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ANTI-ASTHMATIC DRUGS

DRUG MOA INDCN ADR


CNTRIND
Bronchodiltr Activates B2
(SABA) receptor & Asthma Severe Tremor
Salbutamol enzyme adenyl Emphysema bronchospasm
Terbutaline cyclase, Anaphylaxis Tachycardia
Levalbuterol converts ATP Aspirstion Coronary Palpitation
Pirbuterol to artery disease
cAMP leadind Hypokalemia
(LABA) to Aortic stenosis
Salmeterol increased lvl of
formoterol cAMP
bronchodilation

Inhaled Muscarinic Acute Glaucoma Dry mouth


Anticholinergics Receptor asthma
antagonist Urinary Nasal
Ipratropium leading to COPD retention irritation
Tiotropium bronchodilation (chronic
Maintenance) Nose bleeds

Leukotriene Competitively Prophylaxis Headache


Receptor And selectively Chronic Vomiting
Blocks LTD4 None Diarrhea
antagonist treatment
receptor Of asthma
Montelukast Leading to
Zafirlukast bronchodilation

Inhibits PDE
Methylxanthines Increased 2,3 line drug Coronary heart Insomnia
Theophylline cAMP for asthma disease Tremor
Aminophylline And COPD Seizures
Caffeine Inhibits Restlessness
intracellular Neonatal
ca+ apnea Irregular
Relaease leads heartbeat
smooth muscle
contrctn decrse
Inhaled Inhibition of Asthma Oral
corticosteroids mast cell (prophylaxis) candiasis
none
Budesonide degranulation
beclomethasone COPD Dysphonia
inhibition of IL-
4 induced IgE Sore throat
synthesis

Promotes
relaxation via
interfering with
Ca++ influx
into the cell

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