IRIS A5 Cards v2 9319 3/1/07 16:18 Page 1

International Renal Interest Society DOGS

Substaging CKD: urine protein to creatinine ratio (UP/C)

0 0.1 0.2 0.3 0.4 0.5 0.6

NON-PROTEINURIC BORDERLINE PROTEINURIC PROTEINURIC

Substaging CKD: risk of end organ damage from hypertension

Systolic blood pressure mm Hg

130 140 150 160 170 180 190

MINIMAL RISK LOW RISK MODERATE RISK HIGH RISK

An adaptation of this staging system can be used for those breeds known to have higher blood pressure than average e.g. sight hounds

< 10 mm Hg 10-20 mm Hg 20-40 mm Hg 40 mm Hg

above reference range above reference range above reference range above reference range
for breed involved for breed involved for breed involved for breed involved

NB. Any level of proteinuria or hypertension can occur at any stage of CKD i.e. at any level of azotaemia.
IRIS A5 Cards v2 9319 3/1/07 16:18 Page 2

International Renal Interest Society DOGS

Staging System for Chronic Kidney Disease (CKD)

STEP 1. Staging is initially based on fasting plasma creatinine assessed on at least two occasions in the stable patient.
STEP 2. Cases are then sub-staged based on proteinuria and blood pressure.

Plasma creatinine concentration

mol/l
50 100 125 150 180 200 250 300 350 400 440 450 500

STAGE 1 STAGE 2 STAGE 3 STAGE 4

Some other renal abnormality Clinical signs Many systemic clinical Increasing risk of
present e.g. inadequate usually mild signs may be present systemic clinical signs
concentrating ability; (e.g. PU/PD) and uraemic crisis
abnormal renal palpation or may be
absent

mg/dl
1 1.4 2 3 4 5

Plasma creatinine concentrations apply to average size dogs those of extreme size may vary.
www.iris-kidney.com

20070003-01
Supported by Novartis Animal Health Inc.
Based on IRIS 2006 staging of CKD.
IRIS A5 Cards v2 9319 3/1/07 16:18 Page 3

International Renal Interest Society CATS

Substaging CKD: urine protein to creatinine ratio (UP/C)

0 0.1 0.2 0.3 0.4 0.5 0.6

NON-PROTEINURIC BORDERLINE PROTEINURIC PROTEINURIC

Substaging CKD: risk of end organ damage from hypertension

Systolic blood pressure mm Hg

130 140 150 160 170 180 190

MINIMAL RISK LOW RISK MODERATE RISK HIGH RISK

NB. Any level of proteinuria or hypertension can occur at any stage of CKD i.e. at any level of azotaemia.
IRIS A5 Cards v2 9319 3/1/07 16:18 Page 4

International Renal Interest Society CATS

Staging System for Chronic Kidney Disease (CKD)

STEP 1. Staging is initially based on fasting plasma creatinine assessed on at least two occasions in the stable patient.
STEP 2. Cases are then sub-staged based on proteinuria and blood pressure.

Plasma creatinine concentration

mol/l
50 100 140 150 200 250 300 350 400 440 450 500

STAGE 1 STAGE 2 STAGE 3 STAGE 4

Some other renal abnormality Clinical signs usually Many extra-renal clinical Requires
present e.g. inadequate mild (e.g. PU/PD) or may signs may be present intensive
concentrating ability; be absent treatment
abnormal renal palpation

mg/dl
1 1.6 2 2.8 3 4 5

www.iris-kidney.com

20070003-01
Supported by Novartis Animal Health Inc.
Based on IRIS 2006 staging of CKD.