Spring 2017
MWF 9:00 am 9:50 am
Spring 2017
MWF 9:00 am 9:50 am
Option 1: Option 2:
5th Edition 6th Edition
Laboratory
~27% of total grade
~ 3 hrs/week
Lecture
~73% of total grade
~ 2.5hrs/week
Unit IV: Cell Communication, Motility, and Life Beyond the Cell
Cell Communication
Cytoskeleton
Cell Junctions, Adhesion and the Extracellular Matrix
Cancer (part 1-2)
Cell Cycle Online Module Quizzes
Cancer (part 3)
FINAL EXAM: 5/17/17
Cummulative Lecture Exam Material
Todays Lecture Topics:
Structure
Anabolism Catabolism
Information
Energy input Energy output
Storage Communication
Processing
Propagation
I
Organism
YOU!
I
Organ systems are actually interconnected via a myriad
of cell communication processes
I
All diseases are disturbances at the cellular level.
- Rudolph Virchow, (1821-1902)
Father of pathology
AGING
Cellular processes form the molecular basis of human health and disease.
Todays Questions/Objectives
If..
More than 10 million
species Cell Theory states:
Common Threads? Cells are the
Growth and functional units of
reproduction life
Communication with All living
the environment
organisms are
Acquisition and
composed of cells
assimilation of energy
Homeostasis Then.
Each of these
common threads
occurs at the cellular
level
II
8 Common Features of All Cells
Figure 1-30 Molecular Biology of the Cell, Fifth Edition ( Garland Science 2008)
II Feature # 1 (cont)
Cells are constructed from a
hierarchy of molecular organization
II
Feature #2: Cells possess a
genetic program
Seaweed?
Sea urchin?
Mouse?
II Feature # 2 (cont)
Figure 1-1 Molecular Biology of the Cell, Fifth Edition ( Garland Science 2008)
Figure 1-2 Molecular Biology of the Cell, Fifth Edition ( Garland Science 2008)
Figure 1-5 Molecular Biology of the Cell, Fifth Edition ( Garland Science 2008)
Feature # 2 (cont)
II Proteins carry out the tasks specified by
DNA and are the workhorses of the cell
Central Dogma
Flow of information
Specified
task
Figure 1-4 Molecular Biology of the Cell, Fifth Edition ( Garland Science 2008)
II Feature # 4:
Cells are biochemical factories constantly
acquiring and assimilating energy
Cells must accomplish this in a universe that favors this .
Eukaryotic Cells
10 - 100m in
diameter
Nucleus
Figure 1-18a Molecular Biology of the Cell, Fifth Edition ( Garland Science 2008)
Prokaryotes:
Have relatively small and simplified genomes:
DNA is not enclosed by any membrane
Genome is contained within a single circular DNA molecule
Genome size: 500,000 10 million base pairs
III Prokaryotes: Actually form two separate domains of life:
Bacteria and Archaea
Living Environment
Archaea can survive in
harsher environments (e.g.,
high salt, extreme
temperatures)
Structural
cell wall components
plasma membrane lipids