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Colon tumor Carcinoma

WHO classification of colorectal carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 2 January 2017, last major update December 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: WHO classification [title] colorectal



Table of Contents
Definition / general | Classification | Additional references
Cite this page: World Health Organization (WHO) classification of
colorectal carcinoma. website.
Accessed July 10th, 2017.
Definition / general
WHO classification of tumors of the colon and rectum
Currently on 4th edition, published in 2010
Based on histologic appearance, not molecular characteristics
Similar classification used in College of American Pathologists
protocol for examination of colorectal carcinoma specimens

Epithelial tumors:
o Premalignant lesions
Dysplasia (intraepithelial neoplasia, low grade)
Dysplasia (intraepithelial neoplasia, high grade)
o Serrated lesions
Hyperplastic polyp
Sessile serrated adenoma / polyp
Traditional serrated adenoma
o Hamartomas
Cowden associated polyp
Juvenile polyp
Peutz-Jeghers polyp
o Carcinomas
Cribriform comedo type adenocarcinoma
Medullary carcinoma
Micropapillary carcinoma
Mucinous adenocarcinoma
Serrated adenocarcinoma
Signet ring cell carcinoma
Adenosquamous carcinoma
Spindle cell carcinoma
Squamous cell carcinoma
Undifferentiated carcinoma
o Neuroendocrine neoplasms
Neuroendocrine tumor (NET)
NET G1 (carcinoid)
Neuroendocrine carcinoma (NEC)
Large cell NEC
Small cell NEC
Mixed adenoneuroendocrine carcinoma
EC cell, serotonin producing NET
L cell, Glucagon-like peptide producing, and PP /
PYY producing NETs

Mesenchymal tumors:
o Leiomyoma
o Lipoma
o Angiosarcoma
o Gastrointestinal stromal tumor
o Kaposi sarcoma
o Leiomyosarcoma

Secondary tumors
Additional references
WHO: Classification of Tumours of the Digestive System, 4th Edition, 2010