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BJOG.2010Jan117(1):519.doi:10.1111/j.14710528.2009.02351.x.

Vaginalbirthaftertwocaesareansections(VBAC2)asystematicreview
withmetaanalysisofsuccessrateandadverseoutcomesofVBAC2
versusVBAC1andrepeat(third)caesareansections.
TahseenS1,GriffithsM.

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Abstract
BACKGROUND: TrialofvaginalbirthafterCaesarean(VBAC)isconsideredacceptableafterone
caesareansection(CS),however,womenwishingtohavetrialaftertwoCSaregenerallynot
allowedorcounselledappropriatelyofefficacyandcomplications.
OBJECTIVE: Toperformasystematicreviewofliteratureonsuccessrateofvaginalbirthaftertwo
caesareansections(VBAC2)andassociatedadversematernalandfetaloutcomesandcompare
withcommonlyacceptedVBAC1andthealternativeoptionofrepeatthirdCS(RCS).
SEARCHSTRATEGY: WesearchedMEDLINE,EMBASE,CINAHL,CochraneLibrary,Current
ControlledTrials,HMICDatabase,GreyLiteratureDatabases(SIGLE,BiomedCentral),using
searchtermsCaesareansection,caesarian,C*rean,C*rian,andMeSHheadings'Vaginalbirthafter
caesareansection',combinedwithsecondsearchstringtwo,twice,second,multiple.
SELECTIONCRITERIA: Norandomisedstudieswereavailable,caseseriesorcohortstudieswere
assessedforquality(STROBE),20/23availablestudiesincluded.
DATACOLLECTIONANDANALYSIS: Twoindependentreviewersselectedstudiesand
abstractedandtabulateddataandpooledestimateswereobtainedonsuccessrate,uterinerupture
andotheradversematernalandfetaloutcomes.MetaanalyseswereperformedusingRevMan5to
compareVBAC1versusVBAC2andVBAC2versusRCS.
MAINRESULTS: VBAC2successratewas71.1%,uterinerupturerate1.36%,hysterectomyrate
0.55%,bloodtransfusion2.01%,neonatalunitadmissionrate7.78%andperinatalasphyxial
injury/death0.09%.VBAC2versusVBAC1successrateswere4064/5666(71.1%)versus38
814/50685(76.5%)(P<0.001)associateduterinerupturerate1.59%versus0.72%(P<0.001)
andhysterectomyrateswere0.56%versus0.19%(P=0.001)respectively.ComparingVBAC2
versusRCS,thehysterectomyrateswere0.40%versus0.63%(P=0.63),transfusion1.68%
versus1.67%(P=0.86)andfebrilemorbidity6.03%versus6.39%,respectively(P=0.27).Maternal
morbidityofVBAC2wascomparabletoRCS.Neonatalmorbiditydataweretoolimitedtodrawvalid
conclusions,however,nosignificantdifferenceswereindicatedinVBAC2,VBAC1andRCS
groupsinNNUadmissionratesandasphyxialinjury/neonataldeathrates(MantelHaenszel).
CONCLUSIONS: Womenrequestingforatrialofvaginaldeliveryaftertwocaesareansections
shouldbecounselledappropriatelyconsideringavailabledataofsuccessrate71.1%,uterine
rupturerate1.36%andofacomparativematernalmorbiditywithrepeatCSoption.

Commentin
Canvaginalbirthaftercaesareanbejustified? [BJOG.2010]

PMID:19781046[PubMedindexedforMEDLINE]

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