Anexo

Va Intravascular

A
Tiempo Abs C (g/ml) LnC
(min) Por tener la
0 1.268 48.58237 3.8832608
regresin ms
548
cercana a 1 la
5 1.132 43.37164 3.7698059
grfica log ser la
751
10 1.009 38.65900 3.6547797 que se usara para
383
15 0.935 35.82375 3.5786112
479
20 0.843 32.29885 3.4750316
057
25 0.712 27.27969 3.3061426
349
30 0.608 23.29501 3.1482396
916
35 0.568 21.76245 3.0801861
211
40 0.477 18.27586 2.9055812
207
45 0.449 17.20306 2.8450876
513
55 0.353 13.52490 2.6045327
421
65 0.296 11.34099 2.4284241
617
 Va Intrabascular (log)
5.0

4.0
f(x) = - 0.02x + 3.89
3.0 R = 1
Ln(Concentracin) (g/ml)
2.0

1.0
0 10 20 30 40 50 60 70
Tiempo (min)

Va Intrabascular (lineal)
60

40 f(x) = - 0.59x + 44.47

Concentracin (g/ml) R = 0.95
20

0
0 10 20 30 40 50 60 70
Tiempo (min)

Ke=m=0.0232 min1

b
C p 0 =e =48.87 g /ml

1 ln 2
t2 = =29.87 min
Ke

D
Vd=
C p 0 =409.24 ml

C l t =Ke x Vd=9.49 ml /min

 Cp 0
ABC = =2106.4
Ke

Va Extravascular

B
Tiempo Abs C (g/ml) LnC AUC LnC C Cextr- Ln Cext-
(min) Extrapola extrapolada Cobs Cobs
do
0 0.027 1.034482 0.033901 11.97318 3.0896 21.968288 20.93380 3.041365
759 552 01 9 61 37
5 0.098 3.754789 1.323032 26.72413 3.0541 21.202095 17.44730 2.859185
272 164 79 05 58 24
10 0.181 6.934865 1.936561 49.13793 3.0186 20.462623 13.52775 2.604743
9 717 1 95 8 73
15 0.332 12.72030 2.543199 67.14559 2.9831 19.748943 7.028637 1.949992
651 655 39 57 06 81
20 0.369 14.13793 2.648861 71.93486 2.9476 19.060154 4.922223 1.593760
103 33 59 42 39 34
25 0.382 14.63601 2.683485 77.01149 2.9121 18.395388 3.759373 1.324252
533 294 43 35 02 19
30 0.422 16.16858 2.78307 83.42911 2.8766 17.753807 1.585225 0.460726
238 88 5 13 43
35 0.449 17.20306 2.845087 84.77011 2.8551 17.376174 0.173109 -
513 573 49 74 6 1.753830
34
40 0.436 16.70498 2.815706 81.80076
084 929 63
45 0.418 16.01532 2.773546 152.2988
567 118 51
55 0.377 14.44444 2.670309 142.7203
444 873 07
65 0.368 14.09961 2.646147 -
686 624 458.2375
48
 Extravascular (eliminacin)
2.9

2.8
f(x) = - 0.01x + 3.09
2.7 R = 0.94
LnC
2.6

2.5
0 10 20 30 40 50 60 70
Tiempoo (min)

Ke=m=0.0071 min1

b
I =A= =e =21.96 g/ml

ln 2
t 12 Ke= =97.62 min
Ke

( t 2t 1 )(c 1+ c 2)
AUC = =848.94
2

Extravascular (abs)
4
f(x) = - 0.12x + 3.58
2 R = 0.85
Ln Cext-Cobs
0
0 5 10 15 20 25 30 35 40
-2
Tiempo (min)
 1
Ka=m=0.1185 min

b
I =B==e =35.98 g /ml

ln 2
t 12 Ka= =5.84 min
Ka

Tmax ( grafica )=35 min

Cmax ( grafica ) =17.20 g /ml

3943.066 Trapezoide+cpo / Ke
AUC total 36
F 1.87
1039.46
Vd ml
Cl 7.38

T mx
(calculada) 59.25
C mx
(calculada) 23.59

Ka
ln ( )
T mx = Ke C mx= I ( e
Ket Kat
- e )
KaKe