Unit 2: Nervous System Physiology

Lecture 6: Peripheral Nervous System

Learning Objectives:

1. Describe the components and effectors of the peripheral

nervous system.
2. Contrast the stimulated response of the different branches of the
peripheral nervous system.
3. Describe the role of the peripheral nervous system on the
micturition reflex.

1
 Unit 2: Nervous System Physiology
Lecture 6: Peripheral Nervous System
Learning Objectives:

1. Describe the components and effectors of the peripheral

nervous system.
2. Contrast the stimulated response of the different branches of the
peripheral nervous system.
3. Describe the role of the peripheral nervous system on the
micturition reflex.

2
1) Nervous System

3
1) Peripheral Nervous System

4
1) Somatic Nervous System

5
1) Neuromuscular Junction

6
1) Somatic Nervous System
somatic motor neuron
motor neuron

N1
NM

7
1) Amytrophic Lateral Sclerosis

8
1) Peripheral Nervous System

9
1) Parasympathetic Nervous System

N2
NN

REST and DIGEST

Cardiovascular Decrease HR
Respiratory Decrease RR
Renal Stimulate micturition
Gastrointestinal Stimulate digestion/defecation

10
1) Muscarinic Receptors

11
1) Sympathetic Nervous System

M3
FIGHT or FLIGHT
Cardiovascular Increase HR
Respiratory Increase RR
Renal Inhibit micturition
Gastrointestinal Inhibit digestion/defecation

12
1) Adrenergic Receptors

13
1) Sympathetic Nervous System

M3
FIGHT or FLIGHT
Cardiovascular Increase HR
Respiratory Increase RR
Renal Inhibit micturition
Gastrointestinal Inhibit digestion/defecation

14
1) Muscarinic Receptors

15
1) Sympathetic Nervous System

N2
NN

FIGHT or FLIGHT
Cardiovascular Increase HR
Respiratory Increase RR
Renal Inhibit micturition
Gastrointestinal Inhibit digestion/defecation

16
1) Innervation by ANS

17
1) Varicosities

18
1) Varicosities

19
 Unit 2: Nervous System Physiology
Lecture 6: Peripheral Nervous System
Learning Objectives:

1. Describe the components and effectors of the peripheral

nervous system.
2. Contrast the stimulated response of the different branches of the
peripheral nervous system.
3. Describe the role of the peripheral nervous system on the
micturition reflex.

20
2) Innervation by Sympathetic NS

Effector Organ Receptor Response

heart 1 increase heart rate
vasculature 1 vasoconstriction (contraction)
bronchioles 2 bronchodilation (relaxation)
eye 1 pupillary dilation (radial muscle contraction)
GI tract 2 decrease motility (relaxation)
1 sphincter contraction
2 salivary secretion thick, low volume
sweat M3 increased sweating
bladder 2 detrusor muscle relaxation
1 internal urethral sphincter contraction

21
2) Innervation by Parasympathetic NS

Effector Organ Receptor Response

heart M2 decrease heart rate

vasculature minimal effect
bronchioles M3 bronchoconstriction (contraction)
eye M3 pupillary constriction (circular muscle contraction)
GI tract increase motility (contraction)
M3 sphincter relaxation
salivary secretion thin, high volume
sweat no effect
bladder detrusor muscle contraction
M3
internal urethral sphincter relaxation

22
 Review Question
1. Which adrenergic receptor produces its stimulatory
effects by the formation of inositol 1,4,5-triphosphate (IP3)
and an increase in intracellular [Ca2+]?

a. 1 receptors
b. 2 receptors
c. 1 receptors
d. 2 receptors
e. Muscarinic receptors
f. Nicotinic receptors

23
 Review Question
2. Which autonomic receptor mediates secretion of
epinephrine by the adrenal medulla?

a. Adrenergic receptors
b. Adrenergic 1 receptors
c. Adrenergic 2 receptors
d. Cholinergic muscarinic receptors
e. Cholinergic nicotinic receptors

24
 Review Question
3. Which autonomic receptor mediates an increase in heart
rate?

a. Adrenergic receptors
b. Adrenergic 1 receptors
c. Adrenergic 2 receptors
d. Cholinergic muscarinic receptors
e. Cholinergic nicotinic receptors

25
 Review Question
4. Administration of which of the following drugs is
contraindicated in a 10-year-old child with a history of
asthma?

a. Albuterol (adrenergic 2 receptor agonist)

b. Epinephrine
c. Isoproterenol (adrenergic 1/2 receptor agonist)
d. Norepinephrine
e. Propranolol (non-selective blocker)

26
 Answers
1. Answer: A
Explanation: The answer cannot be E because only M3 type muscarinic
receptors activate phospholipase C, not M2. So choice E is not
completely correct. See slides 27 and 28.

2. Answer: E
Explanation: Nicotinic N2 type receptors are found on the cells of the
adrenal medulla. See slide 29.

3. Answer: B
Explanation: See slide 32

4. Answer: E
Explanation: If you block Beta adrenergic receptors, you will prevent
bronchodilation from occurring.

27
 Unit 2: Nervous System Physiology
Lecture 6: Peripheral Nervous System
Learning Objectives:

1. Describe the components and effectors of the peripheral

nervous system.
2. Contrast the stimulated response of the different branches of the
peripheral nervous system.
3. Describe the role of the peripheral nervous system on the
micturition reflex.

28
3) Urinary System

29
3) Urinary Bladder

30
3) Urinary Bladder

31
3) Bladder Filling vs. Voiding

32
 3) Sympathetic Innervation
Detrusor Muscle (2) and Internal Urethral Sphincter (1)
Active during filling Relax DM, Contract IUS
*Storage = Sympathetic

hypogastric nerve
detrusor muscle

Internal
urethral
sphincter
external
urethral
sphincter
33
3) Parasympathetic Innervation
Detrusor Muscle (M3) and Internal Urethral Sphincter (M3)
Active during voiding/micturition Contract DM, Relax IUS
*Peeing = Parasympathetic

detrusor muscle

pelvic nerve Internal

urethral
sphincter
external
urethral
sphincter
34
3) Somatic Innervation
External Urethral Sphincter (N1/NM)
Active during filling Contract EUS

detrusor muscle

internal
urethral
sphincter
external
somatic urethral
sphincter
35
3) Neural Innervation

Muscle Muscle
Filling Micturition
Name Type
Sympathetic NS
Detrusor Smooth Parasympathetic NS M3
2
Muscle Muscle Contraction
Relaxation
Internal Sympathetic NS
Smooth Parasympathetic NS M3
Urethral 1
Muscle Relaxation
Sphincter Contraction
External
Skeletal Somatic NS
Urethral Somatic NS inhibited
Muscle Contraction
Sphincter

36
37
38
3) Voluntary Control

39
3) Spinal Cord Injury

40