5/16/17

Course Business
Today: Continuing Chapter 25

Exam #2 is Thursday 5/18

Covers Chapters 22-24
Additional practice problems + practice exam posted
Seating chart posted
Molecular models are permitted
Review sessions:
Tu 5/16 4:30-6 pm PAA A118
Wed 5/17 4:30-6 pm Sig 134

Amino Acid Structure

Aliphatic

O O O O O O
H 3N H 3N H 3N H 3N H 3N N
H2
O O O O O O

Gly (G) Ala (A) Val (V) Leu (L) Ile (I) Pro (P)

Acidic Amide
Hydroxyl O O O NH2
O O

OH OH
O NH2

O O O O O O
H 3N H 3N H 3N H 3N H 3N H 3N

O O O O O O

Ser (S) Thr (T) Asp (D) Glu (E) Asn (N) Gln (Q)

Basic
H 2N NH2 Aromatic
NH3
H
NH OH N
HN
NH

O O O O O O
H 3N H 3N H 3N H 3N H 3N H 3N

O O O O O O

Lys (K) Arg (R) His (H) Phe (F) Tyr (Y) Trp (W)

Sulfur-containing
S

SH
Table of structures given for exam
H 3N
O
H 3N
O You will need to understand how these
O

Met (M)
O

Cys (C)
subunits make more complex structures

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How Do Biological Systems Control

Chemical Reactions?
O OR' O

RO O
P P
O SLOW
OR' RO
O O

Glu69
Asp165
O
kinase enzyme
O active site
O O

NH 3 Mg 2+
Lys 52 O Asp147

O O O
O
FAST
P P P
O O O O
O O O H
O
Adenosine
ATP Protein
H 3N Substrate

Lys149

Amino acid side chains and functional groups

positioned to accelerate reaction

25.2: Amino Acid Stereochemistry

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*On exam: you will get a table of amino acid structures see PS #7

Poll Everywhere Lecture 14 Q1

Draw the peptide Asp-Leu-Pro-Gln

A) O B) O
O O
O O O O
H H H H
N N N N
H 3N N O H 3N N O
O O O O

O NH2 O NH2

C) O NH2 D) O NH2

O O O O
H H
N N N N
H 3N N O H 3N N O
H H
O O O O
O O
O O

Respond at Pollev.com/jgzchem
Text JGZCHEM to 22333 to join session

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Poll Everywhere Lecture 14 Q1

Draw the peptide Asp-Leu-Pro-Gln

A) O B) O
O O
O O O O
H H H H
N N N N
H 3N N O H 3N N O
O O O O

O NH2 O NH2

C) O NH2 D) O NH2

O O O O
H H
N N N N
H 3N N O H 3N N O
H H
O O O O
O O
O O

25.3: Acid-Base Behavior of Amino Acids

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Isoelectric Point

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Poll Everywhere Lecture 14 Q2

Which amino acid produces the following pH profile?

O HN
A) B) C) D)
OH NH
O

O O O O
H 3N H 3N H 3N H 3N

O O O O

Label pI on the plot Respond at Pollev.com/jgzchem

Text JGZCHEM to 22333 to join session

Poll Everywhere Lecture 14 Q2

Which amino acid produces the following pH profile?

O HN
A) B) C) D)
OH NH
O

O O O O
H 3N H 3N H 3N H 3N

O O O O

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