pigment molecules,
scientists have been able to show that eyes in the iris, which contract and relax to alter the which change shape when they are hit by
have evolved very gradually from just a simple size of the pupil. The light fi rst passes through light, which triggers an electrical message
light-dark sensor over the course of around 100 a tough protective sheet called the cornea, and that then travels to the brain via the
million years. The eye functions in a very then moves into the lens. This adjustable optic nerve.

This pit at the centre of the Ciliary body
back of the eye is rich in light This tissue surrounds the lens and
receptors and is responsible contains the muscles responsible
for sharp central vision. for changing its shape.

Optic nerve
Signals from the retina travel Sclera
to the brain via the optic nerve, A tough white membrane
a bundle of fibres that exits known as the sclera helps
through the back of the eye. to maintain the eyes
spherical shape.

Blind spot The lens is responsible for
At the position where the focusing the light, and can
optic nerve leaves the eye, change shape to
there is no space for light accommodate objects
receptors, leaving a natural near and far from the eye.
blind spot in our vision.

The pupil and iris are
Retina Iris covered in a tough,
The retina is covered in receptors that This circular muscle controls the Pupil transparent membrane,
detect light. It is highly pigmented, size of the pupil, allowing it to be The pupil is a hole that which provides protection
preventing the light from scattering closed down in bright light, or allows light to reach and contributes to
and ensuring a crisp image. opened wide in the dark. the back of the eye. focusing the light.

DID YOU KNOW? 285 million people in the world are estimated to be visually impaired and 39 million of them are blind

How the eye focuses

The tiny rings of muscle that make your vision sharp

ameras and human eyes both focus light
using a lens. This structure bends the
incoming wavelengths so that they hit Lens
The lens is
Accommodation explained
the right spot on a photographic plate, or on the How the lens changes its shape to focus on
responsible for near and distant objects
back of the eye. A camera lens is made from solid focusing the
glass, and focuses on near and distant objects by light on the back
of the eye.
physically moving closer or further away. A Ciliary muscle
A ring of muscle
biological lens is actually squishy, and it focuses surrounding the lens can
by physically changing shape. pull it tight, or let it relax.
In the eye, this process is known as
accommodation, and is controlled by a ring of
smooth muscle called the ciliary muscle. This is
attached to the lens by fibres known as
suspensory ligaments. When the muscle is
relaxed, the ligaments pull tight, stretching the
lens until it is flat and thin. This is perfect for
looking at objects in the distance. Suspensory
When the ciliary muscle contracts, the ligament
ligaments loosen, allowing the lens to become fat The ciliary muscle is
connected to the lens
and round. This is better for looking at objects that by ligaments.
are nearby. The coloured part of the eye (called
the iris) controls the size of the pupil and ensures When the muscle
the right amount of light gets through the lens. relaxes, the
ligaments are
pulled tight. Contracted
When the muscle
contracts, the ligaments
slacken off.

Beneath the iris,

muscles are Far Near
A flat, thin lens is A round, fat lens is
working hard to good for looking at good for looking at
adjust the lens distant objects. nearby objects.

Seeing in three dimensions Individual image

Each eye sees a slightly different Due to the positioning of our eyes,
when objects are closer than about
image, allowing the brain to 5.5m (18ft) away, each eye sees a
perceive depth slightly different angle.

Our eyes are only able to produce two-

dimensional images, but with some clever Combined image
The incoming signals from both
internal processing, the brain is able to eyes are compared in the brain, and
build these flat pictures into a three- the subtle differences are used to
create a three-dimensional image.
dimensional view. Our eyes are positioned
about five centimetres (two inches) apart,
so each sees the world from a slightly Try it for yourself
different angle. The brain then compares By holding your hand in front of
your face and closing one eye at a
the two pictures, using the differences to
time, it is easy to see the different
create the illusion of depth. 2D views perceived by each eye.


Structure Malleus
of the ear One of the three ossicles,

this hammer-shaped
bone connects to the
eardrum and moves with
Auricle (pinna) every vibration bouncing
This is the visible part off the drum.
of the outer ear that

collects sound wave
vibrations and directs
them into the ear.

The human ear
performs a range of
functions, but how External acoustic
do they work? meatus (outer
ear canal) Tympanic membrane
This is the wax-lined tube (eardrum)

he thing to remember when learning that channels sound The slightly concave thin layer of skin
about the human ear is that sound is all vibrations from the outer stretching across the ear canal and
pinna through the skull to separating the outer and middle ear.
about movement. When someone speaks
the eardrum. Vibrations that hit the eardrum are
or makes any kind of movement, the air around
transmitted as movement to the
them is disturbed, creating a sound wave of
three ossicle bones.
alternating high and low frequency. These waves
are detected by the ear and interpreted by the
brain as words, tunes or sounds.
Consisting of air-filled cavities, labyrinthine
fluid-filled channels and highly sensitive cells,
the ear has external, middle and internal parts.
The outer ear consists of a skin-covered flexible
cartilage flap called the auricle, or pinna. This
feature is shaped to gather sound waves and
amplify them before they enter the ear for
processing and transmission to the brain. The Scala vestibuli
first thing a sound wave entering the ear
(vestibular canal)
Incoming vibrations travel
encounters is the sheet of tightly pulled tissue along the outer vestibular
separating the outer and middle ear. This tissue is canal of the cochlea.
the eardrum, or tympanic membrane, and it
vibrates as sound waves hit it.
Beyond the eardrum, in the air-filled cavity of
the middle ear, are three tiny bones called the
ossicles. These are the smallest bones in your
body. Sound vibrations hitting the eardrum pass
to the first ossicle, the malleus (hammer). Next the
waves proceed along the incus (anvil) and then on
to the (stapes) stirrup. The stirrup presses against
a thin layer of tissue called the oval window, and
this membrane enables sound waves to enter the
fluid-filled inner ear.
The inner ear is home to the cochlea, which
consists of watery ducts that channel the Cochlear duct
The cochlear duct separates the
vibrations, as ripples, along the cochleas
tympanic and vestibular canals.
spiralling tubes. Running through the middle of The organ of Corti is found here.
the cochlea is the organ of Corti, which is lined
with minute sensory hair cells that pick up on the
vibrations and generate nerve impulses that are
sent to the brain as electrical signals. The brain
can interpret these signals as sounds.

DID YOU KNOW? The eardrum needs to move less than the diameter of a hydrogen atom in order for us to perceive sound

Incus (anvil)
Connected to the hammer, the
A bony snail-shaped structure,
the cochlea receives vibrations
The vestibular system
incus is the middle ossicle bone
and is shaped like an anvil. from the ossicles and Inside the inner ear are the vestibule
transforms them into electrical and semicircular canals, which
feature sensory cells. From the
Semicircular canal
Stapes (stirrup) signals that are transmitted to
These three loops positioned
The stirrup is the third ossicle bone. It the brain. There are three semicircular canals and at right angles to each other
attaches to the oval window at the fluid-filled channels the maculae, information about are full of fluid that transports
base of the cochlea. Movements vestibular canal, the tympanic
which way the head is sound vibrations to the crista.
transferred from the outer ear to the canal and the cochlea duct
within the spiral of the cochlea.
moving is passed to
middle ear now continue their journey
receptors, which send
through the fluid of the inner ear.
electrical signals Vestibular nerve
Sends information
to the brain as
about equilibrium from
nerve impulses. the semicircular canals
Organ of Corti to the brain.

DK Images
The organ of Corti contains
rows of sensitive hair cells,
the tips of which are
embedded in the tectorial
membrane. When the
membrane vibrates, the hair Macula
receptors pass information A sensory area Vestibule
through the cochlear nerve covered in Inside the fluid-filled
to the brain. tiny hairs. vestibules are two
chambers (the utricle
and saccule), both of
which contain a
Cochlear nerve Crista structure called a
Sends nerve impulses with At the end of each semicircular canal macula, which is
information about sounds from there are tiny hair-filled sensory receptors covered in sensory
the cochlea to the brain. called cristae. hair cells.

A sense of balance
The vestibular system functions to give acceleration (ie, movement of your head)
you a sense of which way your head is in three different directions due to the
pointing in relation to gravity. It enables positioning of the loops along different
you to discern whether your head is planes. Like the organ of Corti, the
upright or not, as well as helping you to semicircular canals employ tiny hair cells
maintain eye contact with stationary to sense movement. The canals are
objects while your head is turning. connected to the auditory nerve at the
Also located within the inner ear, but back of the brain.
less to do with sound and more concerned Your sense of balance is so complex
with the movement of your head, are the that the area of your brain thats purely
semicircular canals. Again filled with dedicated to this one role involves the
fluid, these looping ducts act like internal same number of cells as the rest of your
Scala tympani accelerometers that can actually detect brain cells put together.
(tympanic canal)
The vestibular canal and this, the The surfers semicircular canals
tympanic canal, meet at the apex of are as crucial as his feet when it
the cochlear spiral (the helicotrema). comes to staying on his board

Think of sounds as
movements, or
disturbances of air,
that create waves
Science Photo Library


What are
tonsils for?
What purpose do these fleshy lumps in
the back of our throats serve?

Where you can find
the three pairs of
tonsils in your head

Palatine tonsils Lingual tonsils Pharyngeal tonsils

These are the best-known pair The lingual tonsils are found at These are otherwise known as
of tonsils, as theyre clearly the rear of your tongue one at the adenoids and are located
visible at the back of your throat. either side in your lower jaw. at the back of the sinuses.

onsils are the small masses of flesh found
in pairs at the back of the throats of many
mammals. In humans the word is actually
used to describe three sets of this spongy
lymphatic tissue: the lingual tonsils, the
pharyngeal tonsils and the more commonly Lots of bed rest, fluids
and pain relief like
Tonsillitis in focus
recognised palatine tonsils. Tonsillitis is caused by certain bacteria (eg
paracetamol are all group A beta-haemolytic streptococci), and
The palatine tonsils are the oval bits that hang recommended for
down from either side at the back of your throat sometimes viral infections, that result in a
treating tonsillitis sore and swollen throat, a fever, white spots at
you can see them if you look in the mirror.
the back of the throat and difficulty
Although the full purpose of the palatine tonsils swallowing. Usually rest and antibiotics will
isnt yet understood, because they produce see it off, but occasionally the infection can
antibodies and because of their prominent cause serious problems or reoccur very
position in the throat, theyre thought to be the frequently. In these cases, a tonsillectomy may
first line of defence against potential infection in be considered,where the tonsils are removed.
both the respiratory and digestive tracts. The adenoids are less commonly infected
but, when they are, they become inflamed,
The pharyngeal tonsils are also known as the
obstruct breathing through the nose and
adenoids. These are found tucked away in the interfere with drainage from the sinuses,
nasal pharynx and serve a similar purpose to the which can lead to further infections. In
palatine tonsils but shrink in adulthood.
Thinkstock; DK Images

younger people, constant breathing through

The lingual tonsils are found at the back of the the mouth can stress the facial bones and
tongue towards the root and, if you poke your cause deformities as they grow, which is why
tongue right out, you should spot them. These are children will sometimes have their adenoid
glands removed.
drained very efficiently by mucous glands so they
very rarely get infected.

DID YOU KNOW? The vocal cords remain open when you breathe, but close completely when you hold your breath

How do
speak? The epiglottis stops food
entering the trachea

This muscle, situated in the
The vocal cords and larynx in particular mouth, can affect and
change sound as it travels up
have evolved over time to enable humans to from the vocal cords and out

produce a dramatic range of sounds in order through the mouth.

to communicate but how do they work? Trachea

The vocal cords are situated

ocal cords, also known as vocal As air is expelled from the lungs, the at the top of the trachea,
folds, are situated in the larynx, vocal folds vibrate and collide to which is where air from the
which is placed at the top of the produce a range of sounds. The type of lungs travels up through
trachea. They are layers of mucous sound emitted is effected by exactly from the chest.
membranes that stretch across the how the folds collide, move and stretch
larynx and control how air is expelled as air passes over them. An individual
from the lungs in order to make certain fundamental frequency is Vocal cords
sounds. The primary usage of vocal determined by the length, size and These layers of mucous
cords within humans is in order to be tension of their vocal cords. Movement membranes stretch across
abl to communicate with eachother of the vocal folds is controlled by the the larynx and they open,
close and vibrate to produce
and it is hypothesised that human vagus nerve, and sound is then further
different sounds.
vocal cords actually developed to the fine-tuned to form words and sounds
extent we see now to facilitate that we can recognise by the larynx,
advanced levels of communication in tongue and lips. Fundamental
response to the formation of social frequency in males averages at 125Hz,
groupings during phases of primate, and at 210Hz in females. Children have
and specifically human, evolution. a higher average pitch at around 300Hz.

Differences between male Epiglottis

and female vocal cords This is a flap of skin that
shuts off the trachea when
Male voices are often much lower than success, and individuals with lower an individual is swallowing
Vocal cords open when
female voices. This is primarily due to voices have been seen to be more food. It stops food and liquids
going down the wrong way. breathing, but are pulled
the different size of vocal folds present successful in reproduction. The reason together when speaking
in each sex, with males having larger proposed for this is that a lower tone
folds that create a lower pitched sound, voice may indicate a higher level of Oesophagus
and females having smaller folds that testosterone present in a male. This tube, situated behind
create a higher pitch sound. The the trachea, is where
food and liquid travels
average size for male vocal cords are
down to the stomach.
between 17 and 25mm, and females
are normally between 12.5 and 17.5mm.
From the range in size, however, males
can be seen to have quite high pitch Lips
voices, and females can have quite low Lips are essential for the
pitch voices. production of specific
The other major biological sounds, like b or p.
difference that effects pitch is that
males generally have a larger vocal Larynx
Known as the voice
tract, which can further lower the tone
box, this protects the trachea
of their voice independent of vocal cord and is heavily involved in
size. The pitch and tone of male voices controlling pitch and volume.
has been studied in relation to sexual The vocal cords are situated
within the larynx.


The biological structures

that are so versatile they
enable us to eat a well
varied diet

The trouble T
he primary function of teeth is to
crunch and chew food. For this
reason, teeth are made of strong
the teeth first appear at six months old
and are replaced by secondary teeth after
six or seven years. Some animals develop
disease. From ancient times healers have
sought to try to treat and replace the teeth
with false ones. Examples of this practice
with teeth substances namely calcium, only one set of teeth, while sharks, for date all the way back to the ancient
Tooth decay, also often phosphorus and various mineral salts. instance, grow a new set of teeth every Egyptian times and today, we see
known as dental caries, The main structure of the tooth is two weeks. revolutionary new techniques in the form
affects the enamel and dentine, which is itself enclosed in a With humans, tooth loss can occur of dental implants, which are secured
dentine of a tooth, breaking shiny substance called enamel. This through an accident , old age and gum deep within the bone of the jaw.
down tissue and creating strong white coating is incredibly the
fissures in the enamel. Two hardest material to be found in the
human body. Enamel Pulp
types of bacteria namely The white, outer surface The pulp nourishes the
Streptococcus mutans and Humans have various types of teeth
of the tooth. This can be dentine and keeps the
Lactobacillus which are that function differently. Incisors tear at clearly seen when tooth healthy the pulp is
responsible for tooth decay. food, such as the residue found on bones, looking in the mouth. the soft tissue of the tooth,
Tooth decay occurs after while bicuspids have long sharp which is protected by the
the teeth have had repeated structures that are also used for ripping. dentine and enamel.
contact with different types Bicuspids tear and crush while molars,
of acid-producing bacteria. which have a flatter surface, grind the Cementum
food before swallowing. This aids The root coating, it
Environmental factors also
protects the root
have a strong effect. Sucrose, digestion. Because humans have a varied
canal and the
fructose and glucose cause array of teeth (called collective dentition)
nerves. It is
problems, and diet is also a we are able to eat a complex diet of both connected to the
big factor in maintaining meat and vegetables. Other species, such jawbone through
good oral health. as grazing animals for example, have collagen fibres.
The mouth contains an specific types of teeth. Cows, for example,
enormous variety of have large flat teeth, which restrict them
bacteria, which collects to a simple grazing diet. Blood vessels
around the teeth and gums. Teeth have different functions, in some and nerves Bone
This is the sticky white cases they aid hunting but they also have The blood vessels The bone acts
substance called plaque. strong psychological connotations. Both and nerves carry as an
animals and humans bare their teeth important important
Plaque is known as a biofilm.
when faced with an aggressive situation. nourishment to the anchor for the
After eating, the bacteria in
tooth and are tooth and
the mouth then metabolises Teeth are the most enduring features of
sensitive to keeps the root
sugar, which attacks the the human body. Mammals are pressure and secure within
areas around the teeth. described as diphyodont, which means temperature. the jawbone.
they develop two sets of teeth. In humans

DID YOU KNOW? The ancient Egyptians had severe problems with their teeth. They invented the worlds first dental bridge

Inside your Maxilla

A layout of the upper area

of your mouth
Central incisors

The upper and lower areas of the mouth

are known as the maxilla and the
mandible. The upper area of the mouth
is attached to the skull bone and is often
called the upper arch of the mouth,
while the mandible is the v-shaped bone
that carries the lower set of teeth. Lateral incisors

Canine teeth Canine

Long, pointed teeth that are 1st bicuspid
used for holding and tearing at
the food within the mouth.
2nd bicuspid
Wisdom teeth
Usually appear between the
ages of 17 and 25, and often 1st molar
erupt in a group of four.

2nd molar

3rd molar or
wisdom tooth

Science Photo Library

of teeth
The approximate
ages at which the

Science Photo Library

permanent teeth
begin to erupt
Regular check-
ups help keep
teeth healthy
Age 6
First molar

Tooth 3rd molar or

wisdom tooth
Age 7
Central incisor
anatomy 2nd molar
1st molar
Age 9
The tooth is a complex structure. The
enamel at the surface of the tooth is highly
First premolar
2nd premolar
visible while the dentine is a hard but
porous tissue found under the enamel. 1st premolar Age 10
The gums provide a secure hold for the Second premolar
tooth, while the root is anchored right Canine
into the jawbone. In the centre of the tooth
there is a substance called pulp which Lateral incisors Age 11
contains nerves and blood vessels, the Canine
pulp nourishes the dentine and keeps the
tooth healthy.
Tooth formation begins before birth.
Age 12
Normally there are 20 primary teeth Second molar
(human baby teeth) and later, 28 to 32 Central incisors
permanent teeth, which includes the Age 17 to 21
wisdom teeth. Of the primary teeth, ten
are found in the maxilla (the upper jaw)
A look inside your lower jawbone
First and second or not at all
premolar teeth
and ten in the mandible (lower jaw), while The premolar or bicuspids are
Third molar
the mature adult has 16 permanent teeth Lateral and central incisors located between the canine (wisdom teeth)
in the maxilla and 16 in the mandible. Incisor comes from the Latin word to and molar teeth. They are
cut, they are used to grip and bite. used for chewing.


Anatomy of the neck

Explore one of the most complex and functional areas of the human body

Get it in the neck

he human neck is a perfect blend of form
and function. It has several specific tasks
We show the major features that are packed into
(eg making it possible to turn our heads to
this junction between the head and torso Larynx
see), while serving as a conduit for other vital This serves two main
activities (eg connecting the mouth to the lungs). functions: to connect the
The anatomical design of the neck would Oesophagus mouth to the trachea, and
This pipe connects the to generate your voice.
impress modern engineers. The flexibility of the Sympathetic trunk Cartilage mouth to the stomach,
cervical spine allows your head to rotate, flex and These special nerves run This tough tissue and is collapsed until
tilt many thousands of times a day. alongside the spinal cord, and protects the delicate you swallow Carotid artery
control sweating, heart rate airways behind, something, when its These arteries transmit
The muscles and bones provide the strength and breathing, among other including the larynx. muscular walls stretch. oxygenated blood from
and flexibility required, however the really vital functions. the heart to the brain.
impressive design comes with the trachea, There are two of them
Vertebra (right and left), in case one
oesophagus, spinal cord, myriad nerves and the These bones provide
vital blood vessels. These structures must all find
Phrenic nerve support to prevent the neck
becomes blocked.
These important
space and function perfectly at the same time. collapsing, hold up the skull
nerves come off the
and protect the spinal
They must also be able to maintain their shape third, fourth and fifth
cord within.
neck vertebrae, and
while the neck moves.
innervate the
These structures are all highly adapted to diaphragm, which
achieve their aims. The trachea is protected by a keeps you breathing
(without you having to
ring of strong cartilage so it doesnt collapse,
think about it).
while allowing enough flexibility to move when
stretched. Above this, the larynx lets air move
over the vocal cords so we can speak. Farther
back, the oesophagus is a muscular tube which
food and drink pass through en route to the
stomach. Within the supporting bones of the neck
sits the spinal cord, which transmits the vital
nerves allowing us to move and feel. The carotid
arteries and jugular veins, meanwhile, constantly
carry blood to and from the brain.

How does the head

connect to the neck?
They are connected at the bottom of the skull
and at the top of the spinal column. The first
vertebra is called the atlas and the second is
called the axis. Together these form a special
pivot joint that grants far more movement than
other vertebrae. The axis contains a bony
projection upwards, upon which the atlas
rotates, allowing the head to turn. The skull sits
on top of slightly flattened areas of the atlas,
providing a safe platform for it to stabilise on,
and allowing for nodding motions. These bony
connections are reinforced with strong muscles,
adding further stability. Dont forget that this
amazing anatomical design still allows the vital
spinal cord to pass out of the brain. The cord sits
Spinal cord
Shielded by the vertebrae,
in the middle of the bony vertebrae, where it is the spinal cord sends
protected from bumps and knocks. It sends out motor signals down nerves
nerves at every level (starting right from the top) and receives sensory
which actually control over most of the body. information from all
around the body.

DID YOU KNOW? The hyoid bone at the front of the neck is the only one in the body not connected to another bone

Just say no
The physiology that lets
us shake our heads
The neck in context
The human neck relies on a wide array of bones
and muscles for support, as we see here

Rotation This section
The movement of articulates (moves)
the atlas around around the odontoid
the odontoid peg process which
allows for rotation projects through it.
of the skull above it.

Odontoid Axis
process In the spinal column, this
This bony projection is the second vertebra,
is parallel with the which provides the
longitudinal axis stability for the required
of the spine. upwards bony projection.

Turn your head left and feel the Atlas
right of your neck this is the The first neck (cervical)
muscle doing the turning. vertebra is what
permits the nodding
motion of the head.

When you shrug your
shoulders this broad
muscle tenses up
between your
shoulder and neck.
The second cervical
vertebra allows rotation
of the head. So when
youre shaking your head
to say no, you have got Cervical plexus
this bone to thank. These nerves provide
Jugular vein sensation to the skin and
These vessels
also control the fine
drain blood
movements of the neck.
from the neck,
returning it to
the heart.
Spinal cord
Vertebrae create a
cage of bones to
protect the critical
spinal cord within.

Seventh cervical
This is the bony Splenius capitis
protuberance at the This muscle is an example
bottom of your neck, of one of the many
which you can feel; strap-like muscles which
SPL; Thinkstock

doctors use it as a kind of control the multitude of

landmark so they can fine movements of the
locate the other vertebrae. head and neck.


How the Scapula


human Sternum

Without a skeleton, we would not
be able to live. It is what gives us
our shape and structure and its
presence allows us to operate
on a daily basis. It also is a
fascinating evolutionary
link to all living and Carpals
extinct vertebrates
4. Radius/Ulna

he human skeleton is crucial for us The radius and ulna are the bones
to live. It keeps our shape and situated in the forearm. They
connect the wrist and the elbow.
muscle attached to the skeleton
allows us the ability to move around,
while also protecting crucial organs that
5. Rib cage
we need to survive. Bones also produce This structure of many single rib
blood cells within bone marrow and bones creates a protective
store minerals we need released on a barrier for organs situated in the
daily basis. chest cavity. They join to the
As an adult you will have around 206 vertebrae in the spine at the
bones, but you are born with over 270, back of the body, and the
sternum at the front.
which continue to grow, strengthen and
fuse after birth until around 18 in females
and 20 in males. Skeletons actually do that makes up bone, osseous tissue, is
vary between sexes in structure also. One actually mineralised calcium phosphate,
of the most obvious areas is the pelvis as but other forms of tissue such as marrow,
a female must be able to give birth, and cartilage and blood vessels are also
therefore hips are comparatively contained in the overall structure. Many
shallower and wider. The cranium also individuals think that bones are solid,
becomes more robust in males due to but actually inner bone is porous and full
heavy muscle attachment and a males of little holes.
chin is often more prominent. Female Even though cells are constantly being
skeletons are generally more delicate replaced, and therefore no cell in our
overall. However, although there are body is more than 20 years old, they are
several methods, sexing can be difficult not replaced with perfect, brand-new
because of the level of variation we see cells. The cells contain errors in their DNA
within the species. and ultimately our bones therefore
Bones are made up of various different weaken as we age. Conditions such as
elements. In utero, the skeleton takes arthritis and osteoporosis can often be
shape as cartilage, which then starts to caused by ageing and cause issues with
calcify and develop during gestation and weakening of bones and reduced
following birth. The primary element movement ability. Phalanges

DID YOU KNOW? Around five per cent of all animals have backbones and are therefore classified as vertebrates

Inside our
skeleton Breaking How our joints work
The types of joints in our body explained
How the human
skeleton works and
keeps us upright
bones 1. Ball and socket joints
Both the hip and the shoulder joints are
3. Skull sutures
Although not generally

1. Cranium Whether its a complete break ball and socket joints. The femur and
humerus have ball shaped endings, which
thought of as a joint, all the
cranial sutures present from
The cranium, also known as
the skull, is where the brain
or just a fracture, both can take turn in a cavity to allow movement. where bones have fused in
childhood are in fact
and the majority of the
sensory organs are located.
time to heal properly 2. Vertebrae
immoveable joints.

If you simply fracture the bone, you may just need to keep it Vertebrae fit together to
straight and keep pressure off it until it heals. However, if support the body and allow
you break it into more than one piece, you may need metal bending movements.
pins inserted into the bone to realign it or plates to cover the They are joined by
2. Metacarpals break in order for it to heal properly. The bone heals by
cartilage and are
The long bones in the classified as
producing new cells and tiny blood vessels where the semi-mobile
hands are called
metacarpals, and are fracture or break has occurred and these then rejoin up. For joints.
the equivalent of most breaks or fractures, a cast external to the body will be
metatarsals in the put on around the bone to take pressure off the bone to
foot. Phalanges ensure that no more damage is done and the break can heal.
located close to the
metacarpals make
up the fingers. The skull is actually
seven separate plates
when we are born,
which fuse together
Skull development
When we are born, many of our
bones are still somewhat soft and
are not yet fused this process
occurs later during our childhood
3. Vertebrae The primary reasons for the cranium in particular not to be
There are three main kinds of fully fused at birth is to allow the skull to flex as the baby is
vertebrae (excluding the sacrum and born and also to allow the extreme rate of growth that
coccyx) cervical, thoracic and
occurs in the first few years of childhood following birth.
lumbar. These vary in strength and
structure as they carry different The skull is actually in seven separate plates when we are
born and over the first two years these pieces fuse together 4. Hinged joints 5. Gliding joints 6. Saddle joints
pressure within the spine. Some movement can The only place we see
Both elbows and knees
slowly and ossify. The plates start suturing together early
are hinged joints. These be allowed when flat this joint in humans is
on, but the anterior fontanel commonly known as the soft joints only allow limited bones glide across the thumb. Movement
6. Pelvis spot will take around 18 months to fully heal. Some other movement in one each other. The wrist is limited in rotation,
This is the transitional joint between bones, such as the five bones located in the sacrum, dont bones the carpals but the thumb can
direction. The bones fit
the trunk of the body and the legs. It
fully fuse until late teens or early twenties, but the cranium together and are moved operate like this, move back, forward
is one of the key areas in which we moved by ligaments. and to the sides.
becomes fully fused by around age two. by muscles.
can see the skeletal differences
between the sexes.

7. Femur
3 skulls DK Images

This is the largest and longest single

bone in the body. It connects to the
pelvis with a ball and socket joint.
Baby Six year old Adult
skull skull skull
8. Fibula/Tibia
These two bones form the lower
leg bone and connect to the knee
joint and the foot.

9. Metatarsals
These are the five long bones in
the foot that aid balance and
movement. Phalanges located
close to the metatarsals are the
bones which are present in toes.

The human spine
The human spine is made
up of 33 vertebrae, but how
Cervical Spine curvature
do they support our bodies vertebrae
These are the smallest of As you look at the human spine, you can
while also allowing us the articulating vertebrae, see some distinct curves. The primary
such flexibility? and support the head and reasons for these are to help distribute
C1 (atlas) neck. There are seven weight throughout the spine and support
This is the vertebrae vertebrae, with C1, C2 and aspects of the body. The curve most
which connects the C7s structures quite
spinal column with familiar to us is the lumbar curve, between
unique from the others.

the skull. It is named the ribs and pelvis. This develops when we
he human spine is made up of 33 vertebrae, 24 They sit between the skull
atlas after the and thoracic vertebrae. start to walk at about 12-18 months and
of which are articulated (flexible) and nine of legend of Atlas who helps with weight distribution during
which normally become fused in maturity. held the entire locomotion. Prior to this we develop the
They are situated between the base of the skull to the world on
T cervical curve, which allows us to support
pelvis, where the spine trails off into the coccyx an his shoulders.
the weight of our head at around three-
evolutionary remnant of a tail our ancestors would four months, and two smaller less-obvious
have displayed. C2 (axis)
C2 is the pivot for C1 (atlas), and curves in the spine (the thoracic and pelvic
The primary functions of the vertebrae that make curves) are developed during gestation.
nearly all movement for shaking
up the spine are to support the torso and head, which XXXXXXXX XXXXXXXX XXXXXXXX
your head will occur at this joint
protect vital nerves and the spinal cord and allow the the atlanto-axial joint.
individual to move. By sitting closely together,
separated only by thin intervertebral discs which
work as ligaments and effectively form joints between
the bones, the vertebrae form a strong pillar structure Thoracic vertebrae
The thoracic vertebrae are the
which holds the head up and allows for the body to
intermediately sized vertebrae.
remain upright. It also produces a base for ribs to They increase in size as you Spinal cords
attach to and to protect vital internal organs in the move down the spine, and they
human body. supply facets for ribs to attach
and nerves
Vertebrae are not all fused together because of the to this is how they are The human spinal cord is an immensely
need to move, and the vertebrae themselves are primarily distinguished. complex structure made up of nerve cells
grouped into five types cervical, thoracic, lumbar, and a large amount of supporting,
sacral and coccygeal. The sacral vertebrae fuse protective tissue. It splits into 31 different
during maturity (childhood and teenage years) and sections and stretches 43-45cm, down
become solid bones towards the base of the spine. from the brain to between the first and
The coccygeal vertebrae will fuse in some cases, but second lumbar vertebrae. Although more
studies have shown that often they actually remain commonly referred to in respect of the
separate. Collectively they are referred to as the brain, there is both white and grey matter
coccyx (tail bone). The rest of the vertebrae remain present in the centre of the spinal cord.
individual and discs between them allow them to White matter contains axons tracts
move in various directions without wearing the surrounded by fats, and blood vessels to
bones down. The cervical vertebrae in the neck allow Intervertebral protect them. The grey matter contains
particularly extensive movement, allowing the head discs more of the neural cell bodies, such as
These discs form a joint
to move up and down and side to side. The thoracic are dendrites, more axons and glial cells.
between each vertebrae
far more static, with ties to the rib cage resisting much Spinal cord injuries are normally
and, effectively, work as
movement. The lumbar vertebrae allow modest side- ligaments while also caused by trauma. If the trauma causes
to-side movement and rotation. A particular feature serving as fantastic shock intervertebral discs and vertebrae to
of the spine is how it is actually curved to allow absorbers. They facilitate break, they can pierce the spinal cord,
distribution of the bodys weight, to ensure no one movement and stop the which can result in loss of feeling. Cord
vertebrae takes the full impact. bones rubbing together. severance may result in paralysis.
11 2
5 3

10 9
I ma

Articulated vertebrae enable

1 maximum flexibility
vertebrae are the How is the skull
8 largest of the attached to the
vertebrae and
the strongest, spine?
because they The skull is connected to the spine by the
Spinal column cross-section withstand the atlanto-occipital joint, which is created by
1. Spinal cord 7. Blood vessels largest C1 (atlas) and the occipital bone situated at
This is an immensely important Four arteries, which form a pressures. the base of the cranium (skull). This unique
pathway for information to network called the Circle of Compared with vertebra has no body and actually looks
transfer between the brain and Willis, deliver oxygen-rich blood other vertebrae
more like a ring than any other vertebra. It
the bodys nervous system. It is to the brain. The brains they are more
heavily protected by tissue and capillaries form a lining called compact, lacking
sits at the top of the cervical vertebrae and
vertebrae, as any damage to it the blood-brain barrier, which facets on the connects with the occipital bone via an
can be fatal. controls blood flow to the brain. sides of the ellipsoidal joint, allowing movement such
2. Epidural space 8. Dorsal and vertebrae. as nodding or rotation of the head. An
This is the space between the ventral roots ellipsoidal joint is where an ovoid
outer protective tissue layer, dura These connect the spinal nerves connection (in this case the occipital bone)
mater and the bone. It is filled to the spinal cord, allowing is placed into an elliptical cavity (C1
with adipose tissue (fat), while transition of information vertebrae). The rest of the cervical
also playing host to numerous between the brain and the body.
blood vessels. vertebrae also work to support the weight
9. Spinal nerves of the head.
3. Dura mater Humans have 31 pairs of spinal
This is the tough outer layer of nerves all aligned with
tissue that protects the spinal individual vertebrae, and
cord. The three layers of these communicate information
protection between the from around the body to the
vertebrae and the spinal cord are
DID YOU KNOW? Cartilage (intervertebral discs) actually makes up 25% of the spines length

spinal cord. They carry all

called the spinal meninges. types of information motor, Sacral
sensory and so on and are vertebrae
4. Arachnoid mater commonly referred to as mixed We have five sacral
Named for its spider web
appearance, this is the second
spinal nerves. vertebrae at birth, but by Neck
maturity they will have fused The bones
layer of the tissue protection 10. Grey matter to form a solid bone, which Skull of the neck
provided for the spinal cord. Within the horn-like shapes in
helps support the lumbar vertebrae The vertebrae (cervical
the centre of the spinal cord, sit
5. Pia mater and connect the coccyx to the spine. surround the vertebrae)
most of the important neural cell
This thin, delicate layer sits spinal cord, are part of
bodies. They are protected in
immediately next to the which connects the spine.
many ways, including by the
spinal cord. Coccyx (tailbone) the brain to the
white matter.
The coccyx can display between three and five nervous
6. Subarachnoid space 11. White matter vertebrae. Theyre commonly thought to be fused,
This is the space between the pia system.
This area that surrounds the grey but often are not. Although these vertebrae are a
mater and the arachnoid mater,
matter holds axon trails, but is vestigial remnant of a tail, they have several uses,
which is filled with
primarily made up of lipid tissue L such as supporting weight when sitting.
cerebrospinal fluid. SP SPL

(fats) and blood vessels.

For bones to function
Bone joints
Pivot joint
To turn the head from left to right,
socket joint
The long bones of the legs

together, they are the ring-shaped first vertebra

(known as the atlas) rotates
and arms both end in
ball-like protuberances,
linked by joints around a tiny spoke on the second which fit inside sockets in
the hip and shoulder,
vertebra (known as the axis),

ome bones, like those in the skull, forming a pivot joint. giving these joints a wide
do not need to move, and are range of motion.
permanently fused together with
mineral sutures. These fi xed joints
provide maximum stability. However,
most bones need flexible linkages. In
some parts of the skeleton, partial
flexibility is sufficient, so all that the
bones require is a little cushioning to
prevent rubbing. The bones are joined by
a rigid, gel-like tissue known as cartilage,
which allows for a small range of
compression and stretching. These types
of joints are present where the ribs meet
the sternum, providing flexibility when Movements
breathing, and between the stacked The bones are joined
vertebrae of the spinal column, allowing together with ligaments,
it to bend and flex without crushing the and muscles are attached
by tendons, allowing
spinal cord.
different joints to be
Most joints require a larger range of moved in a variety of
movement. Covering the ends of the different ways.
bones in cartilage provides shock
absorption, but for them to move freely in
a socket, the cartilage must be lubricated
to make it slippery and wear-proof. At Basal joint Ellipsoid joint
The thumb is joined to The bumps at the base of
synovial joints, the ends of the two bones
the rest of the hand by the skull fit inside the ring
are encased in a capsule, covered on the
a bone called the of the first vertebra,
inside by a synovial membrane, which trapezium. It is shaped allowing the head to tip
fills the joint with synovial fluid, like a saddle and up, down and from side
allowing the bones to slide smoothly past allows the thumb to to side.
one another. bend and pivot.
There are different types of synovial
joint, each with a different range of Hinge joint
motion. Ball-and-socket joints are used At joints like the knee and elbow, one
at the shoulder and hip, and provide a bone is grooved, while the other is
rounded, allowing the two to slot
wide range of motion, allowing the
together and move like a hinge.
curved surface at the top end of each
limb to slide inside a cartilage covered
cup. The knees and elbows have hinge
joints, which interlock in one plane, Gliding joint
The joints between the carpal bones
allowing the joint to open and close. For
of the hands and the tarsal bones of
areas that need to be flexible, but do not the feet only allow limited
need to move freely, such as the feet and movement, enabling the bones to
the palm of the hand, gliding joints allow slide past each other.
the bones to slide small distances
without rubbing.

Hypermobility Mobile Semi-mobile Fixed

Some people tend to have particularly The synovial joints are the most Cartilaginous joints do not allow Some bones do not need to move
flexible joints and a much larger range mobile in the body. The ends of the free motion, but cushion smaller relative to one another and are
of motion. This is sometimes known bones are linked by a capsule that movements. Instead of a lubricated permanently fused. For example the
as being double jointed. It is thought contains a fluid lubricant, allowing capsule, the bones are joined by cranium starts out as separate pieces,
to result from the structure of the the bones to slide past one another. fibrous or hyaline cartilage. The allowing the foetal head to change
collagen in the joints, the shape of the Synovial joints come in different linkage acts as a shock absorber, so shape to fit through the birth canal,
end of the bones, and the tone of the types, including ball-and-socket, the bones can move apart and but fuses after birth to encase the
muscles around the joint. hinge, and gliding. together over small distances. brain in a solid protective skull.

DID YOU KNOW? The bone marrow produces between two and three million new red blood cells every second

Why our joints crack

The synovial fluid used to lubricate
the joints contains dissolved
gasses. The fluid is sealed within a
capsule, so if the joint is stretched,
the capsule also stretches, creating
a vacuum as the pressure changes,
and pulling the gas out of solution
and into a bubble, which pops,
The quadriceps muscle
producing a cracking sound.
group runs down the
front of the femur and
finishes in a tendon
attached to the knee cap.

Artery Synovial membrane

The femoral artery The membrane surrounding the
supplies blood to the interior of the joint produces a
lower leg, and its lubricant called synovial fluid.
branches travel around
the knee joint and over
the patella.

Knee cap
The patella prevents the
tendons at the front of the
leg from wearing away at
the joint.

External Patellar ligament

ligaments The patellar ligament connects
The joint is held the kneecap to both the
together by four quadriceps in the thigh and the
ligaments that tibia in the lower leg.
connect the femur
to the bones of the
lower leg. Cartilage
Synovial fluid

Each of the bones is
capped with a
protective layer of
cartilage, preventing
friction and wear.

Thinkstock; Sol 90; Alamy; Corbis; Dreamstime; Medical Artist; DK Images

Capsule Synovial
The end of the fibula
(calf bone) has two
rounded bumps that
are separated by a
Inside a joint
Synovial joints prevent mobile areas of the skeleton from
deep groove. Tibia grinding against one another as they move. The two bones
The rounded
are loosely connected by strips of connective tissue called
ends of the fibula
fit in to two tendons, and the two ends are encased in a capsule that is
concave slots at lined by a synovial membrane. The bones are covered in
the top of the smooth cartilage to prevent abrasion and the membrane
tibia (shin bone). produces a nourishing lubricant to ensure the joint is able
to move smoothly.


How do
Muscles are essential for us to
operate on a daily basis, but how
are they structured and how do
they keep us moving
muscle is a group of tissue fibres that

A contract and release to control movements

within the body. We have three different
types of muscles in our bodies smooth muscle,
cardiac muscle and skeletal muscle.
Skeletal muscle, also known as striated muscle, is
what we would commonly perceive as muscle, this
being external muscles that are attached to the
skeleton, such as biceps and deltoids. These
muscles are connected to the skeleton with
tendons. Cardiac muscle concerns the heart, which
is crucial as it pumps blood around the body,
supplying oxygen and ultimately energy to muscles,
which allows them to operate. Smooth muscle,
which is normally sheet muscle, is primarily 6. Abdominal muscles
Abs are often built up by body
involved in muscle contractions such as bladder
builders and support the body core.
control and oesophagus movements. These are They are also referred to as core
often referred to as involuntary as we have little or muscles and are important in
sports such as rowing and yoga.
no control over these muscles actions.
Muscles control most functions within our
bodies; release of waste products, breathing,
seeing, eating and movement to name but a few. 7. Quadriceps
Actual muscle structure is quite complex, and each The large fleshy muscle
group covering the front
muscle is made up of numerous fibres which work and sides of the thigh.
together to give the muscle strength. Muscles
increase in effectiveness and strength through
8. Gluteus maximus
exercise and growth and the main way this occurs The biggest muscle in the body,
is through small damage caused by each repetition this is primarily used to move
the thighs back and forth.
of a muscle movement, which the body then
automatically repairs and improves.
More than 640 muscles are actually present 9. Hamstrings
across your entire body working to enable your Refers to one of the three
posterior thigh muscles, or to the
limbs to work, control bodily functions and shape tendons that make up the borders
the body as a whole. of the space behind the knee.

More than 300 individual muscles

are present across your body to
enable your limbs to work
DID YOU KNOW? Skeletal muscles account for around 40 per cent of your total body mass

What affects our

muscle strength?
How does the
1. Deltoids
These muscles stretch across
How strong we are is a arm flex?
Biceps and triceps are a pair of muscles that work together
the shoulders and aid lifting. combination of nature and nurture to move the arm up and down. As the bicep contracts, the
Muscle strength refers to the amount of force that a triceps will relax and stretch out and consequently the
2. Trapezius muscle can produce, while operating at maximum arm will move upwards. When the arm needs to move
Large, superficial muscle at the
capacity, in one contraction. Size and structure of down, the opposite will occur with the triceps
back of the neck and the upper
part of the thorax, or chest. the muscle is important for muscle strength, with contracting and the bicep relaxing and being forcibly
strength being measured in several ways. stretched out by the triceps. The bicep is so named a flexor
3. Pectoralis major Consequently, it is hard to definitively state which as it bends a joint, and triceps would be the extensor as it
Commonly known as the pecs,
muscle is actually strongest. straightens the joint out. Neither of these muscles can push
this group of muscles stretch
We have two types of muscle fibre one that themselves straight, they depend on the other to oppose
across the chest.
supports long, constant usage exerting low levels of their movements and stretch them out. Many muscles
pressure, and one that supports brief, high levels of therefore work in pairs, so-called antagonistic muscles.
4. Biceps/triceps
These arm muscles work force. The latter is used during anaerobic activity
together to lift the arm up and down. and these fibres respond better to muscle building.
Each one contracts, causing movement Genetics can affect muscle strength, as can 1. Tricep relaxes
in the opposite direction to the other. usage, diet and exercise regimes. Contractions of
muscles cause injuries in the muscle fibres and it is 2. Bicep contracts
5. Latissmus dorsi the healing of these that actually create muscle
Also referred to as the lats, these
strength as the injuries are repaired and overall
muscles are again built up during
weight training and are used to strengthen the muscle.
pull down objects from above.

Tendons attach muscles

such as biceps to bones, 3. Arm curls
allowing muscles to move
elements of our body 1. Bicep relaxes
3. Arm extends

What are muscles made up of?

Muscles are made up of numerous cylindrical Blood vessels and nerves also run through
2. Tricep contracts
fibres, which work together to contract and the connective tissue to give energy to the
control parts of the body. Muscle fibres are muscle and allow feedback to be sent to the
bound together by the perimysium into small
bundles, which are then grouped together by
brain. Tendons attach muscles such as biceps
and triceps to bones, allowing muscles to move What is a pulled muscle,
the epimysium to form the actual muscle. elements of our body as we wish. and how does it happen?
Epimysium Blood vessel Perimysium
The external layer that covers the This provides oxygen and allows This layer groups They hurt like crazy so heres why
muscle overall and keeps the bundles the muscle to access energy for together muscle fibres its important to warm up
of muscle fibres together. muscle operation. within the muscle.
A pulled muscle is a tear in muscle fibres. Sudden
movements commonly cause pulled muscles, and when an
individual has not warmed up appropriately before
exercise or is unfit, a tear can occur as the muscle is not
prepared for usage. The most common muscle to be pulled
is the hamstring,
Go run
which stretches from get to the
the buttock to the chopper!
Filaments knee. A pulled
Myofibrils are constructed muscle may result in
of filaments, which are swelling and the pain
made up of the proteins can last for several
actin and myosin. days before the fibres
can repair
Endomysium themselves. To
This layer surrounds prevent pulling
each singular muscle muscles, warming up
fibre and keeps the is advised before
Tendon Myofibril myofibril filaments doing any kind of
These attach muscle to bones, which in Located within the single muscle fibres, grouped together.
turn enables the muscles to move parts myofibrils are bundles of actomyosin
physical exertion.
of the body around (off image). filaments. They are crucial for contraction.


Skin colour Keratinocytes

These protective cells are produced
Melanin and skin colour
Basal skin cells manufactured in the
The keratinocytes of

explained in the lower layers of the epidermis.

They take up the melanosomes
produced by the melanocytes.
lower layers of the epidermis grow
through the skin to the surface, where
they are eventually sloughed away.
lighter- skinned
people take up fewer

What is melanin and how does DARK LIGHT

it affect the tone of our skin?

he light-absorbing pigment melanin is a chemical
substance that gives your skin its natural colouring. Skin
can vary from very dark brown to almost completely
white due to a combination of your genes and inherited traits
and the amount of sunlight to which youre exposed.
Skin colour differs depending on the concentration of melanin
present and its distribution throughout the skins layers. Those
with less melanin have lighter skin, while those with more of the
pigment have darker skin. Melanin is produced by specialised
skin cells called melanocytes in the lower layers of the epidermis
and is contained inside a melanosome by a very thin membrane.
Exposure to sunlight stimulates the production of melanin
granules. The melanosomes containing the melanin then move
out towards the skins protective keratinocyte cells along branch
cells called dendrites. Melanin is then stored in the nuclei of the
keratinocytes where it acts as a natural protector against the
Melanocyte Dendrite Melanocyte
effects of the Suns ultraviolet rays. Keratinocytes make up the Melanin is made in the melanocytes. These branching cells pass Those with lighter skin have fewer
bulk around 95 per cent of the outer layers of the skin and People with darker skin, or those melanin to keratinocytes. dendrites in their lower layers and
form the barrier between the body and the outside world. They who live in regions with greater their melanocytes are
sunlight exposure, have more also less active.
take up melanin which can absorb cancer-causing UV radiation Melanosomes Melanosomes
active melanocytes.
These packets of melanin release The melanosomes in lighter skin
so it doesnt get into the bodys internal tissues. melanin granules into the keratinocytes. release far fewer melanin granules.

How skin grafts work

When our bodys largest organ is damaged,
sometimes it needs a helping hand to heal

kin grafting is a medical procedure where a
portion of skin is removed and stitched onto
another part of the body. There are many Gauze
cosmetic and medical reasons why this might be A sterile gauze
is applied while the Stitching
necessary: serious burns, surgery, tattoo removal and skin attaches and Small skin grafts
some medical conditions (skin cancer or diabetes, for a new blood are stitched
supply establishes. while bigger
example) might all necessitate skin grafting.
Autografts are skin grafts taken from the patients own require
body, usually the buttocks, neck or back of the arm. stapling.
Depending on the size of the area that its removed from,
its then stitched or stapled closed again and the new
skin applied to the injured area. Allografts and
xenografts, meanwhile taken from other humans and Donor skin
animals, respectively are temporary grafts. The donor skin is
removed and then
But perhaps most interesting is the artificial skin applied to the
called Integra, made of animal collagen that gives the injured area.

damaged part an organic scaffolding for new skin to

grow into. This is usually used in cases of extreme burns
where there isnt enough healthy skin for an autograft. Skin graft surgery
DID YOU KNOW? All mammals have hair on their skin, including marine mammals which appear hairless

Under the skin

Find out more about the largest organ in your body
ur skin is the largest organ in our bodies with an 5. Subcutaneous
1. Epidermis 3. Nerve ending
average individual skins surface area measuring This is the top, protective layer. It Situated within the dermis, nerve tissue
around two square metres and accounting for up to is waterproof and protects the endings allow us to sense temperature, The layer of fat found in the
body against UV light, disease and pain and pressure. This gives us hypodermis that is present to
16 per cent of total body weight. It is made up of three prevent heat loss and protect
dehydration among other things. information on our environment and
distinct layers. These are the epidermis, the dermis and the stops us hurting ourselves. bone and muscle from
hypodermis and they all have differing functions. Humans damage. It is also a reserve
energy source.
are rare in that we can see these layers distinctly.
The epidermis is the top, waterproofing layer. Alongside
helping to regulate temperature of the body, the epidermis 2. Dermis
The layer that nourishes and
also protects against infection as it stops pathogens entering helps maintain the epidermis,
the body. Although generally referred to as one layer, it is the dermis houses hair
actually made up of five. The top layers are actually dead roots, nerve endings
and sweat glands.
keratin-filled cells which prevent water loss and provide
protection against the environment, but the lower levels,
where new skin cells are produced, are nourished by the
dermis. In other species, such as amphibians, the
epidermis consists of only live skin cells. In these
cases, the skin is generally
permeable and actually may
be a major respiratory organ.
The dermis has the

DK Images
connective tissue and nerve
endings, contains hair
follicles, sweat glands,
lymphatic and blood vessels.
The top layer of the dermis is
ridged and interconnects
securely with the epidermis.
Although the hypodermis
is not actually considered
part of the skin, its purpose
is to connect the upper
layers of skin to the bodys
underlying bone and
muscle. Blood vessels and
nerves pass through this
layer to the dermis. 4. Pore
This layer is actually Used for temperature
crucial for all of regulation, this is
where sweat is
the skins temperature secreted to cool the
regulation, as it contains body down when it is
50 per cent of a healthy becoming too hot.

adults body fat in

subcutaneous tissue. These kinds
of layers are not often seen in other

How your
species, humans being one of few that you
can see the distinct layers within the skin. Not
only does the skin offer protection for muscle, bone
and internal organs, but it is our protective barrier
against the environment. Temperature regulation,
insulation, excretion of sweat and sensation are just a few
skin works
The skin is made of many more elements
more functions of skin. than most people imagine

Heart attacks
heart attack, also known as a generation of coronary artery disease
What causes heart attacks and
how do they kill?

A myocardial infarction, occurs

when a blockage stops blood
oxygenating the heart muscle. If this is not
(CAD). This is where arteries are
constricted due to plaque build-ups and
this layer then ruptures. Blood platelets
corrected quickly, the muscle tissue that is make their way to the site of rupture and
lacking oxygen can become damaged, or start to form blood clots. If these clots are
indeed die. The scale of impact on the left to become too large, the narrowed
individuals health after the attack is artery will block and a heart attack
dependant on how long the blockage enevitably occurs. Heart attacks can
occurs for, what artery it affected and what also be caused by coronary artery
treatment was received. Following the spasms, but these are rare.
initial attack, it is actually possible that Although some people
heart failure or arrhythmias can occur, will be genetically
both of which may prove fatal to the victim. predisposed to heart
However, given the right treatment many attacks, individuals
sufferers go on to make good recoveries can reduce risk by
and can eventually return to their keeping their weight
normal activities. down, watching what they
The most common reason for heart eat, not smoking and exercising
attacks worldwide in humans is the on a regular basis.

1. Coronary arteries
These are the arteries that supply the heart 4. Blockage occurs
with blood. They are crucial to keeping the Either through excess clotting or further deposit build-up, a
heart working effectively. blockage can occur. This means blood flow cannot get through
at all and the lack of oxygen results in heart tissue dying.

Coronary artery Healthy

(supplies blood heart
and oxygen to muscle
heart muscle)
Blood clot
blood flow

3. Plaque rupture
Plaque Plaque becomes hardened as
buildup in it builds up, and it can rupture.
Coronary artery
artery If it ruptures, platelets gather
to clot around the rupture,
which can cause a blockage
to occur.

Heart muscle

5. Dead tissue 2. Plaque build-up

Due to a lack of oxygen, some Plaque, made up of inflammatory cells,
sections of heart muscle can die off. proteins, fatty deposits and calcium,
This can reduce effectiveness of the Dead heart muscle narrows the artery and means that only
muscle as a whole following recovery. a reduced blood flow can get through.

DID YOU KNOW? The heart has four separate chambers, four valves to control blood flow and two main coronary arteries

3. Bypassing
the heart
Blood is removed by pumping
it out of the body, oxygen is
Heart bypass
What happens in surgery?
added to it in a bypass machine
and the blood pumped back in.
This allows oxygenated blood
to continually flow while the
heart is stopped.

Bypass 1. The problem

graft Fatty plaques narrow and
4. Stopping eventually block the
the heart Aorta coronary arteries,
The aorta, the main preventing oxygen-rich
vessel out of the blood flowing to the
heart, is clamped. heart muscle.
The heart is then
cooled and stopped
using a potassium-
rich solution.
6. Restarting
the heart Coronary
Once the new vessels artery
have been secured, the
aorta is unclamped
which washes the
potassium-rich solution
2. Getting to
the heart
from the heart. The
patient is warmed and
The chest is opened Bypass
the heart restarts.
through a cut down the
middle of the breastbone
(sternum). A special bone The body has certain
saw is used to cut through vessels which it can do
the sternum, which doesnt without, and these act as
5. Attaching the damage the heart below.
new vessels conduits when it comes
The new vessels are tested and down to bypass surgery.
then sewn into place. The opening Commonly used, the long
is sewn to one of the large arteries 7. Closing saphenous vein runs from
carrying oxygen-rich blood. The the chest the ankle to the groin.
end of the bypass graft is sewn After making sure there is A shallow incision
beyond the fatty plaque, allowing no bleeding, thin metal allows the vein to be
blood to freely flow to the wires are used to hold the
dissected away from its
affected heart muscles. two halves of the sternum
back together. surrounding tissue. Other
vessels that are often used

How heart
include various different
small arteries from
behind the rib cage or
the arms.

bypasses work
When too little blood is getting to the muscles of the heart, a
the heart
Cardiopulmonary bypass
(where a machine not only
takes over the hearts
surgeon can bypass the blockages using the bodys own vessels pumping action but also
the gas exchange function
lthough the heart pumps oxygen angina. If a vessel becomes The surgeon uses healthy vessels of the lungs) is established

A oxygenated blood around the

body, the hearts muscular
walls need their own blood supply.
completely blocked, no blood is able to
make it through, causing a heart attack
where the heart muscle dies.
from other parts of the patients body to
bypass the blockage, allowing a new
route for blood to flow. This delivers
to provide oxygenated
blood to the rest of the
body. Next, the heart is
stopped. This is achieved
Oxygen-rich blood is delivered to these The first way to treat this type of higher volumes of the oxygen-rich using a potassium-rich
tissues via small vessels on its surface coronary artery disease is with blood to the heart muscles beyond the solution, pumped down
the coronary arteries. These arteries medicines. Secondly, angioplasty can blockage, preventing the pain. the coronary arteries. This
can get narrowed or blocked up with be used, where narrowings in the Most bypasses are performed by stops the heart
cholesterol causing fatty plaques which arteries are stretched using a balloon, stopping the heart and using a contracting. The surgeon
can now carefully attach
slow blood flow. At times of exercise, placing a stent to keep the vessel open. heart-lung bypass machine to deliver
the fresh vessels to bypass
not enough blood gets to the heart Finally, a heart bypass operation is an oxygenated blood to the body. The new the blockages.
muscles, leading to pain due to lack of option for some patients. vessels are then sewn into place.


Kidney Inside
your kidney
As blood enters the kidneys, it is passed
through a nephron, a tiny unit made up of
blood capillaries and a waste-transporting
tube. These work together to filter the blood,
returning clean blood to the heart and lungs
for re-oxygenation and recirculation and
removing waste to the bladder for excretion.
How do your kidneys filter
waste from the blood to
keep you alive?
idneys are two bean-shaped organs

K situated halfway down the back just

under the ribcage, on each side of the
body, and weigh between 115 and 170 grams
Renal cortex
This is one of two broad internal sections of the
kidney, the other being the renal medulla. The
each, dependent on the individuals sex and renal tubules are situated here in the protrusions
that sit between the pyramids and secure the
size. The left kidney is commonly a little larger cortex and medulla together.
than the right and due to the effectiveness of
these organs, individuals born with only one Renal artery
kidney can survive with little or no adverse This artery supplies the
health problems. Indeed, the body can kidney with blood that
is to be filtered.
operate normally with a 30-40 per cent decline
in kidney function. This decline in function
would rarely even be noticeable and shows
just how effective the kidneys are at filtering
out waste products as well as maintaining
mineral levels and blood pressure throughout
the body. The kidneys manage to control all of
this by working with other organs and glands
across the body such as the hypothalamus,
which helps the kidneys determine and
Renal vein
control water levels in the body. After waste has
Each day the kidneys will filter between a been removed, the
clean blood is
staggering 150 and 180 litres of blood, but only
passed out of the
pass around two litres of waste down the kidney via the
ureters to the bladder for excretion. This waste renal vein.
product is primarily urea a by-product of
protein being broken down for energy and
water, and its more commonly known as
urine. The kidneys filter the blood by passing
it through a small filtering unit called a
nephron. Each kidney has around a million of
these, which are made up of a number of
DK Ima es

small blood capillaries, called glomerulus,


and a urine-collecting tube called the renal

tubule. The glomerulus sift the normal cells
and proteins from the blood and then move
the waste products into the renal tubule,
which transports urine down into the bladder
through the ureters.
Alongside this, the kidneys also release
Ureter Renal pelvis Renal medulla Renal
three hormones (known as erythropoietin,
The tube that This funnel-like structure is The kidneys inner section, where blood is capsule
renin and calcitriol) which encourage red transports the waste how urine travels out of the filtered after passing through numerous The kidneys fibrous outer
blood cell production, aid regulation of blood products (urine) to kidney and forms the top part arterioles. Its split into sections called edge, which provides
the bladder following of the ureter, which takes pyramids and each human kidney will protection for the
pressure and aid bone development and
blood filtration. urine down to the bladder. normally have seven of these. kidneys internal fibres.
mineral balance respectively.

DID YOU KNOW? We are able to function with one kidney, which is why we can donate them easily to others

Nephrons the filtration duct system The glomerulus
units of the kidney Proximal tubule
Although not
technically part of the
nephron, this collects all
This group of capillaries is the first step of
filtration and a crucial aspect of a nephron.
Nephrons are the units which filter all blood that passes Links Bowmans capsule
As blood enters the kidneys via the renal
and the loop of Henle, waste product filtered
through the kidneys. There are around a million in each artery, it is passed down through a series of
and will selectively by the nephrons and
kidney, situated in the renal medullas pyramid structures. As facilitates its removal arterioles which eventually lead to the
reabsorb minerals from
well as filtering waste, nephrons regulate water and mineral from the kidneys. glomerulus. This is unusual, as instead of
the filtrate produced by
salt by recirculating what is needed and excreting the rest. Bowmans capsule. draining into a venule (which would lead
back to a vein) it drains back into an
arteriole, which creates much higher
pressure than normally seen in capillaries,
which in turn forces soluble materials
Glomerulus and fluids out of the capillaries. This process
High pressure in the
is known as ultrafiltration and is the first
glomerulus, caused by it
draining into an arteriole
step in filtration of the blood. These then
instead of a venule, pass through the Bowmans capsule
forces fluids and soluble (also know as the glomerular capsule) for
materials out of the further filtration.
capillary and into
Bowmans capsule.
Afferent arteriole Proximal tubule
This arteriole supplies the Where reabsorption of
Bowmans blood to the glomerulus minerals from the
capsule for filtration. filtrate from Bowmans
Also known as the capsule will occur.
glomerular capsule, this
filters the fluid that has
been expelled from the
glomerulus. Resulting
filtrate is passed along
the nephron and
will eventually make
up urine. Glomerulus
This mass of
Distal capillaries is the
convoluted glomerulus.
Partly responsible
for the regulation of
minerals in the
blood, linking to the
collecting duct Bowmans
system. Unwanted Efferent arteriole capsule
minerals are This arteriole is how This is the surrounding
excreted from blood leaves the capsule that will filter
the nephron. glomerulus following the filtrate produced by
ultrafiltration. the glomerulus.

Renal artery
This artery supplies the
kidney with blood. The
blood travels through
this, into arterioles as you What is urine and what
travel into the kidney,
until the blood reaches
the glomerulus.
is it made of?
Urine is made up of a range of organic 94% water
compounds such as various proteins and
hormones, inorganic salts and
numerous metabolites. These are often
Renal vein rich in nitrogen and need to be removed
This removes blood that has
been filtered from the kidney.
from the blood stream through
urination. The pH-level of urine is
typically around neutral (pH7) but
varies depending on diet, hydration
Renal tubule levels and physical fitness. The colour of
Loop of Henle Made up of three parts, the proximal urine is also determined by all of these
The loop of Henle controls the mineral and tubule, the loop of Henle and the distal different factors playing a part, with
convoluted tubule. They remove waste
water concentration levels within the kidney dark-yellow urine indicating dehydration
to aid filtration of fluids as necessary. It also and reabsorb minerals from the filtrate 6% other organic
passed on from Bowmans capsule.
and greenish urine being indicative of
controls urine concentration.
excessive asparagus consumption. compounds


Kidney transplants
The kidneys are the bodys natural filters. You can survive
on just one, but when that fails you may need a transplant
ransplanting organs is a number of patients registered for a someone elses fortune. For those who register to a suitable recipient. A

T complex process, but it can

give a new lease of life to
recipients. The kidney is the most
kidney transplant increases each
year, and has risen by a staggering 50
percent since 2000.
are declared brain-dead, the beating
heart will keep the kidneys perfused
until they are ready to be removed. In
retrieval team from a central
transplant unit (of which there are 20
based around the UK) will go to
frequently transplanted organ, across Kidney transplants come from two some patients, the ventilator will be whichever hospital the donor is in.
the globe. However, there is a main sources: the living and the switched off and its a race against time They will remove the organs, while the
discrepancy between the number of recently deceased. If a healthy, to harvest organs. Either way, consent recipient is being prepared in the base
patients waiting for a transplant and compatible family member is willing from the family is needed, even at such hospital. During the tricky operation,
the number of available organs; only to donate a kidney, they can survive an emotional and pressurised time. the new kidney is plumbed into the
around one third of those waiting per with just one remaining kidney. In When a suitable organ becomes pelvis, leaving the old, non-
year receive their transplant. The other cases, someone elses tragedy is available, it is matched via a national functioning ones in-situ.

How to perform a kidney transplant

Transplanting a kidney is
a case of careful and
clever plumbing. The first 1. The donor 2. Out with the old? 3. Into the pelvis
step is to harvest the The donor kidney is harvested, including enough length of As long as theres no question An incision is made in the
donor kidney, and then artery, vein and ureter (which carries urine to the bladder) of cancer, the original kidneys lower part of the abdomen to
to allow tension-free implantation into the recipient. are left in place. gain access into the pelvis.
its a dash to transplant
the new kidney into the
recipient. When the
brain-dead donor is 7. Whats that
transferred to the lump?
operating theatre for The new kidney can
organ harvest, they are be felt underneath
treated with the same the scar in the
care and respect as if they recipient. These
patients are often
were still alive. When
recruited to medical
consent has been given
student exams .
for multiple organ
harvest, a cut is made
from the top of the chest
to the bottom of the
pelvis. The heart and
lungs are retrieved first, 8. Catheter
followed by the A catheter is left
abdominal organs. in-situ for a short
while, so that the
urine output of the
new kidney can be
measured exactly.

5. Plumbing it in
The renal artery and vein
are connected to the
corresponding iliac artery
and vein in the recipients
body. Holes (arteriotomies)
Science Photo Library

are created in the main

arteries, and the kidneys 4. Make space! 6. The final link
vessels are anastomosed The surgeon will create space in the pelvis, and identify the large The ureter, which drains urine from the kidney, is
(a surgical join between vessels which run from the heart to the leg (the iliac arteries and connected to the bladder. This allows the kidney to
two tubes using sutures). veins). The new kidneys vessels will be connected to these. function in the same way as one of the original kidneys.

DID YOU KNOW? Of the millions of people in the UK suffering from kidney disease, 50,000 will suffer end-stage renal failure

Time is always of

Domino Patient 1 Patient 2 the essence

Patient 1 needs a new kidney but their
family member isnt compatible.
Patient 2 also needs a kidney and has
an incompatible family member as


well. However, patient 2s relation is

compatible with patient 1 and vice

versa. The surgeon arranges a swap

a paired transplant. A longer line of

patients and family members
swapping compatible kidneys can be
arranged a daisy-chain transplant.
A good Samaritan donor, who isnt
related to any of the recipients, can
start the process. This first recipients
family member will subsequently
donate to someone else a domino
transplant effect which can go on for

Science Photo Library

several cycles. From patient 1 From patient 2
family member family member

Who is Antibody
If the antigens are too dissimilar, the hosts existing

immune system thinks the new kidney is a foreign invader
and attacks it with antibodies, leading to rejection. Pack
Of the several million people in
the UK with kidney disease,
The transport of harvested organs
only around 50,000 will develop is time critical the sooner the
end-stage renal failure (ESRF). surgeon can put them into the
For these people, dialysis or recipient the better. As soon as
kidney transplantation are the blood stops flowing to the
only options. Kidney damage harvested tissue, the lack of oxygen
from diabetes is the most damages these cells, which is
common cause of called ischaemia. The retrieval
transplantation. Other causes team have quite a few tricks up
include damage from high blood their sleeves to maximise the
pressure, chronic kidney viability of the precious cargo they
scarring (chronic carry.
pyelonephritis) and polycystic In the operating theatre, just
kidney disease (the normal before they remove the harvested
kidney tissue is replaced with kidney, it is flushed clean of blood
multiple cysts); many other less Antigens with a special cold, nutrient-rich
common causes exist also. Antigens from the recipient kidneys ABO
solution. Once removed, it is quickly
blood group and HLA system should be as
Patients must be selected put in a sterile container with ice.
close a match to the donors as possible.
incredibly carefully due to the The most modern technique is to
scarcity of organs. This means use a cold perfusion machine
that those who have widespread instead of ice, which pumps a
cancer, or severely calcified cooled solution through the kidney
arteries, or persistent substance and improves its lasting power.
abuse and unstable mental
problems mean that transplants When things go wrong While hearts and lungs can only
last around four hours, kidneys can
are likely to fail and that Kidneys need to be carefully matched to suitable donors, or rejection of the new organ last 24-48 hours. Transfer of the
unfortunately means that these will set in fast. Rejection occurs when the host bodys natural antibodies think the affected organ is done via the fastest
patients are actually unsuitable new tissue is a foreign invader and attacks; careful pre-operative matching helps limit method possible; this often involves
to receive an all important the degree of this attack. The most important match is via the ABO blood group type using helicopters or police escorts.
kidney transplant. the blood group must match or rejection is fast and aggressive. Next, the bodys HLA All of these methods prolong the
(human leukocyte antigen) system should be a close a match as possible, although it preservation time of the kidney,
Patients are doesnt need to be perfect. Incorrect matches here can lead to rejection over longer
periods of time. After the operation, patients are started on anti-rejection medicines
although once plugged back in, it
can take a few days for the kidney to
monitored which suppress the hosts immune system (immunosuppressants such as Tacrolimus, start working properly (especially if

for the rest Azathioprine or Prednisolone). Patients are monitored for the rest of their lives for
signs of rejection. These immunosuppressants arent without their risks since they
the organ has been harvested from
a non-heart-beating donor).
of their lives suppress the bodys natural defences, the risks of infections and cancers are higher.


Useless body parts

Why have humans and other animals stopped using certain
organs and functions which were once crucial for survival? Evolutions
harles Darwin is one of historys most famous behavioural responses are functional in other animals,
naturalists. Living in the 19th Century, he but they do not seem to be of any benefit to us; such as
became celebrated for his theories on
evolution. In his seminal work On The Origin Of Species
the appendix and your tailbone. These evolutionary
remnants that no longer serve any purpose are known
The best known of the
vestigial organs, the
he described how similar animals were likely to be as vestigial organs, though this can apply as much to
appendix is used in animals
related by common ancestors, rather than be behaviour and other body structures as it does to
to help digest cellulose found
completely unrelated. As subsequent generations are actual organs.
in grass, but in humans it
born, traits and features that did not bring a survival Evolution has also adapted some of our existing
serves no clear function now.
benefit to that species were eliminated. That, in a features to help us in new ways, in a process known as
complete nutshell, is the theory of evolution. exaptation. For example, birds wings not only help
As a consequence, some organs and traits left in the
body lose their function and are no longer used. This
them to fly but they also keep them warm as well. These
changes may actually take thousands of years to 2Tailbone
The hard
applies to modern human beings as much as other develop, and even in some cases the original purpose bone at the
creatures; some of our physical attributes and can eventually be completely eliminated altogether. bottom of
your spine, the
Appendicitis in focus coccyx, is a
remnant of our evolutionary
What happens when your appendix gets inflamed?
ancestors tail. It has no
function in humans, but you
could break it if you fall over.

Animals use body hair for
insulation from the cold, by
trapping a warm layer of air
Surgery around the body. Each hair
During surgery to remove can stand on end when its
the appendix, the surgeon
own tiny muscle contracts,
ties off the base to prevent
bowel contents leaking, and but as human beings have
removes the whole Progression lost most of their body hair, a
appendix organ. The inflammation can jumper is more effective.
lead to perforation of the
appendix and
inflammation of the
surrounding tissues. The
pain then worsens and
then localises to the
4Plica semilunaris
The fleshy
red fold found
lower right-hand side of
in the corner
the abdomen.
of your eye
used to be a
Blockage transparent inner
A blockage, caused by either a
eyelid, which is still present
tiny piece of waste or swollen
lymphatic tissue in the bowel in both reptiles and birds.
wall, causes appendix swelling.

5 Wisdom teeth
These teeth emerge
during our late teens in each
corner of the gums. Our
ancestors used them to help
Inflammation chew dense plant matter, but
SPL; Thinkstock

Beyond the blockage, inflammation they have no function today,

sets in, which causes intense
abdominal pain.
but can cause a lot of pain.

DID YOU KNOW? Around 15 per cent of us have an extra spleen a small sphere close to but separate from the principal organ

How the spleen works

Perhaps not as well known as famous organs like the heart,
the spleen serves vital functions that help keep us healthy
he spleens main functions are to remove old blood
Inside the spleen
cells and fight off infection. Red blood cells have an The spleen sits underneath the
We take you on a tour of the 9th, 10th and 11th ribs (below
average life span of 120 days. Most are created from the
the diaphragm) on the
marrow of long bones, such as the femur. When theyre old, major features in this left-hand side of the body,
its the spleens job to identify them, filter them out and then often-overlooked organ which provides it with some
protection against knocks.
break them down. The smaller particles are then sent back
into the bloodstream, and either recycled or excreted from
other parts of the body. This takes place in the red pulp,
which are blood vessel-rich areas of the spleen that make up The entrance to the spleen, Splenic vein
about three-quarters of its structure. this is where the splenic artery The waste products
divides into smaller branches from filtration and
The remainder is called white pulp, which are areas filled pathogen digestion
and the splenic vein is formed
with different types of immune cell (such as lymphocytes). from its tributaries. are returned to the main
They filter out and destroy foreign pathogens, which have circulation via this vein
for disposal.
invaded the body and are circulating in the blood. The white Splenic artery
pulp breaks them down into smaller, harmless particles. The spleen receives a blood
supply via this artery,
It is surrounded by a thin, fragile capsule and so is prone to
which arises from a branch
injury. It sits beneath the lower ribs on the left-hand side of of the aorta called the
your body, which affords it some protection, but car crashes, coeliac trunk.
major sports impacts and knife wounds can all rupture the
organ. In the most serious cases, blood loss can endanger the
persons life, and in these situations it needs to be removed by
a surgeon. Since this reduces the bodys ability to fight
infections, some people will need to take antibiotics to boost
their immunity for the rest of their lives.

The immune system

Although the red blood that flows through our bodies gets all the glory,
the transparent lymphatic fluid is equally important. It has its own
body-wide network which follows blood vessel flow closely and allows
for the transport of digested fats, immune cells and more

Spleen Adenoids
This is one of the master These are part of the tonsillar
co-ordinators that actually system that are only present in
staves |off infections and filters children up until the age of five;
old red blood cells. It contains a in adults they have disappeared.

number of lymphocytes that They add an extra layer of

recognise and destroy invading defence in our early years.
pathogens present in the blood
as it flows through the spleen. Bone marrow
This forms the central, flexible
Thymus part of our long bones (eg femur).
White pulp Splenic capsule
A small organ that sits just Bone marrow is essential as it
Making up roughly a The capsule provides some
above the heart and behind the produces our key circulating
quarter of the spleen, protection, but its thin
sternum. It actually teaches cells, including red blood cells,
T-lymphocytes to identify and white blood cells and platelets. the white pulp is and relatively weak. Strong
destroy specific foreign bodies. The white blood cells mature where white blood blows or knife wounds can
Its development is directly into various different types (eg cells identify and easily rupture it and lead to
related to hormones in the body lymphocytes and neutrophils), destroy any type of life-threatening bleeding.
so its only present until puberty which serve as the basis of the invading pathogens.
ends; adults dont need one. human immune system.

Tonsils Lymph nodes

These are masses of lymphoid These are small (about 1cm/
tissue at the back of the throat 0.4in) spherical nodes that are
and can be seen when the mouth packed with macrophages and Red pulp Sinusoid
is wide open. They form the first lymphocytes to defend against Forming approximately Similar to those found in the
line of defence against inhaled foreign agents. These are often three-quarters of the liver, these capillaries allow
foreign pathogens, although linked in chains and are mainly
spleen, the red pulp is for the easy passage of
they can become infected around the head, neck, axillae
where red blood cells are large cells into the splenic
themselves, causing tonsillitis. (armpits) and groin.
filtered and broken down. tissue for processing.


How the liver works

The human liver is he liver is actually the largest internal organ in The liver is the bodys main powerhouse, producing

the ultimate
multitasker it
T the human body and, amazingly, has over
500 different functions. In fact, it is actually the
second most complex organ after the brain and is
and storing glucose as a key energy source. It is also
responsible for breaking down complex fat molecules and
building them up into cholesterol and triglycerides, which
performs many intrinsically involved in almost every aspect of the bodys the body needs but in excess are bad. The liver makes
metabolic processes. many complex proteins, including clotting factors which
different functions The livers main functions are energy production, are vital in arresting bleeding. Bile, which helps digest fat
all at the same time removal of harmful substances and the production of in the intestines, is produced in the liver and stored in the
without you crucial proteins. These tasks are carried out within liver adjacent gallbladder.
cells, called hepatocytes, which sit in complex The liver also plays a key role in detoxifying the blood.
even asking arrangements to maximise their overall efficiency. Waste products, toxins and drugs are processed here into

The hepatobiliary
Two halves
The liver is anatomically split
into two halves: left and right.
There are four lobes, and the
right lobe is the largest.
Eight segments
The gallbladder Functionally, there are
The gallbladder and liver eight segments of the
are intimately related. Bile, liver, which are based
which helps digest fat, is upon the distribution
produced in the liver and of veins draining
stored in the gallbladder. these segments.

The common bile duct

This duct is small, but vital in
the human body. It carries bile
from the liver and gallbladder
into the duodenum where it
helps digest fat.

Feel your liver

Take a deep breath in and feel
just under the right lower
edge of your ribs in some
people the lower edge of the
liver can be felt.
The portal triad
The common bile duct,
hepatic artery and
hepatic portal vein form
the portal triad, which
are the vital inflows and
outflows for this liver.

Once nutrients from food have
been absorbed in the small
intestine, they are transported
The biggest organ to the liver via the hepatic
The liver is the largest of portal vein (not shown here)
the internal organs, sitting in the for energy production.
right upper quadrant of the abdomen,
just under the rib cage and attached to
the underside of the diaphragm.

DID YOU KNOW? The liver can regenerate itself. If up to 75 per cent of the liver is removed, it can grow back to restore itself

The liver also breaks

down old blood cells
and recycles hormones A high demand organ
such as adrenaline The liver deals with a massive amount of blood.
It is unique because it has two blood supplies. 75
branches from the aorta), carrying oxygen
which the liver needs to produce this energy.
per cent of this comes directly from the The blood flows in tiny passages in between the
forms which are easier for the rest of the body to use or intestines (via the hepatic portal vein) which liver cells where the many metabolic functions
excrete. The liver also breaks down old blood cells, carries nutrients from digestion, which the liver occur. The blood then leaves the liver via the
produces antibodies to fight infection and recycles processes and turns into energy. The rest comes hepatic veins to flow into the biggest vein in the
hormones such as adrenaline. Numerous essential from the heart, via the hepatic artery (which body the inferior vena cava.
vitamins and minerals are stored in the liver: vitamins A,
D, E and K, iron and copper.
Such a complex organ is also unfortunately prone to
diseases. Cancers, infections (hepatitis) and cirrhosis (a Liver lobules
form of fibrosis which is often caused by excess alcohol The functional unit which
consumption) are just some of those which can affect
the liver.
3. Sinusoids performs the livers tasks
These blood filled
channels are lined by The liver is considered a chemical factory, as it
hepatocytes and provide forms large complex molecules from smaller
the site of transfer of
1. The lobule ones brought to it from the gut via the blood
molecules between blood stream. The functional unit of the liver is
This arrangement of blood
and liver cells.
vessels, bile ducts and the lobule these are hexagonal-shaped
hepatocytes form the structures comprising of blood vessels
functional unit of the liver. and sinusoids. Sinusoids are the
specialised areas where blood
comes into contact with the
9. Central vein 2. The hepatocyte hepatocytes, where the livers
Science Photo Library

Blood from sinusoids, now These highly active cells biological processes
containing all of its new perform all of the livers
molecules, flows into take place.
key metabolic tasks.
central veins which then
flow into larger hepatic
veins. These drain into
the heart via the 4. Kupffer cells
inferior vena cava. These specialised cells sit
within the sinusoids and
destroy any bacteria which
are contaminating blood.

5. Hepatic
artery branch
Blood from here supplies
oxygen to hepatocytes and
carries metabolic waste
which the liver extracts.
Gallstones are
common but
usually dont cause 6. Bile duct
problems. Bile, which helps digest
fat, is made in
hepatocytes and
secreted into bile ducts.

The gallbladder It then flows into the

gallbladder for storage
before being
Bile, a dark green slimy liquid, is produced in the secreted
hepatocytes and helps to digest fat. It is stored in a into the
reservoir which sits on the under-surface of the liver,
to be used when needed. This reservoir is called the
gallbladder. Stones can form in the gallbladder
(gallstones) and are very common, although most
dont cause problems. In 2009, just under 60,000
gallbladders were removed from patients within the
NHS making it one of the most common operations
performed; over 90 per cent of these are removed via 7. Portal vein
keyhole surgery. Most patients do very well without 8. The portal triad This vein carries nutrient-rich blood
their gallbladder and dont notice any changes at all. The hepatic artery, portal vein and bile duct are known as directly from the intestines, which
the portal triad. These sit at the edges of the liver lobule flows into sinusoids for conversion
and are the main entry and exit routes for the liver. into energy within hepatocytes.


The surface area of

the small intestine Structure of the
is huge in fact,
rolled flat it would
small intestine
even cover a Examine the anatomy of this vital
tennis court! organ in the human digestive tract

This is the space inside the
small intestine in which the
food travels to be digested
and absorbed.


Exploring the The internal lining of the

small intestine where the
plicae circulares (mucosal
folds) and villi are situated.

small intestine
Mucosal folds
These line the small
intestine to increase Submucosa
surface area and help This supports the mucosa
push the food on its way and connects it to the layers
by creating a valve-like of muscle (muscularis) that
Crucial for getting the nutrients we need from the food structure, stopping food make up the exterior of the
travelling backwards. small intestine.
we eat, how does this digestive organ work?
he small intestine is actually one of the most amino acid state. While the duodenum is very and mucosal folds line the passage and increase

T important elements of our digestive system,

which enables us to process food and absorb
nutrients. On average, it sits at a little over six metres,
important in breaking food down, using bile and
enzymes from the gallbladder, liver and pancreas, it
is actually the shortest element of the small bowel,
the surface area dramatically to aid this process.
The ileum is the final section of the small bowel
and its main purpose is to catch nutrients that may
that is 19.7 feet, long with a diameter of 2.5-3 only averaging about 30 centimetres, which is just have been missed, as well as absorbing vitamin B12
centimetres, 1-1.2 inches. The small intestine is made 11.8 inches. and bile salts.
up of three different distinctive parts: the The jejunum follows the duodenum and its Peristalsis is the movement used by the small
duodenum, jejunum and the ileum. primary function is to encourage absorption of intestine to push the food through to the large
The duodenum actually connects the small carbohydrates and proteins by passing the bowel, where waste matter is stored for a short
intestine to the stomach and is the key place for broken-down food molecules through an area with period then disposed of via the colon. This process is
further enzyme breakdown, following already a large surface area so they can enter the automatically generated by a series of different
passing through the stomach, turning food into an bloodstream. Villi small finger-like structures muscles which make up the organs outer wall.

DID YOU KNOW? The small intestine is actually longer than the large intestine, but is so called because of its narrower diameter

This protective outer layer stops
the small intestine from being What exactly are nutrients?
damaged by other organs.
There are three main types of nutrient that we process in the body:
lipids (fats), carbohydrates and proteins. These three groups of
molecules are broken down into sugars, starches, fats and smaller,
simpler molecule elements, which we can absorb through the
small intestine walls and that then travel in the bloodstream to our
muscles and other areas of the body that require energy or to be
repaired. We also need to consume and absorb vitamins and
minerals that we cant synthesise within the body, eg vitamin B12
(prevalent in meat and fish).



Nutrients move through Blood vessels
the tube-like organ to be These sit close to the small intestine
diffused into the body, to allow easy diffusion of nutrients
mainly via the bloodstream. into the bloodstream.

A closer look at villi

Villi What role do these little finger-like
Villi are tiny finger-like
structures that sit all over protrusions play in the bowel?
Longitudinal the mucosa. They help
Epithelium Lacteal
muscle layer increase the surface area (epithelial cells) The lacteal is a
This contracts and extends massively, alongside the
to help transport food with mucosal folds.
These individual cells that Mucosa lymphatic capillary
Circular sit in the mucosa layer The lining of the small that absorbs nutrients
muscle layer the circular muscle layer.
are where individual intestine on which that cant pass directly
This works in partnership microvilli extend from. villi are located. into the bloodstream.
with the longitudinal
muscle layer to push the
food down via a process
called peristalsis.

These are a mini version
of villi and sit on villis
individual epithelial cells.
Corbis; Thinkstock

Capillary bed
These absorb simple
sugars and amino acids as
they pass through the
epithelial tissue of the villi.


Inside the thoracic cavity

It may not look like it at first glance,
but there are more than two dozen
bones that make up the ribcage

Also known as the
collarbone, this pair of
long bones is a support
between the sternum
and the shoulder blades.

True ribs
Rib pairs one through
seven attach to the
sternum directly via
a piece of cartilage.

The human False ribs

Rib pairs eight through
ten connect to the
sternum via a structure
made of cartilage linked
to the seventh true rib.

Ribs are not merely armour for the organs inside

our torsos, as we reveal here
he ribcage also known as the thoracic cage Rib pairs one through seven are called true ribs

T or thoracic basket is easily thought of as

just a framework protecting your lungs,
heart and other major organs. Although that is one
because they attach directly to the sternum. Rib
pairs eight through ten attach indirectly through
other cartilage structures, so theyre referred to as
key function, the ribcage does so much more. It false ribs. The final two pairs the floating ribs What are hiccups?
provides vital support as part of the skeleton and, hang unattached to the sternum. Hiccupping known medically as singultus, or
simply put, breathing wouldnt actually be possible Rib fractures are a common and very painful synchronous diaphragmatic flutter (SDF) is an
without it. injury, with the middle ribs the most likely ones involuntary spasm of the diaphragm that can
All this means that the ribcage has to be flexible. to get broken. A fractured rib can be very happen for a number of reasons. Short-term
causes include eating or drinking too quickly, a
The conical structure isnt just a rigid system of dangerous, because a sharp piece could pierce the
sudden change in body temperature or shock.
bone its actually both bone and cartilage. The heart or lungs. However, some researchers have suggested
ribcage comprises 24 ribs, joining in the back to Theres also a condition called flail chest, in that hiccupping in premature babies who tend
the 12 vertebrae making up the middle of the which several ribs break and then detach from the to hiccup much more than full-term babies is
spinal column. cage, which can even be fatal. But otherwise due to their underdeveloped lungs. It could be an
The cartilage portions of the ribs meet in the theres not much you can do to mend a fractured rib evolutionary leftover, since hiccupping in humans
is similar to the way that amphibians gulp water
front at the long, flat three-bone plate called the other than keep it stabilised, resting and giving it
and air into their gills to breathe.
sternum (breastbone). Or rather, most of them do. time to heal.

DID YOU KNOW? The condition known as flail chest is fatal in almost 50 per cent of cases

This broadest and thickest part Breathe in,
of the sternum connects with
the clavicles and the cartilage
for the first pair of ribs.
breathe out
Consciously take in a breath, and think about the
fact that there are ten different muscle groups
working together to make it happen. The
muscles that move the ribcage itself are the
intercostal muscles. They are each attached to
the ribs and run between them. As you inhale,
the external intercostals raise the ribs and
sternum so your lungs can expand, while your
diaphragm lowers and flattens. The internal
intercostals lower the ribcage when you exhale.
This forces the lungs to compress and release air
(working in tandem with seven other muscles). If
you breathe out gently, its a passive process
that doesnt require much ribcage movement.

Inhalation Contraction
As you inhale, the The diaphragm contracts by
intercostal muscles moving downward, allowing
Sternal angle contract to expand the lungs to fill with air.
This is the angle formed by and lift the ribcage.
the joint between the
manubrium and the body,
often used as a sort of
landmark by physicians.

The main body of the
sternum (breastbone) is
almost flat, with three
ridges running across its
surface and cavities for the
cartilage attaching to rib
pairs three through seven.

Floating ribs
(not shown)
Pairs 11-12 are only attached
to the vertebrae, not the
Xiphoid process sternum, so are often called
This extension from the
the floating, or free, ribs.
sternum starts as cartilage,
but hardens to bone and
fuses to the rest of the
breastbone in adulthood.

Ribs in other animals

Most vertebrates (ie animals with ribs overlap one another with hook-like
backbones) have a ribcage of sorts structures called uncinate processes,
however, ribcages can be very which add strength. Frogs dont have
different depending on the creature. any ribs, while turtles eight rib pairs
For example, dogs and cats have 13 are fused to the shell. A snakes
pairs of ribs as opposed to our 12. ribcage, meanwhile, runs the length
Marsupials have fewer ribs than of its body and can comprise hundreds
humans, and some of those are so tiny of pairs of ribs. Despite the variations Relaxation
they arent much more than knobs of in appearance, ribcages all serve the The intercostal muscles The diaphragm relaxes,
bone sticking out from the vertebrae. same basic functions for the relax as we exhale, moving upward to force

Once you get into other vertebrates, most part: to provide support and compressing and air out of the lungs.
the differences are even greater. Birds protection to the rest of the body. lowering the ribcage.


How the pancreas works

Learn how the workhorse of the digestive system helps to
break down food and control our blood sugar levels
he pancreas is a pivotal organ

T within the digestive system. It sits

inside the abdomen, behind the
stomach and the large bowel, adjacent to
Anatomy of the pancreas
It might not be the biggest organ but the pancreas is a key
facilitator of how we absorb nutrients and stay energised
the spleen. In humans, it has a head, neck,
body and tail. It is connected to the first
section of the small intestine, the
Pancreatic duct
duodenum, by the pancreatic duct, and to Within the pancreas, the digestive
the bloodstream via a rich network of enzymes are secreted into
Body of the
the pancreatic duct,
vessels. When it comes to the function of pancreas
which joins onto
the pancreas, it is best to think about the The central body sits
the common
on top of the main
two types of cell it contains: endocrine bile duct.
artery to the spleen.
and exocrine.
The endocrine pancreas is made up of
clusters of cells called islets of Langerhans,
which in total contain approximately 1
million cells and are responsible for
producing hormones. These cells include
alpha cells, which secrete glucagon, and
beta cells which generate insulin. These
two hormones have opposite effects on
blood sugar levels throughout the body:
glucagon increases glucose levels, while
insulin decreases them.
The cells here are all in contact with
capillaries, so hormones which are
produced can be fed directly into the
bloodstream. Insulin secretion is under
the control of a negative-feedback loop;
high blood sugar leads to insulin
secretion, which then lowers blood sugar
with subsequent suppression of insulin.
Disorders of these cells (and thus
alterations of hormone levels) can lead to
many conditions, including diabetes. The
islets of Langerhans are also responsible Common bile duct
for producing other hormones, like The pancreatic enzymes are
mixed with bile from the
somatostatin, which governs nutrient
gallbladder, which is all sent
absorption among other things. through the common bile
The exocrine pancreas, meanwhile, is duct into the duodenum.
responsible for secreting digestive
enzymes. Cells are arranged in clusters
called acini, which flow into the central Duodenum
pancreatic duct. This leads into the The pancreas empties
its digestive enzymes
duodenum part of the small bowel to into the first part of
come into contact with and aid in the the small intestine.
digestion of food. The enzymes secreted
include proteases (to digest protein),
lipases (for fat) and amylase (for sugar/ Head of the
starch). Secretion of these enzymes is The head needs to be
controlled by a series of hormones, which removed if its affected by
are released from the stomach and cancer, via a complex
operation that involves the
duodenum in response to the stretch from resection of many other
the presence of food. adjacent structures.

DID YOU KNOW? In the UK, 80 per cent of acute pancreatitis cases are caused by gallstones or excessive alcohol ingestion

Tail of the pancreas

This is the end portion of
the organ and is positioned
close to the spleen.

What brings on diabetes?

Diabetes is a condition where a pancreas. Inflammation of the organ
person has higher blood sugar than (ie acute pancreatitis) causes severe
normal. It is either caused by a failure pain in the upper abdomen, forcing
of the pancreas to produce insulin (ie most people to attend the emergency
type 1, or insulin-dependent diabetes department as it can actually be life
mellitus), or resistance of the bodys threatening. In contrast, cancer of the
cells to insulin present in the pancreas causes the individual
circulation (ie type 2, or non-insulin- gradually worsening pain which can
dependent diabetes mellitus). There commonly be mistaken for various
are also other disorders of the other ailments.

Beta cells
It is the beta cells
within the islets of
Insulin released
The vesicle releases its
Langerhans which
stored insulin into the
control glucose
blood capillaries
levels and amount
through exocytosis.
of insulin secretion.

Blood supply
The pancreas derives its blood
supply from a variety of sources, High glucose
including vessels running to the When the levels of
stomach and spleen. glucose within the
bloodstream are high,
the glucose wants to Calcium
move down its diffusion effects
gradient into the cells. The calcium
causes the
vesicles that
store insulin to
move towards
the cell wall.

Does the pancreas vary in

humans and animals?
Every vertebrate animal has a pancreas of some form,
meaning they are all susceptible to diabetes too. The
arrangement, however, varies from creature to creature. In
humans, the pancreas is most often a single structure that sits
at the back of the abdomen. In other animals, the arrangement
varies from two or three masses of tissue scattered around
the abdomen, to tissue interspersed within the connective
tissue between the bowels, to small collections of tissue within
the bowel mucosal wall itself. One of the other key differences GLUT2 Depolarisation Calcium channels
is the number of ducts that connect the pancreas to the bowel. This is a glucose- The metabolism of glucose Changes in potassium
Corbis; Sleyman Habib

In most humans theres only one duct, but occasionally there transporting channel, leads to changes in the levels cause voltage-gated
may be two or three and sometimes even more. In other which facilitates the polarity of the cell wall calcium channels to open in
animals, the number is much more variable. However, the uptake of glucose and an increase in the the cell wall, and calcium
function is largely similar, where the pancreas secretes into the cells. number of potassium ions. ions to flow into the cell.
digestive enzymes and hormones to control blood sugar levels.


When youve got to

go, youve got to go

but really our bodies
are reacting to our
bladders direction Kidneys
The kidneys
turn unwanted
substances in the
blood into urine.

Ureters carry
urine from
the kidneys to
the bladder.


How your
The urethra runs
from the bottom
of the bladder to
the outside world.

bladder works
As a key part of the urinary system, the bladder
This muscular

bag generally
holds around a

is crucial to removing waste from your body pint of urine.

he bladder is one of the key organs in the urinary system the bladder becomes full, or nearly full, the nerves in the

T and it stores urine following production by the kidneys

until the body can release it.
Urine is a waste substance produced by the kidneys as they
bladder communicate with the brain, which in turn induces an
urge to urinate. This sensation will get stronger if you do not go
creating the bursting for a wee feeling that you can
filter our blood of toxins and other unneeded elements. Up to 150 occasionally experience. When ready to urinate, both the
litres (40 gallons) of blood are filtered per day by your kidneys, internal and external sphincters relax and the detrusor muscles
but only around two litres (0.5 gallons) of waste actually pass in the bladder wall contract in order to generate pressure,
down the ureters to the bladder. forcing urine to pass down the urethra and exit the body.
Urine travels down the ureters and through the ureter valves, As well as telling you when you need to pass fluid, the urinary
which attach each tube to the organ and prevent any liquid system also helps to maintain the mineral and salt balance in
passing back. The bladder walls, controlled by the detrusor your body. For instance, when salts and minerals are too highly
muscles, relax as urine enters and allow the organ to fill. When concentrated, you feel thirst to regain the balance.

Incontinence explained
For the bladder to work correctly, several often It is actually caused by involuntary pressure (eg while coughing, laughing or
areas within it must all function properly. spasms by the detrusor muscles which sneezing). This kind of incontinence is
It is most commonly the failure of one of can be a result of either nervous system most common in the elderly.
these features that leads to incontinence. problems or infections. One modern remedy is an implant that
One of the most common types of Another type is stress incontinence, has been specifically developed to replace
urinary incontinence is called urge caused when the external sphincter or post-event incontinence pads. This comes
incontinence. This is when an individual pelvic floor muscles are damaged. This in the form of a collagen-based substance
feels a sudden compulsion to urinate and means urine can accidentally escape, that is injected around the urethra in order
will release urine without control. Most especially if the pelvic floor is under to support it.

DID YOU KNOW? Everyones bladder differs slightly in size. The average maximum capacity is between 600-800ml (1.3-1.7pt)

Inside the bladder

How this organ acts as the middleman between What is
your kidneys and excretion
Bladder wall
urine made
muscles) up of?
BLADDER The detrusor muscles
make up a layer of the A human bladder usually holds around
bladder wall. These 350 millilitres (0.7 pints) of urine, though
Ureters muscles cause the wall
These tubes link the kidneys male bladders can typically hold slightly
to relax and extend as
and the bladder, transporting
urine enters, while more than those of females. Urine is
the urine for disposal. made up of urea, the waste by-product
nerves situated in the
Ureter valves wall measure how full the body forms while breaking down
These sit at the end of the bladder is and will protein across the body. The kidneys will
the ureters and let signal to the brain
urine pass into the
filter this out and pass it with extra water
when to urinate. to the bladder for expulsion. Other waste
bladder without letting
it flow back. products produced or consumed by the
body that pass through the kidneys will
also exit the body via this route.
Internal Typically, urine is made up of 95 per cent
urethral sphincter water and 5 per cent dissolved or
The internal sphincter is suspended solids including urea, plus
controlled by the body. It chloride, sodium and potassium ions.
stays closed to stop urine
passing out of the body.

Pelvic floor muscles External urethral

These hold the bladder in place,
sphincter URINE
and sit around the urethra
(distal sphincter) CONTENTS
This sphincter is controlled
stopping unintended urination.
by the individual, and they
control whether to open or
Uric acid
close the valve.

Potassium ions
EMPTYING Sodium ions

Chloride ions

Bladder wall
(controlled by
Internal urethral muscles)
These muscles contract
to force the urine out
This relaxes when the Urea
of the bladder.
body is ready to expel 25.5g
the waste liquid.
2x DK Images

External urethral Urine travels down this
sphincter passageway to leave the body.
(distal sphincter)
This also relaxes for the urine
to exit the body.


The urinary
system Kidneys

Every day the body produces waste
This is where liquids are
filtered and nutrients are
absorbed before urine
exits into the ureters.

products that enter the bloodstream Ureter These tubes link the

but how do we get rid of them? kidneys and the bladder.

he human urinary systems body, sodium and potassium levels

T primary function is to remove

by-products which remain in the
blood after the body has metabolised
among other electrolytes, blood pressure,
pH of the blood and are also involved in
red blood cell production through the
Inferior vena cava
This carries deoxygenated
blood back from the kidneys
food. The process is made up of several creation and release of the hormone to the right aorta of the heart.
different key features. Generally, this erythropoietin. Consequently, they
system consists of two kidneys, two are absolutely crucial to optimum Abdominal aorta
ureters, the bladder, two sphincter body operation. This artery supplies blood
to the kidneys, via the renal
muscles (one internal, one external) After blood has been filtered by artery and vein. This blood
and a urethra and these work alongside the kidneys, the waste products then is then cleansed by
the intestines, lungs and skin, all of travel down the ureters to the bladder. the kidneys.

which excrete waste products from The bladders walls expand out to
the body. hold the urine until the body can
The abdominal aorta is an important excrete the waste out through the Bladder
artery to the system as this feeds the urethra. The internal and external This is where urine
gathers after being
renal artery and vein, which supply the sphincters then control the release passed down the
kidneys with blood. This blood is filtered of urine. ureters from
by the kidneys to remove waste products, On average, a typical human will the kidneys.

such as urea which is formed through produce approximately a staggering 2.5-3

amino acid metabolism. Through litres of urine in just one day, although
communication with other areas of the this can vary dramatically dependant on
body, such as the hypothalamus, the external factors such as how much water
kidneys also control water levels in the is consumed.

Generally, a human will produce

2.5-3 litres of urine a day
How do the kidneys work?
The kidneys will have around 150-180 litres of blood to filter per day, but only pass
around two litres of waste down the ureters to the bladder for excretion, therefore the
kidneys return much of this blood, minus most of the waste products, to the heart for
re-oxygenation and recirculation around the body.
The way the kidneys do this is to pass the blood through a small filtering unit called a
nephron. Each kidney has around a million of these, which are made up of a number of
small blood capillaries and a tube called the renal tubule. The blood capillaries sift the
normal cells and proteins from the blood for recirculation and then direct the waste
products into the renal tubule. This waste, which will primarily consist of urea, mixes
with water and forms urine as it passes through the renal tubule and then into the
ureter on its way to the bladder.

DID YOU KNOW? On average, you make the same amount of urine in the day as in the night

How do we store waste until

were ready to expel it?
The bladder stores waste products by allowing the urine to enter
through the ureter valves, which attach the ureter to the bladder.
The walls relax as urine enters and this allows the bladder to
stretch. When the bladder becomes full, the nerves in the bladder
communicate with the brain and cause the individual to feel the
urge to urinate. The internal and external sphincters will then
relax, allowing urine to pass down the urethra.

1. Ureters
Bladder These tubes connect to the kidneys and urine
fills flows down to the bladder through them.

2. Internal urethral sphincter

Why do we This remains closed to ensure urine does
not escape unexpectedly.

get thirsty?
Maintaining the balance between the
minerals and salts in our body and water is
very important. When this is out of balance,
the body tells us to consume more liquids to
redress this imbalance in order for the body
to continue operating effectively. 3. External
This craving, or thirst, can be caused by urethral
too high a concentration of salts in the body, sphincter
This secondary
or by the water volume in the body dropping
sphincter also
too low for optimal operation. Avoiding remains closed
dehydration is important as long term to ensure no
dehydration can cause renal failure, among urine escapes.
other conditions. 5. Bladder walls
(controlled by
4. Ureter valves detrusor muscles)
These valves are situated The detrusor muscles in the wall of
at the end of the ureters

The human and let urine in.

the bladder relax to allow expansion
of the bladder as necessary.

urinary Bladder 1. Internal urethral sphincter

system empties This relaxes when the body is ready to expel

2. External
the waste.

urethral sphincter
Renal artery and vein This also relaxes for the urine
This supplies blood to the kidneys to exit the body.
in order for them to operate, and
then removes deoxygenated blood
after use by the kidneys.

The bladder sits in the pelvis,
and the urethra passes through
it for urine to exit the body. 3. Bladder
by detrusor
DK Images

These muscles
Urethra 4. Urethra
contract to force
The urethra is the tube
the urine out of Urine travels down this
that urine travels
the bladder. passageway to exit the body.
through to exit the body.


Inside the human stomach

Discover how this amazing digestive organ stretches, churns and holds corrosive acid
to break down our food, all without getting damaged
he stomachs major role is as a reservoir the rugae flatten, allowing the stomach to cells (G-cells) to make the hormone gastrin,

T for food; it allows large meals to be

consumed in one sitting before being
gradually emptied into the small intestine. A
expand, and the outer muscles relax. The
stomach can accommodate about a litre (1.8
pints) of food without discomfort.
which encourages even more acid production.
The stomach empties its contents into the
small intestine through the pyloric sphincter.
combination of acid, protein-digesting The expansion of the stomach activates Liquids pass through the sphincter easily, but
enzymes and vigorous churning action breaks stretch receptors, which trigger nerve solids must be smaller than one to two
the stomach contents down into an easier-to- signalling that results in increased acid millimetres (0.04-0.08 inches) in diameter
process liquid form, preparing food for production and powerful muscle contractions before they will fit. Anything larger is refluxed
absorption in the bowels. to mix and churn the contents. Gastric acid backwards into the main chamber for further
In its resting state, the stomach is contracted causes proteins in the food to unravel, allowing churning and enzymatic breakdown. It takes
and the internal surface of the organ folds into access by the enzyme pepsin, which breaks about two hours for half a meal to pass into the
characteristic ridges, or rugae. When we start down protein. The presence of partially small intestine and the process is generally
eating, however, the stomach begins to distend; digested proteins stimulates enteroendocrine complete within four to five hours.

Lining under the microscope Chief cells make pepsinogen; at the low pH
The stomach is much more than just a storage bag. in the stomach it becomes the digestive
Take a look at its complex microanatomy now enzyme pepsin, which deconstructs protein.

Gastric pits Mucous cell

These cells secrete alkaline
The entire surface of the
mucus to protect the
stomach is covered in tiny
stomach lining from damage
holes, which lead to the
by stomach acid.
glands that produce mucus,
acid and enzymes.


G-cell (pink)
Also known as
enteroendocrine cells,
these produce hormones
like gastrin, which regulate
acid production and
stomach contraction.



Muscle layers
Parietal cell (blue) The stomach has three layers
These cells produce hydrochloric of muscle running in different
acid, which kills off micro- orientations. These produce
organisms, unravels proteins and the co-ordinated contraction
activates digestive enzymes. required to mix food.

DID YOU KNOW? Stomach rumbling, also known as borborygmus, is actually the noise of air movement in the intestines

The top portion of the
stomach curves up and

Gastric anatomy allows gases created

during digestion to
This major organ in the digestive system has several distinct be collected.
regions with different functions, as we highlight here

The oesophagus empties into
the stomach at the cardia. This
region makes lots of mucus,
but little acid or enzymes.

Pyloric sphincter
The pyloric sphincter is a strong
ring of muscle that regulates the
passage of food from the Antrum
stomach to the bowels. The antrum contains cells that
can stimulate or shut off acid
production, regulating the pH
level of the stomach.

Also called the corpus, this
is the largest part of the
stomach and is responsible
for storing food as gastric
juices are introduced.

Small intestine
The stomach empties into
the first section of the small
intestine: the duodenum.
The bottom of the stomach Large intestine
is located in front of the The large intestine curls
pancreas, although the two around and rests just below
arent directly connected. the stomach in the abdomen.

Why doesnt it Produced by parietal Vomit reflex

digest itself?
cells in the stomach
lining, gastric acid has a
pH level of 1.5 to 3.5 Vomiting is the forceful expulsion
Your stomach is full of corrosive acid and of the stomach contents up the
enzymes capable of breaking down protein if oesophagus and out of the mouth.
left unprotected the stomach lining would Its the result of three co-ordinated
quickly be destroyed. To prevent this from stages. First, a deep breath is
occurring, the cells lining the stomach wall drawn and the body closes the
produce carbohydrate-rich mucus, which forms glottis, covering the entrance to
a slippery, gel-like barrier. The mucus contains the lungs. The diaphragm then
bicarbonate, which is alkaline and buffers the pH contracts, lowering pressure in the
at the surface of the stomach lining, preventing thorax to open up the oesophagus.
damage by acid. For added protection, the At the same time, the muscles of
protein-digesting enzyme pepsin is created from the abdominal wall contract,
a zymogen (the enzyme in its inactive form) which squeezes the stomach. The
pepsinogen; it only becomes active when it combined shifts in pressure both

comes into contact with acid, a safe distance inside and outside the stomach
away from the cells that manufacture it. forces any contents upwards.


he human hand is an important

T feature of the human body, which

allows individuals to manipulate
their surroundings and also to gather large
The human hand
amounts of data from the environment that
the individual is situated within. A hand is
generally defined as the terminal aspect of We take our hands for granted, but they are actually
the human arm, which consists of
prehensile digits, an opposable thumb, and quite complex and have been crucial in our evolution
a wrist and palm. Although many other
animals have similar structures, only
primates and a limited number of other
vertebrates can be said to have a hand due
to the need for an opposable thumb to be
Bones in Distal phalanges
present and the degree of extra articulation
that the human hand can achieve. Due to
the hand A distal phalange (fingertip) is situated
at the end of each finger. Deep flexors
attach to this bone to allow for
this extra articulation, humans have The human hand contains 27 maximum movement.
developed fine motor skills allowing for bones, and these divide up into
much increased control in this limb. three distinct groups: the Intermediate
Consequently we see improved ability to carpals, metacarpals and phalanges
grasp and grip items and development of phalanges. These also then This is where the
superficial flexors attach
skills such as writing. break down into a further
via tendons to allow the
A normal human hand is made up of five three different groups: the digit to bend.
digits, the palm and wrist. It consists of 27 proximal phalanges, the
bones, tendons, muscles and nerves, with intermediate phalanges and
each fingertip of each digit containing then the distal phalanges. phalanges
numerous nerve endings making the hand a Eight bones are situated in the Each finger has three
crucial area for gathering information from wrist and these are collectively phalanges, and this phalange
the environment using one of mans most called the carpals. The joins the intermediate to its
crucial five senses: touch. The muscles metacarpals, which are respective metacarpal.
interact together with tendons in order to situated in the palm of the
allow fingers to bend, straighten, point and, hand account for a further five Metacarpals
in the case of the thumb, rotate. However, out of the 27, and each These five bones make up the
palm, and each one aligns
the hand is an area that sees many injuries finger has three phalanges, the
with one of the hands digits.
due to the number of ways we use it, one in thumb only has two. Intrinsic
ten injuries in A&E being hand related, and muscles and tendons control
there are also several disorders that can movement of the digits and Carpals
affect the hand development whilst still in hand, and attach to extrinsic The carpals (scaphoid, triquetral, trapezium,
the womb, such as polydactyly, where an muscles that extend further up trapezoid, lunate, hamate, capitate and
pisiform) sit between the ulna and radius
individual is born with extra digits, which into the arm, flexing the digits.
and the metacarpals.
are often still in perfect working order.

DID YOU KNOW? Skin is attached to tendons and so when you bend you fingers back, dimples appear on the back of your hand

Muscles and other structures Opposable

The movements and articulations of the hand and more complex mix of tendons and intrinsic muscles
by the digits are not only controlled by tendons but
also two muscle groups situated within the hand
and wrist. These are the extrinsic and intrinsic
to operate (extensors). These muscles will contract
in order to cause digit movement, and flexors and
extensors work in a pair to complement each to
Increased articulation of
muscle groups, so named as the extrinsics are straighten and bend digits. The intrinsic muscles
the thumb has been
attached to muscles which extend into the forearm, are responsible for aiding all extrinsic muscle action
heralded as one of the
whereas the intrinsics are situated within the hand and any other movements in the digits and have
key factors in human
and wrist. The flexors and extensors, which make three distinct groups; the thenar and hypothenar
evolution. It allowed
up the extrinsic muscles, use either exclusively (referring to the thumb and little finger
for increased control
tendons to attach to digits they control (flexors) or a respectively), the interossei and the lumbrical.
and grip, and has
allowed for tool use in
Thenar space order to develop among
Thenar refers to the thumb,
and this space is situated human ancestors as well
between the first digit and as other primates. This has later also
thumb. One of the deep facilitated major cultural advances, such as writing.
flexors (extrinsic muscle) is Alongside the four other flexible digits, the opposable
located in here. thumb makes the human hand one of the most
dexterous in the world. A thumb can only be
classified as opposable when it can be brought
Interossei opposite to the other digits.
This interossei muscle sits
between metacarpal
bones and will unite with
tendons to allow extension
using extrinsic muscles.
Ulnar nerve
This nerve stretches Left handed
down the forearm into
the hand and allows for or right
sensory information
to be passed from
Arteries, veins hand to brain.
and nerves The most common theory for why some individuals
These supply fresh
oxygenated blood (and
Hypothenar are left handed is that of the disappearing twin. This
muscle (intrinsic) supposes that the left-handed individual was
take away deoxygenated Hypothenar refers to the little actually one of a set of twins, but that in the early

blood) to hand muscles. finger and this muscle group is one


stages of development the other, right handed, twin


of the intrinsic muscles.


died. However, its been found that dominance of one


hand is directly linked with hemisphere dominance

Insertion of flexor tendon Mid palmar space in the brain, as in many other paired organs.
Tendons and intrinsic muscles Individuals who somehow damage their dominant
Forearm This is where the tendon attaches the
flexor muscle to the finger bones to
primarily inhabit this space
within the hand.
hand for extended periods of time can actually

muscles allow articulation. change to use the other hand, proving the impact and
importance of environment and extent to which
humans can adapt.
Extrinsic muscles are so
called because they are
primarily situated outside
the hand, the body of the
muscles situated along the
underside or front of the
forearm. This body of
muscles actually breaks
down into two quite distinct
groups: the flexors and the
extensors. The flexors run
alongside the underside of
the arm and are responsible
for allowing the bending of
the individual digits, Science photo library

whereas the extensor

muscles main purpose is the Tendons and
reverse this action, to intrinsics
straighten the digits. There These attach the
are both deep and superficial flexor muscles to the
flexors and extensors, and phalanges, and facilitate Deep flexors Extensors
which are used at any one
bending. Tendons also Thenars Superficial flexors The digits have two extrinsic Extensors on the back of
interact with the intrinsics The intrinsic group of The other flexor that acts on flexors that allow them to bend, the forearm straighten the
time depends on the digit to and extensors in the wrist, muscles is used to flex the the digits is the superior flexor, the deep flexor and the digits. Divided into six
be moved. palm and forearm to thumb and control its which attaches to the superficial. The deep flexor sections, their connection
straighten the digits. sideways movement. intermediate phalanges. attaches to the distal phalanges. to the digits is complex.


What are our

made of?
And how are they formed?
Fingernails are made of a tough protein called keratin (from the Greek
word Kera, meaning horn). Keratin is also what animals hooves and horns
are made from. Most animals have a supportive bone structure in their
horns, although rhinoceros horns are made completely of keratin compacted
together. The only other biological material which has a similar toughness
to keratinised tissue is chitin, the main component of exoskeletons
belonging to arthropods. The half-moon shape that you can see at the
bottom of your nail (apart from maybe your little finger) is called the lanula.
This is a group of cells that produce keratin and other living cells. As these
living cells are automatically pushed forward by newer cells, they die and
merge with the keratin to become keratinised. They then become flattened,
stiff and known as your fingernails.

The half-moon shape that you

can see at the bottom of your
nail is called the lanula

What does
the Achilles
tendon do?
Is it really a weak spot and how
important is it?
his tendon, the strongest in your body, connects the calf muscles to the

T heel. When everything is fine, it pulls the back of the foot up when the
calf muscles contract. This way, your heel raises and your weight goes to
your toes.
It enables us to do such things as sprinting, hopping or jumping. It also stores
elastic energy to do these tasks more efficiently. Biological anthropologists
believe all this was very important for the way we evolved to run around on two
legs and survive.
The Achilles tendon is seemingly named thus after the mythological Greek
character of Achilles, who during the Trojan War - made famous by Homers epic
poem The Illiad - is shot by a poisoned arrow in his unprotected heel - hence the
common phrase describing a persons weak point.

DID YOU KNOW? Knee injuries are common within the sporting world due to the constant muscle strain

The quadriceps, made up
of four muscles,
are on the front of the
thigh and help to

the knee
straighten the leg.

How do our knee joints

allow us to walk and run?
The knee is the largest and also one of
the most complex joints in the human
body, allowing us bipedal humans to
move around and get from point A to
point B. Three different bones meet at
the knee joint and work together to allow
for movement and protection. At the top
of the knee is the lower part of the
thighbone (femur). This rotates on top of Hamstring muscles running
the shinbone (tibia) and the kneecap from the thigh to the knee joint
(patella), the latter of which moves in a are responsible for bending
groove between the femur and tibia. the leg at the knee.
Cartilage within the knee cushions it
from shock that is inevitably caused
by motion, while the ligaments prevent Femur
damage occurring to the joint in case of This bone runs from the hip to
unusual or erratic motion. Muscles the knee joint. It is the thickest
and the longest bone in the
running from the hip down to the knee
human body.
joint are responsible for working the
knee joint and allowing our legs to bend,
stretch, and ultimately allowing us to The knee
ar y
walk, run and skip.

How does everything work in

tandem to allow for movement?


The point at which the three
bones meet is covered in tough,
elastic articular cartilage,
Synovial membrane
allowing smooth movement of
The soft tissue at the centre of the
the joint and absorbing shock.
knee joint contains synovial fluid,
providing lubrication for the
moving knee.
This bone slides at the front of
the femur and tibia as the knee Ligaments
moves, protecting the knee and These elastic bands of tissue
giving the muscles leverage. connect the bones together
and provide stability and
strength to the knee joint.

The three bones are separated
with two discs of connective
tissue called menisci, also
acting as shock absorbers and
enhancing stability.

These tough cords of tissue Tibia
attach muscle to bone, so that This bone connects the knee to The patella, seen
the muscles can bend and the ankle, running parallel to the separated above, is also
straighten the leg as required. thinner fibula bone. known as the kneecap


How do your
feet work?
Feet are immensely complex structures, yet we
put huge amounts of pressure on them every
day. How do they cope?
he human foot and ankle is crucial for locomotion and is

T one of the most complex structures of the human body.

This intricate structure is made up of no less than 26
bones, 20 muscles, 33 joints although only 20 are articulated
Terminal aspects of the foot
that aid balance by grasping
onto the ground. They are the
as well as numerous tendons and ligaments. Tendons connect equivalent of fingers in the
the muscles to the bones and facilitate movement of the foot, foot structure.
while ligaments hold the tendons in place and help the foot
move up and down to initiate walking. Arches in the foot are Muscles including the extensor
formed by ligaments, muscles and foot bones and help to digitorum brevis muscle
distribute weight, as well as making it easier for the foot to Muscles within the foot help the foot lift and
operate efficiently when walking and running. It is due to the articulate as necessary. The extensor digitorum
unique structure of the foot and the way it distributes pressure brevis muscle sits on the top of the foot, and
throughout all aspects that it can withstand constant pressure helps flex digits two-four on the foot.
throughout the day.
One of the other crucial functions of the foot is to aid balance, Blood vessels
and toes are a crucial aspect of this. The big toe in particular These supply blood to the foot,
helps in this area, as we can grip the ground with it if we feel we facilitating muscle operation by
supplying energy and oxygen and
are losing balance.
removing deoxygenated blood.
The skin, nerves and blood vessels make up the rest of the
foot, helping to hold the shape and also supplying it with all the
necessary minerals, oxygen and energy to help keep it moving Ligaments
Ligaments support the
easily and constantly. tendons and help to form the
arches of the foot, spreading
weight across it.

What happens when Tendons (extensor digitorum

you sprain your ankle? longus, among others)
Fibrous bands of tissue which connect
muscles to bones. They can withstand a lot
A sprained ankle is the most common type of soft tissue of tension and link various aspects of the
injury. The severity of the sprain can depend on how you foot, facilitating movement.
sprained the ankle, and a minor sprain will generally
consist of a stretched or only partially torn ligament. Tibia Images
However, more severe sprains can cause the ligament The larger and stronger of the lower
to tear completely, or even force a piece of bone to leg bones, this links the knee and the

break off. ankle bones of the foot.

Generally a sprain will happen when you lose balance
or slip, and the foot bends Fibula
inwards towards the other leg. This bone sits alongside the tibia, also
This then overstretches the linking the knee and the ankle.
ligaments and causes the
damage. Actually, over a quarter
of all sporting injuries are

sprains of the ankle.


The structure
of the foot
and how the
work together
DID YOU KNOW? In a lifetime, a person will walk the equivalent of four times around the globe more than 100,000 miles!

How do
we walk?
Human gait is the term to describe how we
4. Leg swing
The lower leg will
then swing at the
walk. This gait will vary between each knee, under the body,
person, but the basics are the same to be placed in front
of the stationary,
weight- bearing foot.

2. Weight transfer
The weight will transfer fully
to the foot still in contact
with the ground, normally
with a slight leaning
movement of the body.

6. Repeat
3. Foot lift 5. Heel 1. Heel lift The process is
After weight has placement The first step of walking is for then repeated with
transferred and the The heel will normally be the foot to be lifted off the the other foot. During
individual feels the part of the foot thats ground. The knee will raise and normal walking or
balanced, the ball of placed first, and weight the calf muscle and Achilles running, one foot will
the first foot will then will start to transfer back tendon, situated on the back of start to lift as the other
lift off the ground, onto this foot as it hits the leg, will contract to allow starts to come into
raising the thigh. the ground. the heel to lift off the ground. contact with the ground.
The structure of the foot
enables us to stay balanced

Bones of the foot

Distal Proximal Metatarsals Cuneiforms Navicular
phalanges phalanges The five, long bones that are bones (three) This bone, which is
The bones which These bones link the the metatarsals are located Three bones that fuse so named due
sit at the far end metatarsals and the between the tarsal bones together during bone to its resemblance
of the foot and distal phalanges and and the phalanges. These development and sit to a boat, articulates
make up the tips stretch from the are the equivalent of the between the metatarsals with the three A baby is born with 22
of the toes. base of the toes. metacarpals in the hand. and the talus. cuneiform bones. out of a total 26 bones in each foot

Cuboid Talus Calcaneus

One of five irregular bones The talus is the This bone
(cuboid, navicular and three second largest constitutes the
cuneiform bones) which make bone of the foot, heel and is crucial
DK Images

up the arches of the foot. and it makes up for walking. It is

These help with shock the lower part of the largest bone
absorption in locomotion. the ankle joint. in the foot.


98 90
How our The lungs
bones heal explained

76 The science of sleep 99 Making protein 117 What is anxiety?

Understand why we sleep How are they manufactured? What causes us to feel uneasy?
84 The blood-brain barrier 100 The cell cycle 118 Circulatory system
What important role does it play? Inside a vital process How blood gets transported
85 Pituitary gland up close 102 Human pregnancy 120 How your blood works
The master gland explored The different stages explained The miraculous fluid analysed
86 Human digestion explained 104 Embryo development 124 Blood vessels /
The digestion process revealed How a foetus evolves Hyperventilation
What are blood vessels made of
88 Eat too much / Taste buds 106 Altitude sickness / Synapses and why do we hyperventilate?
How do we sense flavours? What causes altitude sickness?
125 Tracheotomy surgery
89 Adrenaline 107 What is the biology of A look at the life-saving operation
How this hormone affects us hunger?
Find out why we get hungry 126 Hormones
90 Human respiration Understand the human
The lungs explained 108 What is saliva? endocrine system
Find out why there is moisture in
92 Dehydration / Sweating our mouths 128 Exploring the sensory system
Why we sweat and using fluids How we experience the world
109 Neurotransmitters and your
93 Scar types feelings 132 Muscle cramps
How different scar types form How do your emotions work? Discover why cramps occur
94 The immune system 110 White blood cells 133 Why do we cry?
Combating viruses How infection is fought The different types of tears
98 Healing bone fractures 112 The science of genetics 134 The other senses
How broken bones are mended How genes define who we are The ones you didnt know about


The role of

Why do
we cry?
The cell cycle


The cell damage 125

from viruses Tracheotomy
DK Images

causes diseases

The science of

Unravelling the mysteries behind insomnia, sleepwalking,
dreams and more

e spend around a third of our lives
sleeping. It is vital to our survival, but
despite years of research, scientists still
arent entirely sure why we do it. The urge to sleep is
all-consuming, and if we are deprived of it, we will
eventually slip into slumber even if the situation is
There have been many ideas and theories proposed
about why humans sleep, from a way to rest after the
days activities or a method for saving energy, to
simply a way to fill time until we can be doing
something useful. But all of these ideas are somewhat
flawed. The body repairs itself just as well when we
are sitting quietly, we only save around 100 calories a
Sleep is an essential habit to mammals, birds and night by sleeping, and we wouldnt need to catch up
reptiles and has been conserved through evolution, on sleep during the day if it were just to fill empty time
despite preventing us from performing tasks such as at night.
eating, reproducing and raising young. It is as One of the major problems with sleep deprivation is
important as food and, without it, rats will die within a resulting decline in cognitive ability our brains just
two or three weeks the same period it takes to die dont work properly without sleep. We will find
of starvation. ourselves struggling with memory, learning,

DID YOU KNOW? Marine mammals sleep with just half of their brain at a time, allowing them to surface for air

Theories of why we sleep

We save around 100 calories per night
by sleeping; metabolic rate drops, the
digestive system is less active, heart
and breathing rates slow, and body
temperature drops. However, the
calorie-saving equates to just one cup
of milk, which from an evolutionary
perspective does not seem worth the
accompanying vulnerability.

One of the major problems with sleep
deprivation is a decline in cognitive
function, accompanied by a drop in
mood, and there is mounting evidence
that sleep is involved in restoring the
brain. However, there is little evidence
to suggest that the body undergoes
more repair during sleep compared to
rest or relaxation.

Evolutionary Memory
An early idea about the purpose of sleep consolidation
is that it is a protective adaptation to fill One of the strongest theories regarding
time. For example, prey animals with sleep is that it helps with consolidation
night vision might sleep during the day to of memory. The brain is bombarded
avoid being spotted by predators. with more information during the day
However, this theory cannot explain than it is possible to remember, so sleep
why sleep-deprived people fall asleep in is used to sort through this information
the middle of the day. and selectively practise parts that need
to be stored.

planning and reasoning. A lack of sleep can actually Without NREM sleep, our ability to form declarative sleep, dreams tend to be more concept-based,
have severe effects on our mood and performance of memories, such as learning to associate pairs of whereas REM sleep dreams are a lot more vivid
everyday tasks, ranging from irritability, through to words, can be seriously impaired. Deep sleep is and emotional.
long term problems such as an increased risk of important for transferring short-term memories into Some scientists argue that REM sleep allows our
heart disease and even a higher incidence of road long-term storage. Deep sleep is also the time of peak brains a safe place to practice dealing with situations
traffic accidents. growth hormone release in the body, which is or emotions that we might not encounter during our
Sleep can be divided into two broad stages: important for cell reproduction and repair. daily lives. During REM sleep our muscles are
non-rapid eye movement (NREM), and rapid eye The purpose of REM sleep is unclear, with the temporarily paralysed, preventing us acting out these
movement (REM) sleep. The vast majority of our sleep, effects of REM sleep deprivation proving less severe emotions. Others think that it might be a way to
actually around 75 to 80 per cent of it, is NREM, which than NREM deprivation; for the first two weeks unlearn memories, or to process unwanted feelings or
is characterised by various electrical patterns in the humans report little in the way of ill effects. REM sleep emotions. Each of these ideas has its flaws, and no one
brain known as sleep spindles and high, slow delta is the period during the night when we have our most knows the real answer.
waves. When this is occuring, this is the time when vivid dreams, but people dream during both NREM We will delve into the science of sleep and attempt
we sleep the deepest. and REM sleep. One curiosity is that during NREM to make sense of the mysteries of the sleeping brain.


The sleep cycle

In the night, you cycle through five separate stages of sleep every 90 to 110 minutes
The five stages of sleep can be distinguished by then by two stages of deep sleep. Your brain activity like wakefulness, and you enter rapid eye movement
changes in the electrical activity in your brain, starts to slow down, your breathing, heart rate and (REM) sleep the time when your most vivid dreams
measured by electroencephalogram (EEG). The first temperature drop, and you become progressively occur. This cycle happens several times throughout
stage begins with drowsiness as you drift in and out more difficult to wake up. Finally, your brain perks the night, and each time, the period of REM sleep
of consciousness, and is followed by light sleep and up again, resuming activity that looks much more grows longer.

How much 30% Other

REM sleep

Growth time is spent stages

hormone in each sleep 50%

release stage? Stage 2

After you fall asleep,

the pituitary gland Low temperature
ramps up its Body temperature falls just
production of before you fall asleep, and is
growth hormone. maintained at a lower level
throughout the night.

Muscle tone drops
during sleep, but you
still change position,
tossing and turning.

Different when
During REM sleep, your
heart rate rises, but your Slow breathing
larger muscles are As you fall into deeper and
paralysed. This mean just deeper sleep, your breathing
your fingers, toes and eyes becomes slower and more rhythmic
twitch as you dream. and your heart rate drops.

Stages of sleep
Not all sleep is the same. There are five separate stages, divided by brain activity


1 Drowsiness 2 Light sleep 3 Moderate sleep

During the first stage of sleep you are just drifting off; After a few minutes, your brain activity slows further, As you start to enter this third stage, your sleep
your eyelids are heavy and your head starts to drop. and you descend into light sleep. On the EEG monitor, spindles stop, this in turn is showing that your brain
During this drowsy period, you are easily woken and this stage is characterised by further slowing in the has entered moderate sleep. This is then followed by
your brain is still quite active. The electrical activity on waves, with an increase in their size and short one- or deep sleep. The trace on the EEG slows still further as
an electroencephalogram (EEG) monitor starts to slow two-second bursts of activity known as sleep your brain produces delta waves with occasional
down, and the cortical waves become taller and spindles. By the time you are in the second phase of spikes of smaller, faster waves in between. As you
spikier. As the sleep cycle repeats during the night, you sleep, your eyes stop moving, but you can still be progress through stage-three sleep, you become much
re-enter this drowsy half-awake, half-asleep stage. woken up quite easily. more difficult to wake up.

DID YOU KNOW? Sleeping in at the weekends causes social jet lag and makes it more difficult to get up on Monday morning

Dreaming versus deep sleep
First Second Third Fourth Fifth
cycle cycle cycle cycle cycle



STAGE 4 Deep sleep Dreaming (REM)

Clearing Brain activity

the mind
The brain is a power-hungry organ; it
makes up only two per cent of the total
mass of the body, but it uses an
enormous 25 per cent of the total
energy supply. The question is, how
does it get rid of waste? The
Nedergaard Lab at the University of
Rochester in New York thinks
sleep might be a time to clean the
brain. The rest of the body relies
Wide awake Deep sleep
The red areas in this scan During the later stages of
on the lymphatic drainage show areas of activity in the NREM sleep, the brain is less
system to help remove waste waking human brain, while active, shown here by the cool
products, but the brain is a the blue areas represent blue and purple colours that
protected area, and these vessels areas of inactivity. dominate the scan.
do not extend upward into the
head. Instead, your central
nervous system is bathed in a
clear liquid called cerebrospinal
fluid (CSF), into which waste can be
dissolved for removal. During the
day, it remains on the outside, but
the labs research has shown that,
during sleep, gaps open up between
brain cells and the fluid rushes in,
following paths along the outside of
blood vessels, sweeping through
every corner of the brain and helping to REM (dream) sleep Light sleep
When we are dreaming, the In the first stages of NREM
clear out toxic molecules.
human brain shows a lot of sleep, the brain is less active
activity, displaying similar than when awake, but you
red patterns of activity to the remain alert and easy to
waking brain. wake up.
Science Photo Library; Alamy; Thinkstock

4 Deep sleep 5 REM sleep

There is some debate as to whether sleep stages three After deep sleep, your brain starts to perk up and its
and four are really separate, or whether they are part electrical activity starts to resemble the waking brain.
of the same phase of sleep. Stage four is the deepest This is the period of the night when most dreams
stage of all, and during this time you are extremely happen. Your muscles are temporarily paralysed, and Sleep deprivation NREM sleep
hard to wake. The EEG shows tall, slow waves which your eyes dart around, giving it the name rapid eye The sleep-deprived brain As you descend through the
are known as delta waves; your muscles will relax and movement (REM) sleep. You cycle through the stages of looks similar to the brain four stages of NREM sleep,
your breathing becomes slow and rhythmic, which sleep about every 90 minutes, experiencing between during NREM sleep, showing your brain in turn becomes
can lead to snoring. three and five dream periods each night. patterns of inactivity. progressively less active.


Sleep Sleepwalking
Sleepwalking affects between one
Sleepwalkers can perform complicated
actions while in deep NREM sleep

There are over 100 different
and 15 per cent of the population,
and is much more common in
children than in adults, tending to
happen less and less after the age
of 11 or 12. Sleepwalkers might just
disorders that prevent a sit up in their bed, but can
sometimes perform complex
good nights sleep behaviours, such as walking,
Sleep is necessary for our health, so disruptions to getting dressed, cooking, or even
the quality or quantity of our sleep can have a driving a car. Although
serious negative impact on daily life, affecting both sleepwalkers seem to be acting
physical health and mental wellbeing. out their dreams, sleepwalking
Sleep disorders fall into four main categories: tends to occur during the
difficulty falling asleep, difficulty staying awake, deep-sleep phase of NREM sleep
trouble sticking to a regular sleep pattern and and not during REM sleep.
abnormal sleep behaviours. Struggling with falling
asleep or staying asleep is known as insomnia, and
is one of the most familiar sleep disorders; around a
third of the population will experience it during
their lifetime. Difficulty staying awake, or
hypersomnia, is less common. The best-known
example is narcolepsy, which is when sufferers
experience excessive daytime sleepiness,
accompanied by uncontrollable short periods of Sleep apnoea
sleep during the day. Trouble sticking to a regular Sleep apnoea is a dangerous sleep disorder. It is protective response, pulling the sufferer out of
sleeping pattern can either be caused by external when the walls of the airways relax so much deep sleep to protect them from damage. This can
disruption to normal day-to-day rhythms, for during the night that breathing is interrupted for cause people to wake up, but often it will just put
example by jet lag or shift work. It can also be the ten seconds or more, restricting the supply of them into a different sleep stage, interrupting their
result of an internal problem with the part of the oxygen to the brain. The lack of oxygen initiates a rest and causing feelings of tiredness the next day.
brain responsible for setting the body clock.
Abnormal sleep behaviours include problems
like night terrors, sleepwalking and REM-sleep Loud breathing
behaviour disorder. Night terrors and sleepwalking People suffering with sleep apnoea Waking up Lack of oxygen
often snore, gasp and breathe The low oxygen level in the blood If the airway is obstructed for
most commonly affect children, and tend to resolve
loudly as they struggle for air triggers the brain to wake up in an ten seconds or more, the
themselves with age, but other sleep behaviours during the night. attempt to fix the obstruction. amount of oxygen reaching
persist into adulthood. In REM-sleep behaviour the brain drops.
disorder, the normal muscle paralysis that
accompanies dreaming fails, and people begin to Muscle collapse
act out their dreams. The muscles supporting
Treatment for different sleep disorders varies the tongue, tonsils and
depending on the particular problem, and soft palate relax during
sleep, causing the throat
sometimes it can even be as simple as making the
to narrow.
individuals bedroom environment more conducive
to restful sleep.

Treatment for
different sleep
disorders varies

A continuous
positive airway
pressure (CPAP) Risk factors
machine pumps Sleep apnoea is much more
air into a common in patients who are
close-fitting overweight, male and over Warning signs
mask, the age of 40. Smoking, Reduced airflow People may not know they have sleep
preventing the alcohol and sleeping pills also Soft-tissue collapse reduces the amount apnoea, but warning signs include
airway from increase the risk. of air entering the lungs or obstructing daytime sleepiness, headaches and
collapsing the airways completely. night sweats.

DID YOU KNOW? After 24 sleepless hours your cognition is at the same level as a person with a blood alcohol content of 0.10%

People with narcolepsy fall
asleep involuntarily
during the day
Insomniacs have difficulty falling
Narcolepsy is a chronic condition
asleep or staying asleep. Sufferers can
that causes people to suddenly fall
wake up during the night, wake up
asleep during the daytime. In the
unusually early in the morning, and
United States, it affects one in every
report feeling tired and drained
3,000 people. Narcoleptics report
during the day. Stress is thought to be
excessive amounts of daytime
one of the major causes of this sleep
sleepiness, accompanied by a lack
disruption, but it is also associated
of energy and impaired ability to
with mental health problems like
concentrate. They fall asleep
depression, anxiety and psychosis,
involuntarily for periods lasting just
and also with underlying medical
a few seconds at a time, and some
conditions that range from lung
can continue to perform tasks such
problems to hormone imbalances.
as writing, walking, or even driving
After underlying causes have been
during these microsleeps. In 70 per
ruled out, management of insomnia
cent of cases, narcolepsy is also
generally involves improving sleep
accompanied by cataplexy, where
hygiene by sticking to regular sleep
the muscles go limp and become
patterns, avoiding caffeine in the
difficult to control. It has been linked
evening and keeping the bedroom
to low levels of the neurotransmitter
free from light and noise at night.
hypocretin, which is responsible for
promoting wakefulness in the brain.

One in three people in the UK will

experience insomnia in their lifetime

Sleep studies
The most common type of sleep
study is a polysomnogram (PSG),
which is an overnight test
performed in a specialist sleep
facility. Electrodes are placed on the
chin, scalp and eyelids to monitor
brain activity and eye movement,
while pads are placed on the chest
to track heart rate and breathing.
Their blood pressure is also
monitored throughout the night,
and the amount of oxygen in the
bloodstream can be tracked using a
device worn on the finger. The
equipment monitors how long it
takes a patient to fall asleep, and
then to follow their brains and Electrodes monitor brain activity,
BSIP SA / Alamy

bodies as they move through each eye movement, heart rate and
breathing in sleep studies
of the five different sleep stages.


How to get a good nights sleep

Understanding your biological clock is
the key to a healthy nights sleep
Your body is driven by an internal brain, preventing the production of
circadian master clock known as melatonin and delaying your sleep.
the suprachiasmatic nucleus, Ensuring you see sunlight in the
which is set on a time scale of morning can help to keep your
roughly 24 hours. This biological circadian clock in line, and sticking
clock is set by sunlight; blue light to a regular sleep schedule, even at
hits special receptors in your eyes, the weekends, helps to keep this
which feed back to the master rhythm regular.
clock and on to the pineal gland. Another important factor in a
This suppresses the production of good nights sleep is the process of
the sleep hormone melatonin and winding down before bed. Certain
tells your brain that it is time to stimulants such as caffeine and
wake up. nicotine will actually keep your
Disruptions in light exposure can brain alert and can seriously
play havoc with your sleep, so it is disrupt your attempts to sleep.
important to ensure that your Even depressants like alcohol can
bedroom is as dark as possible. have a negative effect; even
Many electronic devices produce though it calms the brain, it
enough light to reset your biological interferes with normal sleep
clock, and using backlit screens cycles, preventing proper deep The blue light from televisions, mobile phones and
computer screens disrupts your circadian rhythm
late at night can confuse your and REM sleep.

The dangers of sleep deprivation

Lack of sleep doesnt just make you tired it can have dangerous unseen effects


Sleep deprivation impacts your visual working Sleep deprivation affects the levels of hormones Poor sleep can raise blood pressure, and in the long
memory, making it hard to distinguish between involved in regulating appetite. Levels of leptin (the term is associated with an increased risk of diseases
relevant and irrelevant stimuli, affecting emotional hormone that tells you how much stored fat you have) such as coronary heart disease and stroke. This danger
intelligence, behaviour and stress management. drop, and levels of the hunger hormone ghrelin rise. is increased in people with sleep apnoea.


In the USA it is estimated that 100,000 road accidents Mental health problems are linked to sleep disorders, Severe sleep deprivation can lead to hallucinations
each year are the result of driver fatigue, and over a and having sleep deprivation can play havoc with seeing things that arent really there. In rare cases , it
third of drivers have even admitted to falling asleep neurotransmitters in the brain, mimicking the can lead to temporary psychosis or symptoms that
behind the wheel. symptoms of depression, anxiety and mania. resemble paranoid schizophrenia.

DID YOU KNOW? Sleep deprivation was found to have played a significant role in the nuclear meltdown at Chernobyl in 1986

Sleep myths debunked

The science behind five of the most common myths SLEEP STATS
relating to sleep What are the most common
sleeping positions?
Counting sheep
helps you sleep
This myth was put to the test by the University of Oxford,
who challenged insomniacs to either count sheep,
imagine a relaxing scene, or do nothing as they tried to
fall asleep. When they imagined a relaxing scene, the
participants fell asleep an average of 20
minutes earlier than when they tried
either of the other two methods.

wakes you up How does 16 hours
Yawning has long been associated with
tiredness and was fabled to provide more
sleep time vary INFANTS
oxygen to a sleepy brain, but this is not the
with age?
case. New research suggests that we actually
yawn to cool our brains down, using a deep 9 hours
intake of breath to keep the brain running at TEENS
its optimal temperature. 7 hours

Teenagers What keeps the

are lazy UK up at night?
Sleep habits start to change just before puberty,
and between the ages of ten and 25, people need
around nine hours of sleep every night. Teens can
also experience a shift in their circadian rhythm,
called sleep phase delay, pushing back their
natural bedtime by around two hours, and
67% 36%
13% 34% 19%
Partner Temperature Light
encouraging them to sleep in.
Which country
sleeps the longest?
You should never wake Canada
7h03 6h49

a sleepwalker
Many people have heard that waking a sleepwalker might kill
them, but there is little truth behind these tales. Waking a USA
sleepwalker can leave them confused and disorientated, but 6h31
the act of sleepwalking in itself can be much more dangerous.
Gently guiding a sleepwalker back to their bed is 7h06 Germany

the safest option, but waking them carefully 7h01

shouldnt do any harm.
What do Other
people 14%
Cheese gives dream
you nightmares
Thinkstock; Dreamstime

The British Cheese Board conducted a study in an anger
attempt to debunk this myth by feeding 20g (0.7oz) of 65%
cheese to 200 volunteers every night for a week and Happiness
& excitement Sex
asking them to record their dreams. There were no
nightmares, but strangely 75 per cent of men and 85 per
20% 1%
cent of the women who ate Stilton reported vivid dreams.


What is the blood-

brain barrier?
How does this gateway control the molecules
that pass from the blood into the brain
he blood-brain barrier (BBB) is an

T essential group of cells that line the

blood vessels in the central nervous
system (brain and spinal cord). They allow
Breaking down the barrier
This built-in gateway is the main line of
defence for the central nervous system
passage of materials between the clear fluid
surrounding the brain (cerebrospinal fluid)
and the red blood cells in arteries, veins and Just passing through
capillaries. The key advantage of having such a Some ions are transported
barrier is that it prevents large micro- out of the blood cells and
into the astrocytes, and then
organisms passing into the brain and causing out of the astrocytes and
infections. While infections in other areas are into neurons in the brain.
common (such as after a cut finger, or mild
chest infections), those affecting the brain are
much rarer. However when they do occur (eg
meningitis), they are potentially life
threatening as they are very difficult to treat. Lipophilic
The tight junctions between cells regulate Substances rich in
lipids can diffuse
the size and type of particle that pass between across the barrier
them, this is including not only oxygen with relative ease.
molecules, but also carbon dioxide molecules,
nutrients and hormones. Since its so effective,
it also stops medications from entering the
brain (such as certain antibiotics), so while
they are effective in the rest of the body, they
are ineffective in this vital organ. Overcoming
this is one of the major aims of doctors in the
next decade, and the battle to do so has
already started. Manipulating the blood-brain These numerous
barriers natural transport mechanisms and star-shaped cells provide
also delivering drugs within nanoparticles to biochemical support to the
endothelial cells, and also
squeeze through the tight junctions are just play an important role in
two examples of the modern techniques that transportation and repair.
are under development.

Special transport
Active and passive
Crossing the BBB transporters across this
The endothelial lining of the blood-brain barrier membrane can overcome
loves lipids (fatty molecules), but it hates some of these problems,
particles with high electrical charges (ions) and and be manipulated to
large substances. Thus the ideal substance is deliver medications to
small, rich in lipids and has a low electrical the correct place.
charge. Barbiturates are such an example, as
they freely flow across the blood-brain barrier to
suppress brain function; they act as sedatives
and antidepressants. However this free
movement comes with risks too much of it will Highly charged A tight squeeze
Thinkstock; SPL

accumulate and slow the brain to a point where Highly charged ions are The tiny gaps between
you can lose consciousness and in some cases, repelled, meaning that cells regulate the size
even stop breathing. some medications are and type of particle that
ineffective in the brain. are able to fit through.

DID YOU KNOW? In fish, the intermediate lobe controls skin colour change, while birds have no intermediate lobe at all

Pituitary gland up close

What does this hormone factory do and why couldnt we live without it?
he pea-sized pituitary gland is found at

T the base of the brain, close to the

hypothalamus. It looks a relatively
insignificant part of the brain, but it plays a role
The master gland in context
Where does this vitally important hormone
manufacturer sit within the human brain?
in many vital systems.
Often referred to as the master gland, it not Hypothalamus
only releases hormones that control various The secretion of hormones
from the pituitary gland is
functions, but it also prompts the activity of
directly controlled by this
other glands like the ovaries and testes. part of the brain, which
The pituitary gland comprises three sections links the nervous and
endocrine systems.
called lobes: the anterior, the posterior and the
intermediate the latter of which is considered
part of the anterior lobe in humans. These work
together with the hypothalamus, which
monitors hormones in the blood and stimulates Pituitary stalk
the pituitary gland to produce/release the This is what connects
appropriate hormone(s) if levels fall too low. the pituitary lobes to
the hypothalamus.
The anterior lobe produces seven important
hormones, which include those that regulate
growth and reproduction. Adrenocorticotropic
hormone (ACTH) targets the adrenal glands to
produce cortisol and controls metabolism,
Posterior lobe
while luteinising hormone triggers ovulation in This doesnt produce any
women and stimulates testosterone production hormones itself, but
stores and releases some,
in men. The posterior lobe, meanwhile, doesnt
like ADH, made elsewhere
generate any hormones itself, but stores two: in the hypothalamus.
antidiuretic hormone (ADH), which decreases
urine production by making the kidneys return
more water to the blood, and oxytocin, which
tells the uterus to contract during childbirth
and also prompts milk production.

Hormones are exchanged
Gigantism in focus between the anterior lobe
and the hypothalamus via
The pituitary gland also produces growth a network of capillaries.
hormone, which in adults controls the amount
of muscle and fat in the body and plays a key
role in the immune system. In children, of
course, growth hormone has a very noticeable
effect in increasing height and bulk until
adulthood. However, sometimes the pituitary Anterior lobe
Subdivided into three
gland becomes hyperactive often as a result of
parts, including the thin
a benign tumour and produces excess growth
intermediate lobe, this
hormone. In these cases, a person can grow to a
produces seven kinds
far-beyond-average height, with hands, feet and
of hormone which each Thyroid
facial features growing proportionally. While this
target specific organs. One of the largest
might not seem so bad, gigantism is nearly
always accompanied by other health issues, endocrine glands that
such as skeletal problems, severe headaches regulates metabolism
and more life-threatening conditions like heart is in turn regulated by
disorders. If diagnosed early, treatment such as the pituitary gland.
drugs that inhibit growth hormone production
and surgical removal of the tumour can help

avert the more serious conditions of gigantism.


How does food get turned
into energy? Large intestine
The colon, as the large
intestine is also known, is

he digestive system is a group of organs that process
where waste material will
food into energy that the human body be stored until expelled
can use to operate. It is an immensely complex from the digestive system
system that stretches all the way between the mouth and through the rectum.
the anus.
Primary organs that make up the system are the
mouth, oesophagus, stomach, small intestine, large
intestine and the anus. Each organ has a different function so
that the maximum amount of energy is gained from the food,
and the waste can be safely expelled from the body.
Secondary organs, such as the liver, pancreas and gall
bladder, aid the digestive process alongside mucosa cells,
which line all hollow organs and produce a secretion which
helps the food pass smoothly through them. Muscle
contractions called peristalsis also help to push the food
throughout the system.
The whole digestive process starts when food is taken into
the body through the mouth. Mastication (chewing) breaks
down the food into smaller pieces and saliva starts to break
starch in these pieces of food into simpler sugars as they are Small intestine
swallowed and move into the oesophagus. Once the food has Nutrients that have been
passed through the oesophagus, it passes into the stomach. released from food are
It can be stored in the stomach for up to four hours. absorbed into the blood
stream so they can be
The stomach will eventually mix the food with the
transported to where they are
digestive juices that it produces, which will break down the needed in the body through
food further into simpler molecules. These molecules then the small intestine wall.
move into the small intestine slowly, where the final stage of Further breaking down occurs
chemical breakdown occurs through exposure to juices and here with enzymes from the
enzymes released from the pancreas, liver and glands in the liver and pancreas.
small intestine. All the nutrients are then absorbed through
the intestinal walls and transported around the body
through the blood stream.
After all nutrients have been absorbed from food
through the small intestine, resulting waste material,
including fibre and old mucosa cells, is then pushed into
the large intestine where it will remain until expelled by a
bowel movement.
Nutrients are then
absorbed through the digests
intestinal walls and food
Many different organs
This is where waste

transported around are involved in the

material (faeces) exits
the digestive system.

the body digestion process

DID YOU KNOW? The human digestive system is between 20 to 30 feet long!

This is where food enters the body and first gets broken into
more manageable pieces. Saliva is produced in the glands
and starts to break down starch in the food. How does our
The oesophagus passes the food
into the stomach. At this stage, it
stomach work?

DK Images
This is the control
has been broken down through
mastication and saliva will be valve for letting food The stomach is one of the most crucial
breaking down starch. into the stomach.
organs within the digestive system
This is where stomach The stomachs function is to break down food
acid is situated, into simple molecules before it moves into
consequently it is
the small intestine where nutrients are
where food is broken
down into molecules
absorbed. The organ actually splits into four
that the small intestine distinct parts, all of which have different
can then process. functions. The uppermost section is the
cardia, where food is first stored, the fundus
is the area
above the corpus body, which makes up the
main area of the stomach where food is
mixed with stomach acid. The final section is
the antrum, containing the pyloric sphincter,
which is in control of emptying the stomach
contents into the small intestine. Food is then
automatically passed down into the stomach
Mucosa by mucosa and peristalsis through the
These cells line all of the oesophageal sphincter, and then mixed in
stomach to aid movement of the stomach with acids and juices by
food throughout the organ. muscle contractions.
This is where food is broken
down to smaller molecules
which can then be passed into
the small intestine. Stomach Duodenum
acid and enzymes produced
by the stomach aid this.
The area at the top of the
small intestine, this is
where most chemical
How the
breakdown occurs.

intestine works
The intestine is a crucial
part of the digestive
system that is
heavily involved in
breaking down and
absorbing nutrients released
from ingested food
The intestine splits into two distinct parts,
the small intestine and the large intestine.
The small intestine is where the food goes
through final stages of digestion and
nutrients are absorbed into the blood stream,
the large intestine is where waste is stored
This is where until expelled through the anus. Both the
waste is stored small and large intestines can be further
briefly until it divided into sections, the duodenum,
is expelled by jejunum and ileum are the three distinct
the body.
sections of the small intestine and the
cecum, colon and rectum are the sections of
the large intestine. As well as storing waste,
the large intestine removes water and salt
from the waste before it is expelled. Muscle
Villi contractions and mucosa are essential for the
DK Images

These cells are shaped like fingers intestine to work properly, and we see a
and line the small intestine to increase variation of mucosa, called villi, present in
surface area for nutrient absorption. the lower intestine.


What happens when

you eat too much? Overeating can
Learn about the effects of an all-you-can eat buffet damage your
brains ability to
hen youve just polished off a plate
Ready to pop
tell you when
piled high with food, it can youre full
How does your stomach
sometimes feel like youre going to cope with a big meal? Heartburn
explode. Although it is possible for your Hydrochloric acid, which
stomach to rupture after overeating, your gag your stomach produces
to break down food, can
reflex is likely to kick in long before you reach creep up into your
that point. The average human stomach can oesophagus, creating a
handle between one and one-and-a-half litres burning sensation. Gas
Every time you
of food before getting the urge to throw it back
swallow food, you also
up, but can stretch to accommodate four times swallow air, which
that much before a rupture occurs. takes up space in your
stomach until you
When you eat a meal thats high in fat, sugar
belch it out.
and carbohydrates, your parasympathetic
nervous system tells your body to slow down Feeling full
and focus on digesting the food, causing you to Your fat cells
produce the
feel lethargic. As the food is digested, cells in hormone leptin,
your pancreas produce the hormone insulin, which tells your
which in turn leads to an increase in melatonin brain when youre
no longer hungry.
and serotonin, hormones that makes you feel
drowsy as well as happy. You may also struggle
to keep your eyes open thanks to a spike in
glucose levels from the food youve eaten. This
can interfere with the neurons in your brain
that normally produce the orexin proteins
responsible for keeping you awake and alert.
Your fat cells produce the hormone leptin,
which binds with receptors in the brain to tell
you that youre no longer hungry. Regularly
eating more than your body needs causes your Feeling sick
body to produce more of this hormone, as leptin After a high calorie
meal, cells in your
levels are directly related to the amount of body intestines produce
fat a person has. In such cases, people may the hormone
build up a resistance to leptin, which disrupts peptide tyrosine- Swollen gut
tyrosine (PYY), As you eat, your stomach stretches and
the brains ability to recognise when youre full, which generates a pushes against your other organs,
leading you to overeat and put on weight. queasy feeling. making your abdomen feel swollen.

Your taste buds have

How do taste buds work? very tiny, sensitive hairs

called microvilli which
send messages to your
brain about how
Discover how we distinguish between flavours something tastes.

aste buds are sensory organs that are found in the little bumps (or papillae) on

T the tongue. The tongue contains about 8,000 taste buds and theyre replaced
approximately every two weeks. Sensitive microscopic hairs on the taste buds
(microvilli) pick up dissolved chemicals from food and send electrical signals to the Taste qualities are
found in all areas
brain that distinguishes between five different tastes: sweet, bitter, savoury (umami),
of the tongue,
salty and sour. Varying sensitivity to these tastes occurs across the whole of the tongue. although some
But taste buds alone cannot tell us the exact flavour of food. Other factors such as smell, regions are
more sensitive
spiciness, temperature and texture also contribute to the eventual taste. So if you hold
than others.
your nose while you eat then your brain wont get the full taste story.

Medulla Cortex

Adrenaline At the core of the

adrenal gland, the
adrenal medulla
produces, stores and
releases adrenaline.
At the edge of the adrenal gland, the
cortex produces steroid hormones that
include cortisol (for balancing blood sugar
and carb metabolism) and aldosterone
(for balancing the bodys salts and water).
Discover the science behind your bodys
amazing chemical coping mechanism Kidney
The organ that
estling on a layer of fat located Identified in 1900, adrenaline is a

N just above each of your

kidneys are adrenal glands.
Around 8cm long, the adrenal glands
fast-acting hormone that helps the
body deal with unexpected stresses
not to mention high levels of
filters waste
from the blood.

produce hormones that affect your excitement by upping your heart Fat
bodys consumption of energy as well rate and the flow of blood to Each adrenal
as your stress responses. your muscles. gland is protected
Adrenal glands consist of two main The effect of this is that your blood by a layer of fat.
layers of hormone-secreting cells: the vessels and air passages dilate,
outer cortex and the inner medulla. meaning that more blood passes to
While the cortex produces energy- the muscles and this allows more
balancing hormones, the medulla oxygen into the lungs quickly. This
produces a chemical which is called temporarily improves the bodys
epinephrine, which we know better physical performance and could
as adrenaline. potentially save your life.

Adrenaline is a fast-acting Your

adrenal glands
hormone that helps the
body deal with stresses

Respiration is crucial to an organisms survival. The
process of respiration is the transportation of oxygen
from the air that surrounds us into the tissue cells of
our body so that energy can be broken down

he primary organs used for increases and, consequently, so does
respiration in humans are the the heart rate to ensure that oxygen
lungs. Humans have two reaches tissues that need it. Oxygen is 1. Nasal passage/
oral cavity
lungs, with the left lung being divided then used to break down glucose to These areas are where air
into two lobes and the right into provide energy for the body. This enters into the body so that
three. Lungs have between 300500 happens in the mitochondria of cells. oxygen can be transported into
million alveoli, which is actually Carbon dioxide is one of the waste and around the body to where
its needed. Carbon dioxide
where gas exchange occurs. products of this, which is why we get
also exits through these areas.
Respiration of oxygen breaks into a build up of this gas in our body that
four main stages: ventilation, needs to be transported back into the
pulmonary gas exchange, gas lungs to then be exhaled.
transportation and peripheral gas The body can also respire
exchange. Each stage is crucial in anaerobically, but this produces far
getting oxygen to the bodys tissue, less energy and instead of producing
and removing carbon dioxide. co2 as a byproduct, lactic acid is
Ventilation and gas transportation produced. The body then takes time
need energy to occur, as the to break this down after exertion has
diaphragm and the heart are used to finished as the body has a so-called
facilitate these actions, whereas gas oxygen debt.
exchanging is passive. As air is drawn
into the lungs at a rate of between 5. Alveoli
10-20 breaths per minute while The alveoli are tiny little sacs which are situated
resting, through either your mouth or at the end of tubes inside the lungs and are in
nose by diaphragm contraction, and direct contact with blood. Oxygen and carbon
dioxide transfer to and from the blood stream
travels through the pharynx, then the
through the alveoli.
larynx, down the trachea, and into
one of the two main bronchial tubes.
Mucus and cilia keep the lungs clean
by catching dirt particles and
sweeping them up the trachea.
When air reaches the lungs, oxygen
is diffused into the bloodstream
through the alveoli and carbon
dioxide is diffused from the blood
into the lungs to be exhaled. Diffusion artery
of gases occurs because of differing
pressures in the lungs and blood. This
is also the same when oxygen
diffuses into tissue around the body.
When blood has been oxygenated by
How our
the lungs, it is transferred around the
body to where it is most needed in the
bloodstream. If the body is
lungs work
exercising, the breathing rate
Lungs are the major
Capillary beds respiratory organ in humans
DID YOU KNOW? Trained free-divers can hold their breath underwater for up to nine minutes

2. Pharynx
This is part of both
the respiratory and
digestive system. A flap
of connective tissue
How do we breathe?
The intake of oxygen into the body is complex Chest cavity
called the epiglottis This is the space that
closes over the trachea is protected by the
Breathing is not something that we have to the alveoli at the ends, which are the final
to stop choking when ribs, where the lungs
think about, and indeed is controlled by muscle branching. The chest will be seen to rise and heart are
an individual takes food
into their body.
contractions in our body. Breathing is because of this lung expansion. Alveoli are situated. The space
controlled by the diaphragm, which contracts surrounded by various blood vessels, and changes as the
3. Trachea and expands on a regular, constant basis. oxygen and carbon dioxide are then diaphragm moves.
Air is pulled into When it contracts, the diaphragm pulls air into interchanged at this point between the lungs
the body through the lungs by a vacuum-like effect. The lungs and the blood. Carbon dioxide removed
the nasal passages
expand to fill the enlarged chest cavity from the blood stream and air that was
and then passes into
and air is pulled right through breathed in but not used is then
the trachea.
the maze of tubes that expelled from the lungs by
make up the diaphragm expansion. Lungs
lungs to deflate back to a reduced size
when breathing out.

Deoxygenated blood
arrives back at the
4. Bronchial tubes lungs, where another

DK Images
These tubes lead to either the gas exchange occurs at
left or the right lung. Air passes the alveoli. Carbon
through these tubes into the dioxide is removed and
lungs, where they pass oxygen is placed back
through progressively smaller into the blood.
and smaller tubes until they
reach the alveoli.
This is a sheet of muscle situated Rib cage
This is the bone
DK Images

at the bottom of the rib cage

which contracts and expands to structure which
draw air into the lungs. protects the organs.
The rib cage can
move slightly to
Heart allow for lung
The heart pumps oxygenated expansion.
blood away from the lungs,
6. Ribs around the body to tissue,
These provide protection where oxygen is needed to
for the lungs and other break down glucose
internal organs situated into a usable form
in the chest cavity. of energy.

Oxygen arrives
where energy is
needed, and a gas

DK Images
exchange of
oxygen and carbon
dioxide occurs so
that aerobic
respiration can
occur within cells.

Why do we need oxygen?

We need oxygen to live as it is crucial for the release
of energy within the body
Although we can release our energy through more than a few minutes, an individual will die.
anaerobic respiration temporarily, this method Oxygen is pumped around the body to be used
is inefficient and creates an oxygen debt that in cells that need to break down glucose so that
the body must repay after excess exercise or energy is provided for the tissue. The equation
exertion has ceased. If oxygen supply is cut off for that illustrates this is:

C6H12O6+6O2 = 6CO2+6H2O + energy


Pore Skin

Science Photo Library

Sweat is Once the sweat is on the skins
released directly surface, its absorbed moisture
into the dermis evaporates, transferring the
via the secretary heat into the atmosphere.
duct, which then
filters through
the skins pores
to the surface.
Beads of sweat from the pores in
human skin, taken with a
scanning electron microscope

Why do we sweat?
As your doctor may tell you, its glandular

weat is produced by dedicated sweat glands, a salty, water-based substance to the skins surface.
and is a mechanism used primarily by the This liquid then cools the skin and the body
body to reduce its internal temperature. through evaporation, storing and then transferring
There are two types of sweat gland in the human excess heat into the atmosphere.

DK Images
body, the eccrine gland and the apocrine gland. Both the eccrine and apocrine sweat glands
The former regulates body temperature, and is the only appear in mammals and, if active over
primary source of excreted sweat, with the latter the majority of the animals body, act as the
only secreting under emotional stresses, rather primary thermoregulatory device. Certain
than those involved with body dehydration. mammals such as dogs, cats and sheep only have Secretary Secretary part Nerve fibres
Eccrine sweat glands are controlled by the eccrine glands in specific areas such as paws and duct This is where the Deliver messages to
Secreted sweat majority of the glands glands to produce
sympathetic nervous system and, when the lips warranting the need for them to pant in order
travels up to the secretary cells can sweat when the body
internal temperature of the body rises, they secrete to control their temperature. skin via this duct. be located. temperature rises.

Dehydration Dangers of dehydration

How does a lack of water vary from mild to fatal?
What happens if we dont Thirst is triggered by a
drink enough? 1% Mild concentration of particles
in the blood, indicating a

ust by breathing, sweating and sugar levels going haywire. need to hydrate.
and urinating, the average Enzymatic activity is slowed, toxins 2% Moderate
person loses ten cups of accumulate more easily and your
Other symptoms
water a day. With H2O making up breathing can even become more
3% Dizziness Dry skin Headaches
at this level
as much as 75 per cent of our difficult as the lungs are having to include fatigue, a
body, dehydration is a frequent work harder. dry mouth and
risk. Water is integral in maintaining Babies and the elderly are most 4% constipation.
our systems and it performs susceptible as their bodies are not as
limitless functions. resilient as others. It has been Fever Racing pulse Lack of sweat
Essentially, dehydration strikes recommended to have eight glasses 5% Severe
Dehydration levels

when your body takes in less fluid of water or two litres a day. More
than it loses. The mineral balance in recent research is undecided as to
your body becomes upset with salt how much is exactly needed.
Dehydration is Other symptoms
now so severe include sunken eyes,
that IV fluid low blood pressure
replacement and dark urine.
Too much H2O? 8%
is necessary.

Hydration is all about finding the perfect

balance. Too much hydration is just as
harmful as well as drinking too little;
9% Fatal Delirium
Loss of
consciousness Here symptoms
become much more
this is known as water intoxication. If an
individual has too much liquid in their 10%
? extreme and
cognitive abilities
body, nutrients such as electrolytes and may also suffer.
sodium are diluted and the body suffers.
Your cells will begin to bloat and expand 11% Risk of heat exhaustion or
to such a point that they can even burst, heat stroke is prevalent
and it can be fatal if untreated with IV and can even be fatal.
fluids containing electrolytes. 12%

DID YOU KNOW? There are lots of products on the market to help reduce the appearance of scars

Why does skin scar?

Scars are made up of the same proteins as normal skin,
so why do they look so different?

cars are a natural part of the healing form. The most common is a flat scar these tend to surrounding skin, and are hard, shiny and hairless.
process, with most of us having some form of initially be dark and raised, but will fade and flatten The reason behind why keloids form is poorly
them on our body. The reason why scars look over time as the scar matures. A hypertrophic scar understood, but it is known that people with darker
different compared to normal skin stems from their can be identified by its red appearance and elevated skin tones are more likely to form keloids.
proteins composition. nature. This scar type typically forms when the Pitted scars are generally formed from acne or
Normal skin benefits from a weaved protein dermis is damaged, and this can become itchy and chicken pox, and tend to be numerous in areas
structure, whereas the proteins in scars are aligned painful over time. where these conditions were prevalent. Scar
in one direction. This results in a different Keloid scars are by far the most extreme scar type contractures, meanwhile, usually form after a burn,
appearance compared to normal, healthy skin. Scars when compared to the others. Unlike most scars, and are caused by the skin shrinking and tightening.
are smoother due to a lack of sweat glands and hair they extend beyond the confines of the original The severity of scars depends on their bodily
follicles, so they can often become itchy. There are injury and are formed due to excessive scar tissue location; for example, if a scar formed around a joint
also a number of different types of scar that can being produced. Keloid scars are raised above the it can lead to movement being restricted.

Clotting Epithelial cells Newly formed scar

Clotting occurs due to a combination of By rapidly multiplying, the Once the newly formed epithelium
proteins in the blood, which help a scab to epithelial cells fill in over the thickens, the area contracts and forms
form, protecting the wound from infection. newly formed granulation tissue. a scar on the skins surface.

illustration by Nicholas Forder

Inflammatory chemicals White blood cells Granulation tissue Scar tissue
The body recognises that it has sustained To help fight off potential The new granulation tissue Once fully formed, this tissue is known as scar
an injury, and white blood cells release infection, white blood cells replaces the clotted blood, and tissue. Due to excessive collagen production this
inflammatory chemicals to help protect seep into the area and flock helps restore the blood supply to tissue often lacks in flexibility, which can lead to pain
the area. to the wound. the damaged area. and dysfunction.

Can scars be treated? A neat, even scar is the best

you can hope for even with
todays technology
Scars cannot be stopped from forming, but there are This can be used to change the shape of the scar, however
various treatments available to help reduce their there is a risk of worsened scarring if unsuccessful.
appearance. Silicone gels or sheets have been shown to There are also certain steps that can be taken to help
effectively minimise scar formation and are often used reduce the risk of an unsightly scar forming from an
when people have been burnt. These must be applied or injury. By cleaning dirt and dead tissue away from the
worn throughout the scars maturation phase to maximise wound, you are increasing the chance that the scar will
their efficacy. Corticosteroid injections can be used to form neatly. It is also vital that you dont pick or scratch the
reduce any inflammation (swelling) around the scar and to scar, as this will slow down its formation, resulting in a

flatten it as well. A riskier treatment for scars is surgery. more obvious appearance.


How your immune

system works

Human anatomy subscribes to the notion
that good fences make good neighbours.
Your skin, made up of tightly packed cells
and an antibacterial oil coating, keeps
most pathogens from ever setting foot in
body. Your bodys openings are well-
fortified too. Pathogens that you inhale
face a wall of mucus-covered membranes
in your respiratory tract, optimised to
trap germs. Pathogens that you digest end
up soaking in a bath of potent stomach
acid. Tears flush pathogens out of your

Your body is locked in a constant eyes, dousing bacteria with a harsh

enzyme for good measure.

war against a viscous army

ts true: while youre simply sitting around host cells and replicate inside them; and fungi, a Just about everything in our environment is

I watching TV, trillions and trillions of foreign

invaders are launching a full scale assault on the
trillions of cells that constitute you. Collectively
type of plant life.
Bacteria and viruses are by far the very worst
offenders. Dangerous bacteria release toxins in the
teeming with these microscopic intruders, including
you. The bacteria in your stomach alone outnumber
all the cells in your body, ten-to-one. Yet, your
known as pathogens, these attackers include body that cause diseases such as E. coli, anthrax, microscopic soldiers usually win against pathogens,
bacteria, single-celled creatures that live to eat and and the black plague. The cell damage from viruses through a combination of sturdy barriers, brute
reproduce; protists, larger single-cell organisms; causes measles, the flu and the common cold, among force, and superior battlefield intelligence,
viruses, packets of genetic information that take over numerous other diseases. collectively dubbed the immune system.

DID YOU KNOW? Dr Karl Landsteiner first identified the major human blood groups A, B, AB and O in 1901

The adaptive immune system

Fighting the good fight, and white blood cells are 2. Bacterium antigen
right on the front line These distinctive molecules allow your
immune system to recognise that the
When a pathogen is tough, wily, either disarm a specific pathogen bacterium is something other than a body cell.
or numerous enough to survive or bind to it, marking it as a target 4. Engulfed
bacterium 3. Macrophage 1. Bacterium
various non-specific defences, for other white blood cells. When These white blood
During the initial Any bacteria that enter
its down to the incredibly T-cells find their target, they lock inflammation reaction, cells engulf and digest
your body have
adaptive immune system to clean on and release toxic chemicals a macrophage engulfs any pathogens they
characteristic antigens
up the mess. The key forces in the that will destroy it. T-cells are the bacterium. come across.
on their surface.
adaptive immune system are especially adept at destroying
white blood cells which are your bodys cells that are infected
called lymphocytes. Unlike their with a virus.
macrophage cousins, these This entire process takes
lymphocytes are engineered to several days to get going and may
attack only one specific type of take even longer to conclude. All
pathogen. There are two types of the while, the raging battle can
lymphocytes: B-cells and T-cells. make you feel terrible.
These cells join the action Fortunately, the immune system
when macrophages pass along is engineered to learn from the
information about the invading past. While your body is
pathogen, through chemical producing new B-cells and T-cells
messages called interleukins. to fight the pathogens, it also
After engulfing a pathogen, a produces memory cells copies of 7. Non-
macrophage communicates the B-cells and T-cells, which stay
matching B-cells
Other B-cells, engineered to
details about the pathogens in the system after the pathogen attack other pathogens,
antigens telltale molecules that is defeated. The next time that dont recognise the antigen.
actually characterise particular pathogen shows up in your body,
pathogens. Based on this these memory cells help launch a
5. Presented
information, the immune system counter-attack much more bacterium antigen
identifies specific B-cells and quickly. Your body can wipe out After engulfing the bacterium, the
T-cells equipped to recognise and the invaders before any infection macrophage presents the
battle the pathogen. Once they takes hold. In other words, you bacteriums distinctive antigens,
are successfully identified, these develop immunity. communicating the presence of
cells rapidly reproduce, Vaccines accomplish exactly the specific pathogen to B-cells.
assembling an army of cells that the same thing as this by simply
are ready and equipped to take giving you just enough pathogen 6. Matching B-cell 9. Memory cell
down the attacker. exposure for you to develop The specific B-cell that
The matching B-cell also
recognises the antigen, and
The B-cells flood your body memory cells, but not enough to replicates to produce
can help defeat the pathogen,
with antibodies, molecules that make you sick. memory cells, which will
receives the message.
rapidly produce copies of
itself if the specific

Non-specific How B-cells

bacteria ever returns.

As good as your physical defence system is, pathogens
do creep past it regularly. Your body initially responds B-cells target and
with counterattacks known as non-specific defences, destroy specific
so named because they dont target a specific type bacteria and invaders
of pathogen.
After a breech bacteria rushing in through a cut, for
11. Phagocyte
example cells release chemicals called inflammatory White blood cells
mediators. This triggers the chief non-specific defence, called phagocytes
known as inflammation. Within minutes of a breach, recognise the antibody
your blood vessels dilate, allowing blood and other fluid marker, engulf the
to flow into the tissue around the cut. bacteria, and
The rush of fluid in inflammation carries various types digest them.
of white blood cells, which get to work destroying 10. Antibodies
The plasma cells release
intruders. The biggest and toughest of the bunch are
antibodies, which
macrophages, white blood cells with an insatiable disable the bacteria by
appetite for foreign particles. When a macrophage detects latching on to their 8. Plasma cell
a bacteriums telltale chemical trail, it grabs the intruder, antigens. The antibodies The matching B-cell
engulfs it, takes it apart with chemical enzymes, and also mark the bacteria replicates itself,
spits out the indigestible parts. A single macrophage can for destruction. creating many
swallow up about 100 bacteria before its own digestive plasma cells to fight
chemicals destroy it from within. all the bacteria of this
type in the body.


Your tonsils can help 1. Tonsils

fight bacteria Lymphoid tissue loaded with
lymphocytes, which attack
bacteria that get into the body
through your nose or mouth.

Ed Uthman, MD
2. Left subclavian vein
One of two large veins that serve
as the re-entry point for lymph
Klem 2007

returning to the bloodstream.

3. Right lymphatic duct 6. Lymph

Passageway leading from lymph vessels node cluster
to the right subclavian vein. Located along lymph vessels
throughout the body, lymph nodes

Disorders of 4. Right subclavian vein

filter lymph as it makes its way back
into the bloodstream.

the immune The second of the two subclavian

veins, this one taking the opposite
path to its twin.
7. Left
lymphatic duct
system 5. Spleen
Passageway leading from
lymph vessels to the left
An organ that houses white subclavian vein.
Who watches blood cells that attack
pathogens in the
the watchmen? bodys bloodstream.
8. Thymus gland
Organ that provides area for
The immune system is a powerful set of lymphocytes produced by bone
defences, so when it malfunctions, it marrow to mature into
can do as much harm as a disease. specialised T-cells.
Allergies are the result of an
overzealous immune system. In 9. Thoracic duct
response to something that is relatively The largest lymph vessel
benign, like pollen for example, the in the body.
immune system will trigger excessive
measures to expel the pathogen. In
extreme cases, allergies cause
anaphylactic shock, which is a
potentially deadly drop in blood 11. Peyers patch
Nodules of lymphoid tissue supporting
pressure, sometimes accompanied by
white blood cells that battle pathogens
breathing difficulty and loss of in the intestinal tract.
consciousness. In autoimmune
disorders such as rheumatoid arthritis, 12. Bone marrow
10. Lymph vessels The site of all white blood
the immune system fails to recognise Lymph collects in tiny capillaries,
the bodys own cells and attacks them. cell production.
which expand into larger vessels.
Skeletal muscles move lymph
through these vessels, back into
the bloodstream.

The nodes
lymphatic Lymph nodes
filter out

The lymphatic system is a network
through your
lymph vessels
Your immune system depends
of organs and vessels that collects on these .04-1-inch swellings
lymph fluid that has drained from to fight all manner of
the bloodstream into bodily tissues pathogens. As lymph makes
and returns it to your bloodstream. It its way through a network of
DK Images

also plays a key role in your immune fibres in the node, white blood
In an allergic reaction, the body may resort to system, filtering pathogens from lymph cells filter it, destroying any
sneezing to expel a fairly harmless pathogen and providing a home-base for pathogens they find.
disease-fighting lymphocytes.

DID YOU KNOW? In 2008, approximately 33 million people worldwide were living with HIV or AIDS

3. Capsule 1. Flagella
Know your
Protects the
inner contents
Flagella swish
for movement
2. Pili
The pili anchor to
cell surfaces Bacteria
Bacteria are the smallest and, by far, the most populous form of
life on Earth. Right now, there are trillions of the single-celled
creatures crawling on and in you. In fact, they constitute about
four pounds of your total body weight. To the left is a look at
bacteria anatomy

What is HIV
and how does it affect the
immune system?
The human immunodeficiency virus (HIV) is a retrovirus (a
4. Nucleoid
The nucleoid contains
virus carrying ribonucleic acid, or RNA as its known),
genetic material transmitted through bodily fluids. Like other deadly
viruses, HIV invades cells and multiplies rapidly inside.
Specifically, HIV infects cells with CD4 molecules on their
surface, which includes infection-fighting helper T-cells.
6. Cell wall HIV destroys the host cell, and the virus copies go on to
Provides structural
infect other cells. As the virus destroys helper T-cells, it
steadily weakens the immune system. If enough T-cells are
8. Cytoplasm lost, the body then becomes highly susceptible to a range of
Home of all material different infections, a condition known as acquired
5. Ribosomes outside the nucleoid immune deficiency syndrome (AIDS).
These help with protein
7. Cell membrane
The cells interior barrier

Inside these
microorganisms anatomy

1 Major points of the lymph node

1. Outgoing lymph 7. Sinus
2 vessel A channel that slows the
4 The vessel that carries flow of lymph, giving
filtered lymph out of the macrophages the
5 lymph node opportunity to destroy any
2. Valve detected pathogens
11 6
A structure that prevents 8. Incoming lymph
lymph from flowing back vessel
into the lymph node A vessel that carries lymph
10 into the lymph node
3. Vein
Passageway for blood 9. Lymphocyte
leaving the lymph node The T-cells, B-cells and
7 natural killer cells that
4. Artery
Supply of incoming blood fight infection
9 for the lymph node 10. Germinal centre
5. Reticular fibres This is the site of
Divides the lymph node lymphocyte multiplication
into individual cells and maturation
6. Capsule 11. Macrophage Scanning electron micrograph of HIV-1 budding (in green) from
8 8 The protective, shielding Large white blood cells that cultured lymphocyte. This image has been coloured to highlight the
fibres that surround the engulf and destroy any
8 detected pathogens
most important features. Multiple round bumps on the cell surface
lymph node represent sites of assembly and budding of virions.


Bone fracture
healing process
Learn how your body mends broken bones

f a bone has too much pressure put on it, or is hit bridge being constructed from either side
or landed on in a particular way, there is a of a river until both ends meet in the middle.
chance it will break. Your body has ways of Once both sections of bone are connected again,
repairing these breaks, but it takes time and care. specialised cells called osteoblasts enter to
There are different kinds of break, ranging from a produce bone cells. These new cells replace the All-star cast
hairline fracture to a fully shattered bone, but they callus, returning the bone to its original shape. Most breaks on an arm or a leg will have a plaster
all mend in a similar way. Much like repairing a broken toy with glue, the cast put on them to prevent the bone from
As a bone breaks, the blood vessels are also bone needs to be kept straight and steady in order setting at a wonky angle or not setting at all.
severed. Blood leaks out and forms a clot called a for the fusion to happen correctly. This is exactly It will generally be made from plaster of Paris.
fracture haematoma. This stops blood flow to the why doctors will put a cast on the broken bone. The This is a mixture of water and gypsum that sets
really hard once it has dried. The broken bone is
area and also helps keep both pieces of bone cast provides the essential support, protection and
bandaged and the wet mixture is applied to the
aligned, ready for healing. stability the bone needs, and this ensures the gauze. Once it has dried then it should provide
The body then makes fibrous cells and cartilage, broken bone doesnt move. A cast will generally safety and stability for the bone.
which reinforce the bond and strengthen it. This stay on for a few weeks until the bond has become Fibreglass is an increasingly common cast
creates a callus, which is essentially a weakened strong enough, but depending on the fracture it material. As with the plaster cast, the broken
bone. Over time, the callus builds up and the two can actually take a few months for a properly set bone is bandaged up. Next, another bandage,
parts of the bone gradually fuse together, like a bone to fully recover. made of fibreglass and layered with resin, is
soaked in water. This makes it flexible enough to
be wrapped around the bone before it hardens as
Much like repairing a broken toy with glue, it dries. This is much lighter than a plaster cast
and the outer layer is waterproof.
the bone needs to be kept straight

The stages of bone repair

New Healed
Blood blood
clot fracture
forms Internal callus
(fibrous tissue
and cartilage)

Ruptured callus
External Blood flow
callus improves

Blood clot Tissue growth Remodelling

When a bone breaks, the blood vessels A few days later, the blood clot called the fracture Bone-forming cells called osteoblasts work in
that run through the bone are severed. haematoma is gradually replaced by tougher teams to build a new bone, creating a more solid
The blood forms a clot to align the bones. tissue, which becomes a soft callus. Fibrous tissue structure called a hard bone callus. It takes
This creates a solid yet weak structure to and cartilage are produced that begin to bridge the several months to fill the cavity with harder bone,
prepare for mending. The clot also cuts off gap between the fractured ends. New blood vessels strengthened by various nutrients like calcium
blood flow to the edges of the broken bone, begin to form and the callus usually lasts around and phosphorus. However, it may take longer for

so these cells die. three weeks. the bone to be completely healed.

DID YOU KNOW? Around half of your bodys non-water mass is made up of proteins

1. Cell
The body is made up of millions
of cells, none of which could
Protein production
survive without protein, for Protein is generated in the nucleus of a cell using genetic coding
repair and replacement. information held within our DNA. To produce protein, DNA
unravels to allow messenger RNA (or mRNA) to copy it and form
a template. This template is translated by ribosomes into amino
acids, which then line up to form a protein. Parts of DNA code
will serve as punctuation, telling
the ribosome when to start
and stop, and some parts will
instruct the cell how
frequently it must produce
the specific protein.

6. mRNA 5. DNA
This type of genetic acid
DNA (deoxyribonucleic
forms a template based on
acid) holds the information
DNA sequences, which is
necessary for amino acid
then used to produce amino 7. Ribosome and ultimately protein
acids by the ribosome. This is the protein-making production in the letter
machine in the cell. It uses sequence in its structure.
mRNA templates to synthesise
the specific protein needed.

8. Amino acid
These small molecules
combine in specific string 4. Nucleosomes
sequences to generate the These are balls formed of
9. Protein different types of protein. DNA strands and histones
Proteins are made up of long chains of (spool-like proteins) which
amino acids. Each protein has a specific sit inside chromosomes.
function which suits its role and is
crucial to our bodies being able to
operate effectively.
Why are
amino acids
3. Chromosome important?
Most human cells have a set of Amino acids are vital to
46 chromosomes and these our bodies being able to
2. Nucleus contain our genetic information
This is the control centre of
operate as they are the
which, among other things, building blocks of

the cell where all important instructs the cell which protein
genetic data is stored. proteins. Each type of
to make and also how.
amino acid performs a
job, which aids protein

How do we make protein? activity in the body and

determines the proteins
own primary function(s).
Without these, proteins
Proteins are the building blocks of the human body, would not be able to help
the body with movement,
but how do we go about manufacturing them? defending it against
roteins are large complex molecules made up of a chain and T) and these short sequences, which are known as triplets various diseases,

P of amino acids. Every cell in our body needs protein to

stay alive as it is necessary for tissue repair and
replacing dead cells.
or codons, then code mRNA templates; these templates are
translated by cell ribosomes into amino acids.
Each protein is made up of hundreds of thousands of amino
processing food or
co-ordinating general
growth and development.
They have many other functions as well as aiding cell repair acids, which are in long chains. There are 20 different types of There are nine
and production including forming antibodies to help fight off amino acid that can be combined to build a protein and it is the essential amino acids for
disease, forming enzymes which speed up or trigger chemical sequence of amino acids that determines each proteins unique humans that must be
reactions and co-ordinating processes within the body (via three-dimensional structure and its function. absorbed from external
hormone regulation, for instance). Proteins also provide However, not all amino acids can be made by the body. The protein sources (eg meat/
support for cells and form structural elements of the body, such ones that need to be consumed via our diet are called essential fish) as they cannot be
as nails and teeth, as well as facilitating the transportation of amino acids. If possible, the body will also conserve energy by synthesised by the body.
some small molecules around various systems. using amino acids from food rather than producing them itself. Without the required
We build proteins using information encoded in our genetic Protein deficiency can cause diseases such as kwashiorkor, a amount of amino acids,
code. DNA code utilises groups of three letters (a mix of A, G, C form of malnutrition common in poverty-stricken areas. the body will suffer.


The cell cycle

Inside one of the bodys most vital processes

he continuous cycle of cell division and
growth is essential to all life on Earth.
Without it, no organism on the planet
would be able to reproduce or develop. The cell
cycle consists of three main stages: interphase,
mitosis and cytokinesis.
During interphase, the cell expands and
makes the new proteins and organelles it will
need for division. It then makes copies of its
chromosomes, doubling the amount of DNA in
the cell and ensuring the conditions are right to
begin the next phase.
In mitosis, the membrane surrounding the
nucleus breaks down, which then exposes the
chromosomes, which are pulled to opposite
sides of the cell by tiny spindle fibres. A new
nuclear envelope then forms around the
chromosomes at each end of the cell. During
cytokinesis the cytoplasm splits in half to create
two daughter cells, each with their own
nucleus and organelles.
The cycle is managed by regulating enzymes
known as CDKs. These act as a checkpoint
between the phases of division, giving the
signal for the next stage in the cycle to begin.
The cell cycle of prokaryotic cells (those
without a nucleus) is slightly different. Bacteria
and other prokaryotes divide via a process
called binary fi ssion, in which the cell
duplicates its genetic material before doubling
in size and splitting in two. Meiosis is another
type of cell division and is concerned with
sexual reproduction as opposed to the asexual
organic growth of tissue in mitosis.

Cancer and the cycle

Cell duplication
Explore the key stages of mitosis now
If the cell cycle goes wrong, cancerous
tumours are a possible consequence. It all
depends on the levels of proteins in the cycle. A
protein called p53 halts the process if DNA is
damaged. This provides time for the protein to
repair the DNA as the cells are then killed off
and the cycle begins anew. On the rare
occasions this process fails, cells can
reproduce at a rapid rate and tumours can
form. Chemo- and radiotherapy work by
destroying these mutated cells. A p53 mutation Prophase Prometaphase Metaphase Anaphase
is the most frequent one leading to cancer. An Chromosomes The nuclear envelope In this phase, all the Now, the spindle fibres
extreme case is Li Fraumeni syndrome, where condense, becoming breaks down and spindle spindle fibres are pull the chromosomes
a genetic defect in p53 leads to a high thicker and shorter. fibres extend from attached and the apart, with the
frequency of cancer in those affected. Sister chromatids form either side of the cell to chromosomes are chromatids moving to
when the chromosomes attach to the middle of arranged in a line along opposite ends or poles
replicate themselves. each chromatid. the equator of the cell. of the cell.

100 | How It Works

DID YOU KNOW? A common theory is that every living cell is descended from a single ancestral cell from 3-4bn years ago

Every step of the cell

division cycle is vital for life
as we know it
An experts view
Paul Nurse, Nobel Prize winner and director of the Francis Crick Institute, chats
about cell cycle
What is the cell cycle? Why do skin cells divide so quickly and nerve
The cell is the basic unit of life for all living things. cells so slowly?
One of its many properties is the ability to reproduce. Cells change at varying rates and sometimes some
The cell cycle is a series of processes that occur nerve cells barely divide at all. This is one reason why
between the birth of the cell and its division into two. it is difficult to regenerate the nervous system when
it becomes damaged. Because the body has to deal
What is mitosis? with cuts and abrasions, it is much easier to get skin
Mitosis describes what happens near the end of the cells to divide.
cycle. The replicated chromosomes are separated
from each other into opposite ends of the cell just What is tissue culture and why is it important?
before the cell divides. It is simply a way of growing cells from animals and
plants in test tubes. They will divide under these
What are the different parts of the cycle? circumstances so you can study the cell cycle away
The other major part occurs before mitosis and is the from the complexities of an animal or plant.
process in which the DNA that makes up the
chromosomes replicates itself. This is called the What are the differences between plant and
S-phase or DNA synthetic phase [which is part of animal cell cycles?
interphase]. The S-phase replicates and mitosis Fundamentally, not very much. They do both
separates and divides. undergo the same processes but are subject to
different overall controls.
What is the difference between mitosis and
meiosis and does cell division occur in both? What is proteolysis and how does that
Meiosis is usually considered to be the mitotic full mechanism help the cell cycle?
cycle and also leads towards cell reproduction. It is a biochemical mechanism that breaks down
However, in meiosis there are two M-phases or protein. It then takes away certain proteins as part of
divisions so the number of DNA and chromosomes a regulatory system for a variety of biological
are halved. Meiosis uses gametes for fertilisation in process such as the cell cycle. It is then used at the
diploid cells in animal and plants. end of the cycle to destroy excess protein and
prepare for the next cycle.
Does it occur in eukaryotic or prokaryotic cells?
Only in eukaryotic cells. In prokaryotic cells there is a You discovered CDK (Cyclin-dependent kinase).
cell cycle but it is not mitosis. This [process] is How do they contribute to the cell cycle?
simply the copying of DNA and then a much less CDK is a type of enzyme and my research group was
obvious separation of the copied DNA into the two involved in discovering that they were the major
cells that have divided. regulators in the cycle. CDK brings about the S-phase
and mitosis and controls them.
Why did you use yeast in your experiments?
Yeast is a very simple eukaryote, which reproduces How can the cycle help understand potential
in much the same way as more complex cells in us. It cures for cancer?
only has 5,000 genes compared to our 25,000. It To be able to understand how cancer, works you
simplifies cell division so is extremely convenient to have to be able to understand how the cell cycle
study. Its got fantastic genetics and genomics, works. Crudely blocking the cell cycle is a problem as
which allow you to investigate complicated a therapy as our body is full of other cells that have
processes like the cell cycle. to divide.

Dreamstime; BBC; Thinkstock; Dr. Cecil Fox; Corbis

Telophase Cytokinesis Paul Nurse is also the

The two new sets of The cytoplasm divides former director of Cancer
chromosomes form and two or more Research UK and president
groups at each pole and daughter cells are of the Royal Society
a new envelope forms produced. Mitosis and
around each as the the cell cycle have now
spindle disappears. reached their end.

How It Works | 101


Human pregnancy
Nine months of change and growth Weight gain
The average woman gains 12.5kg
regnancy is a unique period in a womans life that brings about physical and

during pregnancy. This consists of
(These figures vary according to several factors
emotional changes. When it occurs, there is an intricate change in the balance including the age, race, diet and the
of the oestrogen and progesterone hormones, which causes the cessation of pre-pregnancy weight and size of the person)

menstruation and allows the conditions in the uterus (womb) to become suitable for
the growth of the fetus. The lining of the uterus, rather than being discharged,
thickens and enables the development of the baby.
At first, it is a collection of embryonic cells no bigger than a pinhead. By week four

the embryo forms the brain, spinal cord and heart inside the newly fluid-filled


amniotic sac. Protected by this cushion of fluid, it becomes recognisably human and R B GE


enters the fetal stage by week eight. TFE


Many demands are put on the mothers body and she is likely to experience

sickness, tiredness, lower-back pain, heartburn, increased appetite and muscle
cramps, as well as the enlargement of her breasts and stretch marks. Her blood sugar 0.8k
levels, heart rate and breathing also increase to cope with the growing demands of kg g SURRO AM
0.9 0.7
the fetus.

RU kg

As the date of labour approaches, the mother feels sudden contractions known as UT

g EX
Braxton-Hicks, and the neck of her uterus begins to soften and thin out. Meanwhile, AY AC




the lungs of the fetus fill with surfactant. This substance enables the lungs to soften, US




making them able to inflate when it takes its first breath of air. Finally, chemical


signals from the fetus trigger the uterus to go into labour.



At first, it is a collection of embryonic
cells no bigger than a pinhead

This begins after the last menstrual period, when an egg is The fetus grows rapidly and its organs Hair and teeth
released and fertilised. It takes about nine weeks for the mature. By week 20 its movements can At 16 weeks, fine hair
resulting embryo to develop into a fetus. During this period, be felt. At week 24 it can suck its thumb (lanugo) grows over the fetal
body. By 20 weeks, teeth
the mother will be prone to sickness and mood swings due to and hiccup, and can live independently start forming in the jaw and
hormonal changes. of the mother with medical support. hair grows.

Head Week 9 Heart Week 16 Movement

Face begins to All the internal By week 16 the eyes
look human and organs are formed can move and the
the brain is and the heart is able whole fetus makes vigorous
developing rapidly. to pump blood movements.
around its body.

Sound and light

The fetus will respond to
light and is able to hear
sounds such as the
mothers voice.

By 20 weeks, this
white, waxy
4 x trimester images Science Photo Library

substance covers
the skin,
protecting it from
the surrounding
amniotic fluid.
Movement Weight
Fetus moves around Week 16: 140g
to encourage muscle Week 20: 340g
development. An increase in
Length blood circulation
Weight Length Week 16: 18cm causes mother to
10g 5.5cm Week 20: 25cm sweat more.

DID YOU KNOW? 200 extra calories a day are needed in mid-pregnancy, which is 10 per cent more than the usual

Whartons jelly
The placenta
The placenta is an essential interface between the
The umbilical blood vessels are coated with
this jelly-like substance and protected by a
tough yet flexible outer membrane.
mother and fetus. When mature it is a 22cm
diameter, flat oval shape with a 2.5cm bulge in
the centre. The three intertwined blood
vessels from the cord radiate from the centre
to the edges of the placenta. Like tree roots,
these villous structures penetrate the
placenta and link to 15 to 20 lobes on the
maternal surface.
The five major functions of the
placenta deal with respiration,
nutrition, excretion of waste
products, bacterial protection
and the production of hormones.
Is firmly attached to the inside
of the mothers uterus.

Maternal surface
Blood from the mother is absorbed and
transferred to the fetal surface.

Fetal surface
Blood vessels radiate out from the umbilical
cord and penetrate the placenta. The surface
is covered with the thin amnion membrane.

Umbilical cord
Consists of three blood vessels. Two carry carbon
dioxide and waste from the fetus, the other supplies
oxygen and nutrients from the mother.
Science Photo Library

THIRD TRIMESTER (2840 weeks)

Breathlessness Movement Now almost at full term, the fetus can recognise and
The increased size of By the 28th week, respond to sounds and changes in light. Fat begins The three
the fetus by 24 weeks
causes compression of
due to less room in
uterus, the fetus will
to be stored under the skin and the lungs are the
very last organs to mature.
rib cage and discomfort
for mother.
wriggle if it feels
uncomfortable. blood vessels
Week 24 Hands Week 32
radiate from
The fetus can move
its hands to touch
the centre to
its umbilical cord at
24 weeks.
the edges of
the plancenta
By 28 weeks, the
uterus has risen to a
position between
the navel and the
Under pressure
Pressure on the diaphragm and
other organs causes indigestion and
heartburn in the mother. She will
find it difficult to eat a lot.

Head positions itself downwards, in
Weight Head preparation for labour.
Week 24: 650g The head
Week 28: 1,250g can move Weight
at 28 weeks 1,500g
Length and the eyes Sleep patterns
Week 24: 34cm can open Length Fetus will sleep and wake in
Week 28: 38cm and see. 41cm 20-minute cycles.


How does an Week 5

Pharyngeal arches that develop in the

embryo develop?
face, jaws, throat and neck appear
between the head and body. A
complex network of nerves and blood
vessels are developing. The embryos
eyes have formed and the ears are
becoming visible. The spleen and
Discover how a fertilised egg transforms into pancreas are beginning to develop in
the central part of the gut. The thymus
an embryo and eventually a new human being and parathyroid glands develop from
the third pharyngeal arch. The arms

fter fertilisation, the single-celled zygote splits into or outer coat, will become, among other things, the placenta and legs begin to emerge
two, then the two cells double to four, four to eight that nourishes the baby; the inner cells, known as the inner as paddle-shaped buds.
and so on. The journey along the fallopian tube is cell mass, will become the foetus itself. On contact, the
quite slow, while growth continues. On its way, the zygote blastocyst burrows into the uterine wall for nourishment in
divides to make a clump of 32 cells, known as the morula a process known as implantation. Blastocyst formation
stage. If the early embryo splits into two clumps before this, usually occurs on the fifth day after fertilisation.
it may develop into identical twins. Every cell in the morula The embryonic stage begins in the fifth week. From
could still become part of the growing embryo. weeks five to eight, development is rapid, as major organs
By the time the womb cavity is reached, the cell cluster and systems begin to emerge. At this time, the first bone
becomes hollow and filled with fluid. It is now referred to as cells will also appear. By the end of the eighth week, the
the blastocyst, which is an embryo that has reached the embryo is known as a foetus and increasingly looks like a
stage where it has two different cell types. The surface cells, mini human.

Fertilisation and IVF explained

Natural fertilisation takes place via sexual where it implants into the uterine lining. In vitro
intercourse. An egg, or ovum, is released by an fertilisation (IVF) is a form of assisted reproductive
ovary and is fertilised by a sperm. Fertilisation technology, where the sperm nucleus is combined Ovulated egg
occurs when the sperm and egg unite in one of the with an egg cell in a lab. The resultant embryo is The sperm cells are
females Fallopian tubes. The fertilised egg, known manually introduced to the uterus, where it chemically attracted to the
as a single-celled zygote, then travels to the uterus, develops in the same way as a natural conception. egg and attach themselves
in an attempt to break
Uterus (womb) through the outer coat.
The whole process from ejaculation to
fertilisation can take less than an hour. If a Ovary
woman has an average 28-day menstrual A woman usually has two tubes and
cycle, fertilisation is counted as having taken two ovaries, one either side of her
place around day 14, not on day one. uterus. Every month one of the
ovaries releases an egg, which
passes slowly along its Fallopian
tube towards the womb.

Fallopian tube
Fertilised egg If a woman has sexual
Only one sperm will be intercourse during the
successful. The egg will days of her monthly cycle,
then lose its attraction, just before or after an egg
harden its outer shell and has been released from Week 3
the other sperm will let the ovary, a sperm cell At the start of week 3 a groove will
go. If eggs are not from her partner could form towards what will become the
fertilised within 12 hours travel to the Fallopian tube tail end of the embryo; this is the
of release, they die. and fertilise the ovum. primitive streak. A new layer of tissue
the mesoderm will develop from
the primitive streak. The spinal cord,
Sperm kidneys and major tissues will all grow
During sexual intercourse, millions of sperm are
from this. Cells from the ectodermal
ejaculated into the vagina, with only thousands
tissue create the neural fold and plate,
In vitro (in glass) surviving to make the journey to meet the egg.
the first stages in the development of
IVF is the process by which eggs are
the nervous system. The neural
removed from the ovaries and mixed
groove will go on to form the spine.
with sperm in a laboratory culture dish.
Fertilisation takes place in this dish.

DID YOU KNOW? In 2009, almost two per cent of all babies born in the UK were conceived as a result of IVF

Week 7
Journey of an embryo
The first eight weeks is an immense time of change for a just-conceived human
The embryos eyelids begin to form from a single
membrane that remains fused for several days. At
this stage in development, the limb muscles are
beginning to form. The chest cavity will be
separated from the abdominal cavity by a band of
muscles; this will later develop into the diaphragm.

Week 8
Between the fourth and eighth
weeks, the brain has grown so
rapidly that the head is extremely
large in proportion to the rest of the
body. The gonads, or sex glands, will
now start to develop into ovaries or
testes. The elbows, fingers, knees
and toes are really taking shape.
Inside the chest cavity, the lungs are
developing too. At the end of the
eight-week period, the embryo
becomes a foetus.

Week 6
42 tissue blocks have formed along the embryos
back and the development of the backbone, ribs and
muscles of the torso begins. The length of the embryo is
now 7-8mm (0.3in) . The embryos heart has established a
regular rhythm and the stomach is in place. Ears, nose,
fingers and toes are just beginning to appear.

Week 4
The kidneys are forming from mesodermal tissue and the mouth is
emerging. A basic spinal cord and gut now run from the head to the tail.
The head and tail fold downward into a curve as a result of the embryo
developing more rapidly from the front. The heart tube bends into a U
shape and blood begins to circulate around the body.

Week 2
The inner cells of the embryo divide into two
layers: the ectoderm and the endoderm. The
tissues and organs of the body will eventually
develop from these. The amniotic sac, which
will soon form a protective bubble around the
embryo, also starts to develop. The embryo, Week 1
now completely embedded in the womb, Within one week of conception, the
is a disc-shaped mass of cells, fertilised egg, known as a blastocyst, will
measuring roughly 0.2mm make its way to the uterus. Within days the
(0.008in) in diameter. cells will arrange themselves into two
masses: the outer coat will become the
placenta, while the inner cell mass
becomes the foetus. All being well, the
developing embryo will settle into the folds
of the womb lining.

What is amniotic fluid?

The amniotic sac is a bag of fluid in
the uterus, where the unborn baby
develops. Its filled with a colourless
fluid mainly made of water that
helps to cushion the foetus and
provides fluids which enable the baby
to breathe and swallow. The fluid also
guards against infection to either the
foetus or the uterus. Amniotic fluid
plays a vital role in the development
of internal organs, such as the lungs
and kidneys; it also maintains a
constant temperature. The amniotic The body of this foetus is really taking
sac starts to form and fill with fluid shape, safe within the amniotic sac
3x SPL

within days of conception.


What causes
High altitude sickness can have a
severe physical effect on the
human body. Descending to
lower altitudes is the only way to
ease symptoms

altitude sickness?
Discover the effects that dizzying heights can have
on the human body
dventurous explorers can spend months In order to compensate, your heart rate will

A training prior to scaling mountain peaks, but

regardless of fitness level, high altitudes can
take its toll on the human body.
increase and the body will produce more red blood
cells, making it easier to transport oxygen around
the body.
Between around 1,524 and 3,505 metres (5,000 and The low humidity levels at high altitude can also
11,500 feet) above sea level is considered high cause moisture in the skin and lungs to evaporate
altitude. At this level, most travellers will start to feel quicker, so dehydration is a real threat. Your face,
the effects of high altitude sickness as they attempt legs and feet may start to swell as the body attempts
to acclimatise to the change in atmosphere that to retain fluid by holding more water and sodium in
happens at this height. the kidneys.
The most common symptom is actually shortness Difficulty sleeping is also common, and symptoms
of breath, which is due to a lack of atmospheric of high altitude sickness can get progressively worse
pressure. At these heights, air molecules are the higher you climb, including mood changes,
more dispersed, so less oxygen can be inhaled. headaches, dizziness, nausea and loss of appetite.

How does a synapse work?

The sending nerve cell
contains a nucleus, which Neurotransmitter molecules
holds the cells genes and When the nerve signal reaches the synapse, it
controls its functions. is converted into neurotransmitters, which are
the chemicals that bind to the receptor nerve
As well as a long extension
cell, causing an electrical impulse.
called the axon, each neuron
has multiple branch-like Axon
extensions called dendrites, The nerve signals travel in Vesicle
which take in nerve messages one direction along the axon This is the tiny membrane that stores
from other neurons. to the synaptic knob at the neurotransmitter molecules. The vesicles travel
end of the axon. from the sending neuron to the synapse, where
they fuse with the presynaptic membrane and
release the neurotransmitters.

Nerve impulse Ions

A nerve impulse is initiated The flow of these charged
when a stimulus (change in particles is the basis of
the internal or external the propagation of a
environment) alters the nerve impulse.
electrical properties of the
neuron membranes.

Neurons carry messages around the

body, but how do they pass them on? membrane
he nervous system involves a complex collection of nerve cells called

Synaptic cleft
neurons. Nerve messages can travel along neurons as electrical nerve Postsynaptic
impulses caused by the movement of lots of electrically charged ion membrane
particles. In order to cross the minuscule gaps between two neurons, the nerve The cell membranes of
message must be converted into a chemical message capable of jumping the the sending neuron Ongoing message
gap. These tiny gaps between neurons are called synapses, forming the main (presynaptic membrane) Once the neurotransmitters
and the receiving neuron cross the gap between the two
contact zone between two neurons. Each neuron consists of a cell body and
(post-synaptic neurons, ion channels in the
branching structures known as axons and dendrites. Dendrites are receiving neuron open, allowing
DK Images

membrane) are separated

responsible for taking information in via receptors, while axons transmit the positive ions to flow into the
by a fluid-filled gap called
information away by passing electrical signals across the synapse. the synaptic cleft.
receiving neuron.

DID YOU KNOW? We get hangry because without energy our glucose levels are low, making emotions harder to regulate

The stress hormone, cortisol, can increase

appetite and cause a person to overeat

The biology
of hunger
Grab a snack, and then find out whats
really going on in your rumbling tummy
he feeling is all too familiar: a growling in brain then commands the release of a second at which food is emptied from the stomach into

T the pit of your stomach that usually starts

around late morning when breakfast is
just a memory and lunchtime is still a tiny speck
hormone called neuropeptide Y, which actually
stimulates appetite.
Once you have answered the call and filled
the small intestine, as well as stimulating the
production of molecules that help to break
down food. GLP-1 tells the pancreas to release
on the horizon. Its hunger a feeling that begins up on a good meal, your stomach gets to work more insulin and also reduces appetite. The
with the hormone known as ghrelin. Once your on digestion. Nerves in your stomach sense hormone PYY is secreted into the bloodstream
body has finished digesting and using up the stretching that lets your brain know youre full by the small intestine after eating. It binds to
energy from your last meal, your blood sugar and up. Three other hormones also secreted by your receptors in the brain to make you feel full up.
insulin levels drop. In response to this, ghrelin is digestive system take messages to the brain: Once all of the food is digested, the blood sugar
produced in the gut and travels to the brain, cholecystokinin (CCK), GLP-1 and PYY. CCK helps and insulin levels drop and ghrelin is produced
letting it know that sustenance is needed. The to improve digestion by slowing down the rate once more, so the hunger cycle continues.

Hungry hormones When the mind

Whether youre a bit peckish or
totally ravenous, its all down to
Hunger strikes
The gut produces After eating takes over...
the hormones in your system ghrelin to let your brain Once youve
When our bodies tell us we are
know youre hungry. eaten, your
hungry, its an innate reaction the
body digests the
hormones in our systems let us
food and energy
Feeling full is extracted.
know of the need for sustenance.
Once youre full, fat cells But when our minds get involved,
secrete a hormone called its a whole different story.
leptin that actually inhibit Theres not much nutritional
your appetite so you value in a bacon sandwich or a
dont keep eating. frosted cronut, for example, so its
not a need for a treat, its a
want. This is because the very
first time you experienced a
cronut, the mesolimbic centre of
your brain (the region that
processes pleasure) lit up, as the
fatty, sugary goodness of the treat
released chemicals known as
opioids that bind with receptors in
Energy storage the brain.
Insulin moves glucose This triggers the release of
from the blood into dopamine, the feel-good hormone
your bodys cells, so it that makes us happy. Its actually
can be used during the same one that is released
exercise, for example. when we fall in love! Your brain
remembers this response, and is
encouraging you to munch on that
Role of the liver delicious cronut to repeat the
The liver keeps the level pleasurable feeling.
of blood glucose and
insulin within a healthy
range and stops
excessive fluctuations.
Dreamstime; Thinkstock

Insulin control Blood chemistry

This hormone works to Hormones stimulate
speed up the rate at your pancreas to Its the reward circuit in your brain
which cells in the body release more insulin that creates the urge for sweat treats!
take up glucose. into your bloodstream.


What is saliva?
Find out this frothy liquids
vital role in maintaining
human health
umans can produce an incredible two

H litres (half a gallon) of saliva each day. It

is made up of 99.5 per cent water, so how
is it able to perform so many important
functions in our mouths? The answer lies in the
remaining 0.5 per cent, which contains a host of
enzymes, proteins, minerals and bacterial
Parotid duct Parotid gland
compounds. These ingredients help to The parotid duct The parotid glands are the
digest food and maintain oral hygiene. allows saliva to move largest salivary glands.
As soon as food enters the mouth,
Digestive enzymes easily from the They are made up of serous
The digestion process parotid gland to
salivas enzymes start to break it cells which produce thin,
begins in the mouth, as the mouth. watery saliva.
down into its simpler components, saliva contains enzymes
that start to break down
while also providing lubrication to
starches and fats.
enable even the driest snack to slide
easily down the throat. Saliva is also important
in oral health, as it actually helps to protect the
teeth from decay and it also controls bacterial
levels in the mouth in order to help reduce the
overall risk of infection. Without sufficient
saliva, tongue and lip movements are not as
smooth, which, in extreme cases, can make it
very difficult to speak.
With advanced scientific techniques and
research, an individuals saliva can reveal a great
deal of information. New studies have shown that
a saliva test can be used to find out whether a
person is at risk of a heart attack, as it contains
C-reactive protein (CRP). This can be an indicator
of heart disease when found at elevated levels in
the blood. A saliva test is much less intrusive than
a blood test and gives doctors a rough estimate of
the health of a patients heart. Whats more,
saliva contains your entire genetic blueprint.
Even tiny amounts, equivalent to less than half a Sublingual gland
teardrop, can provide a workable DNA sample Composed primarily of Submandibular gland Submandibular duct
that can be frozen and thawed multiple times mucous cells, these glands These glands produce roughly Also known as the Wharton
secrete only a small amount of 70 per cent of your saliva. They duct, this drains saliva from
without breaking down. saliva, accounting for about are composed of both serous both the submandibular and
five per cent. and mucous cells. sublingual glands.

Saliva performs
a variety of Can saliva speed up healing?
functions and
Many animals do it instinctively, but it They created two dishes of cells, one
can actually help
turns out that there is a benefit to that was treated with saliva and one that
wounds to heal
humans licking their wounds. A study was left open. The scientists were
found that there is a compound in human astounded when after 16 hours the
saliva, namely histatin, which can speed saliva-treated wound was almost
up the healing process. Scientists completely closed, yet the untreated
Alamy; Thinkstock

conducted an experiment using epithelial wound was still open. This demonstrated
cells from a volunteers inner cheek, that saliva does aid the healing of at least
creating a wound in the cells so that the oral wounds, something that has been
healing process could be monitored. suspected but unproven until this study.

DID YOU KNOW? It is estimated that there are 86 billion neurones in the human brain, linked together by trillions of synapses

and your feelings
Are our moods and emotions really just brain chemistry?

essages are passed from one nerve cell that are normally associated with more Schizophrenia Anxiety Happiness
to the next by chemical messengers addictive behaviour types.
called neurotransmitters. Each has a Noradrenaline is similar in structure to the
slightly different effect and by looking at what hormone adrenaline and is involved in the fi ght
happens when neurotransmitter levels change, or fl ight response. In the brain, it keeps us alert
we are discovering that different combinations and focussed. In contrast, GABA reduces the
play a role in a range of complex emotions. activity of the nerves that it interacts with and is
Acetylcholine excites the nerve cells that it thought to reduce feelings of fear or anxiety.
touches, triggering more electrical activity. It Serotonin is sometimes known as the happy
plays a role in wakefulness, attention, learning hormone and transmits signals involved in
and memory, and abnormally low levels are body temperature, sleep, mood and pain. People Depression Love Fight or flight
found in the brains of people with dementia with depression have been found to have lower
caused by Alzheimers disease. serotonin levels than normal, though raising
Dopamine is a chemical that also excites serotonin levels with antidepressant
nerve cells. It plays a vital role in the control of medications does not always help.
movement and posture, and low levels of There are many more neurotransmitters in
dopamine underlie the muscle rigidity that the brain and other chemicals like hormones
exists in Parkinsons disease. Dopamine is also can also influence the behaviour of nerve cells.
used in the brains reward circuitry and is one of It is these interactions that are thought to
the chemicals responsible for the good feelings underlie the huge range of human emotions. Dopamine Serotonin Oxytocin
Noradrenaline Adrenaline
Different levels of neurotransmitters have been
associated with different mental states
The synapse Nerve cells can only respond to a
Neurotransmitters pass messages specific neurotransmitter if they Feelings
from one nerve cell to the next have the right corresponding The combined activity
receptors to detect it. across this complex
system is what
underpins our thoughts,
feelings and emotions.
release is only
triggered when
there is enough
electrical activity
in the nerve cell.

These chemical messengers
travel across the small gap
New signal
If a neighbouring nerve
- called the synaptic cleft -
receives the right
and stick to receptors on
chemical messages it
nearby nerve cells.
will trigger a new
electrical signal.

Nerve cells communicate by
releasing neurotransmitters at
BSIP SA / Alamy; Thinkstock

specialised junctions called synapses.

Part of a network
Each nerve cell makes thousands of
connections to its neighbours and
has its own mix of different
neurotransmitters and receptors.


How do white Monocyte

Monocytes help prepare us
for another infection by
presenting pathogens to the

blood cells work? body, so that antibodies can

be created. Later in their life,
monocytes move from the
bloodstream into tissue,
and then evolve into
macrophages which can
One of the bodys main defences against infection and foreign conduct phagocytosis.

pathogens, how do these cells protect our bodies?

Types of leukocyte
hite blood cells, or leukocytes, are the
bodys primary form of defence
against disease. When the body is Different kinds of WBC have different roles, which
invaded by a pathogen of any kind, the white complement one another to defend the body
blood cells attack in a variety of ways; some
produce antibodies, while others surround and
ultimately devour the pathogens whole.
In total, there are five types of white blood
cell (WBC), and each cell works in a different
way to fight a variety of threats. These five cells
sit in two groupings: the granulocytes and the
agranulocytes. The groups are determined
based on whether a cell hxas granules in the
cytoplasm. These granules are digestive
enzymes that help break down pathogens.
Neutrophils, eosinophils and basophils are all
granulocytes, the enzymes in which also give
them a distinct colouration which the
agranulocytes do not have.
As the most common WBC, neutrophils make
up between 55 and 70 per cent of the white
blood cells in a normal healthy individual, with
the other four types (eosinophils, basophils,
monocytes and lymphocytes) making up the
rest. Neutrophils are the primary responders to
infection, actively moving to the site of infection
following a call from mast cells after a pathogen
is initially discovered. They consume bacteria
and fungus that has broken through the bodys
barriers in a process called phagocytosis.
Lymphocytes the second-most common
kind of leukocyte possess three types of Lymphocyte
defence cells: B cells, T cells and natural killer These release antibodies
cells. B cells release antibodies and activate T as well as attack virus and
tumour cells through three
cells, while T cells attack diseases such as
differing types of cell. As a
viruses and tumours when directed, and group, they are some of
regulatory T cells ensure the immune system the longest lived of the
returns to normal after an attack. Natural killer white blood cells with the
cells, meanwhile, aid T cell response by also memory cells surviving for
attacking virus-infected and tumour cells, years to allow the body to
which lack a marker known as MHC. defend itself if repeat
attacks occur.
The remaining types of leukocyte release
chemicals such as histamine, preparing the
body for future infection, as well as attacking
other causes of illness like parasites.

Natural killer cells Eosinophils are the white
blood cells that primarily
aid T cell response deal with parasitic
infections. They also have
by also attacking a role in allergic reactions.
They make up a fairly small
virus-infected and percentage of the total

tumour cells white blood cells in our

body about 2.3 per cent.

DID YOU KNOW? WBCs have colour but appear white when blood is put through a centrifuge, hence their group name

White blood cells at work

The body has various outer defences against infection, including the
external barrier of the skin, but what happens when this is breached?

Skin breach Mast cells WBCs arrive Macrophages Healing

A foreign object breaks Mast cells release cytokines Macrophages move to the consume bacteria Following removal of the
through the skin, and then WBCs are called site via the bloodstream to Bacteria are absorbed into bacteria, the body will start
introducing bacteria (shown into action to ensure the start defending against cytoplasm and broken to heal the break in the skin
in green) into the body. infection does not spread. invading bacteria. down by the macrophages. to prevent further infection.

A microscopic illustration
of a neutrophil the most
abundant WBC

Basophils are involved in
allergic response via
releasing histamine and
heparin into the
bloodstream. Their
functions are not fully
known and they only
account for 0.4 per cent of
the bodys white blood
cells. Their granules
appear blue when viewed
under a microscope.

A faulty immune system
If the immune system stops working properly, We can often treat these conditions with
Neutrophils are the most
we are at risk of becoming ill. However, immunosuppressants, which deactivate
common of the leukocytes.
another problem is if the immune system elements of the immune system to stop the
They have a short life span
actually goes into overdrive and starts body attacking itself. However, there are
so need to be constantly
attacking the individuals own cells, mistaking drawbacks with this treatment as, if the
produced by the bone
them for pathogens. There are a large number person exposes themselves to another
marrow. Their granules
of autoimmune ailments seen across the pathogen, they would not have the normal
appear pink and the cell
world, such as Crohns disease, psoriasis, white blood cell response. Consequently, the
SPL; Thinkstock

has multi-lobed nuclei

lupus and some cases of arthritis, as well as a individual is less likely to be able to fight
which make them easily
large number of diseases that are suspected normally low-risk infections and, depending on
differentiated from other
to have autoimmune roots. the pathogen, they can even be fatal.
types of white blood cell.


From inheritance to genetic diseases, what secrets are hidden
in our genes and how do they determine who we are?

DID YOU KNOW? If all 46 human chromosomes were stitched together and stretched they would measure nearly 2m (6.6ft)

How is our genetic code stored?

enes define who we are. They are the
basic unit of heredity, each containing
a coded set of instructions to make Genetic information is coded into DNA using just four
a protein. Humans have an estimated nucleobases: A, C, G and T
20,500 genes, varying in length from a few Chromosome
hundred to more than 2 million base pairs. Humans have 46
chromosomes thats 23
They affect all aspects of our physiology, pairs containing around
providing the code that determines our 20,500 genes.
physical appearance, the biochemical reactions
that occur inside our cells and even, many
argue, our personalities.
Every individual has two copies of every gene
one inherited from each parent. Within the
population there are several alleles of each Nucleus
gene that is, different forms of the same code, Surrounded by a double-
thickness membrane, the
with a number of minor alterations in the nucleus contains the genetic
sequence. These alleles perform the same information of the cell.
underlying function, but it is the subtle
differences that make each of us unique.
Double stranded
DNA has two complementary strands
Inside each of our cells (except red blood one forms a template to make the
cells) is a nucleus, the core which contains our other, allowing accurate replication.
genetic information: deoxyribonucleic acid
(DNA). DNA is a four-letter code made up of
bases: adenine (A), guanine (G), cytosine (C) and
thymine (T). As molecular biologist Francis
Crick once put it, DNA makes RNA, RNA makes Base pairs
protein and proteins make us. Our genes are The bases of DNA
are always found
stored in groups of several thousand on 23 in pairs: adenine
pairs of chromosomes in the nucleus, so when Double helix pairs with thymine,
a cell needs to use one particular gene, it DNA is arranged in a double helix and guanine pairs
shape, with the bases forming the with cytosine.
makes a temporary copy of the sequence in the ladder-like rungs in the centre.
form of ribonucleic acid (RNA). This copy
contains all of the information required to

DNAs chemical structure

We put deoxyribonucleic acid under Nucleotide
the microscope DNA is a polymer made up of building blocks called nucleotides.

Phosphate groups
link the sugars of
adjacent nucleotides
together, forming a
phosphate backbone.

T Hydrogen bond
Two bases interact with

A each other by hydrogen

bonds (weak electrostatic
interactions that hold the
strands of DNA together).

Sugar Each nucleotide contains a
Each base is attached base, which can be one of four:
to a five-carbon sugar adenine (A), thymine (T),
called deoxyribose. guanine (G) or cytosine (C).


make a protein the building blocks of the genome available to study is making the task of Genetic mutations are the source of variation
human body. identifying the genetic risk factors much easier. in all organisms. Most genetic mutation occurs
The Human Genome Project aimed to map Interestingly, the Human Genome Project as the DNA is being copied, when cells prepare
the entire human genome; this map is discovered we have far fewer genes than to divide. The molecular machinery responsible
effectively a blueprint for making a human. first predicted; in fact, only two per cent of for duplicating DNA is prone to errors, and often
Using the information hidden within our our genome codes for proteins. The remainder makes mistakes, resulting in changes to the
genetic code, scientists have been able to of the DNA is known as non-coding and DNA sequence. These can be as simple as
identify genes that contribute to various serves other functions. In many human accidentally substituting one base for another
diseases. By logging common genetic variation genes are non-coding regions called introns, (eg A for G), or can be much larger errors, like
in the human population, researchers have and between genes there is intergenic adding or deleting bases. Cells have repair
actually been able to identify over 1,800 DNA. One proposed function is that these machinery to correct errors as they occur, and
disease-associated genes, affecting illnesses sequences act as a buffer to protect the even to kill the cell if it makes a big mistake, but
ranging from breast cancer to Alzheimers. The important genetic information from mutation. despite this some errors still slip through.
underlying genetic influences that affect Other non-coding DNA acts as switches, which Throughout your life you will acquire many
complex diseases such as heart disease are still helps the cell to turn genes on and off at the cell mutations. Many of these are harmless,
not yet fully understood, but having the right times. either occurring in non-coding regions of DNA,

The Human Mapping the human genome

Genome How does our genetic makeup compare
to that of other creatures?
The Human Genome Project, an Zebrafish
Divergence between fish and
initiative to map the sequence of mammals occurred very early
the entire human genetic code, in evolution, so similarities in
began in 1990 and was completed our genes are very Chicken
in 2003. The 3.3-billion base pair fragmented. Despite the fact
that we are not
sequence was broken into closely related to
sections of around 150,000 base birds, the chicken
pairs in length and the sequence Human still has regions of
for each identified. These were This ring represents DNA that are quite
the genes on a similar to ours.
then joined and used to map the
human chromosome,
information on to chromosomes
with the numbers
to determine which genes were providing a
found on each and in what order. representation Dog
The genome map (right) shows a of scale. Some regions of the
human chromosome compared canine genome are
very different to ours,
with other animals; the colours
but the pink bands
are a heat map demonstrating show an area that has
areas where genetic information been conserved.
has been conserved through
evolution (the more fragmented
the pattern, the more differences
there are in the genetic code).
The mouse and rat genomes
have similar patterns,
One of our closest living
demonstrating these rodents
relatives the solid bands
close evolutionary relationship.
demonstrate we share a great
deal of genetic information (ie
98 per cent).

There is less in common between
human and mouse (90 per cent), but
we are sufficiently similar that mice
make a good scientific model for
studying human disease.

DID YOU KNOW? Certain genetic elements are more dominant than others, which is why more people have brown hair

or changing the gene so nominally that the

protein is virtually unaffected. However, some
Before the Industrial Revolution the
mutations do lead to disease.
If mutations are introduced into the sperm
majority had white wings
and egg cells they can be passed on to the next light-coloured moths struggled to hide oxygen in red blood cells, to misfold. Instead of
generation. However, not all mutations are bad, themselves against the darker environment, so forming its proper shape, the haemoglobin
and this process of randomly introduced black moths flourished. They survived much clumps together, causing red blood cells to
changes in the DNA sequence provides the longer, enabling them to pass on their mutation deform. They then have trouble fitting through
biological underpinning that supports Darwins to their offspring and altering the gene pool. narrow capillaries and often become damaged
theory of evolution. This is most easily observed It is easy to see how a genetic change like the or destroyed. However, this genetic mutation
in animals. Take, for example, the peppered one that occurred in the peppered moth could persists in the population because it has a
moth. Before the Industrial Revolution the give an advantage to a species, but what about protective effect against malaria. The malaria
majority of these moths had white wings, genetic diseases? Even these can work to our parasite spends part of its life cycle inside red
enabling them to hide against light-coloured advantage. A good example is sickle cell blood cells and, when sickle cells rupture, it
trees and lichens. A minority had a mutant anaemia a genetic disorder thats quite prevents the parasite from reproducing.
gene, which gave them black wings; this made common in the African population. Individuals with one copy of the sickle cell gene
them an easy target for predators. When A single nucleotide mutation causes and one copy of the healthy haemoglobin gene
factories began to cover the trees in soot, the haemoglobin, the protein involved in binding have few symptoms of sickle cell anaemia,

Using genetics to Why do we look

convict criminals like our parents?
Forensic scientists can use traces of DNA to
Its a common misconception that we inherit
identify individuals involved in criminal activity.
entire features from our parents eg You have
Only about 0.1 per cent of the genome differs
your fathers eyes. Actually inheritance is much
between individuals, so rather than sequencing
more complicated several genes work together
the entire genome, scientists take 13 DNA
to create traits in physical appearance; even eye
regions that are known to vary between
colour isnt just down to one gene that codes for
different people in order to create a DNA
blue, brown or green, etc. The combinations of
fingerprint. In each of these regions there are
genes from both of our parents create a mixture of
two to 13 nucleotides in a repeating pattern
their traits. However, there are some examples of
hundreds of bases long the length varies
single genes that do dictate an obvious physical
between individuals. Small pieces of DNA
characteristic all on their own. These are known as
referred to as probes are used to identify
Mendelian traits, after the scientist Gregor Mendel
these repeats and the length of each is
who studied genetic inheritance in peas in the
determined by a technique called polymerase
1800s. One such trait is albinism the absence of
chain reaction (PCR). The odds that two people
pigment in the skin, hair and eyes due to a defect
will have exactly the same 13-region profile is
in the protein that makes melanin.
thought to be one in a billion or even less, so if
all 13 regions are found to be a match then
scientists can be fairly confident that they can
tie a person to a crime scene. Carrier parents
Each parent carries the
albinism gene (dark pink), but
they have one normal gene
Carrier children (light pink), so they are able
Two out of four will be to make melanin.
carriers, like their parents,
with one normal and one
faulty gene.
Each child inherits one
gene from the mother and
one from the father.

Healthy child
One in four children will Affected child
receive one healthy gene One in four children will
from the father and one receive two copies of the
from the mother. faulty gene and as a
result will be unable to
produce melanin.


but are protected from malaria too, allowing

them to pass the gene on to their children. Environmental influences can alter
Genetics is a complex and rapidly evolving
field and more information about the function
the way that DNA is packaged
of DNA is being discovered all the time. It is now
known that environmental influences can alter Repairing faulty genes
the way that DNA is packaged in the cell, We reveal how donated cells can be used to mend any
restricting access to some genes and altering damaged genes within the human body
protein expression patterns. Known as
Target gene
epigenetics, these modifications do not actually The healthy gene is
alter the underlying DNA sequence, but isolated from the DNA
regulate how it is accessed and used by the cell. of the donor individual.

Epigenetic changes can be passed on from one

cell to its offspring, and thus provide an
additional mechanism by which genetic
information can be modified across generations
of humans. The gene is
packaged into a
delivery vector,
like a virus, to
help it get inside Fertilised egg
the target cell. A fertilised human egg is a
source of undifferentiated
stem cells, which can
become any type of cell.

Embryonic The new gene is introduced
stem cells into the stem cells produced
The fertilised egg by the fertilised egg.
becomes a blastocyst,
which contains

When our genes undifferentiated

embryonic stem cells.

go wrong
Cancer is not just the result of one or two
genetic mutations in fact, it takes a whole
series of mistakes for a tumour to form. Cells
contain oncogenes and tumour suppressor
genes, whose healthy function is to tell the cell
when it should and should not divide. If these
become damaged, the cell cannot switch off its Differentiation
cell division programme and it will keep making Chemical signals are
copies of itself indefinitely. Each time a cell added to the stem cells to
divides there is a risk that it will make a mistake force them to differentiate
when copying its DNA, and gradually the cell into the desired cell type,
makes more and more errors, accumulating eg liver cells. Transplant
The new cells are transplanted into the recipient,
mutations that allow the tumour to progress
carrying with them the healthy gene.
into malignant cancer.

How tumours develop

SPL; Alamy; Thinkstock

Tumour-associated Mutagens Localised Invasion Metastasis

genes Environmental factors, or Cancer usually starts with just As the tumour grows in Further mutations allow cells
Genes normally involved in mutagens such as radiation one or a few mutated cells; size it starts to invade of the tumour to break free and
regulating cell behaviour can and chemicals can cause these begin to divide the surrounding area, enter the bloodstream. From
go on to cause cancer if they damage to the DNA, leading to uncontrollably in their local taking over here they can be distributed
become mutated. mutations in key genes. area creating a tumour. neighbouring tissues. throughout the body.

DID YOU KNOW? It is thought that one in ten people suffer from a form of anxiety disorder

What is anxiety?
How our brains trigger a fight or flight response
nxiety affects a huge number of people When we become anxious our fight or flight

A and can be so severe that it stops many

sufferers from leaving their homes or
doing their jobs. In the US, over 40 million
response is triggered, flooding our bodies with
epinephrine (adrenaline), norepinephrine
(noradrenaline) and cortisol, which help
people aged 18 or over endure an anxiety increase your reflexes and reaction speed. Your
related disorder, while in the UK one in 20 body prepares itself to deal with danger by
people are affected. Some researchers believe increasing the heart rate, pumping more blood
that modern day technology has influenced the to the muscles and by getting the lungs to
rise of anxiety related conditions; we are hyperventilate.
constantly on high alert with texts, emails, At the same time, the brain stops thinking
social media and news updates. about pleasurable things, making sure that all
Anxiety is a natural human response that of its focus is on identifying potential threats.
serves a purpose. From a biological point of In extreme cases, the body will respond to
view, it functions to create a heightened sense anxiety by emptying the digestive tract by any Some people who suffer
of awareness, preparing us for potential means necessary, as this ensures that no anxiety find it hard to
leave the house
threats. In a way, its natures panic button. energy is wasted on digestion.

How your brain reacts Once the amygdala and hippocampus
have received a stimulus, the cortexs
The bodys primal response to danger can be role is to find out whats caused the fear
triggered by non-threatening situations response. Once the perceived danger is
over, a section of the prefrontal cortex
signals the amygdala to cease its
activity. It is vital to turning off anxiety.
Visual and auditory stimuli are first
processed by the thalamus which
filters the incoming information
and sends it to the areas where it Locus caeruleus
can be interpreted. This area of the brain stem is
triggered by the amygdala to
initiate the physiological
responses to anxiety or stress,
such as an increase in heart
Two paths rate and pupil dilation.
A startling signal such as a sudden
loud noise will be sent from the
thalamus via two paths: one
travels directly to the amygdala -
where it can quickly initiate the
fear response - and the other Hippocampus
passes through the cortex to be The hippocampus is the brains
processed more thoroughly. memory centre, responsible
for encoding any threatening
events that we experience in life
into long-term memories.
Stria terminalis
The bed nucleus of the stria
terminalis (BNST) is responsible
for maintaining fear once this
emotion has been stimulated by
the amygdala, leading to
longer-term feelings of anxiety.

This is where the fear response is
triggered. The amygdala can quickly
Alamy; Thinkstock

put your body on high alert, and

research suggests that if this area
of the brain is overactive, it may
cause an anxiety disorder.


Most of the amyloid

consisted of acellular pink

Inside the
globules that effaced and
expanded the node, but
this image shows the
characteristic involvement
of blood vessel walls

Arteries and veins form the plumbing system that carries

Ed Uthman, MD
blood around the body. Find out more about the circular
journey it takes...
he network of blood vessels in the human (oxygenated) blood is what the body uses for together, like small back-roads connecting

T body must cope with different volumes of

blood travelling at different pressures.
These blood vessels come in a multitude of
energy, and is bright red. After it has been used,
this oxygen-depleted (deoxygenated) blood is
returned for recycling and is actually dark red (not
motorways to dual carriageways.
Arteries and veins are constructed differently
to cope with the varying pressures, but work
different sizes and shapes, from the large, elastic blue, as is often thought). in tandem to ensure that the blood reaches its
aorta down to very tiny, one-cell-thick capillaries. Blood is carried in vessels, of which there are final destination. However, sometimes things
Blood is the ultimate multitasker. It carries two main different types arteries and veins. go wrong, lead to certain medical problems:
oxygen for various tissues to use, nutrients to Arteries carry blood away from the heart and deal varicose veins from failing valves; deep vein
provide energy, removes waste products and even with high pressures, and so have strong elastic thrombosis from blood clots blocking the deep
helps you warm up or cool down. It also carries walls. Veins