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7/29/2017 Bone Remodeling - Basic Science - Orthobullets.

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MSKBIOLOGY

BONEBASIC Bone 7 2 0 6 3 8
Remodeling

BasicScience
SCIENCE

BONEFORMATION& Author:
Derek

HEALING
Moore
Embryology

EndochondralBone
Formation

IntramembranousBone
Formation

BoneRemodeling

FractureHealing

Nonunion

BoneGrowthFactors

BoneGrafting
Introduction
PTH&VitDPhysiology
Wolff'sLaw
BIOLOGICTISSUES
boneremodelsinresponsetomechanical
MOLECULAR
stress
BIOLOGY

Piezoelecticcharges
boneremodelsisresponsetoelectric
MATERIALSCIENCE
charges
compressionsideiselectronegativeand
SYSTEMICDISEASE stimulatesosteoblastformation
METABOLICBONE
tensionsideiselectropostiveandstimulates
DISEASE

osteoclasts
HueterVolkmannLaw
JOINTDISEASES
theorythatboneremodelsinsmallpackets
ofcellsknownasBasicMulticellularUnits
BLOODCONDITIONS
(BMUs)
NEUROLOGIC theorysuggestthatmechanicalforces

DISEASES influencelongitudinalgrowth
compressiveforcesinhibitgrowth
SYSTEMIC mayplayroleinscoliosis

DISEASES

METABOLIC RemodelingMechanism

DISEASE
Corticalbone
MEDICATIONS&TOXICITY remodelsbyosteoclastictunneling(cutting
cone)
MEDICATIONS
osteoclasticresorption>layering
TOXICOLOGY
ofosteoblasts>layeringof
lamellae>cementlinelaiddown
CLINICALSCIENCE osteoclastmakeupheadof
cuttingcone,followedby
CLINICALSTUDIES
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7/29/2017 Bone Remodeling - Basic Science - Orthobullets.com

capillariesandthenosteoblasts
whichlaydowntheosteoidtofill
thecuttingcone
sclerostininhibits
osteoblastogenenesisto

decreaseboneformation
BasicScience corticalbonecontinuestochangeovertime

corticalareadecreasesasage
increases
linkedtoincrease
fracturerisk
medullarycanalvolume
increasesasageincreases
Cancellousboneremodelsby
osteoclasticresorption
osteoblasticdepositionoflayersoflamellae

Pleaseratetopic. Average4.0of29Ratings

QUESTIONS(2)

QUESTIONS
Previous
1of 2 0%

Next
(OBQ10.16)Thefemurradiographofahealthy25yearoldfemaleis
compared to the femur radiograph of a healthy 85yearold female.
Which of the following best describes the 25yearold's femur?
ReviewTopic

QID: 3104

1 Increased cortical thickness and a smaller medullary canal


volume

2 Decreased cortical thickness and a larger medullary canal


volume

3 Equivalent cortical thickness and medullary canal volume

4 Increased cortical thickness and larger medullary canal volume

5 Decreased cortical thickness and a smaller medullary canal


volume

SelectAnswertoseePreferredResponse
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7/29/2017 Bone Remodeling - Basic Science - Orthobullets.com

CASES(2)

??(C1620) 9/6/2013
BasicScienceBoneRemodeling 61
BasicScience HPIpainrightshoulderfor 0
whatisyourdiagnosis??? 1

Melorheostosisinvolvin 4/15/2013
GeneralBoneRemodeling 407
HPIPaininLkneex3yea 4
Whatwouldbeyourdefiniti 8

EVIDENCE&REFERENCES(7)

Tested(/Site/EFootprints/ViewForTopic/9008?mode=Tested)
All(/Site/EFootprints/ViewForTopic/9008?mode
evidenceFootprint

100%

80%
CostEffectiveness(more)

60%

40%

20%

0%
0 1 2 3
ClinicalImpact(increase)

Key

SHOWEVIDENCE

TOPICCOMMENTS(6)

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