JANUARY 2016
magnification, 3200).
Table 1. Causes of Declining Kidney Function in Malignancy Can Be Classified Both Mechanistically and by the Kidney
Compartment Affected
Intrinsic
Treatment related NSAIDs, CNIs, Collapsing FSGS AIN TTP/HUS Crystal uropathy
hepatic sinusoidal (pamidronate) (methotrexate)
obstruction
syndrome after
BMT, hypovolemia
from diarrhea,
nausea, vomiting
Cancer related: MIDD, amyloid Infiltration, MIDD Infiltration of Tumor lysis, cast Uretheral/
direct effect renal veins nephropathy bladder
obstruction
Cancer related: Hypercalcemia Membranous GN Hypercalcemia
paraneoplastic
effect
Immunosuppression Sepsis Acute tubular
related necrosis, BK
nephropathy
Abbreviations: AIN, allergic interstitial nephritis; BMT, bone marrow transplantation; CNI, calcineurin inhibitor; FSGS, focal segmental glo-
merulosclerosis; GN, glomerulonephritis; MIDD, monoclonal immunoglobulin deposit disease; NSAID, nonsteroidal anti-inflammatory drug;
TTP/HUS, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome.
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