Konsentrasi Obat Branded Konsentrasi Obat Generik Massa Terlarut (branded) (m

Tablet Waktu 1 2 1 2 1
1 50.304 82.801 40.576 48.391 45.274
2 5 menit 44.370 84.598 42.656 40.203 39.933
3 68.058 66.797 63.167 29.996 61.252
1 87.641 94.964 80.399 97.101 78.877
2 10 menit 74.366 103.569 74.362 84.714 66.929
3 100.511 104.558 97.822 54.714 90.460
1 120.261 122.500 104.366 128.149 108.235
2 15 menit 105.772 114.739 104.623 129.681 95.195
3 116.036 125.203 123.333 71.663 104.433
1 129.707 131.192 134.080 153.402 116.736
2 30 menit 132.199 131.272 137.359 138.837 118.979
3 133.000 130.620 136.362 153.971 119.700
1 136.221 132.801 140.772 169.072 122.599
2 45 menit 135.116 134.290 135.380 151.391 121.604
3 134.264 128.768 138.793 154.710 120.838
1 130.917 132.344 142.156 164.870 117.825
2 60 menit 129.572 131.214 139.217 157.710 116.615
3 128.935 132.232 142.221 138.670 116.041

1
ssa Terlarut (branded) (mg) Massa Terlarut (gen) % Disolosi (brand) RT Rata % Disolusi (gen) TT
2 1 2 1 2 Rata 1 2
74.521 36.518 43.552 30.183 49.680 39.693 24.346 29.035
76.138 38.390 36.183 26.622 50.759 25.593 24.122
60.117 56.850 26.997 40.835 40.078 37.900 17.998
85.467 72.359 87.391 52.585 56.978 56.561 48.239 58.261
93.212 66.926 76.242 44.620 62.141 44.617 50.828
94.102 88.040 49.242 60.307 62.735 58.693 32.828
110.250 93.929 115.334 72.157 73.500 70.451 62.620 76.889
103.265 94.161 116.713 63.463 68.843 62.774 77.809
112.683 111.000 64.497 69.622 75.122 74.000 42.998
118.073 120.672 138.062 77.824 78.715 78.799 80.448 92.041
118.145 123.623 124.953 79.320 78.763 82.415 83.302
117.558 122.726 138.574 79.800 78.372 81.817 92.383
119.521 126.695 152.165 81.733 79.680 80.146 84.463 101.443
120.861 121.842 136.252 81.070 80.574 81.228 90.835
115.891 124.914 139.239 80.559 77.261 83.276 92.826
119.110 127.940 148.383 78.550 79.407 78.521 85.293 98.922
118.092 125.296 141.939 77.743 78.728 83.530 94.626
119.009 127.999 124.803 77.361 79.339 85.333 83.202
Rataan RT 67.362

F1 0.079 Pembeda
F2 99.995 Similaritas

2
Rata RT-TT
Rata
26.499

48.911

66.182

85.401

89.012

88.484

RT-TT RT-TT^2 n habla habl RT-TT*N N*RT

67.415 -0.053 0.003 6 0.0004685 -0.318116 404.171

3
4
Obat Generik 2
Tablet Waktu A1 A2 A3 Rata-rata Konsentrasi (ppm)
1 0.3586 0.3656 0.3666 0.3636 48.3913043478
2 5 menit 0.2945 0.2929 0.2774 0.2882666667 40.2028985507
3 0.1893 0.1988 0.195 0.1943666667 29.9963768116
1 0.8244 0.7885 0.8223 0.8117333333 97.1014492754
2 10 menit 0.6849 0.7036 0.7048 0.6977666667 84.7137681159
3 0.4131 0.422 0.4302 0.4217666667 54.7137681159
1 1.0915 1.1264 1.0742 1.0973666667 128.1485507246
2 15 menit 1.108 1.1224 1.104 1.1114666667 129.6811594203
3 0.584 0.5746 0.5745 0.5777 71.6630434783
1 1.314 1.2997 1.3754 1.3297 153.402173913
2 30 menit 1.1864 1.1906 1.2101 1.1957 138.8369565217
3 1.3427 1.3388 1.3233 1.3349333333 153.9710144928
1 1.2805 1.7999 1.3412 1.4738666667 169.0724637681
2 45 menit 1.2592 1.3032 1.3712 1.3112 151.3913043478
3 1.3311 1.3301 1.364 1.3417333333 154.7101449275
1 1.4317 1.4669 1.407 1.4352 164.8695652174
2 60 menit 1.3571 1.3906 1.3603 1.3693333333 157.7101449275
3 1.1281 1.2385 1.2159 1.1941666667 138.6702898551

Obat Branded 1
Tablet Waktu A1 A2 A3 Rata-rata Konsentrasi (ppm)
1 5 menit 0.6772 0.6802 0.6831 0.6801666667 82.8007246377
2 0.694 0.6954 0.7007 0.6967 84.597826087
3 0.5206 0.54 0.5382 0.5329333333 66.7971014493
1 10 menit 0.7992 0.7826 0.7944 0.7920666667 94.9637681159
2 0.883 0.8514 0.8793 0.8712333333 103.5688405797
3 0.9052 0.8514 0.8844 0.8803333333 104.5579710145
1 15 menit 1.0582 1.0276 1.0504 1.0454 122.5
2 0.9664 0.9897 0.9659 0.974 114.7391304348
3 1.087 1.0819 1.0419 1.0702666667 125.2028985507
1 30 menit 1.0827 1.1451 1.1483 1.1253666667 131.1920289855
2 1.1401 1.1209 1.1173 1.1261 131.2717391304
3 1.1285 1.1101 1.1217 1.1201 130.6195652174
1 45 menit 1.1583 1.141 1.1212 1.1401666667 132.8007246377
2 1.1643 1.1765 1.1208 1.1538666667 134.2898550725
3 1.122 1.0881 1.0991 1.1030666667 128.768115942
1 60 menit 1.1729 1.096 1.139 1.1359666667 132.3442028986
2 1.1482 1.1268 1.1017 1.1255666667 131.2137681159
3 1.1345 1.1468 1.1235 1.1349333333 132.231884058

Obat Branded 2
Tablet Waktu A1 A2 A3 Rata-rata Konsentrasi (ppm)

5
 1 0.3721 0.3868 0.3847 0.3812 50.30434783
2 5 menit 0.3316 0.3252 0.323 0.3266 44.36956522
3 0.546 0.5433 0.5443 0.544533333 68.05797101
1 0.7191 0.7315 0.7235 0.7247 87.64130435
2 10 menit 0.6024 0.5989 0.6064 0.602566667 74.36594203
3 0.8389 0.8482 0.8422 0.8431 100.5108696
1 1.0028 1.0155 1.0561 1.0248 120.2608696
2 15 menit 0.8788 0.8898 0.9059 0.8915 105.7717391
3 0.9873 0.9787 0.9918 0.985933333 116.0362319
1 1.0955 1.1166 1.123 1.1117 129.7065217
2 30 menit 1.1317 1.1116 1.1606 1.134633333 132.1992754
3 1.1378 1.1534 1.1348 1.142 133
1 1.1653 1.1803 1.1693 1.171633333 136.2210145
2 45 menit 1.1652 1.1626 1.1566 1.161466667 135.115942
3 1.1465 1.1369 1.1775 1.153633333 134.2644928
1 1.1107 1.128 1.1298 1.122833333 130.9166667
2 60 menit 1.1154 1.1045 1.1115 1.110466667 129.5724638
3 1.0936 1.1217 1.0985 1.1046 128.9347826

Tablet Waktu A1 A2 A3 Rata-rata Konsentrasi(ppm)

1 0.2913 0.2915 0.2923 0.2917 40.5761
2 5 menit 0.3079 0.3077 0.3169 0.3108 42.6558
3 0.4961 0.5074 0.4951 0.4995 63.1667
1 0.653 0.6558 0.6654 0.6581 80.3986
2 10 menit 0.6029 0.6051 0.5996 0.6025 74.3623
3 0.8215 0.8238 0.8098 0.8184 97.8225
1 0.8836 0.8632 0.8889 0.8786 104.3659
2 15 menit 0.8797 0.881 0.8821 0.8809 104.6232
3 1.0372 1.0687 1.0533 1.0531 123.3333
1 1.1232 1.1598 1.1728 1.1519 134.0797
2 30 menit 1.1782 1.1763 1.1918 1.1821 137.3587
3 1.1804 1.1489 1.1895 1.1729 136.3623
1 1.2184 1.2067 1.2154 1.2135 140.7717
2 45 menit 1.148 1.165 1.1787 1.1639 135.3804
3 1.1733 1.2317 1.1809 1.1953 138.7935
1 1.2132 1.2423 1.2232 1.2262 142.1558
2 60 menit 1.2351 1.1575 1.2050 1.1992 139.2174
3 1.2154 1.2009 1.2642 1.2268 142.2210