General Comments: Question paper will have two parts, Part-A (General
aptitude & General Biotechnology) and Part-B (General plus specialized branches
in Biotechnology). Part-A will have all compulsory 50 MCQ questions in General
science, Mathematics, Chemistry, General aptitude, analytical, quantitative ability,
general biotechnology etc. There will be 150 questions in Part B, out of which only
50 questions need to be answered. Questions in Part B will also include general
biotechnology in addition to the specialized areas listed below.
Aptitude:
Questions may include Comprehension based, where a written paragraph is given for
the students to read and then questions based on that paragraph is asked. They may
be designed to test non-verbal reasoning capacity (e.g., by finding the odd one out in a
series of abstract pictures), they may also be of quantitative type; designed to test the
students ability to comprehend large numbers and do simple calculations.
General Biotechnology
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g) Chemical kinetics: Concepts of order and molecularity of a chemical reaction.
Derivation of first and second order rate equation, measurement of rate
constants. Concept of activation energy.
h) Enzymology: Introduction to enzymes. Types of enzymatic reaction mechanisms,
Michaelis-Menten kinetics. Competitive, Non-competitive and Un-competitive
inhibition. Bi-substrate reaction kinetics. Allostery.
2) Methods in Biotechnology
a) Concepts of precision and accuracy in experimental measurements. Concept of
signal to noise ratio.
b) Biostatistics: Measures of Central Tendency. Fundamental ideas of probability
and probability distributions: Binomial, Poisson and Gaussian distributions.
Concept of the Central Limit Theorem. Hypothesis testing: Use of Students t and
2 tests. Correlation and regression. Basic concepts of design of Experiments.
c) Biochemical Methods: Chromatography: Ion exchange, Gel Filtration and Affinity
chromatography. Electrophoresis: Native and SDS-PAGE. Isoelectric focusing.
2D-PAGE and its applications.
d) UV/Vis spectrophotometry. Beer-Lamberts law and its use in determination of
protein/ nucleic acid concentration.
e) Fluorescence Spectroscopy: Basic concepts of excitation and emission.
Quenching, Stern-Volmer Plots. Theory and applications of FRET and
fluorescence lifetime measurements.
f) Fundamentals of CD, IR and Raman spectroscopy and their use in the study of
biomolecular conformation.
g) Centrifugation: Basic concepts of centrifugation. Calculation of g value from
RPM. Density gradient centrifugation. Sedimentation velocity and Sedimentation
equilibrium. Separation of sub-cellular components and macromolecules using
high speed and ultracentrifugation.
h) Microscopy: Bright field, phase contrast, fluorescence, confocal, and electron
microscopy.
i) Fundamentals of X-ray, NMR and cryo-electron microscopy for determination of
biomolecular structure.
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b) Structural organization and functions of cell organelles: nucleus, mitochondria,
Golgi bodies, endoplasmic reticulum, lysosomes, Chloroplast, peroxisomes,
vacuoles. Cytoskeletons structure and motility function.
c) Organization of genomes: genes and chromosomes, Operon, unique and
repetitive DNA, interrupted genes, gene families, structure of chromatin and
chromosomes, heterochromatin, euchromatin, transposons.
d) Cell division and cell cycle: Mitosis and meiosis, their regulation, Cell cycle and
its regulation, Apoptosis, Necrosis and Autophagy.
e) Cell transformation and cancer, oncogenes and proto-oncogenes, tumor
suppressor genes, metastasis. Therapeutic interventions of uncontrolled cell
growth.
4) Cellular processes
f) Cell signaling: Hormones and their receptors, cell surface receptor, signaling through
G-protein coupled receptors, signal transduction pathways, second messengers,
regulation of signaling pathways, bacterial and plant two-component systems, light
signaling in plants, bacterial chemotaxis and quorum sensing.
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g) Cellular communication: General principles of cell communication, cell adhesion and
roles of different adhesion molecules, tight junctions, communicating junctions,
extracellular matrix, integrins, neurotransmission and its regulation. Regulation of
hematopoiesis, differentiation and development.
h) Innate and adaptive immune system: Cells and molecules involved in innate and
adaptive immunity, antigens, antigenicity and immunogenicity. B and T cell epitopes,
structure and function of antibody molecules. generation of antibody diversity,
monoclonal antibodies, antibody engineering, antigen-antibody interactions, MHC
molecules, antigen processing and presentation, activation and differentiation of B and
T cells, B and T cell receptors, humoral and cell-mediated immune responses, primary
and secondary immune modulation, the complement system, Toll-like receptors, cell-
mediated effector functions, inflammation, hypersensitivity and autoimmunity, immune
response during bacterial (tuberculosis), parasitic (malaria) and viral (HIV) infections,
congenital and acquired immunodeficiencies, vaccines.
b) Isolation and purification of DNA (genomic and plasmid) and RNA. Various methods
of separation, characterization of nucleic acids including Southern and Northern
hybridizations.
c) Generation of genomic and cDNA libraries. Plasmid, phage, cosmid, BAC and YAC
vectors. In vitro mutagenesis and deletion techniques, gene knock out in bacterial and
eukaryotic organisms.
d) Isolation and amplification of specific nucleic acid sequences, PCR, RT PCR and
qRT PCR
f) Methods for analysis of gene expression at RNA and protein level, large scale
expression, such as micro array based techniques.
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a) Chromosomal inheritance: Principles of Mendelian inheritance, codominance,
incomplete dominance, gene interactions, pleiotropy, genomic imprinting, linkage and
cross-over, sex-linked inheritance, Population Genetics and Hardy-Weinberg
equilibrium.
d) Genetic analysis: Linkage maps, mapping with molecular markers, tetrad analysis,
gene transfer in bacteria: transformation, conjugation, transduction, sex-duction, fine
structure analysis of gene.
f) DNA finger printing and its applications, DNA bar coding, marker assisted selection
and QTL mapping.
c) DNA Microarray technology: Basic principles and design: cDNA and oligonucleotide
arrays; Applications: Global gene expression analysis, Comparative transcriptomics,
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Differential gene expression; Genotyping/SNP detection; Detection technology;
Computational analysis of microarray data.
a) Types of IP: Patents, Trademarks, Copyright & Related Rights, Industrial Design,
Traditional Knowledge, Geographical Indications, Protection of New GMOs;
International framework for the protection of IP. IP as a factor in R&D; IPs of relevance
to Biotechnology and few Case Studies; Introduction to History of GATT, WTO, WIPO
and TRIPS
c) Types of patents; Indian Patent Act 1970; Recent Amendments; Filing of a patent
application; Precautions before patenting-disclosure/non-disclosure; WIPO Treaties;
Budapest Treaty; PCT and Implications; Role of a Country Patent Office; Procedure for
filing a PCT application
d) Patent application- forms and guidelines, fee structure, time frames; Types of patent
applications: provisional and complete specifications; PCT and convention patent
applications; International patenting-requirement, procedures and costs; Financial
assistance for patenting-introduction to existing schemes; Publication of patents-gazette
of India, status in Europe and US Patenting by research students, lecturers and
scientists-University/organizational rules in India and abroad, credit sharing by workers,
financial incentives, Patent infringement- meaning, scope, litigation, case studies and
examples.
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Risk Assessment; Risk management and communication; Overview of National
Regulations and relevant International Agreements including Cartagena Protocol.
Agricultural Biotechnology:
1. Plant Biology, physiology, molecular biology and seed technology
a) Plant cell structure and function, phloem transport, plant storage proteins and
protein biosynthesis, natural pesticides. Concept of plasticity in plant
development; Analyzing plant growth; Seed Germination and Seedling Growth;
Tropisms.
b) Hormonal control of seed germination and seedling growth. Floral Induction and
Development; Photoperiodism and its significance; Vernalization and hormonal
control; Inflorescence and floral determination; Molecular genetics of floral
development and floral organ differentiation
c) Photosynthesis - Light harvesting complexes; mechanisms of electron transport;
C3, C4 and CAM pathways. Respiration and photorespiration Citric acid cycle;
plant mitochondrial electron transport and ATP synthesis; alternate oxidase;
photorespiratory pathway, Carbon Assimilation
d) Nitrogen Fixation and regulation, Role of lectins; Nod factors; nif genes;
Nitrogenases; Leghaemoglobin, Nodulins; Nitrogen metabolism - Nitrate and
ammonium assimilation; amino acid biosynthesis.
e) Biosynthesis of secondary metabolites. Hormonal and environmental control of
senescence; PCD in the life cycle of plants. Biosynthesis and structure and
molecular mechanisms of plant hormones. Signal Transduction Basic concepts;
Phospholipid and Ca2+-calmodulin cascade; MAP kinase cascade.
f) Light Control of Plant Development: Molecular mechanisms of light perception,
signal transduction and gene regulation; Biological clocks. Structure, function and
mechanisms of action of phytochromes, cryptochromes and phototropins;
stomatal movement.
g) Solute transport and photoassimilate translocation uptake, transport and
translocation of water, ions, solutes and macromolecules from soil.
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h) Plant microbe interaction: Molecular biology of Agrobacterium Infection,
Molecular biology of Rhizobium infection (molecular mechanisms in symbiosis).
Arabidopsis in molecular biology, Forward and Reverse Genetic Approaches,
RNA interference, Transcriptional gene silencing, Gene traps/ T-DNA and
transposable element insertion / activation lines.
i) Seed science and technology: seed processing, seed treatments, Seed storage,
Seed sanitation and certification.
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d) Development of ESTs. Molecular markers for plant genotyping and germplasm
analysis; Fidelity analysis; settling IPR issues.
e) Marker Assisted Breeding for various traits, Foreground and background selection,
gene introgression and pyramiding, Non-gel based techniques for plant genotyping.
f) Genome organization, Structural and Functional genomics, Proteomics,
Metabolomics, Nutrigenomics, interactomics, Metagenomics.
5. Biodiversity
a) Biodiversity Act 2002; Agricultural biodiversity; International Treaty on Plant Genetic
Resources for Food and Agriculture (PGRFA); Conservation strategies for seed
gene bank; Climate change and conservation of plant genetic resources; Global
efforts for management of crop genetic resources; Strategies on PVFR and
Biodiversity Acts.
b) Biodiversity Legislation in India; Indian Biodiversity Act and provisions on crop
genetic resources.
c) Impact of GE crops on Biodiversity. Functions of International union for the
protection of new varieties of plants (UPOV); International treaties relating to
Biodiversity.
Animal Biotechnology:
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3. Animal Parasitology: Host parasite interactions, transmission of parasites, parasite
specificity, tissue reaction, protozoa and their development. Parasitic infections of
domestic animals.
4. Animal Virology: DNA and RNA viruses causing diseases in livestock and poultry.
Immunity to viral infections. Development of laboratory animal models of virus
infections.
7. Animal Genetics: Animal breeding, out breeding and inbreeding, open nucleus
breeding systems. Conservation of germplasm, breeding of laboratory animals, genetic
health monitoring. Concept of production of specific pathogen free (SPF) and germ free
laboratory animals. Development of various chimeras.
2. Engineering Principles: Material and energy balance, Steady state energy and
material balance, Properties of substances, Introduction to transport phenomena,
momentum transfer, heat and mass transfer, Introduction to mass transfer equipments
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3.Thermodynamics in Biological Systems: First and second law of thermodynamics,
Biological systems as open non-equilibrium systems, Failure of classical
thermodynamics in describing biological processes, Concepts of thermodynamics flux
and force, Concept of entropy production, Constitutive equations, Thermodynamics of
coupled biochemical reactions, Thermodynamic analysis of oxidative phosphorylation,
Glycolytic oscillations; biological clocks
6. Bioprocess Plant Design: General design information, Material and energy balance,
Process flow sheet, Scale up and scale down issues, Scale up and downstream
processes. Selection and specifications of bioprocess equipments, Facility design
aspects. Utilities, Process economics,
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organization of protein structure like CATH,SCOP, FSSP .
7. DNA & RNA secondary and tertiary structures, t-RNA tertiary structure
8. Classification and comparison of protein 3D structures: Secondary structure
prediction: Algorithms viz. Chou Fasman, GOR methods, Tertiary Structure
prediction: Fundamentals of the methods for 3D structure prediction (sequence
similarity/identity of target proteins of known structure, fundamental principles of
protein folding etc.) Homology/comparative Modeling, fold recognition, threading
approaches, and ab initio structure prediction methods. CASP. Computational
design of Promoters, Proteins & Enzymes.
9. Application in drug design: Chemical databases like NCI /PUBCHEM.
Fundamentals of Receptor-ligand interactions. Structure-based drug design:
Identification and Analysis of Binding sites and virtual screening. Ligand based drug
design: Structure Activity Relationship QSARs & Pharmacophore etc. In silico
predictions of drug activity and ADMET.
Environmental Biotechnology
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9. Environment friendly technologies: Biosurfactants, biofertilizers,biopesticides,
microbially enhanced oil recovery, resource management, integrated waste
management; production of biomass, biogas and biofuel from waste.
11. Global environmental problems: Ozone depletion, UV-B and green house gases
Marine Biotechnology
5. Types of marine microbes and their biology: Structure of Bacteria, fungi, algae,
protozoa and viruses; Classification of microbes (Genetic level) conventional and
modern methods. Biology of microorganisms used in genetic engineering
(Escherichia coil, Agrobacterium tumefaciens, Saccharomyces cerevisiae, phage
lambda).
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7. Role of microbes in marine environment: Microbial nitrogen fixation; Carbon,
nitrogen and phosphorus cycle; Decomposition of organic matter; Bioleaching and
biodeteroriation of natural and synthetic materials.
13. Disease diagnosis: Tools for disease diagnosis in cultivable organisms; Enzyme
immunoassays; Dot immunobinding assay; Western blotting; Latex agglutination
test; Monoclonal antibodies; DNA based diagnosis; Cryopreservation.
15. Pollution & Biomaterial interaction: Marine pollution-major pollutants (heavy metal,
pesticide, oil, thermal, radioactive, plastics, litter and microbial); Biological indicators
(Marine microbes, algae and crustaceans) and accumulators: Application of protein
biomarkers; Biosensors and biochips. Biodegradation and Bioremediation;
Biodegradation of natural and synthetic waste materials; Bioremediation;
Separation, purification and bio removal of pollutants.
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16. Fouling and corrosion: Biofouling; Biofilm formation; Marine fouling and boring
organisms - their biology, adaptation; Factors influencing the settlement of
macrofoulers; Antifouling and Anti boring treatments; Corrosion process and control
of marine structures.
Medical Biotechnology
1. Vaccinology: Active and passive immunization; Live, killed, attenuated, sub unit
vaccines; Vaccine technology- Role and properties of adjuvants, recombinant DNA
and protein based vaccines, plant-based vaccines, reverse vaccinology; Peptide
vaccines, conjugate vaccines; Antibody genes and antibody engineering- chimeric
and hybrid monoclonal antibodies; Catalytic antibodies and generation of
immunoglobulin gene libraries. Rational vaccine design based on clinical
requirements: Hypersensitivity, Immunity to Infection, Autoimmunity,
Transplantation, Tumor immunology, immunodeficiency; Transfusion of immuno-
competent cells, Stem cell therapy; Cell based vaccines.
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5. Genetics of Neurogenetic disorders: Charcot-Marie tooth syndrome, Spino-
muscular atrophy, Alzheimers disease & Syndromes due to triplet nucleotide
expansion, Genetic basis of muscle disorders: Dystrophies (Duchenne Muscular
dystrophy and Becker Muscular Dystrophy), Myotonians & Myopathies; Genetic
disorders of Haemopoitic systems: Overview of hematopoisis, Blood cell types and
haemoglobin, Sickle cell anemia, Thalassemias & Hemophilias.
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12. Infections of the Nervous System: Viral encephalitis and Aseptic meningitis; Rabies;
Cysticercosis and other CNS parasitic infections; Tetanus.
13. Sexually Transmitted Diseases and Congenital Infections: Herpes Simplex virus
infections; HIV infection and AIDS; Chlamydial infection; Syphilis; Mycoplasma and
Ureaplasma infection; Gonorrhea and other bacterial STD; Congenital viral
infections; Toxoplasmosis.
15. DNA based diagnosis: Biochemical disorders; Immune, Genetic and Neurological
disorders; Molecular techniques for analysis of these disorders; Assays for the
Diagnosis of inherited diseases; DNA sequencing and diagnosis; PCR and Array
based techniques in diagnosis; Single nucleotide polymorphism and disease
association; Two dimensional gene scanning.
17. Proteomics based diagnosis: Protein profiling for disease diagnosis ; 2D analysis of
isolated proteins associated with disease by sequencing individual spots by Mass
Spectrometry; Protein Micro array; Present methods for diagnosis of Specific
diseases like Tuberculosis, Malaria and AIDS.
18. Gene therapy: Intracellular barriers to gene delivery; Overview of inherited and
acquired diseases for gene therapy; Retro- and adeno- virus mediated gene
transfer; Liposome and nanoparticles mediated gene delivery.
19. Cellular therapy: Stem cells: definition, properties and potency of stem cells;
Sources: embryonic and adult stem cells; Concept of tissue engineering; Role of
scaffolds; Role of growth factors; Role of adult and embryonic stem cells; Clinical
applications; Ethical issues.
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22. Gene silencing technology: Antisense therapy; siRNA; Tissue and organ
transplantation; Transgenics and their uses; Cloning; Ethical issues.
23. Human disease genes: DNA polymorphism including those involved in disease;
Hemoglobin and anemia; Phenylketonuria (monogenic) and diabetes (multigenic)
genetic disorders; disease gene vs. susceptibility gene; SNP detection:
hybridization based assays (allele specific probes); Polymerization based assays
(allele specific nucleotide incorporation, allele-specific PCR); Ligation based assays
(allele specific oligonucleotide ligation); Polymorphism detection without sequence
information: SSCP; Proteomics and drug discovery; High throughput screening for
drug discovery; Identification of drug targets; Pharmacogenomics and
pharamacogenetics and drug development; Toxicogenomics; Metagenomics.
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Tumour specific markers
Cancer and environment: physical, chemical and biological carcinogens
Concept and theories of evolution: Microevolution in Mendelian population, Mendelian
Population, Allele frequencies and genotype frequencies, Hardy-Weinberg equilibrium
and conditions for its maintenance.
Elemental forces of evolution: Mutation, Selection (Types of selection, selection
coefficient, selection in natural populations), Genetic drift, Migration.
Molecular population genetics: Molecular evolution (neutral theory, punctuated
equilibrium), DNA-based phylogenetic trees, Human phylogeny (Hominid evolution:
(Anatomical, Geographical, Cultural), Molecular phylogenetics of Homo sapiens,
Peopling of continents (Europe, Africa, Asia)
4. Human Genome:
The Genome project: History, organization and goals of human genome project,
Mapping strategies, current status of various maps, DNA segment nomenclature,
Human genome diversity, human genome databases.
Organization of human genome: Mitochondrial genome, Gross base composition of
nuclear genome, Gene density. CpG islands, RNA-encoding genes, Functionally
identical/similar genes, Diversity in size and organization of genes, Annotation
Gene families: Multigene families Classical gene families, families with large
conserved domains, families with small conserved domains, Gene superfamilies, Gene
families in clusters, Pseudogenes, Repetitive DNA and transposable elements, Origin of
gene families
Functional genomics: Transcriptome and its analysis, Proteome and Proteomics, Gene
silencing
Implications of human genome on research and society.
Neuroscience
2. Glial cells: Structure and function of glial cells: astrocytes type I & II astrocytes,
fibrous and protoplasmic astrocytes, Importance of astrocytes in glutamate
metabolism and blood brain barrier, Functions of other glial cells: oligodendrocyte
and microglial cells, Microglial phenotypes, Overview of glial and neuronal
relationship in the CNS, Glial neuronal interplay in the CNS.
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Rotarod; grip strength meter; Pain sensitivity testing with the help of tail-flick
instrument and paw test.
5. Patterning, polarity and regionalization of the nervous system; Fate mapping of cell
determination, differentiation of nerve cells and cell lineage, acquisition of
neurotransmitter property and electrical excitability.
6. Birth and migration of neurons, Control of neuronal and glial cell population;
Histogenesis of cerebral cortex and cerebellar cortex. Adult neurogenesis.
8. Neurotrophic factors: Nerve growth factor (NGF). Axon growth, path finding and
nerve patterns: Growth Cone, Axonal navigation and axon elongation, Synapse
formation and elimination: Selective synaptic connections: Skeletal muscle,
autonomic ganglia, spinal cord and CNS. Denervation and regeneration of synaptic
connections.
11. Synaptic transmission and cellular signaling: Synthesis, action and distribution of
acetylcholine, catecholamine, dopamine, serotonin, and neuropeptide
neurotransmitters.
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12. Sensation and perception: Receptors, Structure, function & connections of sensory
cortex; Sensory Transduction: Phototransduction, olfactory transduction, taste,
mechanoreception; Somatic sensation: Peripheral and central mechanisms
Touch: somatic sensory system, mechanoreceptors and other receptors,
representation of body surfaces in the brain. Pain: Nociceptors, control of pain,
opioid peptides and pain. Taste: Taste receptors and taste buds, Innervation by
cranial nerves, Modulation of taste activity in the Medulla. Olfaction: Odor stimuli,
Information processing in the dendrodendritic synapses in Accessory Olfactory
Bulb.
13. Fundamentals of Motor Systems: Spinal cord as central pattern generator; Posture
and voluntary movement, Basal nuclei and cerebellum; Focusing and coordinating
movement. Muscle, Motor neurons and Motor neuron pools: Motor neuron pools,
Muscle afferents. Spinal Motor control, Reflexes and locomotion: Basic Principles,
Reflexes, Interneurons associated with movements, Locomotion
Supraspinal Descending Control: Postural reflexes of the head and the body,
vestibular damage & disorders of the postural control. Voluntary Descending
Control: Control of voluntary movements by the motor cortex. Eye Movements:
Gaze-stabilization mechanisms, Gaze-shifting Mechanisms.
14. Chemical Control of Brain and Behavior: Role of hypothalamus, pituitary hormones
and ANS
15. Neural Control of the Breathing: Breathing & gas exchange, CNS & Breathing,
Respiratory Rhythm Generation, Sensory Inputs and Altered Breathing, Modulation
of Respiratory Motor Out-put, Suprapontine Structures and Breathing, Respiratory
neurons and their discharge pattern.
16. Neural Control of Heart, Cardiovascular Homeostasis: The Nervous System and the
Long-term control of the Cardiovascular System.
17. Sleep and Dreaming: The two states of sleep- slow wave and rapid eye movement.
Circadian Timing: Pineal and Circadian Rhythms, The Suprachiasmatic Nucleus,
Light as the Dominant Stimulus. Sex and behavior: Neuronal basis of sexual
behaviour, Sex Hormones and Brain.
18. Cognitive development and aging; Neuronal basis of object recognition; Spatial
cognition; Neural system of spatial cognition: Parietal cortex, Frontal cortex,
Hippocampus and adjacent cortex. Learning and Memory: Basic Systems; Long-
term potentiation, Classical conditioning in vertebrates, Mechanism of memory
storage. Major memory systems in mammalian brain; Executive brain functions;
Consciousness.
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19. Clinical neurochemistry and neuropathology: Molecular, genetic aspects and
diagnostic characteristics; Neurochemical and molecular mechanisms of peripheral
Neuropathy; Multiple sclerosis and other demyelinated disorders; Duchenne
Muscular dystrophy, Wernicke-Korsakoft syndrome; Pellagra; Metabolic
Encephalopathies and Coma, Ischemia and hypoxia; Epileptic seizures; Genetics
and diagnosis of Huntington disease and other triplet repeat disorders; Alzheimers
disease, Parkinsons disease, Motor Neuron Diseases; Prions Disease;
Biochemical aspects of the psychotic disorders; Biochemical basis of mental illness:
Anxiety disorders; Mood disorders; Attention disorders; Schizophrenia
Pharmaceutical Biotechnology
3. Enzymes and microbial technology: Enzymes in organic solvents and ionic liquids,
biocatalysts, enzyme engineering, random and rational approach to protein
engineering, Biocatalysis with different enzymes: lipase, amidase, aminopeptidase,
acylase, hydantoinase, lyases, oxidoreductase, nitrilase, epoxide hydrolase,
hydoxylase, aldolases, decarboxylases; techniques of immobilization of enzymes
and whole cells-design, operation and kinetics of immobilized enzyme reactors-
Diffusional resistance and Thieles modules- multi step immobilized enzyme
systems. Microorganisms in degradation of xenobiotics and removal of heavy
metals; stereo selective production of drug intermediates, biocatalyst for synthesis
of some chiral pharmaceutical intermediates such as synthesis of ACE inhibitors,
synthesis of anti-cholesterol drugs by biocatalytic routes, calcium channel blocking
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drugs, potassium-channel openers, anti-arrythmic compounds, anti-psychotic
compounds, anti-infective drugs, anti-inflammatory drugs, antiviral drugs,
prostagladin synthesis.
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