File: README.

TXT

Acute-to-Chronic Estimation (ACE)

with Time-Concentration-Effect Models

Version 2.0, December, 2003

Center for Exposure Assessment Modeling (CEAM)

National Exposure Research Lab - Ecosystems Research Division
Office of Research and Development (ORD)
U.S. Environmental Protection Agency (U.S. EPA)
960 College Station Road
Athens, Georgia 30605-2700
706/355-8400

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CONTENTS
INTRODUCTION
DOCUMENTATION
INSTALLATION
TECHNICAL HELP CONTACT
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INTRODUCTION
ICE and ACE were developed by the U.S. EPA in collaboration with other
federal agencies, industry, and universities to address data gaps in species
sensitivity and reduce reliance on uncertainty factors in ecological risk
assessment.
The Acute-to-Chronic Estimation (ACE) with Time-Concentration-Effect Models
software allows prediction of chronic toxicity from acute toxicity datasets.
ACE uses linear regression and accelerated life testing to predict no-effect
and low-effect concentrations for chronic mortality.
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DOCUMENTATION
Users should refer to the documents listed below to operate and apply the
model system. These documents should be retained by the requester for
reference.
Document Name File Name
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~~~~~~~~~~~~~~~
ACE installation and user support guide README.TXT
ACE system abstract ABSTRACT.TXT
Acute-to-Chronic Estimation (ACE) with Ace.pdf
Time-Concentration-Effect Models User
Manual (EPA/600/R-03/107)
The user's manual (Ace.pdf) is included in the self-extracting Zip file
program ACE_Manual.EXE.
Files with a file name extension of .PDF are in Adobe Acrobat format and
require Adobe Acrobat Reader software available at no charge from
http://www.adobe.com/.
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INSTALLATION
System Requirements:
Microsoft Windows 95, 98, 2000, NT and XP (Windows 98 or later is suggested)
Minimum 16 MB RAM (64 MB or greater is suggested)
CPU speed of over 200 MHz is suggested (ACE will work with less, but is
very slow)
6 MB available hard disk space
Mouse or pointing device
Printer (optional).
Remove any existing versions of ACE before installing the new one or
malfunctions may occur.
To remove old ACE software:
1. Double click My Computer.
2. Double click Control Panel.
3. Double click Add/Remove Programs.
4. Click ACE.
5. Click Delete or Change/Remove.
To install new ACE software:
1. Place the ACE CD in the CD ROM drive.
2. Click Start button.
3. Select Run from the menu.
4. Select Browse from the Run window.
5. Select drive letter associated with the CD drive from Browse window
(or ACE 2003 [D:]).
6. Double-click Setup file or D:\SETUP.EXE file.
7. Click OK.
8. Windows now walks you through the installation process. If a "Yes" or
"No" question is encountered, choose "Yes".
9. Following installation, the ACE program can be accessed by clicking
Start, Programs, and then ACE. You can create an icon on the Desktop
screen by placing the mouse pointer on the ACE icon, holding down on the
control button, and dragging the icon to desired location on the screen.
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TECHNICAL HELP CONTACT
For questions or information concerning the distribution or installation of
CEAM software, documentation, or data please contact CEAM at:
Phone: 706-355-8400
Fax: 706-355-8104
 E-mail: ceam@epamail.epa.gov
Mail:
Center for Exposure Assessment Modeling (CEAM)
National Exposure Research Laboratory - Ecosystems Research Division
U.S. Environmental Protection Agency (U.S. EPA)
960 College Station Road
Athens, Georgia 30605-2700
CEAM operates and maintains a listserver system named CEAM-USERS. The CEAM-
USERS listserver is an automated mailing list system which broadcasts up-to-
date information concerning CEAM software product updates and releases as
well as hints on software installation and use. Subscribers may broadcast
messages to other list subscribers to ask and answer questions about exposure
assessment modeling topics. Instructions for subscribing, posting messages,
and managing membership setting are available on the CEAM Web site at the
URL:
http://www.epa.gov/ceampubl/listserv.htm

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