49]
Original Article
Email:afitapozdelikara@gmail.com
Received: November 15, 2016, Accepted: February 17, 2017
ABSTRACT
Objective: Patients receiving chemotherapy struggle with that the difference between the total mean scores of INVR
the side effects of this treatment. These side effects obligate in the experimental and control groups was significant on
the patients to use not only the pharmacological methods the onset and first and second measurements, and the
but also nonpharmacological relaxing methods. This study difference between total mean scores of development and
was conducted to determine the effect of reflexology on distress between the groups was statistically significant
chemotherapyinduced nausea, vomiting, and fatigue in in the third measurement (P < 0.05). The results of the
breast cancer patients. Methods: The study was conducted study showed that the BFI mean scores of patients in the
as a pretestposttest experimental design. The study was experimental group gradually decreased in the first, second,
conducted with sixty patients, thirty as the control and thirty and third measurements(P<0.05). Conclusions: The present
as the experimental groups. Asociodemographic form, study proved that reflexology decreased the experience,
Rhodes index of nausea, vomiting, and retching (INVR), and development, distress of nausea, vomiting, and retching as
Brief Fatigue Inventory (BFI) were used to collect the data. well as fatigue in the experimental group. Hence, the use
Analysis of variance, ttest, percentage calculations, and of reflexology is recommended for chemotherapyinduced
Chisquare methods were used to evaluate the data. The nausea, vomiting, and fatigue.
data obtained were assessed using the Statistical Package
for Social Science 21.0 software. Results: It was determined Key words: Breast cancer, nausea, nursing, reflexology
DOI: Cite this article as: zdelikara A, Tan M. The effect of reflexology on
10.4103/apjon.apjon_15_17 chemotherapy-induced nausea, vomiting, and fatigue in breast cancer
patients. Asia Pac J Oncol Nurs 2017;4:241-9.
2017 Ann & Joshua Medical Publishing Co. Ltd|Published by Wolters KluwerMedknow 241
[Downloaded free from http://www.apjon.org on Saturday, July 29, 2017, IP: 137.97.8.49]
a caterpillar technique with the thumb was mostly used. development, and vomiting distress, it was found statistically
Organs of the gastrointestinal and urinary systems were significant in all other areas(P<0.05). In the first, second,
the primary focus on both feet. The practice ended with and third measurements where reflexology was applied, on
solar plexus pressure on both feet. the other hand, the difference between the experimental
and control groups was found statistically significant in all
Statistical analysis
areas(P<0.05).
The data obtained as a result of the study were assessed
Examining the total mean scores of nausea, vomiting,
through computer using the Statistical Package for Social
and retching experience, it was determined that patients
Science 21.0(IBM SPSS version21.0) packaged software.
in the experimental group had higher onset mean scores
While percentage and Chisquare tests were used to analyze
compared to the control group; however, the mean scores of
descriptive characteristics of patients, the ttest was used
first, second, and third measurements were lower, and while
to determine whether there was a statistically significant
this difference was significant in the onset, first, and second
difference between the means of two independent samples.
measurements(P<0.05, P<0.001), it was statistically
Ethical consideration insignificant in the third measurement(P>0.05)[Figure1].
Before conducting the study, the Ethics Committees As a result of the evaluation of the total mean scores
approval was obtained from Atatrk University Health of nausea, vomiting, and retching development between
Science Institute, and written permission was received from the groups, the mean scores of first, second, and third
the Ambulatory Chemotherapy Unit of Ondokuz Mays measurements were lower in the experimental group.
University Medical Faculty Hospital, where the study would The difference between these groups was statistically
be conducted. After patients were informed about the study significant in the onset and first, second, and third
and their questions were answered, their written and verbal measurements(P<0.05)[Figure2].
consents were obtained. Examining the total mean scores of nausea, vomiting,
and retching distress, it was determined that patients in
Results the experimental group had lower mean scores in the first,
The age average was determined as 50.9311.27 in second, and third measurements, and the difference between
the experimental group and 51.0610.97 in the control the groups was statistically significant in the onset and first,
group. About 53.3% of the patients in the experimental second, and third measurements(P<0.05)[Figure3].
and control groups were 50 and older. Furthermore, 80% Table2 illustrates the comparison of the groups in terms
of those in the experimental group and 66.7% in the control of the BFI mean scores of patients in the experimental
group were married, and 40% of patients in both groups and control groups. Examining Table2, it was determined
were primary school graduates. Majority of patients were that the mean scores of fatigue severity and daily activity
housewives(73.3% in the experimental group and 86.7%
exposure levels were higher in the onset in patients in the
in the control group), lived in the city center(60% in the
experimental group compared to those in the control group;
experimental group and 53.3% in the control group), and
however, they decreased in the first, second, and third
were diagnosed with Stage II breast cancer(76.7% in the
measurements and were also lower in the first, second, and
experimental group and 73.3% in the control group). All
third measurements. This difference between the groups was
the patients in the experimental and control groups had
statistically significant in the onset and first, second, and
social insurance.
third measurements[Figures4 and 5](P<0.05).
Table1 illustrates the comparison of patients in the
experimental and control groups in terms of mean scores
of nausea, vomiting, and retching experience.
Accordingly, even though the patients in the experimental
group had higher mean scores of nausea, vomiting, and
retching, experience, development, and distress in the onset
measurement compared to the control group were distinctly
lower in the experimental group in the first, second, and
third measurements where reflexology was applied.
As a result of the statistical examination, while the
difference between the groups in terms of the onset
measurement mean scores was found statistically
insignificant in the areas of vomiting experience, vomiting Figure 1: Total scores of patients in the subscale of experience
Table1: Comparison of groups in terms of Rhodes index of nausea, vomiting, and retching mean scores of patients after reflexology
INVR Group Onset First measurement Second measurement Third measurement
Subscale of experience
Nausea experience Experimental 8.633.16 2.532.80 2.562.94 2.063.33
Control 4.964.55 5.464.15 6.164.01 6.564.09
t 3.62 3.20 3.95 4.67
df 58 58 58 58
P 0.001 <0.001 0.000 0.000
Vomiting experience Experimental 4.034.08 0.831.57 0.861.97 0.962.39
Control 3.264.16 3.834.29 4.503.63 4.003.29
t 0.72 3.59 4.80 4.08
df 58 58 58 58
P >0.05 0.001 0.000 0.000
Retching experience Experimental 5.332.45 1.231.27 0.961.77 0.861.92
Control 2.803.04 3.602.76 3.962.72 4.003.29
t 3.54 4.26 5.05 4.50
df 58 58 58 58
P 0.001 0.000 0.000 0.000
Experience score Experimental 18.007.51 4.604.76 4.405.52 3.906.89
Control 11.0311.24 12.9010.49 14.639.62 6.564.09
t 2.82 3.94 5.05 1.82
df 58 58 58 58
P <0.05 0.000 0.000 >0.05
Subscale of symptom development
Nausea development Experimental 5.862.14 1.832.05 1.802.02 1.432.35
Control 3.333.02 3.702.79 4.202.74 4.402.82
t 3.74 2.94 3.85 4.41
df 58 58 58 58
P 0.000 <0.05 0.000 0.000
Vomiting development Experimental 2.662.66 0.561.07 0.561.25 0.631.56
Control 2.032.72 2.402.82 2.802.36 2.402.02
t 0.910 3.32 4.56 3.77
df 58 58 58 58
P >0.05 <0.05 0.000 0.000
Retching development Experimental 2.561.43 0.600.67 0.561.10 0.431.00
Control 1.401.54 1.731.38 2.061.41 2.201.37
t 3.03 4.02 4.58 5.68
df 58 58 58 58
P <0.05 0.000 0.000 0.000
Symptom development score Experimental 11.104.74 3.003.22 2.933.60 2.504.34
Control 6.766.85 7.836.41 9.065.91 9.005.29
t 2.84 3.68 4.84 5.19
df 58 58 58 58
P <0.05 0.000 0.000 0.000
Subscale of distress development
Nausea distress Experimental 2.761.19 0.700.83 0.761.00 0.630.99
Control 1.631.54 1.761.38 1.961.37 2.161.34
t 3.18 3.61 3.85 5.02
df 58 58 58 58
P <0.05 0.001 0.000 0.000
Vomiting distress Experimental 1.361.47 0.260.52 0.300.79 0.330.84
Control 1.231.59 1.431.56 1.701.36 1.601.35
t 0.33 3.86 4.84 4.34
df 58 58 58 58
P >0.05 0.000 0.000 0.000
Retching distress Experimental 2.761.19 0.260.52 0.400.72 0.430.97
Control 1.401.54 1.861.43 1.901.37 1.961.21
t 3.83 5.75 5.29 5.39
Contd...
Table1: Contd...
INVR Group Onset First measurement Second measurement Third measurement
df 58 58 58 58
P 0.000 0.000 0.000 0.000
Distress score Experimental 6.902.90 1.601.65 1.462.06 1.402.59
Control 4.24.47 5.064.13 5.563.82 5.733.55
t 2.70 4.26 5.16 5.39
df 58 58 58 58
P <0.05 0.000 0.000 0.000
INVR: Rhodes index of nausea, vomiting, and retching
Table2: Comparison of the groups in terms of Brief Fatigue Inventory mean scores
BFI Group Onset First measurement Second measurement Third measurement
Fatigue severity Experimental 3.671.94 1.621.41 1.281.61 1.201.44
Control 1.971.59 2.632.09 2.111.48 2.331.65
t 3.70 2.19 2.05 2.83
df 58 58 58 58
P 0.000 <0.05 <0.05 <0.05
Daily life activity exposure levels Experimental 1.881.26 0.531.17 0.510.98 0.410.65
Control 1.011.16 1.662.00 1.170.97 1.471.52
t 2.78 2.65 2.60 3.53
df 58 58 58 58
P <0.05 <0.05 <0.05 0.001
BFI: Brief Fatigue Inventory
Figure 2: Total scores of patients in the subscale of symptom Figure 3: Total scores of patients in the subscale of distress
development
Figure 4: Fatigue severity scores of patients after reflexology Figure 5: Daily life activity exposure level scores of patients regarding
daily life activities after reflexology
Taking these studies into consideration, it could be asserted group gradually decreased, but those of the control group
that both pharmacological and nonpharmacological increased in subsequent measurements in comparison to
methods could be used in coping with and removing the the initial measurement. Previous studies conducted with
chemotherapyinduced nausea, vomiting, and fatigue, and cancer patients also determined that reflexology decreased
the results of relevant studies will make a contribution to fatigue.[3335] In another study in which chemotherapyrelated
the nursing literature. fatigue conditions of breast cancer patients were examined,
In the end of this research, when the average of the total reflexology was found to reduce fatigue levels in patients.[22]
score of INVR of the patients was examined, it was observed Unal and Akpnar also reported that reflexology applied to
that the average of the total score of nausea, vomiting, and hemodialysis patients in eight sessions significantly reduced
retching experience, formation, and distress of the patients fatigue in patients.[36] Kohara and colleagues reported that
in the experimental group gradually decreased but that of reflexology application with aromatherapy decreased
the patients in the control group gradually increased. It fatigue rates of patients in their study with twenty cancer
was also found that this difference between the average of patients in the terminal period.[33] There are studies showing
the total score of INVR in the intergroup was statistically that reflexology reduces fatigue in patients with rheumatoid
significant and that the average of the total score of nausea, arthritis and hemodialysis in cancer patients.[3337] There are
vomiting, and retching experience, formation, and distress of many reasons for fatigue which develops during the process
the patients in the experimental group decreased. Mindoab of chemotherapy treatment. Accumulation of metabolic
etal. reported in their study with 37 cancer patients that wastes in the body, loss of appetite, nausea, and anemia are
reflexology had no positive effect on nausea and vomiting; among these reasons.[6] A number of studies showed that
however, this treatment decreased the severity and number relaxation and massage therapies decreased fatigue.[32,3841]
of vomiting within the first 4 h after chemotherapy.[22] In his These, in turn, would impinge on the nerve endings on the
study that conducted with breast cancer patients receiving feet and obstruct lymph flow. Massaging these areas would
chemotherapy, Yang also determined that the reflexology break down the crystalline deposits so that they could
practice decreased nausea and vomiting symptoms.[23] be reabsorbed and eliminated.[42] Reflexology improves
Furthermore, as a result of a metaanalysis study, it was circulation and may help with the disposal of waste products
determined that foot reflexology did the same for cancer of tissue metabolism, particularly lactic acid.[43,44] Practices
patients. [24] It was also determined that the massage such as yoga grounded on decreasing stress also have
applied on cancer patients receiving chemotherapy bore positive effects on fatigue.[45] Similarly, the acupuncture
the same outcome.[24] In literature, it has been reported method, originating from the traditional Chinese medicine
that reflexology had decreased nausea and vomiting.[2530] and applied on certain points on the energy lines/meridians,
Reflexology also aims homeostasis, decreases stress, evokes is proven to decrease fatigue as well.[4649] On the other hand,
natural healing mechanisms, and provides an advanced it is indicated that reflexology decreases stress and anxiety
relaxation. It could be asserted that reflexology opens with the help of a deep relaxation and an intensive relaxing,
the energy canals just like acupuncture and acupressure, and it also provides recirculation of energy by opening the
decreases stress just like bodymind therapies, and provides blocked energy canals throughout the body and decreases
relaxation and homeostasis as do massage and relaxation fatigue symptoms[4] by removing toxins from the body.[29,5052]
methods.[13,31] As it is indicated in literature, reflexology The present study also implied that a decrease of nausea,
helps contractions that push the chewed food through the which is depicted as a reason of fatigue, could be effective
digestive tract by functioning the reflexes of the digestive on the decrease of fatigue as well.[53]
system from mouth to stomach with the stimulation
of reflex points of the digestive system.[31] Reflexology, Conclusion
acupuncture, and acupressure are methods based on the As a result, reflexology was found to have positive
idea of the existence of energy canals/meridians.[13] The effects the on nausea, vomiting, and retching and fatigue
literature has numerous studies revealing the decreasing of breast cancer patients receiving chemotherapy and was
effect of massage, relaxation, acupuncture, and acupressure considered to have potential benefits as it significantly
as well as bodymind therapies such as hypnosis, yoga, and reduced chemotherapy and diseaserelated symptoms. This
meditation on nausea and vomiting.[18,19,25,30,32] study has shown that reflexology reduces the symptoms of
When the averages of the total score of fatigue severity chemotherapy(nausea, vomiting, fatigue, etc.,) in breast
of patients and the level of how much fatigue interfered cancer patients. In accordance with the findings of this
their daily activities were examined, it was observed that study, reflexology may be suggested as a complementary
these total score averages and levels of the experimental treatment method in the fight against chemotherapy
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