GuillainBarr syndrome
From Wikipedia, the free encyclopedia
Contents
1 Signs and symptoms
1.1 Respiratory failure
1.2 Autonomic dysfunction
2 Causes
3 Mechanism
4 Diagnosis
4.1 Spinal fluid
4.2 Neurophysiology
4.3 Clinical subtypes
5 Treatment
5.1 Immunotherapy
5.2 Respiratory failure
5.3 Pain
5.4 Rehabilitation
6 Prognosis
7 Epidemiology
8 History
9 Research directions
10 References
11 Further reading
12 External links
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The first symptoms of GuillainBarr syndrome are numbness, tingling, and pain, alone or
in combination. This is followed by weakness of the legs and arms that affects both sides
equally and worsens over time.[7][8] The weakness can take half a day to over two weeks to
reach maximum severity, and then becomes steady.[8] In one in five people, the weakness
continues to progress for as long as four weeks.[4] The muscles of the neck may also be
affected, and about half experience involvement of the cranial nerves which supply the head
and face; this may lead to weakness of the muscles of the face, swallowing difficulties and
sometimes weakness of the eye muscles.[4] In 8%, the weakness affects only the legs
(paraplegia or paraparesis).[4] Involvement of the muscles that control the bladder and anus
is unusual.[8] In total, about a third of people with GuillainBarr syndrome continue to be
able to walk.[4] Once the weakness has stopped progressing, it persists at a stable level
("plateau phase") before improvement occurs. The plateau phase can take between two days
and six months, but the most common duration is a week.[4] Pain-related symptoms affect
more than half, and include back pain, painful tingling, muscle pain and pain in the head
and neck relating to irritation of the lining of the brain.[4]
Many people with GuillainBarr syndrome have experienced the signs and symptoms of
an infection in the 36 weeks prior to the onset of the neurological symptoms. This may
consist of upper respiratory tract infection (rhinitis, sore throat) or diarrhea.[8]
In children, particularly those younger than six years old, the diagnosis can be difficult and
the condition is often initially mistaken (sometimes for up to two weeks) for other causes of
pains and difficulty walking, such as viral infections,[4] or bone and joint problems.[9]
On neurological examination, characteristic features are the reduced power and reduced or
absent tendon reflexes (hypo- or areflexia, respectively). However, a small proportion has
normal reflexes in affected limbs before developing areflexia, and some may have
exaggerated reflexes.[4] In the "Miller Fisher variant" subtype of GuillainBarr syndrome
(see below), a triad of weakness of the eye muscles, abnormalities in coordination, as well
as absent reflexes can be found.[8][10] The level of consciousness is normally unaffected in
GuillainBarr syndrome, but the Bickerstaff brainstem encephalitis subtype may feature
drowsiness, sleepiness, or coma.[5][11]
Respiratory failure
A quarter of all people with GuillainBarr syndrome develop weakness of the breathing
muscles leading to respiratory failure, the inability to breathe adequately to maintain healthy
levels of oxygen and/or carbon dioxide in the blood.[8][4][12] This life-threatening scenario is
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complicated by other medical problems such as pneumonia, severe infections, blood clots in
the lungs and bleeding in the digestive tract in 60% of those who require artificial
ventilation.[8]
Autonomic dysfunction
The autonomic or involuntary nervous system, which is involved in the control of body
functions such as heart rate and blood pressure, is affected in two thirds of people with
GuillainBarr syndrome, but the impact is variable.[4] Twenty percent may experience
severe blood-pressure fluctuations and irregularities in the heart beat, sometimes to the
point that the heart beat stops and requiring pacemaker-based treatment.[8] Other associated
problems are abnormalities in perspiration and changes in the reactivity of the pupils.[5]
Autonomic nervous system involvement can affect even those who do not have severe
muscle weakness.[5]
Causes
Two thirds of people with GuillainBarr syndrome have
experienced an infection before the onset of the condition.
Most commonly these are episodes of gastroenteritis or a
respiratory tract infection. In many cases, the exact nature
of the infection can be confirmed.[4] Approximately 30% of
cases are provoked by Campylobacter jejuni bacteria,
which cause diarrhea. A further 10% are attributable to
cytomegalovirus (CMV, HHV-5). Despite this, only very
few people with Campylobacter or CMV infections
develop GuillainBarr syndrome (0.250.65 per 1000 and
0.62.2 per 1000 episodes, respectively).[8] The strain of
Campylobacter involved may determine the risk of GBS;
different forms of the bacteria have different
A scanning electron microscope-derived
lipopolysaccharides on their surface, and some may induce image of Campylobacter jejuni, which
illness (see below) while others will not.[4] triggers about 30% of cases of Guillain
Barr syndrome
Links between other infections and GBS are less certain.
Two other herpesviruses (EpsteinBarr virus/HHV-4 and
varicella zoster virus/HHV-3) and the bacterium Mycoplasma pneumoniae have been
associated with GBS.[8] The tropical viral infection dengue fever and Zika virus have also
been associated with episodes of GBS.[13][14] Previous hepatitis E virus infection has been
found to be more common in people with GuillainBarr syndrome.[4][6]
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Some cases may be triggered by the influenza virus and potentially influenza vaccine. An
increased incidence of GuillainBarr syndrome followed influenza immunization that
followed the 1976 swine flu outbreak (H1N1 A/NJ/76); 8.8 cases per million recipients
developed the complication. Since then, close monitoring of cases attributable to
vaccination has demonstrated that influenza itself can induce GBS. Small increases in
incidence have been observed in subsequent vaccination campaigns, but not to the same
extent.[15] The 2009 flu pandemic vaccine (against pandemic swine flu virus
H1N1/PDM09) did not cause a significant increase in cases.[8] It is considered that the
benefits of vaccination in preventing influenza outweigh the small risks of GBS after
vaccination.[16] Even those who have previously experienced GuillainBarr syndrome are
considered safe to receive the vaccine in the future.[4] Other vaccines, such as those against
poliomyelitis, tetanus or measles, have not been associated with a risk of GBS.[9]
Mechanism
The nerve dysfunction in Guillain
Barr syndrome is caused by an Structure of a typical neuron
immune attack on the nerve cells of Neuron
the peripheral nervous system and Dendrite Axon
their support structures. The nerve terminal
cells have their body (the soma) in the Node of
spinal cord and a long projection (the Soma Ranvier
axon) that carries electrical nerve
impulses to the neuromuscular Axon
junction where the impulse is
transferred to the muscle. Axons are Schwann
wrapped in a sheath of Schwann cells Nucleus
Myelin sheath cell
that contain myelin. Between
Schwann cells are gaps (nodes of Ranvier) where the axon
is exposed.[8] Different types of GuillainBarr syndrome
feature different types of immune attack. The
demyelinating variant (AIDP, see below) features damage
to the myelin sheath by white blood cells (T lymphocytes
and macrophages); this process is preceded by activation of GuillainBarr syndrome nerve
a group of blood proteins known as complement. In damage
contrast, the axonal variant is mediated by IgG antibodies
and complement against the cell membrane covering the
axon without direct lymphocyte involvement.[8]
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Various antibodies directed at nerve cells have been reported in GuillainBarr syndrome.
In the axonal subtype, these antibodies have been shown to bind to gangliosides, a group of
substances found in peripheral nerves. A ganglioside is a molecule consisting of ceramide
bound to a small group of hexose-type sugars and containing various numbers of N-
acetylneuraminic acid groups. The key four gangliosides against which antibodies have
been described are GM1, GD1a, GT1a, and GQ1b, with different anti-ganglioside
antibodies being associated with particular features; for instance, GQ1b antibodies have
been linked with Miller Fisher variant GBS and related forms including Bickerstaff
encephalitis.[8] The production of these antibodies after an infection is probably the result of
molecular mimicry, where the immune system is reacting to microbial substances but the
resultant antibodies also react with substances occurring naturally in the body.[8][17] After a
Campylobacter infection, the body produces antibodies of the IgA class; only a small
proportion of people also produce IgG antibodies against bacterial substance cell wall
substances (e.g. lipooligosaccharides) that crossreact with human nerve cell gangliosides. It
is not currently known how this process escapes central tolerance to gangliosides, which is
meant to suppress the production of antibodies against the body's own substances.[18] Not
all antiganglioside antibodies cause disease, and it has recently been suggested that some
antibodies bind to more than one type of epitope simultaneously (heterodimeric binding)
and that this determines the response. Furthermore, the development of pathogenic
antibodies may depend on the presence of other strains of bacteria in the bowel.[18]
Diagnosis
The diagnosis of GuillainBarr syndrome depends on findings such as rapid development
of muscle paralysis, absent reflexes, absence of fever, and a likely cause. Cerebrospinal
fluid analysis (through a lumbar spinal puncture) and nerve conduction studies are
supportive investigations commonly performed in the diagnosis of GBS.[4][6][8] Testing for
antiganglioside antibodies is often performed, but their contribution to diagnosis is usually
limited.[4] Blood tests are generally performed to exclude the possibility of another cause
for weakness, such as a low level of potassium in the blood.[8] An abnormally low level of
sodium in the blood is often encountered in GuillainBarr syndrome. This has been
attributed to the inappropriate secretion of antidiuretic hormone, leading to relative retention
of water.[19]
In many cases, magnetic resonance imaging of the spinal cord is performed to distinguish
between GuillainBarr syndrome and other conditions causing limb weakness, such as
spinal cord compression.[4][8] If an MRI scan shows enhancement of the nerve roots, this
may be indicative of GBS.[4] In children, this feature is present in 95% of scans, but it is not
specific to GuillainBarr syndrome, so other confirmation is also needed.[9]
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Spinal fluid
Cerebrospinal fluid envelops the brain and the spine, and lumbar puncture or spinal tap is
the removal of a small amount of fluid using a needle inserted between the lumbar
vertebrae. Characteristic findings in GuillainBarr syndrome are an elevated protein level,
usually greater than 0.55 g/L, and fewer than 10 white blood cells per cubic millimeter of
fluid ("albuminocytological dissociation").[20] This combination distinguishes Guillain
Barr syndrome from other conditions (such as lymphoma and poliomyelitis) in which both
the protein and the cell count are elevated. Elevated CSF protein levels are found in
approximately 50% of patients in the first 3 days after onset of weakness, which increases to
80% after the first week.[4]
Repeating the lumbar puncture during the disease course is not recommended. The protein
levels may rise after treatment has been administered.[4]
Neurophysiology
Directly assessing nerve conduction of electrical impulses can exclude other causes of acute
muscle weakness, as well as distinguish the different types of GuillainBarr syndrome.
Needle electromyography (EMG) and nerve conduction studies may be performed. In the
first two weeks, these investigations may not show any abnormality.[4][16] Neurophysiology
studies are not required for the diagnosis.[8]
Formal criteria exist for each of the main subtypes of GuillainBarr syndrome (AIDP and
AMAN/AMSAN, see below), but these may misclassify some cases (particularly where
there is reversible conduction failure) and therefore changes to these criteria have been
proposed.[21] Sometimes, repeated testing may be helpful.[21]
Clinical subtypes
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Other diagnostic entities are often included in the spectrum of GuillainBarr syndrome.
Bickerstaff's brainstem encephalitis, for instance, is part of the group of conditions now
regarded as forms of Miller Fisher syndrome (anti-GQ1b antibody syndrome),[11] as well as
a related condition labelled "acute ataxic hypersomnolence" where coordination problems
and drowsiness are present but no muscle weakness can be detected.[22] BBE is
characterized by the rapid onset of ophthalmoplegia, ataxia, and disturbance of
consciousness, and may be associated with absent or decreased tendon reflexes and as well
as Babinski's sign.[22] The course of the disease is usually monophasic, but recurrent
episodes have been reported. MRI abnormalities in the brainstem have been reported in
11%.[11]
Whether isolated acute sensory loss can be regarded as a form of GuillainBarr syndrome
is a matter of dispute; this is a rare occurrence compared to GBS with muscle weakness but
no sensory symptoms.[16]
Treatment
Immunotherapy
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Plasmapheresis and intravenous immunoglobulins (IVIG) are the two main immunotherapy
treatments for GBS. Plasmapheresis attempts to reduce the body's attack on the nervous
system by filtering antibodies out of the bloodstream. Similarly, administration of IVIG
neutralizes harmful antibodies and inflammation. These two treatments are equally
effective, but a combination of the two is not significantly better than either alone.[24]
Plasmapheresis speeds recovery when used within four weeks of the onset of symptoms.[25]
IVIG works as well as plasmapheresis when started within two weeks of the onset of
symptoms, and has fewer complications.[25] IVIG is usually used first because of its ease of
administration and safety. Its use is not without risk; occasionally it causes liver
inflammation, or in rare cases, kidney failure.[26] Glucocorticoids alone have not been
found to be effective in speeding recovery and could potentially delay recovery.[27]
Respiratory failure
Respiratory failure may require intubation of the trachea and breathing support through
mechanical ventilation, generally on an intensive care unit. The need for ventilatory support
can be anticipated by measurement of two spirometry-based breathing tests: the forced vital
capacity (FVC) and the negative inspiratory force (NIF). An FVC of less than 15 ml per
kilogram body weight or an NIF of less than 60 cmH2O are considered markers of severe
respiratory failure.[28]
Pain
While pain is common in people with GuillainBarr syndrome, studies comparing different
types of pain medication are insufficient to make a recommendation as to which should be
used.[29]
Rehabilitation
Following the acute phase, around 40% of people require intensive rehabilitation with the
help of a multidisciplinary team to focus on improving activities of daily living (ADLs).[30]
Studies into the subject have been limited, but it is likely that intensive rehabilitation
improves long-term symptoms.[31] Teams may include physical therapists, occupational
therapists, speech language pathologists, social workers, psychologists, other allied health
professionals and nurses. The team usually works under the supervision of a neurologist or
rehabilitation physician directing treatment goals.[30]
Physiotherapy interventions include strength, endurance and gait training with graduated
increases in mobility, maintenance of posture and alignment as well as joint function.
Occupational therapy aims to improve everyday function with domestic and community
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tasks as well as driving and work. Home modifications, gait aids, orthotics and splints may
be provided.[30] Speech-language pathology input may be required in those with speech and
swallowing problems, as well as to support communication in those who require ongoing
breathing support (often through a tracheostomy). Nutritional support may be provided by
the team and by dietitians. Psychologists may provide counseling and support.
Psychological interventions may also be required for anxiety, fear and depression.[30]
Prognosis
GuillainBarr syndrome can lead to death as a result of a number of complications: severe
infections, blood clots, and cardiac arrest likely due to autonomic neuropathy. Despite
optimum care this occurs in about 5% of cases.[8]
There is a variation in the rate and extent of recovery.[8] The prognosis of GuillainBarr
syndrome is determined mainly by age (those over 40 may have a poorer outcome), and by
the severity of symptoms after two weeks. Furthermore, those who experienced diarrhea
before the onset of disease have a worse prognosis.[12] On the nerve conduction study, the
presence of conduction block predicts poorer outcome at 6 months.[12] In those who have
received intravenous immunoglobulins, a smaller increase in IgG in the blood two weeks
after administration is associated with poorer mobility outcomes at six months than those
whose IgG level increased substantially.[12] If the disease continues to progress beyond four
weeks, or there are multiple fluctuations in the severity (more than two in eight weeks), the
diagnosis may be chronic inflammatory demyelinating polyneuropathy, which is treated
differently.[4]
The health-related quality of life (HRQL) after an attack of GuillainBarr syndrome can be
significantly impaired. About a fifth are unable to walk unaided after six months, and many
experience chronic pain, fatigue and difficulty with work, education, hobbies and social
activities.[33] HRQL improves significantly in the first year.[33]
Epidemiology
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In Western countries, the number of new episodes per year has been estimated to be
between 0.89 and 1.89 cases per 100,000 people. Children and young adults are less likely
to be affected than the elderly: the risk increases by 20% for every decade of life.[3] Men are
more likely to develop GuillainBarr syndrome than women; the relative risk for men is
1.78 compared to women.[8][3]
The distribution of subtypes varies between countries. In Europe and the United States, 60
80% of people with GuillainBarr syndrome have the demyelinating subtype (AIDP), and
AMAN affects only a small number (67%). In Asia and Central and South America, that
proportion is significantly higher (3065%). This may be related to the exposure to different
kinds of infection, but also the genetic characteristics of that population.[4] Miller Fisher
variant is thought to be more common in Southeast Asia.[8][11]
History
French physician Jean-Baptiste Octave Landry first
described the disorder in 1859.[35] In 1916, Georges
Guillain, Jean Alexandre Barr, and Andr Strohl
diagnosed two soldiers with the illness and described the
key diagnostic abnormalityalbuminocytological
dissociationof increased spinal fluid protein
concentration but a normal cell count.[5][6] [36]
exchange was first used in 1978 and its benefit confirmed in larger studies in 1985.[42]
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exchange was first used in 1978 and its benefit confirmed in larger studies in 1985.[42]
Intravenous immunoglobulins were introduced in 1988, and its non-inferiority compared to
plasma exchange was demonstrated in studies in the early 1990s.[42]
Research directions
The understanding of the disease mechanism of GuillainBarr syndrome has evolved in
recent years.[16] Development of new treatments has been limited since immunotherapy was
introduced in the 1980s and 1990s.[16][42] Current research is aimed at demonstrating
whether some people who have received IVIg might benefit from a second course if the
antibody levels measured in blood after treatment have only shown a small increase.[12][42]
Studies of the immunosuppressive drug mycophenolate mofetil, brain-derived neurotrophic
factor and interferon beta (IFN-) have not demonstrated benefit to support their widespread
use.[42]
An animal model (experimental autoimmune neuritis in rats) is often used for studies, and
some agents have shown promise: glatiramer acetate, quinpramine, fasudil (an inhibitor of
the Rho-kinase enzyme),[16] and the heart drug flecainide.[42] An antibody targeted against
the anti-GD3 antiganglioside antibody has shown benefit in laboratory research.[16] Given
the role of the complement system in GBS, it has been suggested that complement
inhibitors (such as the drug eculizumab) may be effective.[42]
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Further reading
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External links
Classification ICD-10: V T D
G61.0 (http://ap
GuillainBarr syndrome (https://dmoztools.net/Health/
ps.who.int/class
Conditions_and_Diseases/Neurological_Disorders/Demy
elinating_Diseases/GuillainBarre_Syndrome/) at ifications/icd10/
DMOZ browse/2016/en
GBS/CIDP Foundation International (http://www.gbs-cid #/G61.0) ICD-
p.org/) 9-CM: 357.0 (h
ttp://www.icd9d
ata.com/getICD
Retrieved from "https://en.wikipedia.org/w/index.php?
title=GuillainBarr_syndrome&oldid=801806075" 9Code.ashx?icd
9=357.0)
OMIM: 139393
(https://omim.or
This page was last edited on 22 September 2017, at g/entry/139393)
00:03.
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External MedlinePlus:
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Patient UK:
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