Global Product Strategy (GPS) Safety Summary

Diethyl ether

This GPS Safety Summary is a high-level summary intended to provide the general public with an
overview of product safety information on this chemical substance. It is not intended to provide
emergency response, medical or treatment information, nor to provide an overview of all safety
and health information. This summary is not intended to replace the Safety Data Sheet. For
detailed guidance on the use or regulatory status of this substance, please consult the Safety Data
Sheet and the Product Stewardship Bulletin (PSB).

Chemical Identity

Name: Diethyl ether

Brand names: Diethyl ether, ethyl ether
Chemical name (IUPAC): Ethane, 1,1-oxybis-
CAS number: 60-29-7
EC number: 200-467-2
Molecular formula: C4H10O

Uses and Applications

Diethyl ether is available in four grades: Refined, Military, Anhydrous, and a Pharmaceutical grade
(USP) which is compliant with the requirements of the Unites States Pharmacopeia and is
manufactured under current Good Manufacturing Practices (cGMP). Both the anhydrous and USP
grades meet ACS specifications defined by the American Chemical Society (ACS).
Diethyl ether is a common laboratory reagent and solvent, often used in liquid-liquid extraction
processes and as a solvent for waxes, resins and gums. Because of its high cetane number it is
used in gasoline and diesel engine starting fluids. It is also used to manufacture agricultural
chemicals.
The USP grade may be used in the manufacture of pharmaceutical and personal care applications
such as in liniments, analgesics and perfumes.

Physical / Chemical Properties

At ambient temperature diethyl ether is a colorless liquid with a sweet, pungent odor. The
substance is of low molecular weight and is considered to be extremely flammable. The flash point
for diethyl ether is -45C (-49F). The boiling and freezing points of diethyl ether are 34-35C (93-
95F) and -116.3C (-177.3F) respectively.

Diethyl ether has been classified as hazardous under GHS (Globally Harmonized System on
Classification and Labeling) for its extreme flammability of both the liquid and vapor. Diethyl ether
may form explosive peroxides when exposed to light and air. Peroxide formation may be reduced
with the addition of antioxidants such as butylated hydroxytoluene (BHT).
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Health Effects

Diethyl ether has been classified under GHS as hazardous for acute oral toxicity, respiratory
irritation and single exposure narcotic effects.

The table below gives an overview of the health effects assessment results for diethyl ether.

Effect Assessment Result

Acute Toxicity
Oral / inhalation / dermal
Irritation / corrosion
Skin / eye/ respiratory tract
Sensitization
Toxicity after repeated exposure
Oral / inhalation / dermal
Genotoxicity / Mutagenicity
Carcinogenicity
Toxicity for reproduction
Harmful if swallowed. Ingestion may cause Central
Nervous System (CNS) effects (excitement, dizziness,
drowsiness, headache, loss of consciousness and death)
and gastrointestinal tract irritation and distention. Low
concern for acute toxicity from inhalation and dermal
exposure. May cause cardiac sensitization and
arrhythmias at high concentrations.
Not irritating to skin but may cause slight transient eye
irritation.
Not known to be a sensitizer
Low concern for repeated exposure systemic toxicity.
Repeated contact may dry the skin causing dryness or
cracking.
Not mutagenic/genotoxic.
Not considered to be a human cancer concern.
No adverse effects on fertility and not selectively toxic to
the embryo/fetus.

Environmental Effects

Diethyl ether has very low toxicity to aquatic life and has accordingly not been classified under
GHS as hazardous.

The table below gives an overview of the environmental assessment results for diethyl ether.

Effect Assessment Result

Aquatic Toxicity Very low toxicity to aquatic life

Fate and behaviour Result

Biodegradation Not expected to be biodegradable
Bioaccumulation potential Not expected to bioaccumulate
PBT / vPvB conclusion Not considered to be either PBT or vPvB.

PBT = Persistent, Bio-accumulative and Toxic in the environment.

vPvB = very Persistent and very Bio-accumulative in the environment.

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Exposure

Human health
When using a diethyl ether containing consumer product at home, all instructions and precautions
should be read, understood and followed.

Exposure to diethyl ether of personnel in manufacturing facilities is considered very low because
the process, storage and handling operations are enclosed. It is not used in a widespread or
dispersive manner. Also, transfer (loading and transport) of diethyl ether is done with dedicated
equipment in dedicated containers to prevent any release from the system. However, worker
exposure can potentially occur during operations such as product transfer, product sampling, or
maintenance / repair activities on product containing systems. The risk of accidental exposure
should be controlled by selecting and applying the appropriate Risk Management Measures.

Environment
The manufacture of diethyl ether is in a closed and automated process with no aqueous effluent or
gaseous effluent released to the environment. Also, transfer (loading and transport) of diethyl ether
is conducted with dedicated equipment in dedicated containers to prevent any release from the
system.

Risk Management Measures

For detailed guidance on the use of diethyl ether, the Safety Data Sheet should be consulted.

Diethyl ether should be handled only by knowledgeable and trained personnel.

Flammability
Because of its flammability potential, diethyl ether should not be handled and stored near heat,
sparks, open flame or other ignition sources. Vapors can travel to a source of ignition and flash
back. Also, equipment should be grounded and bonded to prevent build-up of static electricity.

Human health
When using chemicals make sure that there is adequate ventilation. Always use appropriate
chemical-resistant gloves to protect your hands and skin, always wear eye protection such as
chemical goggles and always wear flame-retardant clothing. Do not eat, drink, or smoke where
chemicals are handled, processed, or stored. Wash hands and skin following contact. If the
substance gets into your eyes, rinse eyes thoroughly for at least 15 minutes with tap water and
seek medical attention.

In the case of transfer or maintenance operations, always clear transfer lines prior to decoupling,
and flush/drain to a closed system for recycle prior to opening equipment.

In cases where engineering controls cannot maintain airborne substance concentrations below
exposure limits, or in cases with a risk of accidental exposure, additional risk management
measures may be necessary for safe use, such as the use of a complete suit protecting against
chemicals and supplied air, a self-contained breathing apparatus or respirator.

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Environmental
In case of accidental release or spill, do not allow the product to enter sewers, surface or ground
water.

Regulatory Information / Classification and Labeling

For a detailed overview of the regulatory status of this substance, please refer to the Product
Stewardship Bulletin which is available from the LyondellBasell corporate website.

Under GHS (Globally Harmonized System on Classification and Labeling) substances are
classified according to their physical, health and environmental hazards. The hazards are
communicated via specific labels on the product packaging and the Safety Data Sheet. GHS
attempts to standardize hazard communication so that the intended audience (workers,
consumers, transport workers, and emergency responders) can better understand the hazards of
the chemicals in use.

For a detailed overview of the classification and labeling of this substance, please refer to the
regional Safety Data Sheet, which can be found on the LyondellBasell corporate website.

Conclusion Statements

Diethyl ether is used as a chemical solvent or reagent for laboratory or industrial purposes only.
The USP grade is used in pharmaceutical or personal care applications.
Diethyl ether has been classified as hazardous. The main hazards are extreme flammability,
acute oral toxicity, respiratory irritation and narcotic effects.
Exposure to human health and environment is considered very low as the diethyl ether
manufacturing process, storage and handling operations are enclosed.

Contact Information within Company

For further information on this product in general, please consult the LyondellBasell corporate
website (www.lyb.com).

Date of issue

Date of issue: 17 August 2015.

Disclaimer

Before using a product sold by a company of the LyondellBasell family of companies, users should
make their own independent determination that the product is suitable for the intended use and
can be used safely and legally. SELLER MAKES NO WARRANTY; EXPRESS OR IMPLIED
(INCLUDING ANY WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE OR ANY WARRANTY) OTHER THAN AS SEPARATELY AGREED TO BY THE
PARTIES IN A CONTRACT.

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LyondellBasell prohibits or restricts the use of its products in certain applications. For further
information on restrictions or prohibitions of use, please contact a LyondellBasell representative.

Users should review the applicable Safety Data Sheet before handling the product.

Diethyl ether is a product of Equistar Chemicals, LP

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