The Bi-annual Newsletter for the Michigan Alzheimers Disease Center | Spring 2017
Roger Albin, MD
University of Michigan (U-M), which five junior investigators each year will
Research Education Component Core Leader Michigan State University and Wayne receive training and mentoring in cutting
Peter Lichtenberg, PhD State University. This cross university edge dementia research from prominent
Research Education Component Core Co-Leader
collaboration will create vast opportunities experts in the field. These trainees will
Hiroko Dodge, PhD
Data Management and Statistical Core Leader for the advancement of novel research learn about the many aspects of dementia
Ivo Dinov, PhD Data Management and in Alzheimers disease and related research through an individualized mentoring
Statistical Core Co-Leader
dementias, as well as opportunities for plan. They will have the opportunity to
Andrew Lieberman, MD, PhD
Neuropathology Core Leader community engagement across the state. establish crucial skills in grant preparation
Scott Roberts, PhD
Outreach and Recruitment Core Leader
and team leadership, as well as to learn
This grant has not only allowed the about how to incorporate community
MADC to establish and maintain this engagement in recruitment and retention of
MADC Website
research participants.
alzheimers.med.umich.edu
UMHS Michigan Health Blog The REC Core is led by Roger Albin, MD, a
healthblog.uofmhealth.org
physician-scientist at U-M, whose extensive
Interested in research experience in clinical research makes him an
participation?
ideal core leader.
Stephen Campbell
E-mail: stepcamp@med.umich.edu
Phone: 734-763-2361 With the NIH grant funding, the MADC will
Questions about education or host an annual research symposium and
wellness programs? community health fair, the first of which will
Erin Mobley
E-mail: elmobley@med.umich.edu
take place in Ann Arbor on June 1-2, 2017. See
Phone: 734-615-5319 page 10 for more information on these events.
Interested in making a donation?
Michelle Davis
E-mail: bardma@umich.edu
Meet This Years Trainees
Phone: 734-763-3555 Roger Albin, MD, REC Core Leader on page 4
MIND MATTERS
Note from the DIRECTOR
Greetings from a newly minted University of Michigan Road Scholar just back
from his travels! Thats right, I was one of two dozen U-M faculty selected by
the University to tour Michigan for a full week. We visited cities from Detroit to
Sault Ste. Marie, Traverse City to Lansing, learning about the diverse people and
activities that make this state great.
Why did I do it? As director of a center striving for a state-wide reach, I wanted to
learn more about the people we serve. I certainly did -- it was a great experience!
I returned home excited about the prospect of linking activities across the state in
our efforts to tackle the problem of dementia.
Dr. Hank Paulson
And there is indeed good reason to be excited: We were awarded one of the highly
Table of competitive National Institutes of Health (NIH) Alzheimers Disease Core Center (ADCC) grants
CONTENTS
this year. A unique feature of our center is that it directly links dementia activities at the
three major research universities in the state Michigan State University and Wayne State
About Us University, in addition to U-M. Through this unique partnership, we will be able to help people
1 MADC Receives $9 Million from all walks of life and all regions of the state. In the following pages I encourage you to
Grant from NIH learn more about our newly funded ADCC and its wide range of activities to better understand
2
and treat Alzheimers disease and related dementias.
Note from the Director
Another linkage unique to our center that makes me proud? The Carl Rinne Lewy Body
Whats New In Research:
3 Dementia initiative, now in its second year. We are expanding our outreach and care for this
Reveal Scan
underappreciated cause of dementia through new support groups among other activities,
4 MADC Receives $9 Million which you can read about on page 6.
Grant from NIH (cont)
The talents and creativity of our faculty and staff are key reasons why were already making a
The Carl Rinne Lewy Body difference in the lives of those with dementia. One great example is the work this semester of
5
Dementia Initiative a team of graduate students, including three members of our center, to develop The Evergreen
Experience, an adult day program connecting older adults with memory loss to meaningful
A Year in Review (cont)
6
Thank You to Our Donors
and stimulating activities on a farm. Pretty cool, right? The judges in the Innovation in Action
competition sure thought so, awarding the students a prize for their creative plan. Learn more
Share Your Story: about The Evergreen Experience on page 8.
7
Belle Isle Senior Events
There is much more in these pages so dont let me slow you down! As you read about
Staffing Changes us, keep in mind that the great work of our faculty and staff could not happen without you.
8 MADC Staff Develop Whether by participating in a research study, support group, wellness program, or by making
The Evergreen Experience a donation to allow these programs to take place, you are making things happen. And for that,
9 Be a Link
we are grateful!
The MADC is Committed to Memory & Aging Research, Clinical Care, Education and Wellness 3
MIND MATTERS
Michigan Alzheimers Disease Center Receives $9 Million Grant from NIH
Story continued from page 1
GOAL 1:
Provide Support to Families
To help meet the Initiatives first goal
of providing support to families who
are living with a Lewy body dementia
diagnosis, the LBDI now provides three
Lewy body dementia specific support
groups in Southeast Michigan. These
monthly groups are held in Brighton,
Ann Arbor, and Southfield, and they
The MADC staff with
all offer concurrent groups that meet Dr. James Galvin
separately for those living with Lewy after his talk on LBD
body dementia and their caregivers,
families, and friends. This is the only
group of its kind in the country.
The MADC is Committed to Memory & Aging Research, Clinical Care, Education and Wellness 5
MIND MATTERS
A Year in Review: Lewy Body Dementia
The Carl Rinne Lewy Body Dementia Initiative Support Groups
continued from page 5
Ann Arbor
GOAL 3: When
Increase Awareness Across the State 2 Tuesday of each month 2:00-3:30 PM
nd
Where
The third goal of the Initiative is to focus on increasing awareness of Lewy
Huron Woods Towsley Health Building
body dementia across the state of Michigan. The LBDI provided information
5361 McAuley Drive
at resource tables at 17 general public events and 12 professional events,
Ann Arbor, MI 48106
distributing over 1,000 Initiative brochures. There were 8 Lewy body dementia
articles submitted to the University of Michigan Health Systems Health Blog,
Brighton
attracting more than 40,000
When
views on social media sites.
2 Wednesday of each month 6:00-7:30 PM
nd
Where
Finally, to celebrate Carl
242 Community Church Brighton Campus
Rinne, Tamaras late
7526 Grand River Ave
husband, while also
Brighton, MI 48114
increasing community
awareness and raising
Southfield
the funds needed to
When
expand support groups, the Initiative partnered with the UMHS Development
4th Thursday of each month 2:00-3:30 PM
Department to host a fundraising event at Karls Cabin in Plymouth, Michigan.
Where
The Sunday Afternoon of Jazz event featured live jazz music, great food, and
Alzheimers Association (MARS Building)
friends in a cozy atmosphere and raised nearly $9,000 for the Rinne Lewy Body
25200 Telegraph Rd
Dementia Initiative.
Southfield, MI 48033
The increase in awareness over the past year and the realization of the need for
For more information about Lewy body dementia
support, education, and research around Lewy body dementia has led to 143
support groups or other Carl Rinne Lewy Body
new donors to the initiative in 2016, bringing in over $52,000. The momentum
Dementia Initiative activities, contact Renee Gadwa
is high, and we are excited to continue making a difference in the lives of those
at rgadwa@med.umich.edu or 734-764-5137
touched by Lewy body dementia.
Thank you to our generous donors for being Victors for the MADC!
6
S H A R E your S T O R Y
The MADC is Committed to Memory & Aging Research, Clinical Care, Education and Wellness 7
STAFFING CHANGES
MIND MATTERS
at the Michigan Alzheimers Disease Center!
Please welcome our new team members and acknowledge a couple of changes in roles at the Center:
Drug Treatment Studies Risk Evaluation and Education of Mind n MOTION: Investigating the use
RVT-101: This is a Phase 2, double- Alzheimers Disease the Study of of Mindfulness-Based Stress Reduction
blind, randomized, placebo-controlled Communicating Amyloid Neuroimaging and multifactorial balance control training
crossover study evaluating the effect of (REVEAL-SCAN): The purpose of this as a method for reducing fall risk. Study
RVT-101 on gait and balance in people study is to learn about the best ways to is looking for adults with mild cognitive
ages 55-89 with Alzheimers disease, communicate educational information impairment age 55 and older. Contact
Lewy body dementia, or Parkinsons about amyloid imaging brain scans Laura Rice-Oeschger at lerice@med.
disease dementia. Contact Christine and risk information about the chance umich.edu or 734-936-8332.
Minderovic at cmindero@med.umich.edu of developing AD. Study is enrolling
or 734-998-8420. cognitively normal adults ages 65 to Enhancing Safe Mobility among Older
80, have/had at least one first-degree Drivers: Investigating how older drivers
Brain Stimulation Studies relative (i.e., parent or siblings) with might change their driving behavior over
Promoting adaptive neuroplasticity Alzheimers disease. Contact Brent Doil time and what influences any changes
in mild cognitive impairment (Merit): at bmdoil@umich.edu or 734-763-2881. that might occur. Study is looking for
Examining the benefits of two types of healthy adults age 65 or older. Contact
treatments for memory impairment Lifestyle Intervention Studies Jennifer Zakrajsek at jzak@umich.edu or
cognitive rehabilitation and electrical University of Michigan Memory and 734-615-4740.
brain stimulation. Study is looking for Aging Project (UM-MAP): Investigating
adults with mild cognitive impairment changes in cognitive functioning over Decision Making for Cardiovascular
over the age of 50. Contact Oliver time to learn more about normal aging Therapy in Adults with Mild Cognitive
Calhoun at occ@med.umich.edu or and neurodegenerative diseases. Study is Impairment (MCI DeM): Investigating
734-764-7282. looking for adults with or without cognitive what adults with cognitive impairment
changes over the age of 55. Contact and the friends or family involved in
NeuroRehabilitation Study: Examining Stephen Campbell at stepcamp@med. medical care think about health risks and
cognitive rehabilitation techniques, umich.edu or 734-763-2361. preferences for medical treatment if they
including transcranial electrical were to become seriously ill because of
stimulation (TES) and magnetic ACT-OUT: This study takes place a heart attack or stroke. Study is looking
resonance imaging (MRI) of the brain, at Wayne State University and is for adults age 65 or older who have a
to see the benefit on cognitive abilities. investigating participation in activities diagnosis of mild cognitive impairment
This study is looking for adults 50 and places outside the home of older and are fluent in English. Contact Bailey
years of age and older with or without adults with dementia to examine what Green at greenba@med.umich.edu or
cognitive complaints. Contact Alina people do and where they participate 734-647-3971.
Lesnovskaya at askaya@med.umich.edu in everyday life as they age. This study
or 734-764-4709. involves completing a survey and Caregiver Studies
answering interview questions. The Health-Related Quality of Life in
study is looking for adults over the age Caregivers: Investigating important
Neuroimaging and Biomarker of 55 who are living with dementia. issues associated with health-related
Studies Contact Susan Lawrence, PhD at susan. quality of life for care partners
Examination of the earliest symptoms lawrence2@wayne.edu or 313-577-1217. and caregivers of individuals with
and biomarkers of FTLD MAPT carriers: mild cognitive impairment and the
Investigating the earliest clinical Community Urban effectiveness of a widely used caregiver
features of frontotemporal dementia in Electroencephalography Study (CUES): intervention. Study is looking for care
an effort to improve early detection of Investigating new markers for detection partners and caregivers (spouses, family
the disease. Study is looking for adults of the earliest signs of cognitive members, or friends) of someone with
age 18 and older with a family member changes in healthy African Americans mild cognitive impairment age 18 and
who has frontotemporal dementia. who may be at risk for developing older. Contact the study coordinator at
Contact Stephen Campbell memory or other thinking problems. 734-936-7360.
at stepcamp@med.umich.edu or Study is looking for African American
734-763-2361. adults age 65 and older. Contact For a complete list of studies and for more information,
Stephanie Nava at senava@med.umich. contact Stephen Campbell at 734-763-2361 or visit our
edu or 734-615-0612. website, alzheimers.med.umich.edu
The MADC is Committed to Memory & Aging Research, Clinical Care, Education and Wellness 9
MIND MATTERS
Summer
2017
UPCOMING EVENTS
MADC Wellness Initiative
Spring Caregiver Wellness Day
Health and Aging Fair Friday, June 9, 2017 10:00 am 3:00 pm
Friday, June 2, 2017 8:30 am 12:00 pm Matthaei Botanical Gardens
University of Michigan North Campus 1800 N. Dixboro Road
Research Complex Building 18 Dining Hall Ann Arbor, MI
2800 Plymouth Road Ann Arbor, MI
Registration is FREE but required
This event is open to the public and registration Register online at:
1st Annual Research Symposium: alzheimers.med.umich.edu/wellness-initiative
is not required. Please contact Erin Mobley at
Beyond Amyloid or by calling the MADC at 734-936-8803
734-615-5319 or elmobley@med.umich.edu
Thursday, June 1, 2017 7:30 am 4:00 pm with any questions.
University of Michigan North Campus Following the June 1 Research Symposium, the Twice yearly, the MADC Wellness Initiative holds
Research Complex Building 18 Dining Hall
Michigan Alzheimers Disease Core Center will Caregiver Wellness Day Retreats. These are free,
2800 Plymouth Road Ann Arbor, MI
hold its first annual Health and Aging Fair. Join half-day wellness, creativity, and social retreats
Please register online at us for this half day event to learn about local for care partners of adults living with memory
madcc.eventbrite.com community health organizations, current research loss held at the scenic and calming University
in dementia and resources for seniors. The event of Michigan Matthaei Botanical Gardens in Ann
The Michigan Alzheimers Disease Core will feature presentations by multiple MADCC Arbor. We welcome all newcomers and returning
Center is hosting its first annual research staff as well as Dr. Suzanne Craft, PhD, from participants to the retreat this June to enjoy lunch,
symposium Beyond Amyloid. Keynote Wake Forest University. chair massages, and restorative activities. This
lectures will be complemented by shorter talks Springs retreat features guest facilitators Beth
from investigators across our three partnering Spencer, LMSW, and Carolyn Rose Stone, MFA.
Michigan research universities University
of Michigan, Wayne State University, and
Michigan State University. MEMORY, AGING & EXPRESSIVE ARTS
Course Completes Successful Semester
The theme of this years symposium is that of our
ADCCs overall theme: the non-amyloid contributions The Michigan Alzheimers Disease Center is a proud sponsor of the 2017
to brain dysfunction and neuronal cell death in Memory, Aging and Expressive Arts (MAEA) course through the University
Alzheimers disease and related dementias. of Michigan Stamps School of Arts and Design. Led by Anne Mondro,
Associate Professor at the University of Michigan Stamps School of Arts and Design, the MAEA course
Keynote Presenters include: introduces students to key issues in memory and aging and explores the use of expressive arts as an outlet.
Suzanne Craft, PhD Students who participated in the course this semester learned from an interdisciplinary
Co-Director, Sticht Center for Healthy Aging Director team of professionals in Psychology, Neurology, Public Health, Social Work, and Art. MADC
Alzheimers Disease Core Center personnel Nancy Barbas, MD, MSW, Laura Rice-Oeschger, LMSW, and Scott Roberts, PhD
Wake Forest University helped develop the curriculum and served as guest faculty this semester, leading several class
Leading expert on the relationship between sessions focused on topics such as diagnosis and treatment of Alzheimers disease and related
metabolic disorders and dementia
dementias, caregiving issues, and the public health impact of the disease.
Karen Hsaio Ashe, MD, PhD Most importantly, the students learned from those with memory loss themselves, and used the
Edmund Wallace and Ann Marie Tulloch Chairs in semester to build relationships, using expressive arts as a vehicle in the process.
Neurology and Neuroscience
University of Minnesota The course concluded at a beautiful exhibition held on April 13, 2017 at University of Michigan
Internationally renowned investigator of Matthaei Botanical Gardens in Ann Arbor where each student/elder team showcased their work
Alzheimers disease and related dementias. to University of Michigan staff and faculty, families, and friends.
10
MADC Investigators to Take Part in 2017 Alzheimers
Association International Conference
T
he Michigan Alzheimers Disease Center will be well
represented at the upcoming Alzheimers Association
International Conference (AAIC), the worlds largest international
conference focused on dementia research. This July, the AAIC will
convene in London, England and bring together investigators from over
70 countries to present their latest findings in basic and translational
research related to diagnosis, prevention and treatment of Alzheimers
disease and other dementias. Presentations from MADC researchers
will include the following:
B
runo Giordani, PhD, will present his research on computerized neuropsychological testing in the identification of mild
cognitive impairment compared to healthy older adults in a sample of African American and Caucasian seniors. Other topics
include spatial navigation in older adults with and without mild cognitive impairment, and an examination of factors that
influence change in scores on neuropsychological testing in African American seniors with subjective memory complaints.
S
cott Roberts, PhD, will present on an ongoing clinical trial, the REVEAL-SCAN study, designed to examine the impact
of providing amyloid neuroimaging results to cognitively normal older adults interested in learning more about their risk of
Alzheimers disease.
H
iroko Dodge, PhD, chairs the Professional Interest Area Clinical Trials Advancement and Methods and will present an
educational workshop focusing on modern clinical trial methods.
Scott Counts, PhD, Associate Professor of Translational Science and Molecular Medicine, Michigan State University, and
Co-investigator in the MADCs Neuropathology Core, will present his research on mitochondrial unfolded protein response
(mtUPR) dysfunction during the progression of Alzheimers disease.
In addition, the MADCs Isadore & Margaret Mezey Fund will support conference attendance for two junior investigators.
Established with the generous support of the Mezey family, the Fund sponsors participation at national or international
conferences for junior investigators with a keen interest in dementia-related research. At last years AAIC meeting in Toronto,
the following investigators were supported by a Mezey Fund award:
The MADC is Committed to Memory & Aging Research, Clinical Care, Education and Wellness 11
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Ann Arbor, MI 48105
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