Hydrogen-rich water for the Prevention and Treatment of Diabetes

Introduction

Hydrogen (H2) has recently been extensively studied for its therapeutic properties as a
health regulator, anti-oxidant, anti-inflammatory and anti-apoptotic (ie protection
against cell damage) effects. These studies have analysed the benefits of hydrogen in
the prevention and treatment of over 60 diseases including the following:

Diabetes
Cancers
Cardiovascular
Neurodegenerative diseases such as Alzheimers
Organ dysfunction

The UltraStream, invented and designed by AlkaWay in Australia and made in

the USA is the first ever drinking water filter specifically made to produce pure,
contaminant free and hydrogen rich, alkaline water.

Independent scientific tests conducted by AquaSciences LLP show that water

produced by the UltraStream under normal drinking conditions creates 1.1 parts per
million H2; 3 times more molecular Hydrogen than top of the range electronic water
ionizers.

The UltraStream creates hydrogen via a chemical reaction that occurs when water
(H2O) comes in contact with pure magnesium in the filter.

The purpose of this document is to summarise the studies that have been completed in
a user-friendly language and format.

FDA and TGA Disclaimer

These statements have not been evaluated by the Food and Drug Administration in the
USA or the Therapeutic Goods Administration in Australia. This information is not
intended to diagnose, treat, cure or prevent any disease. Please consult your health
care provider for health issues.

Legal Disclaimer
The information provided herein is for informational purposes only and is not meant
to substitute for the advice provided by your own physician or other medical
professional. The results reported may not necessarily occur in all individuals.
AlkaWay is providing this information and makes no representations or warranties of
any kind with respect to its contents. The author of this work will not be liable for
damages arising out of or in connection with inappropriate use of this information.
This is a comprehensive limitation of liability that applies to all damages of any kind,
including (without limitation) compensatory, direct, indirect or consequential
damages, loss of data, income or profit, loss of or damage to property and claims of
third parties.
The link between Hydrogen and Oxidation Reduction Potential (ORP)

One of the characteristics of UltraStream water is that it exhibits a high negative ORP
up to -500 mV without having excessively high pH (which would cause it to taste
bad). ORP is an important concept for water treatment processes. 1

Oxidation occurs when electrons are removed, such as when a free radical steals an
electron from a cell. The cell is oxidized (an increase in its oxidation state); whereas,
the free radical was reduced. Therefore reduction means a receiving or gaining of
electrons (decrease in its oxidation state), such as when an antioxidant donates an
electron to a free radical. The free radical is reduced and the antioxidant is oxidized.
The antioxidant is said to be the reducing agent, it reduced the free radical; whereas,
the free radical is called the oxidizing agent, it oxidized the antioxidant.

The potential is characteristic of the chemical species to undergo an oxidation-

reduction reaction. It is not the actual reaction; rather it is stored energy that has the
ability to do work and is measured in volts; thus, the greater the voltage potential, the
greater the ability and propensity to undergo a redox reaction. The higher the species
positive potential, (i.e. free radical) the greater affinity it has for electrons, and thus a
higher tendency to oxidize (steal electrons) from another species, like a cell
membrane. Conversely the lower the species redox potential (i.e. antioxidants) the
lower its affinity for electrons and thus a higher tendency to be a reducing agent
(neutralize a free radical). A high positive ORP is desired in sewage treatment,
swimming pools and spas, because the higher the ORP the more oxidation will occur,
thus killing the bacteria and unwanted pathogens, by stealing electrons from the
bacterias DNA, cell membranes and proteins. Chlorine is added to water because it
has a high ORP and is thus an effective disinfectant. Oxygen also has an extremely
high ORP and thus also damages DNA and protein.

Conversely hydrogen exhibits a very negative ORP and is thus a reducing agent or
antioxidant.

Therefore with a healthy view point in mind, it makes sense that the optimal drinking
water is one with a negative ORP. Normal tap water, bottled water, rain water, etc. all
have a positive ORP generally between 200-400 mV 2 and even as high as 500-600
mV depending on location.

The World Health Organization (WHO) recommends that the ORP of drinking
water should not exceed 60 mV 3(31). This is compatible with certain human
biological fluids. For example, the oral fluid of a healthy human and mothers
milk both have negative ORP -70 mV. 2
Hydrogen Prevention and Treatment of Diabetes

Have you heard of the Nordenau Phenomenon?

People suffering from a range of degenerative diseases have been travelling to

Nordenau, Germany to drink the so-called healing waters. Clinical trials consisting
of over 2000 diabetic patients have verified that this water can indeed improve
important blood parameters. Furthermore, it has also been revealed that the main
agent responsible for these benefits is hydrogen gas.

"I have had Diabetes type 2 and have been drinking UltraStream water for 6 months
and along with dietary changes and drinking the water my Diabetes is now in
remission" John: Clontarf, Qld

Diabetes Type 2 is characterised by high blood sugar and predisposes the sufferer to
chronic complications affecting the eyes, blood vessels, nerves and kidneys.

Impaired Glucose Tolerance with resultant high blood sugar has an important role in
the development of diabetic complications. It creates the gradual build-up of
Advanced Glycation Endproducts (AGEs) in body tissues which create Reactive
Oxidation Species (free radicals) which in turn cause oxidative stress and the chronic
complications of Diabetes.

One study in Kyoto, Japan4 of patients with Diabetes and also impaired glucose
tolerance (a.k.a pre-diabetic Metabolic Syndrome) found:

With impaired glucose tolerance, intake of hydrogen-rich water normalized

oral glucose tolerance tests. (A glucose tolerance test is a medical test in
which glucose is given orally and blood samples taken afterward to determine
how quickly it is cleared from the blood).
Intake of hydrogen-rich water was also found to significantly decrease levels
of oxidised LDL and oxidative stress within the body.
 Hydrogen-rich water decreased levels of free fatty acids. Free fatty acids
inhibits insulin-stimulated glucose uptake in the blood stream.
Hydrogen-rich water increased levels of a protein in the blood which is
involved in regulating glucose levels
Hydrogen-rich water increased levels of extracellular-superoxide dismutase
which helps the body to convert free radicals to a harmless substance.

Furthermore, other studies have found insulin resistance marks the pathway to alpha
and beta cell dysfunction ultimately leading to chronic Diabetes Type 25. Once
hyperglycaemia becomes apparent, insulin secretion declines, due to -cell
granulation and significant decreases in the amount of pancreatic -cells6. Much of
this can be contributed to oxidative stress7, especially because of the relatively low
expression of antioxidant enzymes in the pancreatic islets8.

In one study researchers using diabetic mice discovered that, not only did hydrogen-
rich water significantly lower blood glucose, ameliorate glucose tolerance and
hyperglycemia in diabetic mice, but also examinations revealed that the water
prevented the loss of -cell mass, which resulted in an increase of insulin secretory
capacity9.

In conclusion, these results suggest that hydrogen-rich water may have a

beneficial role in the prevention and treatment of Diabetes Type 2 and insulin
resistance.

References

1. (Wareham, D G., et al. Real-time control of wastewater treatment systems

using ORP. Instrumentation, Control and Automation of water and wastewater
treatment and transport systems 1993. Vol.28, no. 11-12, pp. 273-282. 1993)
2. V.V. Goncharuk, et al. The use of Redox potential in Water Treatment
Processes. Journal of Water Chemistry and Technology, 2010, vol. 32, No 1,
p.1-9. Allerton Press, Inc,. 2010
3. (S. Okouchi, et al. Water Desirable for the Human Body in Terms of
Oxidation-Reduction Potential (ORP) to pH Relationship. Journal of Food
Science. V.67. Iss. 5, p. 1594-1598. 2002)
4. http://www.ncbi.nlm.nih.gov/pubmed/19083400
5. (Mohammed F. Saad, et al. A two step model for development of non-
insulin dependent diabetes. American Journal of Medicine. V. 90 Iss. 2 p. 229-
235 Feb 1991)
6. (I. swenne. Pancreatic Beta - cell growth and diabetes mellitus review.
Diabetologia V. 35, p. 193-201. 1992)
7. (Marc Y. Donnath, et al. Mechanisms of - cell death in type 2 diabetes.
American diabetes associatioin. V, 54, p. S108-S113. supplement 2, Dec.
2006)
8. (M. Tiedge, et al. Relation between antioxidant enzyme gene expression and
antioxidative defense status on insulin - producing cells. American diabetes
association. V. 46 No. 11, p. 1733-1742. Nov 1997)
9. (Mi - Ja Kim, et al. Preservative effect of electrolyzed reduced water on
pancreatic - cell mass in diabetic db/db mice. Biol. Pharm. Bull. v, 30,Iss. 2,
p. 234-236 2006).