ADRENERGIC RECEPTORS

ALPHA-1 RECEPTORS ALPHA-2 RECEPTORS BETA-1 RECEPTORS BETA-2 RECEPTORS

Vascular smooth muscles of the cuta Sympathetic postganglionic nerve terminals SA node, AV node, ventricular muscle of Vascular smooth muscles of the skeletal
GIT and bladder sphincters Platelets the heart muscle
Radial muscle of the iris Fat cells Bronchial smooth muscle
Walls of the GIT Walls of the GIT and bladder
Gq protein Gi protein Gs protein Gs protein
Stimulation of phospholipase C and Inhibition of adenylate cyclase and Stimulation of adenylate cyclase and Stimulation of adenylate cyclase and
increase in inositol triphosphate and decrease in cAMP increase in cAMP increase in cAMP
intracellular calcium
Produce excitation Produce inhibition Produce excitation Produce relaxation
Contraction Relaxation increased heart rate dilation of vascular smooth muscles
Constriction Dilation increased conduction velocity dilation of bronchioles
increased contractility relaxation of the bladder wall
Equally sensitive to norepinephrine and Sensitive to both norepinephrine and More sensitive to epinephrine than to
epinephrine epinephrine epinephrine
(Only norepinephrine released from More sensitive than alpha-1 receptors More sensitive to epinephrine than the
adrenergic neurons is present in high alpha-1 receptors
concentrations to activate alpha-1 receptors)
Agonist Antagonist Agonist Antagonist Agonist Antagonist Agonist Antagonist
Norepinephrine Phenoxybenzamine Clonidine Yohimbine Norepinephrine Propranolol Isoproterenol Propranolol
Phenylephrine Phentolamine Isoproterenol Metoprolol Albuterol Butoxamine
Prazosin Dobutamine