Male erectile dysfunction

Clinical Pharmacology and sildenafil 20-25-100 mg tab PO

Therapeutics
pathologic parkinsonism
rasagilie 0.5-1mg tab
pramipexole (D3)
ANS Drugs
ropinirole (D2)
Orthosthatic hypotension due to Promethazine
A-adrenergic blocker
huntingtons tremor propanolol
huntingtons disease haloperidol
Baroreceptor mechanism to normal BP
syndenhams chorea olanzapine
midodrine 5-10 mg tab

neurogenic bladder (bladder atony)

bethanicol 25-50 tab CARDIOVASCULAR DRUGS
atherosclerosis
neostigmine 15 mg tab
simvastatin 20-40 mg tab
Intestinal atony (paralytic ileus) amlodipine 5-10 mg tab
bethanicol 5 mg/ml SC
cardiogenic shock
neostigmine 2-5 mg/ml IM
dobutamine 12.5-50 mg/ml vial or amp IV
Myesthenia gravis
hyperlipidemia (dyslipidemia)
Neostigmine
15 mg tab simvastatin
Pyridostigmine fenofibrate
30-60 mg tab niacin
5 mg/ml IM
PAD (Raynauds disease)
Glaucoma Diltiazem 30-120 mg tab
Pilocarpine Ophth 10% / 5 mg tab pentoxifylline 400 mg tab PO

CHF (left-sided & right sided heart failure)

Hypotensive shock furosemide 20-40 tab
Ephedrine captopril 25-50 mg tab
1:1000 (1 mg/ml) SC | 1-2 % Ophth carvedilol 6.25-25 mg/tab (class III)

Stress urinary incontinence Atrial fibrillation

Norepinephrine Dofetilide 125-500 mcg cap PO
1 mg/ml IV dronedarone 400 mg tab PO
Digoxin 250 mcg tab/day
Hypertensive crisis female
Pseudoephedrine Angina pectoris
60-120-240 mg tab or cap Nitroglycerine
5-10 mg patch
Pheochromocytoma 400 mcg tab SL
Na nitropruside 50 mg / vial IV Isosorbide DiNO3
clonidine 75-150 mcg/ml IV 5 mg tab SL
phentolamine 5 mg/vial IV 5-20 mg tab or cap
phenoxybenzamine 10 mg cap PO

BPH with HPN

alfuzosime tyrosine 250 mg cap

Essential HPN
Hydrochlorothiazide
Amlodipine 5-10 mg tab

Suni Neri | Clinical Pharmacology Dr. L. Torres 1

ENDOCRINE DRUGS Androgen-replacement tx (anabolic aging)
Pituitary D.I. type 1 Testosterone (nandrolone) 40 mg cap
Desmopressin
100-200 mcg tab Hirsutism and Satyriasis
15 mcg/ml amp IM/SC Cyproterone Ac 50 mg tab, 100 mg/ml amp IM
0.1-1.5 mg ml sol nasal
AdenoCA Prostate
Nephrogenic D.I. type 2 flutamide 250 mg tab
Hydrochlorothiazide 25-50 mg/tab bicalutamide 50 mg tab
nilutamide 50-150 mg tab
Hypothyroidism / Myxedema coma / Cretenism
Na levothyroxine 25-150 mcg tab Growth stimulator (delayed puberty)
Methyl-testosterone
Hyperthyroidism (Graves disease) 10-25 mg tab cap | 10 mg buccal tab
PTU 50 mg tag
methimazole 5-10 mg tab DM type 1
rh-Regular insulin SL
Toxic nodular goiter 100 IU/ml, 3 ml and 10 ml IM/IV/SC
RAI-131 1-250 MCI cap | 3.5-150 MCI vial lispro human analog U100 +
pramlintide vial 0.6-1 mg/ml SC
Hashimotos thyroiditis
Propanolol 10-40 tab cap DM type 2
NSAID and Steroids Metformine
500-850mg-1gm tab + glyclazide 30-60 mg tab
Thyroid storm (crisis)
Propanolol 10-40 tab cap
PULMONARY DRUGS
Thyroid adenoma (benign) Allergic rhinitis / Rhinoconjunctivitis
rh-TSH (throthropin) 1.1 mg / vial Intranasal steroid DFI 300 doses Inhalation
mometasone 110-220 mcg
Addisons disease
hydrocortisone 50-125-250-500- mg / vial IM/IV COPD (emphysema)
fludrocortisones 0.1 mg tab Ipratropium
18 mcg / puff
BPH finasteride 5 mg tab 20 mcg
200 dose MDI
Congenital Adrenal hyperplasia thiotropium 18 mcg / puff dose in 6 packs
hydrocortisone 5-20 mg tab
prednisone 5-20-30 mg tab | 10 mg/5 ml syrup PAD (intermittent claudication)
fludrocortisones 0.1 mg/tab pentoxyfylline 400 mg/tab
cilostazol 50-100 mg tab
Ovulation control / OCP
(sequential, minipill, post coital) ARDS (children)
E-estradiol 30 mcg + Surfactant (Beractant)
L-norgestrel 150 mcg/tab L 25 mg /ml susp
Post menopausal osteoporosis Betamethasone
raloxifene 60 mg tab 5 mg/ml
Denosumab (RankL) 60 mg/ml SC 1 ml amp or 2 ml vial via intratracheal

Metastatic adenoCA breast Bronchial Asthma with mild HPN

tamoxifen 10-40 mg/tab Verapamil 40-60 mg tab
anastrazole 1 mg tab
Stubborn cough
Ovulation-induction dextromethorphan 10 mg tab, 5 mg/5ml syrup
GnRH-agonist butamirate citrate citrate 50 mg tab, 7.5 mg/5
goserelin 3.6-10.8 mg syringe SC ml syrup
naferelin 2 mg/ml nasal

Suni Neri | Clinical Pharmacology Dr. L. Torres 2

Derma Drugs
Herpes simplex 1 & 2 / Herpes zoster
Acyclovir
3% ointment
200-300 mg tab
25 mg/ml
pencyclovir
1% cream
Atopic dermatitis
Pimecrolimus 0.03-1% ointment
Eczematous dermatitis / P. versicolor
ketoconazole 200 mg tab
2% cream / shampoo
Scabies / pediculosis capitis & pubis
Permethrin 1-5% lotion | 1% shampoo
benzyle alcohol 5-25% lotion 60-120 ml
Hyperpigmentation
hydrochloroquin 1% lotion
Hypopigmentation (vitiligo)
triosalen + 320-400 nm UVA therapy
Sunburns sunblock
PABA / Benzophenones SPF 15-50
Actinic keratosis
5-FU 1-5% cream / gel
Allergic contact dermatitis (ACD)
clobetasol 0.05% cream / shampoo
Alopecia areata / androgenic alopecia
Minoxidil 2-5% lotion
keloids / hyperthropic scars
intralesional corticosteroids
halobetasol 5 mg/ml
Hyperkeratosis (humectants)
urea 2-20% cream / lotion
Suni Neri | Clinical Pharmacology Dr. L. Torres
Autocoids
Allergic dermatitis / urticaria
diphenhydramine 25-50 mg cap
prednisone 5-20 mg tab
Motion sickness
meclizine 12.5-25 mg tab
scopolamine 0.4 mg tab
Pre-medication anti-emetic
promethazine 12.5-50 mg tab / 6.25 tab
Nausea and vomiting of pregnancy
Meclizine 12.5-25 mg/tab
Parkinsonism (antidote to anti-psychotic overdose)
MONOCLONAL ANTIBODIES
Kawasaki disease
Immunoglobulin IV 2 gm/kg 5-10% sol
2.5 gm powder IV (SLE, ITP)
CLL
Alemtuzumab 30 mg/ml vial IV
Bevacizumab 25 mg/ml IV
metastatic carcinoma
MSCLC
GBM
metastatic kidney CA
neovascular macular disease
Cetuximab 2 mg/ml vial IV
metastatic carcinoma
head and neck cancer
Rituximab 10 mg/ml vial IV
Non Hodgkin
SA
CLL
RA
Multiple sclerosis
SLE
Trastuzumab 150 mg lyo powde IV infusion
breast CA
metastatic gastric CA
gastroesophageal CA
3
ANTI-TNF-A MABs ANTI-CANCER (NEOPLASIA)
Rheumatoid Arthritis (RA) colorectal CA stage III
Adalimumab 2040 mg / vial SC 5-FU + oxaliplatin

ETANERcept 25-50 mg lyp powder IV infu ALL

Juvenile arthritis MTX + Ivermectacin + vincristine
RA
plaque psoriasis AML
psoriatic arthritis cytarabine + Idarubicin
ankylosis spondylitis
CML
Infliximab 100 mg lyo powder IV infu Imatinib + busulfan + interferon A
Crohns
RA CLL
plaque psoriasis cyclophosphamide + vincristine + prednisone
psoriatic arthritis
ankylosis spondylitis Multiple myeloma
MP (melphalan + prednisone) + thalidomide
ABATAcept 250 mg vial lyo powder (relapse)
Rheumatoid arthritis VAD (vincristine + doxorubricin +
Juvenile arthritis dexamethasone)

Plaque Psoriasis breast adenoCA stage I & II

ALEFAcept 250 mg vial CMF
o (cyclophosphamide + MTX + 5-FU) +
Organ rejection in renal transplant tamoxifen
Basilidiximab 20 mg IV FAC
Daclizumab 25 mg/5 ml vial IV infusion o (5-FU + doxorubicin + cyclophosphamide) +
tamoxifen
Multiple sclerosis & Crohns Disease FEC
Natalizumab 300 mg/15 ml IV infu o (5-FU + efirubricin + cyclophosphamide) +
tamoxifen or anastrozole
Adult allergic asthma
Omalizumab 150 mg powder SC Pancreatic CA
cemetidine + erlotinib or 5-FU + leuco
Anti-GPII-B/IIIA, Anti-thrombotic
ABCiximab 2 mg/ml sol IV Lung CA
platinum doublets (cisplatin + carboplatin)
Post menopausal osteoporosis paclitaxel
Denosumab (RANKL) 60 mg/ml SC vinorelbine
bevacizumab
RSV pneumonitis cisplatin + etoposide
Pallivizumab cisplatin +irinotecan
50-100 mg vial topotecan (SCLC)

I-vitreal neo macular degenaration Ovarian CA

Ranibizumab 10 mg/ml carboplatin + Paclitaxel
Pegaptanib 0.3 ml

Adult RA Malignant melanoma

Anti-IL-1
Anakinra 100 mg/ml syringes SC
Anti-IL1B MAB
Canakinumab 100 mg Lyo powder SC
Anti-IL-1R1 / Anti-IL-1RAcP
Rilonacept 200 mg Lyo powder SC
cryopyrin-associated PS
IFN-A + IL-2
dacarbazine + temozolomide + cisplatin
Brain CA
PCV (procarbazine + carmustine + vincristine) +
bevacizumab + temozolomide

Suni Neri | Clinical Pharmacology Dr. L. Torres 4

TOXICOLOGY ANG DRUG OVERDOSE ASA overdose
Pb Poisoning Gastric lavage activated charcoal USP grade
Succimer PO 100 mg. cap powder slurry
IM EDTA 200 mg/ml amp IM IV fluid LRS 500 ml 1 bottle/bag IV infusion

As Poisoning Beta blocker overdose

Inorganic Glucagon 1 mg lyo powder IM, IV, SC
unithiol PO cap or IV 50 mg/ml
Organic Ca channel blocker overdose
Hemodialysis Ca gluconates IV 10% | 10-20 ml amp vial IV
glucagon 1 mg lyo powder IM, IV, SC
Hg Poisoning high dose insulin 100 IU / ml IV,SC
unithiol PO cap glucose 250 ml 1 L / bottle/bag IV infusion
succimer PO cap 100 mg. Verapamil 40-120 mg tab, 5 mg/2 ml IM, IV
(intalipid)
Acetaminophen overdose
Acetylcysteine CO poisoning
600 mg effervescent tab hyperbaric O2 200%
sachet 100 mg/5 ml suspension
200 mg/ml amp IV infusion Organo-PO4 / Organo-Cl poisoning
200 mg/ml bottle IV infu atropine 600 mcq tab | 1 mg/ml amp IM/IV
pralidoxime 50 mg/ml vial IV
Methamphethamine overdose
Lorazepam carbamate poisoning
0.5-2 mg tab atropine 1 mg/ml amp IM/IV
2-4 mg/ml IV
Cooling / dantrolene CN poisoning
35-50 mg cap NaNO2 30 mg/ml amp vial IV
30 mg/vial
60 ml IV Digoxin
digoxine Ab (Fab-antibodies)
Atropine overdose 34-4-0 mg / vial IV
Physostigmine 1 mg/ml amp IM/IV
Sedative hypnotic (Benzodiazepines)
TCA overdose flumazinil 100 mcg/ml amp IV infusion
NE (hypotension)
1m/ml amp IM/IV Ethylene Glycol and Methanol
NaHCO3 (wide QRS complex) Ethanol 95% USP grade ABS 1 ml amp IV
1 meq/ml fomepizole 1 gm/ml vial IV
10 ml vial IV infusion (pedia)
50-200 ml amp/vial IV infusion (adult) Fe overdose
deferasirox
MAOI HPN crisis tx 125-250-500 mg tab
Na nitroprusside 50 mg powder amp IV infusion deferoxamine
clonidine 75-150 mcg tab | 150 mcg/ml amp IV 500 mg vial powder
2 gm vial powder IM, IV, SC
SSRI / Serotonin syndrome
Cryproheptadine 4 gm tab, 2 mg/5 ml syrup Opioid overdose
Chlorpromazine 10-200 mg tab | 25 mg/ml IM Naloxone
20 mcg/ml
Neuroleptic Malignant syndrome 400 mcq mcg/ml vial amp
diazepam 2-10 mg tab | 5 mg/ml IM/IV
Diphenhydramine 50 mg/ml amp vial IM/IV
dantrolene 25-50 cap | 20 mg/vial 60 ml IV

Suni Neri | Clinical Pharmacology Dr. L. Torres 5

Theophylline overdose
Activated charcoal femoral to popliteal
esmolol cardiovascular risk propofol + fentanyl
100 mg/ml vial IV
Phenobarbital cigarette smoking cessation
1530-90 mg tab bupropion 25-27 mg tab
120 mg/ml amp IM, IV
alzheimers dementia
Rattlesnake envenomation donepizil 5-10 mg tab
IV antivenom / Antivenin 800 IU/ml amp IV memantine 5-10 mg tab
infusion
Rehab tx of alcohol and opioid addiction
Bupropione overedose naltrexone 50 mg tab
lorazepam 4 mg/ml amp IM/IV
diazepam (drug induced seizure) 5 mg / ml Gambling addiction
activated charcoal MAOI (selegiline) 5 mg tab / cap, 6-9-12 mg
patch
Methamphetamine overdose
Ammonium chloride (NHCl) forced dieresis Chronic alcoholism
Chlorpromazine acamprosate 333 mg tab delayed-releases
50-200 mg tab
25 mg/ml amp Wernickes-korsakoff psychosis
Lorazepam Thiamine (B1)
0.5-1.2 mg tab 10-100-300 mg tab
2-4 mg/ml injection 100 mg/ml amp IV

Nicotine / mushroom poisoning

atropine ANESTHESIA
Pre-medication (skeletal muscle relaxation)
Opioid overdose succinylcholine 20 mg/ml IV
naloxone 20-400 mcg/ml amp rocoronium 10 mg/ml | 2.5-5-10 ml amp IV

Spinal anesthesia (knee arthroplasty)

Psychiatric Drugs
Lennox-Gastaut syndrome
lamotrigine 25-200 mg tab
topiramate 25-200 mg tab | 15-25 mg/5 ml
syrup
rufinamide 200-400 mg tab
absence epilepsy (petit mal)
ethosuximide 250 mg cap | 250 mg/ ml syrup
valproate Na 250 mg tab | 250 mg/5 ml syrup
bupicaine (no cardiotoxicity)
lidocaine (with cardiotoxicity)
local anesthesia for burn wounds
benzocaine
6% cream | 20% gels | 20% ointment | 0.8%
lotion |
20% spray | 20% liquid
MPTP IV catheterization prior to venipuncture
EMLA (2.5 % lidocaine + 2.5% prilocaine)

status epilepticus
diazepine titration
ORGAN TRANSPLANTATION
acetazolamide 250 mg tab | 500 mg cap
Kidney
prednisone / cyclosforine
infantile spasm
OKT-3 / ALG (Equine)
clonazepam

geriatric insomnia
eszopiclone 1-2-3 mg tab

methanol toxicity
benzodiazepine-flumazenil 100 mcg/ml amp IV

Suni Neri | Clinical Pharmacology Dr. L. Torres 6

ANTI-BACTERIAL, ANTI-FUNGAL, ANTI-PARASITIC
DRUGS
HIV + Hepa B
Emtricitabine + tenofovir + efavirenz (non-pregnant)
Malaria (falciparum)
Uncomplicated
malarone (atovaquone + proguanil) +
mefloquine
Complicated
artesunate (Co-artem + artemether +
lumefantrine)
asymptomatic intestinal amoebiasis
diloxanide furoate
paromomycin
intestinal amoebiasis (moderate to severe) and
extraintestinal
metronidazole
Gardiasis / trichomoniasis
Metronidazole 250 mg 3x OD for 5-7 days
Pneumocystis jirovechi pneumonia
sulfamethoxazole + trimetroprim
400-800 mg + 80-160 mg tab cap
400 mg + 80 mg amp IV infusion
toxoplasmosis
pyrimethamine + clindamycin + folinic acid
(leucovorin Ca)
25 mg tab +
75-300 mg cap | 75 mg/5 ml susp +
15-25 mg tab cap | 3-5-7-10 mg/ml vial IM/IV
toxoplasmosis in pregnancy
spiramycin 3 gms OD until delivery
hydatid disease (echinococciasis)
Albendazole 400 mg tab | 200 mg/5 ml susp
aspiration biopsy
multiple roundworm infection
Albendazole 400 mg tab | 200 mg/5 ml susp
single roundworm infection (ascariasis)
Mebendazole 100-500 mg tab cap | 50 mg/ml
susp
strongiloidiasis / onchocerciasis
ivermectin 6 mg tab (DOH)
Schistosomiasis, Paragonimiasis, Clonorchiasis
Praziquantel 600 mg tab (DOH)
Suni Neri | Clinical Pharmacology Dr. L. Torres
taeniasis (saginata, solium, latum)
Niclosamide / PZQ 600 mg tab (DOH)
Neurocysticercosis
Albendazole 400 mg tab | 200 mg/5 ml susp
Salmonella (typhoid fever)
ciprofloxacin 250-500 mg tab
ceftriaxone 250-500 mg vial IV/IM
H. pylori (duodenal ulcer)
omeprazole 10-40 mg cap +
amoxicillin 250500 mg cap | 250 mg/5 ml
powder susp +
clarithromycin 250-500 tab | 125 mg/5 ml poder
sus
Vibrio cholera
tetracycline 250-500 mg cap
ciprofloxacin 250-500 mg tab
Legionnaires disease
azithromycin
250-500 mg tab cap | 200 mg/5 ml powder susp
levofloxacin
250-500-700 mg tab | 5 mg/5 ml powder susp
strep viridians infection
pen-G crystalline 500,000 units | 1-5 units vial
IM/IV
staph aureus (boils)
dicloxacilline 250-500 cap | 125 mg/5 ml units
vial IM/IV
nafcillin 1-2 gm / IV piggyback units
MRSA
vancomycin 500 mg 1 gm vial IV
leptospirosis
Pen-G benzathine 1.2-2.4 m. units vial IM
systemic candiasis
AMB 50-100 mg vial IV infusion + 5-FC 500 mg
tab
caspofungin 50-70 mg powder injection
Otitis media
co-amoxiclav
125-200-250-400mg +
31-28.5-62.5-5.57 mg / 5ml powder susp |
503-875 mg + 125 mg tab
Cellulitis
dicloxacillin 250-500 mg cap
7
SBE in RHD IMMUNOPHARMACOLOGY
clindamycin 150-300 mg cap Hemolytic disease of newborn (Rh-)
anti-Ro (D)-IgG
RHD 2 ml IM mother 24-72 hours after birth of the
benzathine pen-G 1.2-2.4 m units vial IM Rh+ infant

meningococcemia Autoimmune diseases

Rifampin 300-600 mg tab | 100-200 mg/5 ml prednisone 5-10 mg tab /5 ml susp
susp cyclophosphamide 50 mg tab | 100-500 mg/1gm
Ciprofloxacin 250-500 mg tab | 2 mg/ml vial IV vial IV
susp
Ceftiaxone 250-500 mg vial IM/IV sjogrens syndrome
cevimeline 30 mg cap
Acne vulgaris
Retinoic acid (vitamin A)
0.05%, 0.1%, 0.3% cream/gel

ALTERNATIVE DRUGS
Hepatitis Silybum marianum (milk thistle)
70-80% conc

BPH Saw palmetto (serenoa repens)

150 mg PO 2x/day (85-95% sterols)

Depression St John s wort

900 mg/day for 4-12 days

HPN / IHD Co-Q-10 (ubiquinone)

100-600 mg/day 2-3x

Atherosclerosis Allium sativum (garlic)

600-900 mg/day (1 clove or raw garlic)

Anti-stress Ginseng
120-240 mg 2-3x/day

Vasodilator Ginko biloba

120-240 mg 2-3x/day

Cough / Bronchodilator Vitex negundo

300-600 mg tab
300 mg/5ml syrup

Suni Neri | Clinical Pharmacology Dr. L. Torres 8

OTHER DRUGS
Paracetamol Biotransformation
glutathione-conjugation, liver
300-600 mg tab
Clinical drug trial design
FDA approval
meta-analysis / randomized controlled
UIS after prostatectomy (BPH)
oxybutin 5-10 mg tab
tolterodine 2-5 mg cap
hypermotility GIT disorder
hyoscine M-bromide 10 mg tab
Ophthalmologic exam
2-5% homatropine (prevent synechiae PO)
Cancer pain / MI / pulmonary edema
Hypocalcemic tetany
Ca gluconate IV 10% / 10 ml amp or vial IV
Osteoporosis
Vitamin D (Ca + PO4)
10,000-50,000 IU/ml tab or cap
Pagets Disease (bone)
Calcitonin nasal 200 IU / puff or 200 IU/ml
injection
hypercalcemia in malignancy
gallium NO3 25 mg/ml IV
Idiopathic hypercalciuria
hydrochlorothiazide 25-50 mg/tab
Marasmus-Kwashiorkor
High protein preparationformula (high caloric)

Neuroleptic malignant syndrome

Diazepam
2-5-10 mg tab
5 mg / ml amp IM/IV
diphenhydramine
50 mg/ml amp IM/IV

Serotonin syndrome
Diazepam
2-5-10 mg tab
5 mg/ml amp IM/IV
cryproheptadine
4 mg tab
2 mg/5 ml syrup
5 mg/5 ml syrup

Malignant hyperthermia
Dantrolene
20 mg/vial IV
25-50 mg cap

Shivering
Meperidine
50-100 mg tab
10-100 mg

Anti-aging
A-tocopherol
10 mg/ml syrup
4-10 mg tab

Hemorrhagic Diathesis
vitamin K1 (phytonadione)
10 mg/ml amp IM/SC

Suni Neri | Clinical Pharmacology Dr. L. Torres 9