SYNTHESIS OF PYRAZOLE DERIVATIVES OF

NAPHTHYL

PROPIOPHENONES AS POTENTIAL
CYTOTOXIC AGENTS AND

CHEMICAL INVESTIGATION OF PIPER

ATTENUATUM

GURINDERDEEP SINGH

REGISTRATION NO: 80404446001

B.PHARM

I.S.F. COLLEGE OF PHARMACY

MOGA

THESIS
SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENTS

FOR THE DEGREE OF

MASTER OF PHARMACY IN PHARMACEUTICAL CHEMISTRY

OF THE
 PUNJAB TECHNICAL UNIVERSITY

JALANDHAR

JULY, 2010

DEDICATED

TO MY

BELOVED PARENTS
 CONTENTS
PAGE NUMBER
I. Certificate
II. Acknowledgement
III. Abbreviations

Part-1

Synthesis of pyrazole derivatives of naphthyl propiophenones as potential

cytotoxic agents

1.1
Introduction…………………………………………………………
……….……………1

1.2 Aim of
work…………………………………………………………………
…………...12

1.3 Results and

Discussion…………………………………………………….
……....15

1.4 Experimental Work.

………………………………………………………………….31

Part-2

Chemical investigation of Piper Attenuatum

2.1
Introduction…………………………………………………………
………………..…34
2.2 Review of
literature……………………………………………………………..
..…38

2.3 Aim of
work…………………………………………………………………
……...……49

2.4 Results and

Discussion………………………………………………….…….
……51

2.5
Experimental………………………………………………………
………….….….…53

2.6
Bibliography………………………………………………………
……………….….…58

Part 3

3.1
Abbreviations………………………………………………………
…………..………67

3.2 General
remarks………………………………………………….………….
…….…68

CERTIFICATE

This is to certify that the work reported in the thesis entitled “Synthesis of
pyrazole derivatives of naphthyl propiophenones as potential cytotoxic
agents and Chemical investigation of Piper Attenuatum’’ has been carried out
by Mr. Gurinderdeep Singh himself under our supervision at ISF College of
Pharmacy , Moga,Punjab(India)during the academic session 2009-2010. The
work reported in the thesis has not been submitted for the award of any other
degree.

Supervisor Co-Supervisor

Dr. K. L. Dhar Mr Kunal Nepali

Head of Department Lecturer

Pharmaceutical chemistry ISF College of Pharmacy

ISF College of Pharmacy Moga-142001(INDIA)

Moga-142001(INDIA)

Forwarded by:

Supervisor

Dr. T. R. Bhardwaj Dr. K. L. Dhar

Director, PG Studies Head of Department

ISF College of Pharmacy Pharmaceutical Chemistry

Moga-142001(INDIA) ISF College of Pharmacy

Moga-142001(INDIA)

DECLARATION
I hereby declare that the work reported in the thesis entitled “SYNTHESIS OF
PYRAZOLE DERIVATIVES OF NAPHTHYL PROPIOPHENONES AS
POTENTIAL CYTOTOXICAGENTS AND CHEMICAL INVESTIGATION
OF PIPER ATTENUATUM.” has been carried out by me under the joint
supervision of Prof. K.L. Dhar and Mr. Kunal Nepali at I.S.F. College of
Pharmacy, Moga, Punjab (India) during the academic session 2009-2010.The
work reported in the thesis has not been submitted for the award of any other
degree.

Place: Moga Gurinderdeep Singh

Date:

Acknowledgement

A journey is easier when you travel together. Interdependence is

certainly more valuable than independence. It gives me immense

pleasure to acknowledge with gratitude, the help and guidance

rendered to me by a lot of people.

I feel great pleasure in expressing my profound indebtedness to Mr.

Parveen Garg, Chairman, ISF college of Pharmacy for giving me an

opportunity to work in their esteemed institute.

I wish to express my profound sense of respect and gratitude to my

guide Dr. K. L. Dhar, Scintific advisor, Professor and head of

department of Pharmaceutical chemistry, ISF College of Pharmacy,

Moga, and for his keen interest, invaluable guidance, untiring efforts,

and constant encouragement during the course of present

investigation. Their affection and guidance is something I will cherish

all my life.

I also owe thanks to Dr. O. P. Suri and to my co-guide Mr. kunal

nepali for their affectionate encouragement and untiring efforts to

develop independent thinking in me.

My cordial wishes and thanks to Dr. G. S. Sarma, Dr. Manish

Gupta, Dr. Rajkumar,Dr. Vikramdeep monga,Mr. Mukunda S

Bande and Mrs. Shilpi, Mr. Sameer Sapra and Mr. Sunil Yadav

for their time to time help in lab.

I am also thankful to lab technicians and non teaching staff of the

college.
I Am Also Thankful to All My Classmates for Their Help, Care,

Encouragement and Moral Support during My Training .My feelings

towards my parents and my Sister are to be felt to be believed. I

extend my heartiest gratitude to them for their constant cooperation

and guidance during this work, because without their sincerity, power

of their blessings and warmth of their love, the completion of this work

would have remained a distant dream.

Gurinderdeep

Singh
 Part-1
SYNTHESIS OF PYRAZOLE DERIVATIVES OF NAPHTHYL

PROPIOPHENONES AS POTENTIAL CYTOTOXIC AGENTS

1.1 Introduction
1.2 Aim of work
1.3 Results and
Discussion
1.4 Experimental
Work
 Part-2
CHEMICAL INVESTIGATION OF PIPER ATTENUATUM
 2.1
Introduction
2.2 Review of
Literature
2.3 Aim of work
2.4 Results and
Discussion
2.5 Experimental
Work
2.6 Bibliography
Part-3
3.1 Abbreviations
3.2 General Remarks