com
MSKBIOLOGY
BONEBASIC Bone 7 2 0 6 3 8
Remodeling
BasicScience
SCIENCE
BONEFORMATION& Author:
Derek
HEALING
Moore
Embryology
EndochondralBone
Formation
IntramembranousBone
Formation
BoneRemodeling
FractureHealing
Nonunion
BoneGrowthFactors
BoneGrafting
Introduction
PTH&VitDPhysiology
Wolff'sLaw
BIOLOGICTISSUES
boneremodelsinresponsetomechanical
MOLECULAR
stress
BIOLOGY
Piezoelecticcharges
boneremodelsisresponsetoelectric
MATERIALSCIENCE
charges
compressionsideiselectronegativeand
SYSTEMICDISEASE stimulatesosteoblastformation
METABOLICBONE
tensionsideiselectropostiveandstimulates
DISEASE
osteoclasts
HueterVolkmannLaw
JOINTDISEASES
theorythatboneremodelsinsmallpackets
ofcellsknownasBasicMulticellularUnits
BLOODCONDITIONS
(BMUs)
NEUROLOGIC theorysuggestthatmechanicalforces
DISEASES influencelongitudinalgrowth
compressiveforcesinhibitgrowth
SYSTEMIC mayplayroleinscoliosis
DISEASES
METABOLIC RemodelingMechanism
DISEASE
Corticalbone
MEDICATIONS&TOXICITY remodelsbyosteoclastictunneling(cutting
cone)
MEDICATIONS
osteoclasticresorption>layering
TOXICOLOGY
ofosteoblasts>layeringof
lamellae>cementlinelaiddown
CLINICALSCIENCE osteoclastmakeupheadof
cuttingcone,followedby
CLINICALSTUDIES
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capillariesandthenosteoblasts
whichlaydowntheosteoidtofill
thecuttingcone
sclerostininhibits
osteoblastogenenesisto
decreaseboneformation
BasicScience corticalbonecontinuestochangeovertime
corticalareadecreasesasage
increases
linkedtoincrease
fracturerisk
medullarycanalvolume
increasesasageincreases
Cancellousboneremodelsby
osteoclasticresorption
osteoblasticdepositionoflayersoflamellae
Pleaseratetopic. Average4.0of29Ratings
QUESTIONS(2)
QUESTIONS
Previous
1of 2 0%
Next
(OBQ10.16)Thefemurradiographofahealthy25yearoldfemaleis
compared to the femur radiograph of a healthy 85yearold female.
Which of the following best describes the 25yearold's femur?
ReviewTopic
QID: 3104
SelectAnswertoseePreferredResponse
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CASES(2)
??(C1620) 9/6/2013
BasicScienceBoneRemodeling 61
BasicScience HPIpainrightshoulderfor 0
whatisyourdiagnosis??? 1
Melorheostosisinvolvin 4/15/2013
GeneralBoneRemodeling 407
HPIPaininLkneex3yea 4
Whatwouldbeyourdefiniti 8
EVIDENCE&REFERENCES(7)
Tested(/Site/EFootprints/ViewForTopic/9008?mode=Tested)
All(/Site/EFootprints/ViewForTopic/9008?mode
evidenceFootprint
100%
80%
CostEffectiveness(more)
60%
40%
20%
0%
0 1 2 3
ClinicalImpact(increase)
Key
SHOWEVIDENCE
TOPICCOMMENTS(6)
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Pleaselogintoaddcomment.
BasicScience
POCLFREECME
JOBBANK
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