PHARMACOKINETICS SAMPLE PROBLEMS |DR.

RAVELO

A 17-year old took a tablet of naproxen for A. Oral mucosa

headache. Naproxen is a weak acid with a B. Stomach
pka of 5.2. What percentage of the drug was C. Small intestine
most likely water soluble in the patients D. Colon
plasma?
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A. 99%
The pharmacokinetic properties of five new
B. 24%
drugs (P, Q, R, S, and T) were studies in healthy
C. 50%
D. >99% volunteers. The same dose of each drug was
administered intravenously (IV) and orally to
Acidic drug (ph is not given but plasma ph is the same subject on two separate occasions.
7.35-7.45) The results were the following

[Rationalization] Drug AUC Oral

(mg h/L)
AUC IV
(mg h/L)
P 50 600
ph = pka +log I/UI Q 200 2000
R 30 400
I/UI = 10 ph - pka = 10 7.4 - 5.2 = 158.5/1 S 100 120
% I = I/I + UI x 100 = 158.5/158.5 + 1 x 100 = >99% T 45 90

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A 19-year old male was brought to the ER Which of the following drugs most likely has the
because of attempted suicide using aspirin. At highest oral bioavailability?
the hospital, administration of sodium A. Drug P
bicarbonate to increase the elimination of B. Drug Q
salicylate was started. Which of the following C. Drug R
best explains the mechanism of this increase D. Drug S
elimination?
[Rationalization]
A. Decrease tubular active transport of
salicylate FAbs = Foral/FIV, hence Drug S would yield the
B. Decrease renal biotransformation of greatest answer
salicylate ------------------------------------------------------
C. Decrease bioavailability of salicylate
D. Urinary ion trapping of salicylate Four different oral dosage forms of the same
dose of a drug were administered to a healthy
------------------------------------------------------ volunteer on four separate occasions. The
plasma concentration-time curves are plotted
A 63-year old man recently diagnosed with
hypertension started a therapy with below
hydrochlorothiazide, one tablet daily.
Hydrochlorothiazide is an acidic drug with a
pka of about 9. Which of the following parts of
the digestive tract most likely represents the
main site of absorption of that drug?
Ajm 2018
PHARMACOKINETICS SAMPLE PROBLEMS |DR. RAVELO

A. 500
B. 800
C. 1,200
D. 1,500
E. 2,000

[Rationalization]

ER = Qextracted/Q presented = 80/100 = 0.8

Or F = 1 ER
Which of the following features best explains ER = 1 0.2 = 0.8
why formulation W produces the largest
plasma concentration-time curve of the drug? CIH = QH x ERH = 1,500ml/min x 0.8 = 1,200
ml/min
A. Highest absorption through gut wall
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B. Lowest first pass effect
C. Lowest hepatic clearance A 67-year-old woman recently diagnosed with
D. Lowest drug elimination atrial fibrillation started treatment with atenolol,
100 mg/d. With this dose, the percentage of
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the atenolol bound to plasma proteins is about
A 26-year-old man became inebriated after 5%. Which of the following would have been
drinking several glasses of alcoholic beverage bound to percentage of atenolol if a dose of
at a party. Ethanol is polar, nonionizable drug 50 mg/d had been administered to the same
with an approximate molecular weight of 46 patient?
daltons. Which of the following permeation
A. 2.5%
processes mediated the mans intestinal
B. 5%
absorption of ethanol?
C. 10%
A. Aqueous diffusion D. 1.25%
B. Lipid diffusion
C. Facilitated diffusion
D. Active diffusion

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When studied in healthy volunteers, the oral

bioavailability of a new drug turned out to be
20%. Knowing that in this case the entire
administered drug reached the portal
circulation, which of the following will be the
hepatic clearance (in mL/min) of the drug? Thank you Vien Lansangan for the
(liver blood flow = 1,500 ml/min) rationalizations!

Ajm 2018