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Datasheet of STF-62247

Description:.
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal
cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50
= 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in
mice.1,2,3 STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations
(IC50 = 16 M).
Chemical Information
Catalog DC10456

Purity of current batch: >98%

Molecular Weight (MW) 267.3

Molecular Formula C15H13N3S

CAS No. 315702-99-9

Solubility (25C) DMSO

Storage Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.