aminoquinolin species of malaria 50% bound to resistant Parenteral es: Accumulates in plasma Liver damage administration CHLOROQUI the acidic vesicle Slowly Neuro and can cause NE of the parasite excreted in hemato disease hypotension raises vesicular urine *not to be Cardiac PH interfere with administer with depression degradation of mefloquine arrhythmias hemoglobin by ,amiodarone* parasite lysozyme Quinoline- Highly Dizziness methanol: in chloroquine plasma Nausea MEFLOQUIN resistance protein bound Mefloquine Vomiting E Mefloquine and resistant SERIOUS complex damages concentrated Interacts with Ataxia the membrane of in different quinidine causes Anxiety parasite organ. cardiac arrest Hallucinations Erythrocytic primarily schizontocide secreted in bile Cinchona Kills vivax Completely Pregnancy Cinchonism alkaloid: gametes absorbed in causes Diarrhea QUININE oral hemorrhage Flushing Same as Metabolizes In patient with Fever chloroquine certain Falciparum Tachypnea fraction in malaria results liver by hemoglobinuria CYP3A4 and liver damage
Proguanil Cycled in body to metabolized *SAFE IN upset triazine derivative and excreted PREGNANCY* Vomiting inhibits plasmodial in urine Occasional DHFRase stomatitis hematuria Pyrimethami Inhibits Good but Epileptic Rashes ne plasmoidal slow seizures Nausea DHFRase ,doesnt absorption Liver problems occasional need conversion from G.I.T Kidney diseases to cyclic triazine Inadequate folic Schizogony stops acid Decreased bone marrow function
Sulfonamide Schizontocidal Readily In pregnancy Abdominal pain
pyrimethamin Have effect In absorbed In G6-PD GI upset e primary as well as after oral deficiency Weakness secondary tissue ingestion condition TOXIC Combination: phase of malarial POTENTIAL: PRIMAQUIN parasite Dose related E Highly active hemolysis against Methaemoglobi gametocyte and naemia hypnozoites Artemisinin Endoperoxide Prodrugs Antiarrhythmic Nausea derivatives: bridge interacts drugs, Vomiting ARTESUNAT with haeme and antidepressants, Abdominal pain E iron mediated phenothizine Itching cleavage of bridge causes cardiac Drug fever releases a highly conduction reactive species defect of free radical leading to damage to endoplasmic reticulum