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Complete List of Authors: Mitchell, Theresa; University of the West of England, Health and
Life Sciences
Dhany, Asha; Gloucestershire Hospitals NHS Foundation Trust,
Midwifery:Birthing Unit
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Page 1 of 25 Journal of Alternative and Complementary Medicine
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4 Results: In the AMIS Group overall analgesia usage was higher for
TENS 34% compared with 15.9% (p<0.001 allowing for parity) and
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for Nitrous Oxide and Oxygen 87.6% compared with 80.8%
6 (p<0.001). Pethidine use did not differ after adjustment for parity
7 30.1% compared with 24.2% (p=0.27). Rates were lower in the
8 AMIS Group for epidural anaesthesia 29.7% compared with 33.8%
9 (p=0.004 allowing for parity), spinal anaesthesia 6% compared
10 with 12.1% (p<0.001) and general anaesthesia 0.8% compared
11 with 2.3% (p=0.033).
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Conclusion: Having an AMIS appears to have a positive impact on
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reducing rates of all types of intrapartum anaesthesia.
14 The Service is recognised as a beneficial addition to conventional
15 midwifery practice which may influence mode of delivery and
16 reduce general anaesthesia rates.
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22 Job Title; Lead Midwife, The Birthing Unit, Gloucestershire Royal Hospital,
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Great Western Road, Gloucestershire, GL1 3NN. UK
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28 2) Theresa Mitchell RGN Dip.N (London) B.Ed. (Hons) PhD
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E-Mail; Theresa.Mitchell@uwe.ac.uk
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44 3) Chris Foy MA MSc CStat
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47 Affiliation; Gloucestershire Hospitals NHS Foundation Trust
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50 Job Title; Medical Statistician
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54 Word Count; 3205
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57 (All correspondence to second author please)
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26 introduced. Using a retrospective case analysis design the birth records of
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28 1079 women who chose to use the service were compared to an equal
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31 number of similar women who did not, comprising a comparison group.
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22 public in response to increased demand from expectant mothers for more
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24 choice, control and continuity in labour.
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27 The aim in this paper is to report on results relating to the effects of an
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29 Aromatherapy and Massage Intrapartum Service (AMIS) upon type of
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analgesia chosen by women in labour, and on rates of anaesthesia; one
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34 aspect of the full study. The study was conducted in a general maternity unit
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36 in south west England, UK.
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41 Design: A quantitative research approach was taken whereby
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43 contemporaneously completed service evaluation forms of 1079 women (601
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46 nulliparous and 478 multiparous women) (AMIS Group) were retrospectively
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48 analysed in comparison with the birth records of an equal number of similar
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50 women (Comparison Group). Data analysis was achieved by inputting data
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53 from the forms and comparison sample into the SPSS package and running
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55 statistical tests.
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26 Conclusion: Having an AMIS appears to have a positive impact on reducing
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28 rates of all types of intrapartum anaesthesia.
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31 The Service is recognised as a beneficial addition to conventional midwifery
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40 5 Key words; Aromatherapy Massage Labour Analgesia Anaesthesia
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26 complementary therapies and alternative medicine (CAM) has escalated
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28 among midwives and the general public. Incorporating CAM into healthcare
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31 settings provides a more holistic approach which not only cares for the body
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33 but also the mind, spirit and the environment the person is in. After reviewing
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35 literature surrounding the use of CAM within the maternity arena, it became
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in order to offer a wider provision of care with a more naturalistic,
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45 individualised option.
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47 There is a dearth of credible experimental research about the
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effectiveness of CAM use in pregnancy and labour. However from anecdotal
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52 evidence, the benefits are thought to include increased choice of coping
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mechanisms in labour with a more naturalistic option improved continuity of
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57 care as the midwife spends longer with the woman which is known to be a
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59 critical component to achieve improved birth outcomes and a possible
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reduction in medical intervention as well as possible reductions in labour
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Page 7 of 25 Journal of Alternative and Complementary Medicine
21 the AMIS upon analgesia types and rates given to women in labour.
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26 Methods
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28 The full study aimed to identify comparisons between two samples of women
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31 who had given birth in one maternity unit since 2007.
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(those with diminished autonomy who deserve greater protection of their
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44 12,13,14
45 rights) for subjects of research and to randomise to an intervention
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47 group could be considered unethical. Therefore data were collected
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contemporaneously using evaluation forms from the AMIS group. The form
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52 requested clinical information including name, hospital number, age, ethnicity,
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54 parity, gestation, pre-existing medical conditions and pregnancy
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57 complications. The women were asked to express agreement or
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59 disagreement to questions on a five or seven point Likert scale. Each degree
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26 nulliparous women and 478 multiparous women. These records were taken
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28 from the first woman who received the AMIS since the service was launched
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31 in July 2007.
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33 Clinical data of women who had not used the AMIS were accessed via
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35 mandatory computerised data which represented a Comparison Group (CG).
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40 outcomes of the AMIS Group and CG.
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Every woman who gives birth in the local maternity unit has
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45 comprehensive pregnancy, labour and delivery records entered onto a
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47 computer system. This computer system enables labour and delivery
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statistics to be retrieved and filtered. Anonymised data of all women who had
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52 given birth between July 2007 and July 2010 and who had not used the AMIS
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54 were retrieved (5,500 records).
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57 In order to obtain a similar size sample to the AMIS group, the records
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59 of every 5th person in the computerized data were obtained. Women were
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nulliparous and multiparous women greatly vary . The parity breakdown of
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these samples was 56% (n=601) Nulliparous women (Nullips) and 44%
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26 (n=478) Multiparous women (Multips).
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28 We used the statistical software SPSS to analyse the data. SPSS
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31 requires a codebook approach whereby defining and labelling each variable
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38 approach used. Maimon and Rokach explain how data entry and
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40 acquisition is prone to errors; therefore, after all data had been inputted, a
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process of data cleansing took place 17,18.
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45 We aimed to gather data from the AMIS and Comparison Groups and
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47 identify the differences between these samples. Independent Sample t-tests
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between the groups were conducted for numerical variables, and chi-square
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52 tests were undertaken for categorical variables. Logistic regression was used
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54 to estimate the effects of AMIS versus no AMIS on use of analgesia and
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57 anaesthesia, and on mode of delivery, while allowing for the effects of parity,
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Journal of Alternative and Complementary Medicine Page 10 of 25
21 to proceed was also sought from the NHS Trusts Head of Midwifery and
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Medical Director.
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26 One of the prime ethical considerations for this study was that data
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28 were taken from a clinical record documentation form and NHS birth
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31 database. Both contain confidential information regarding individual womens
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33 age, parity, medical and pregnancy history, labour and delivery information,
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35 usage of the service and personal comments. The forms and the extracted
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40 into SPSS.
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45 Results
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47 The mean age of women in the AMIS group was 30.43 with a standard
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deviation of 6.05 compared with a mean age of 29.86 in the Comparison
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52 group and standard deviation of 6.08. The mean gestational age of women
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54 included in the AMIS sample was 40.04 weeks with a standard deviation of
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57 2.15. This was compared with a mean gestational age of 39.72 weeks in the
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59 Comparison Group with a standard deviation of 1.65. Classification of
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ethnicity for this study was in accordance with the UK National Statistics
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26 and Comparison Group (CG). Results of the logistic regressions are shown in
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28 Table 2.
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31 Use of a TENS machine in labour was higher in the AMIS Group (34%
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33 compared with 15.9% in the CG); the difference in use was seen in both
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35 nulliparas (41% compared with 19%) and multiparas (26% compared with
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40 AMIS than in the CG after adjustment for parity.
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Use of Nitrous Oxide and Oxygen (Entonox) was higher in the AMIS
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45 Group (88%) than in the CG (81%). (nulliparas: 88% versus 80%; multiparas
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47 87% versus 82%). Entonox use was statistically significantly more likely
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(p<0.001) in the AMIS than in the CG after adjustment for parity.
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52 For pethidine overall comparison revealed that 30% of the AMIS Group
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54 received Pethidine in labour compared to 24% in the CG (nulliparas 34%
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57 versus 31%; multiparas 26% versus 16%). After adjustment for parity,
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59 Pethidine use did not differ significantly by AMIS or CG (p=0.27).
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26 adjustment for parity.
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28 An overall comparison of General Anaesthesia (GA) intrapartum use
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31 revealed that GA was used less in the AMIS Group (0.8% compared with
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33 2.3% in the CG; nulliparas 1.2% versus 3.0%; multiparas 0.4% versus 1.5%).
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35 GA use was statistically significantly less likely (p=0.033) in the AMIS than in
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CG was spontaneous; AMIS 77% compared with CG 74% (nulliparas 73%
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45 versus 75%; multiparas 76% versus 79%). This difference was not
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47 statistically significant (p=0.30 after adjustment for parity) (Table 1).
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52 Discussion
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54 The experience of labour pain differs amongst women and the response to
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59 Alehagen et al. explain how labour discomfort is thought to arise from the
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fear of the unknown, which leads to sympathetic arousal producing tension in
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26 aromatherapy and massage was to reduce fear and anxiety, therefore it is
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28 likely that when midwives perceive a woman to be particularly anxious or
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31 frightened they would have offered the AMIS. These anxious and frightened
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33 women, who may be struggling to deal with the pain of labour, are therefore
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35 perhaps pre-disposed to being offered the AMIS as the midwife perceives the
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40 chemical physiology of anxieties increasing pain these women perhaps
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subsequently have increased pharmacological requirements, increasing their
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45 need for Pethidine.
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47 One of the main aims of this study was to explore whether the use of
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the AMIS reduced use of pharmacological analgesia and anaesthesia. In
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52 addition to these pharmacological modes of analgesia are TENS machines
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54 which are commonly used as a naturalistic, non pharmaceutical option 24.
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57 The Gate Control Theory suggests that stimulation of larger peripheral
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59 nerve fibres inhibits pain signals entering the central pain pathway, reducing
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perception of pain TENS provides this stimulation, additionally, it is believed
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Journal of Alternative and Complementary Medicine Page 14 of 25
21 to pharmacological analgesia. This may also account for the epidural rate
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being significantly lower in the AMIS Group. The midwife may also influence
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26 choice of analgesia and those promoting aromatherapy and massage may be
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28 keen to avoid pharmacological analgesia if possible.
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31 Entonox acts as an effective analgesic when it is inhaled, can be used
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33 during all stages of labour and has no known effects on the fetus . Entonox
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35 is often a first option analgesia offered to women in labour and is extremely
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40 offer 25. The use of Entonox is significantly higher in the AMIS Group, but our
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records do not account for the amount used because this is not possible to
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45 assess. The increased use of Entonox may be a contributory factor to a
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47 reduction in the Epidural rates in this group. In future it would be interesting to
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record recommendations and dialogue between women and midwives about
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52 analgesia and the considerations upon which decisions are made.
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54 Although Entonox is a pharmacological substance, it is not
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57 accumulative and has a short life in the body (excreted from the body after 2-5
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59 minutes and does not cross the placenta) , it is considered a fairly
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naturalistic option of analgesia and does not have the side effects and long
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26 higher in the AMIS Group.
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28 Pethidine is a synthetic phenylpiperdine derivative which is commonly
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31 administered intramuscularly (IM) during labour . Pethidine is well known to
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33 cross the placenta and has been shown to make babies sleepier, less
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35 attentive and less able to establish breastfeeding. Despite these well
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40 systemically used opioid for the relief of pain during childbirth . Contrary to
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Burns et al.s (8) finding that the use of systemic opioids was greatly reduced
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45 with the use of aromatherapy and massage in labour (6% in 1990 reduced to
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47 0.4% in 1997) this study found that the use of Pethidine did not differ overall
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between AMIS and comparison groups, and, in the multiparas, use was
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52 higher in the AMIS group. .
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54 The possible reasons for this were explored with a group of midwives
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57 and it was considered that if women had received Pethidine in their first labour
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59 and liked its effects they might opt for it again. Nilsson and Lundgren
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explain that previous birth experience is central to shaping subsequent labour
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Greulich and Tarrant identify how both Pethidine and aromatherapy
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31 are often used as a relief measure in the latent phase of labour, when women
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33 have not yet met the criteria of being able to have Entonox or an Epidural.
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40 Use of TENS, Entonox and Pethidine was higher in the AMIS group possibly
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because these women chose to have less invasive modes of analgesia.
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45 It should be acknowledged that the AMIS group had significantly lower
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47 incidence of epidural, spinal and general anaesthesia. However, when there
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are more normal deliveries and less instrumental and operative deliveries,
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52 inevitably anaesthesia rates will be lower.
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54 Women who have epidurals in labour are more likely to have longer second
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57 stages of labour, increased need for syntocinon augmentation, experience
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59 hypotension, increased risk of an instrumental delivery, will be unable to
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mobilise during labour or for a period of time after birth and are more likely to
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21 addition, if mother has a GA during birth she is consequently not able to enjoy
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the moment of birth ; this has been associated with having a negative
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26 influence upon mother and baby bonding and may impact upon the
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28 establishment of breastfeeding. Therefore any measure to reduce the
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31 likelihood of a mother needing a GA is beneficial.
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33 The financial equability of having the AMIS service in place has been
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35 acknowledged through considering the approximate annual cost of running
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To put this into context, a years supply of aromatherapy and massage
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45 oils costs 333.74 in the centre in which this research was conducted where
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47 there are 3000 births per year. From this information it is recognised that the
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use of the AMIS is inexpensive and may have the potential for significant
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52 savings.
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57 Despite the methodological limitations of conducting a retrospective case
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59 analysis rather than a prospective trial, we consider that the sample size of
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27 Acknowledgements
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30 The authors would like to thank Dr Lesley Lockyer and Abby Sabey for their
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32 contribution to the statistical analyses in this study.
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36 Author Disclosure Statement
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39 No competing financial interests exist.
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27 of Traditional, Complementary and Alternative Medicine. Text volume. Kobe:
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34 complementary therapies in the maternity services. Complementary
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36 Therapies in Clinical Practice. 2007: 13:129-135.
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39 6. Association of Womens Health, Obstetric and Neonatal Nurses
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labouring women. Washington D C. 2000
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46 7. Hodnett ED, Gates S, Hofmeyr GJ and Sakala C. Continuous support for
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48 women during childbirth (Cochrane Review). The Cochrane Database of
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51 Systematic Reviews. [online]. Available from:
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53 http//:www.thecochranelibrary.com 2009 [Accessed 12 June 2010].
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55 8. Burns E, Blamey C, Ersser S, Lloyd A, and Barnetson L. The Use of
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58 Aromatherapy in Intrapartum Midwifery Practice. Research and Development
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60 Report No. 7, Oxford: Oxford Brookes University. 1999
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22 Complementary Therapies in Clinical Practice. 2006:12: 222-231.
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24 11. Mousley S. Audit of an aromatherapy service in a maternity unit.
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labour. Journal of Obstetric, Gynaecologic & Neonatal Nursing. 2006:15 (5):
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49 15. Pallant J. SPSS Survival Manual. 3rd ed. Glasgow: Open University
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Press. 2007
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55 16. Maimon OZ. and Rokach L. Data mining and knowledge discovery
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24 20. American College of Nurse-Midwives. Position Statement: Nitrous Oxide
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26 for Labor Analgesia [Online]. Available from: http//:www.midwife.org 2009
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Analgesia Sample Number Percentage
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6 TENS AMIS 366 34%
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8 Comparison 171 15.9%
9
10 ENTONOX AMIS 944 87.6%
11
12
13 Comparison 871 80.8%
14
15 PETHIDINE AMIS 324 30.1%
16
17 Comparison 259 24.2%
18
Fo
19
20
EPIDURAL AMIS 320 29.7%
21
22 Comparison 362 33.8%
r
23
24 SPINAL AMIS 65 6%
Pe
25
26
Comparison 130 12.1%
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28
er
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Mary Ann Liebert Inc., 140 Huguenot Street, New Rochelle, NY 10801
Page 25 of 25 Journal of Alternative and Complementary Medicine
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7 Odds ratio AMIS versus no AMIS Multiparous versus
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9 (95% confidence interval), Nulliparous
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11 p value
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13
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15 TENS 3.07 (2.36, 4.00), p<0.001 0.67 (0.48, 0.95), p=0.022
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17
Entonox 1.89 (1.37, 2.60), p<0.001 1.12 (0.82, 1.52), p=0.48
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Fo
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20 Pethidine 1.15 (0.90, 1.46), p=0.27 0.43 (0.32, 0.58), p<0.001
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22 Epidural 0.71 (0.57, 0.90), p=0.004 0.22 (0.16, 0.29), p<0.001
r
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24 Spinal anaesthetic 0.50 (0.35, 0.72), p<0.001 0.50 (0.34, 0.74), p<0.001
Pe
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26 General anaesthetic 0.38 (0.16, 0.92), p=0.033 0.48 (0.20, 1.17), p=0.11
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28 Table 2. Results of logistic regressions on use of analgesia and anaesthesia by AMIS versus
er
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30 comparison group and by parity.
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Mary Ann Liebert Inc., 140 Huguenot Street, New Rochelle, NY 10801
Journal of Alternative and Complementary Medicine Page 26 of 25
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Product Quantity used Cost
7
8 Apr 2009-Apr2010
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10
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12 Base Oil 6x1 Litre = 6 Litres 61.50
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14 Bergamot Essential Oil 2x50mls =100mls 22.30
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17 Clary Sage Essential Oil 1x25mls 1x50mls= 75mls 15.15
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Fo
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20 Frankincense Essential Oil 2x50mls = 100mls 43.10
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22 Jasmine Essential Oil 1x50mls = 50mls 139.95
r
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24
Pe
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30 Rose Essential Oil 1x10mls = 10mls 29.05
31
32
Re
37 5% Discount =333.74
38
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ew