Alhasan SA, Aranha O, Sarkar FH. 2001. Genistein elicits pleiotropic molecular
effects on head and neck cancer cells. Clin Cancer Res; 7(12):4178-
4181.
Argyle DJ, Nasir L. 2003. Telomerase: a potential diagnostic and therapeutic tool
in canine oncology. Veterinary Pathol; 40:17.
Ben-Porath I, Weinberg RA. 2004. When cells get stressed: an integrative view of
cellular senescence. J Clin Invest; 113:813.
Blackburn EH, Greider CW, Szostak JW. 2006. Telomeres and telomerase: the
path from maize, Tetrahymena and yeast to human cancer and aging.
Nature Medicine; 12:11331138.
82
Blasco MA. 2005. Telomeres and human disease: ageing, cancer and beyond.
Nature Rev Genetics; 6:611622.
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB,
Shay JW, Lichtsteiner S, Wright WE. 1998. Extension of life-span by
introduction of telomerase into normal human cells. Science; 279:349
352.
Burger AM, Dai F, Schultes M, Reszka AP, Moore MJ, Double JA, Neidle S.
2005. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor
growth, consistent with telomere targeting and interference with
telomerase function. Cancer Res; 65:14891496.
Campisi J. 2003. Cancer and ageing: rival demons?. Nat Rev Cancer; 3:339
349.
Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS,
Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko
V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. 2006. Genome-
wide analysis of estrogen receptor binding sites. Nat Genet; 38:1289
1297.
Chen Z, Trotman LC, Shaer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher,
HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandol PP. 2005. Crucial
role of p53-dependent cellular senescence in suppression of Pten-
decient tumorigenesis. Nature; 436:725730.
Cha MS, Lee MJ, Je GH, Kwak JY. 2001. Endogenous production of nitric oxide
by vascular endothelial growth factor down-regulates proliferation of
choriocarcinoma cells. Biochem Biophys Res Comm; 282(4):1061-1066.
83
SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA,
Katzenellenbogen BS, Shaul PW. 2010. Non-nuclear estrogen receptor-
signaling promotes cardiovascular protection but not uterine or breast
cancer growth in mice. J Clin Invest; 120:23192330.
Clark GM, Osborne CK, Levitt D, Wu F, Kim NW. 1997. Telomerase activity and
survival of patients with node-positive breast cancer. J Natl Cancer Inst;
89:18741881.
Cheung An, Zhang DK, Liu Y, et al. 1999. Telomerase activity in gestational
trophoblastic disease. J Clin Pathol; 52:588-592.
Chinni SR, Alhasan SA, Multani AS, Pathak S, Sarkar FH. 2003. Pleotropic
effects of genistein on MCF-7 breast cancer cells. Int J Mol Med;
12(1):29-34.
Clarke M. 2006. Meta-analyses of adjuvant therapies for women with early breast
cancer: the Early Breast Cancer Trialists Collaborative Group overview.
Ann Oncol; 17 Suppl 10:5962.
Corthorn J, Germain AA, Chac_on C, Rey S, Soto GX, Figueroa CD, et al. 2006.
Expression of kallikrein, bradykinin b2 receptor, and endothelial nitric
oxide synthase in placenta in normal gestation, preeclampsia, and
placenta accreta. Endocrine; 29:491-499.
Costa M, Sourris K, Lim SM, Yu QC, Hirst CE, Parkington HC, Jokubaitis VJ,
Dear AE, Liu HB, Micallef SJ. Koutsis K, Elefanty AG, Stanley EG.2013.
Derivation of endothelial cells from human embryonic stem cells in fully
defined medium enables identification of lysophosphatidic acid and
platelet activating factor as regulators of eNOS localization. Stem Cell
Research; 10:103117.
de Lange T. 2005. Shelterin: the protein complex that shapes and safeguards
human telomeres. Genes & Dev; 19:21002110.
84
associated with a substance specific modulation of uterine gene
expression. Mol Cell Endocrinol; 221:2132.
Forstermann U, Sessa WC. 2012. Nitric oxide synthases: regulation and function.
Eur Heart J; 33:829-837.
Fukumura D, Kashiwagi S, Jain RK. 2006. The role of nitric oxide in tumour
progression. Nat Rev Cancer; 6:521-534.
Fulton D, Fontana, J, Sowa G, Gratton JP, Lin M, Li KX, Michell B, Kemp BE,
Rodman D, Sessa WC. 2002. Localization of endothelial nitric-oxide
synthase phosphorylated on serine 1179 and nitric oxide in Golgi and
plasmamembrane defines the existence of two pools of active enzyme. J
Biol Chem; 277(6):42774284.
Ghobrial IM, Wizig TE, Adjei AA. 2005. Targeting apoptosis pathways in cancer
therapy. CA Cancer J Clin; 55:178-194.
Gielis JF. Lin JY, Wingler K, Van Schil PEY, Schmidt HH, Moens AL. 2011.
Pathogenic role of eNOS uncoupling in cardiopulminary disorders. Free
Rad Biol Med; 50:765-776.
85
Gisselsson D, Jonson T, Petersen A, Strombeck B, Dal Cin P, Hoglund M,
Mitelman F, Mertens F, Mandahl N, 2001. Telomere dysfunction triggers
extensive DNA fragmentation and evolution of complex chromosome
abnormalities in human malignant tumors. Proc Natl Acad Sci USA:
23:1268312688.
Goetz RM, Thatte HS, Prabhakar P, Cho MR, Michel T, Golan DE. 1999.
Estradiol induces the calcium-dependent translocation of endothelial
nitric oxide synthase. Proc Natl Acad Sci USA; 96:27882793.
Gorosito SV, Lorenzo AG, Cambiasso MJ. 2008. Estrogen receptor alpha is
expressed on the cell-surface of embryonic hypothalamic neurons.
Neuroscience; 154:11731177.
Granger MP, Wright WE, Shay JW. 2002. Telomerase in cancer and aging. Crit
Rev Oncol/Hematol; 41:2940.
Greider CW. 1998. Telomerase activity, cell proliferation, and cancer. Proc Natl
Acad Sci USA; 95:9092.
86
Hahn WC. 1999. Inhibition of telomerase limits the growth of human cancer cells.
Nature Med; 5:11641170.
Hannan NJ, Paiva P, Dimitriadis E, Salamonsen LA. 2010. Models for study of
human embryo implantation: choice of cell lines? Biol Reprod; 82:235-
245.
Harley CB, Futcher AB, Greider CW. 1990. Telomeres shorten during ageing of
human broblasts. Nature; 345:458460.
Henson JD, Hannay JA, McCarthy SW, Royds JA, Yeager TR, Robinson RA,
Wharton SB, Jellinek DA, Arbuckle SM, Yoo J, Robinson BG, Learoyd
DL, Stalley PD, Bonar SF, Yu D, Pollock RE, Reddel RR. 2005. A robust
assay for alternative lengthening of telomeres in tumors shows the
signicance of alternative lengthening of telomeres in sarcomas and
astrocytomas. Clin Cancer Res; 11:217225.
Herbert BS, Wright AC, Passons CM. 2001. Effects of chemopreventive and
antitelomerase agents on the spontaneous immortalization of breast
epithelial cells. J Natl Cancer Inst; 93:3945.
Hirata S, Shoda T, Kato J, Hoshi K. 2003. Isoform/variant mRNAs for sex steroid
hormone receptors in humans. Trends Endocrinol Metab; 14:124129.
87
Hiyama E, Gollahon L, Kataoka T. 1996. Telomerase activity in human breast
tumours. J Natl Cancer Inst; 88:116122.
Holt SE, Aisner D, Baur J. 1999. Functional requirement of p23 and hsp90 in
telomerase complexes. Gene Dev; 13:817826.
Holt SE, Shay JW. 1999. Role of telomerase in cellular proliferation and cancer. J
Cell Physiol; 180:1018.
Honor EK, Williams JK, Anthony MS, Clarkson TB. 1997. Soy isoflavones
enhance coronary vascular reactivity in atherosclerotic female
macaques. Fertil Steril; 67:148154.
Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB,
Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D,
Weiss J, Back T, et al. 2008. Nitric oxide is a key component in
inflammation accelerated tumorigenesis. Cancer Res; 68:71307136.
Jiang SW, Lloyd RV, Jin L, Eberhardt NL. 1997. Estrogen receptor expression
and growth-promoting function in human choriocarcinoma cells. DNA
Cell Biol 16:969-977.
Keith WN, Bilsland A, Hardie M, Evans TR. 2004. Drug insight: Cancer cell
immortality-telomerase as a target for novel cancer gene therapies.
Nature Clin Pract Oncol; 1:8896.
Khaw AK, Yong JW, Kalthur G, Hande MP. 2012. Genistein induces growth
arrest and suppresses telomerase activity in brain tumor cells. Genes
Chromosomes Cancer; 51(10):961-974.
88
Kiefer F, Arnold K, Kunzli M, Bordoli L, Schwede T. 2009. The SWISS-MODEL
repository and associated resources. Nucleic Acids Res; 37:387-392.
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM,
Wright WE, Weinrich SL, Shay JW. 1994. Specic association of human
telomerase activity with immortal cells and cancer. Science; 266:2011
2015.
Klatt P, Pfeiffer S, List BM, Lehner D, Glatter O, Bachinger HP, Werner ER,
Schmidt K, Mayer B. 1996. Characterization of heme-deficient neuronal
nitric oxide synthase reveals a role for heme in subunit dimerization and
binding of the amino acid substrate and tetrahydrobiopterin. J Biol
Chem; 271:73367342.
Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q,
Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R,
Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. 2002. Reversal of
bone loss in mice by nongenotropic signaling of sex steroids. Science;
298:843846.
89
Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. 1996. Cloning
of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad
Sci USA; 93:59255930.
Langford LA, Piatyszek MA, Xu R, Schold SC, Shay JW. 1997. Telomerase
activity: a prognostic indicator in ordinary meningiomas. Hum Pathol;
28:416420.
Lavelle F, Riou JF, Laoui A, Mailliet P. 2000. Telomerase: a therapeutic target for
the third millennium?. Critical Rev in Oncol Hematol; 34:111126.
Le X, Wei D, Huang S, Lancaster Jr, JR, Xie K, 2005. Nitric oxide synthase II
suppresses the growth and metastasis of human cancer regardless of its
upregulation of protumor factors. Proc Natl Acad Sci USA; 102:8758
8763.
Li L, Haynes MP, Bender JR. 2003. Plasma membrane localization and function
of the estrogen receptor- variant (ER46) in human endothelial cells.
Proc Natl Acad Sci USA; 100:48074812.
Liu D, Homan LL, Dillon JS. 2004. Genistein acutely stimulates nitric oxide
synthesis in vascular endothelial cells by a cyclic adenosine 5-
monophosphate-dependent mechanism. Endocrinol; 145:55325539.
Liu J, Zou WG, Lang MF, Luo J, Sun LY, Wang XN, Qian QJ, Liu XY. 2002.
Cancer-specic killing by the CD suicide gene using the human
telomerase reverse transcriptase promoter. International J Oncol;
21:661666.
Long S, Argyle DJ, Campbell S, Gault E, Nasir L. 2005. The canine telomerase
catalytic subunit (dogTERT): characterisation of the gene promoter and
identication of proximal core sequences necessary for specic
transcriptional activity in canine telomerase positive cell lines. Gene;
358:111120.
90
Longo M, Brama M, Marino M, Bernardini S, Korach KS, Wetsel WC, Scandurra
R, Faraggiana T, Spera G, Baron R, Teti A, Migliaccio S. 2004.
Interaction of estrogen receptor- with protein kinase C alpha and c-Src
in osteoblasts during differentiation. Bone; 34:100111.
Lurain JR, Brewer JI. 1982. Invasive mole. Semin Oncol; 9:174-180.
Mrquez DC, Pietras RJ. 2001. Membrane-associated binding sites for estrogen
contribute to growth regulation of human breast cancer cells. Oncogene;
20:54205430.
Matsutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks, M.W.,
Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn
WC. 2003. Telomerase maintains telomere structure in normal human
cells. Cell; 114:241253.
Mattila JT, Thomas AC. 2014. Nitric oxide synthase: non-canonical expression
patterns. Front Immunol; 5:478.
McKenna NJ, and OMalley BW. 2002. Combinatorial control of gene expression
by nuclear receptors and coregulators. Cell; 108:465474
Minshall RD, Sessa WC, Stan RV, Anderson RG, Malik AB. 2003. Caveolin
regulation of endothelial function. Am. J. Physiol. Lung Cell Mol Physiol;
285(6):L1179L1183.
91
expression and inhibit adrenocortical H295R cell proliferation. J Mol
Endocrinol; 35:245256.
Muller CY, Cole LA. 2009. The quagmire of hCG and hCG testing in gynecologic
oncology. Gyneologic Oncol; 112:663-672.
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J,
Harley CB, Cech TR. 1997. Telomerase catalytic subunit homologs from
ssion yeast and human. Science; 277:955959.
Nishida CR, Ortiz de Montellano PR. 1998. Electron transfer and catalytic activity
of nitric oxide synthases: chimeric constructs of the neuronal, inducible,
and endothelial isoforms. J Biol Chem; 273:55665571.
92
Nugent CI, Lundblad V. 1998. The telomerase reverse transcriptase. Genes Dev;
12:107385.
OReilly M, Teichmann SA, Rhodes D. 1999. Telomerases. Curr Opin Struct Biol;
9:5665.
Park M, Bruice TC. 2010. Development of potential anticancer agents that target
the telomers sequence. Bioorg Med Chem; 20:3982-3986.
Prabhakar P, Thatte HS, Goetz RM, Cho MR, DGolan DE, Michel T. 1998.
Receptor-regulated translocation of endothelial nitric-oxide synthase. J
Biol Chem; 273:27383-27388.
Raman CS, Li H, Martasek P, Kral Vm Masters BS, Poulos TL. 1998. Crystal
structure of constitutive endothelial nitric oxide synthase: a paradigm for
pterin function involving a novel metal center. Cell; 95:939950.
Rameshbabu K, Sharma R, Singh KP, George A, Chauhan MS, Singla SK, et al.
2012. Presence of nitric oxide synthase immunoreactivity and mRNA in
buffalo (Bubalus bubalis) oocytes and embryos. Reprod Domest Anim;
47:22-25.
93
Rthel TR, Leikert JF, Vollmar AM, Dirsch VM. 2005. The soy isoflavone
genistein induces a late but sustained activation of the endothelial nitric
oxide-synthase system in vitro. Br J Pharmacol; 144:394399.
Raynaud CM, Sabatier L, Philipot O, Olaussen KA, Soria JC. 2008. Telomere
length, telomeric proteins and genomic instability during the multistep
carcinogenic process. Crit Rev Oncol Hematol; 66:99117.
Refaat B, Simpson H, Britton E, Biswas J, Wells M, Aplin JD, et al. 2012. Why
does the fallopian tube fail in ectopic pregnancy? The role of activins,
inducible nitric oxide synthase, and MUC1 in ectopic implantation. Fertil
Steril; 97:1115-1123.
Reif A, Frohlich LG, Kotsonis P, Frey A, Bommel HM, Wink DA, Pfleiderer W,
Schmidt HH. 1999. Tetrahydrobiopterin inhibits monomerization and is
consumed during catalysis in neuronal NO synthase. J Biol Chem
274:2492124929.
Renwick MG, Argyle DJ, Long S, Nixon C, Gault EA, Nasir L. 2006. Telomerase
Activity and cTERT expression in canine lymphoma: correlation with
Ki67 immunoreactivity. Vet Comp Oncol; 4:141150.
Rettenmaier MA, Khan HJ, Epstein HD, Nguyen D, Abaid LN, GoldsteinBH.
2013. Gestational choriocarcinoma in the Fallopian tube. J Obstet
Gynaecol; 33(8):912914.
Ries L, Eisner M, Kosary C, Hankey BF, Miller BA, Clegg L, Edwards BK. 2001.
SEER Cancer Statistics Review, 19731998, Table II-3. Bethesda, MD:
National Cancer Institute: 137.
Rodier F, Kim SH, Nijjar T, Yaswen P, Campisi J. 2005. Cancer and aging: the
importance of telomeres in genome maintenance. Int J Biochem Cell
Biol; 37:977990.
Russell KS, Haynes MP, Sinha D, Clerisme E, Bender JR. 2000. Human vascular
endothelial cells contain membrane binding sites for estradiol, which
mediate rapid intracellular signaling. Proc Natl Acad Sci USA; 97:5930
5935.
94
Sengupta J, Dhawan L, Lalitkumar PG, Ghosh D. 2005. Nitric oxide in blastocyst
implantation in the rhesus monkey. Reproduction; 130:321-32.
Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson
RG, Michel T. 1996. Acylation targets endothelial nitric-oxide synthase to
plasmalemmal caveolae. J Biol Chem; 271:6518-6522.
Shay JW, Gazdar AF. 1997. Telomerase in the early detection of cancer. J Clin
Pathol; 50:106109.
Simon NM, Smoller JW, McNamara KL, Maser RS, Zalta AK, Pollack MH,
Nierenberg AA, Fava M, Wong KK. 2006. Shortening and mood
disorders: preliminary support for a chronic stress model of accelerated
aging. Biol Psychiatry; 60:432435.
95
on endothelial function in postmenopausal women: a randomized,
double-blind, controlled study. Am J Med; 114:470476.
Taylor CK, Levy RM, Elliott JC, Burnett BP. 2009. The effect of genistein
aglycone on cancer and cancer risk: a review of in vitro, preclinical, and
clinical studies. Nutr Rev; 67:398-415.
Thomas T, Gallo MA, Thomas TJ. 2004. Estrogen receptors as targets for drug
development for breast cancer, osteoporosis and cardiovascular
disease. Curr Cancer Drug Targets; 4:483499.
Titu LV, Loveday RL, Madden LA, Cawkwell L, Monson JR, Greenman J. 2004.
Cytotoxic T-cell immunity against telomerase reverse transcriptase in
colorectal cancer patients. Oncology Rep; 12:871876.
Tsui KH, Li HY, Cheng JT, Sung YJ, Yen MS, Hsieh SLE, Wang PH. 2015. The
role of nitric oxide in the outgrowth of trophoblast cells on human
umbilical vein endothelial cells.Taiwan J Obstet Gynecol; 54:227-231.
van Dijk M, Bonvin AMJJ. 2008. 3D-DART: a DNA structure modelling server.
Nucleic Acids Res; 37:235-239.
Wang T, Mei SC, Fu R, Wang HQ, Shao ZH. 2014. Expression of shelterin
component POT1 is associated with decreased telomere length and
immunity condition in humans with severe aplastic anemia. J Immunol
Res; Article ID 439530, 9 pages.
96
Wang Q, Patton WF, Hechtman HB, Shepro D. 1997. A novel anti-inflammatory
peptide inhibits endothelial cell cytoskeletal rearrangement, nitric oxide
synthase translocation, and paracellular permeability increases. J Cell
Physiol; 172: 171-182.
Wang Z, Zhang X, Shen P, Loggie BW, Chang Y, Deuel TF. 2006. A variant of
estrogen receptor-, hER- 36: Transduction of estrogen- and
antiestrogen-dependent membrane-initiated mitogenic signaling. Proc
Natl Acad Sci USA; 103:90639068.
Wong SC, Yu H, Moochhala SM, So JB. 2003. Antisense telomerase induced cell
growth inhibition, cell cycle arrest and telomerase activity down-
regulation in gastric and colon cancer cells. Anticancer Res; 23: 465
469.
Wright WE, Tesmer M, Huffinan KE. 1997. Normal human chromosomes have
long G-rich telomeric overhang at one end. Gene Dev; 11:28012809.
Xu W, Liu LZ, Loizidou M, Ahmed M, Charles IG. 2002. The role of nitric oxide in
cancer. Cell Res; 12:311320.
Yi X, Tesmer VM, Savre-Train I, Shay JW, Wright WE. 1999. Both transcriptional
and posttranscriptional mechanisms regulate human telomerase
template RNA levels. Mol Cell Biol; 19:39893997.
Yoshiko T, Makoto K, Fuyuki I. 2000. Aging mechanisms. Proc Natl Acad Sci;
23:12407-408.
97
You Y, Pu P, Huang Q, Xia Z, Wang C, Wang G, Yu C, Yu JJ, Reed E, Li QQ.
2006. Antisense telomerase RNA inhibits the growth of human glioma
cells in vitro and in vivo. IntJ Oncol; 28:12251232.
Zhang Q, Church JE, Jagnandan D, Catravas JD, Sessa WC, Fulton D. 2006.
Functional relevance of Golgi- and plasma membrane-localized
endothelial NO synthase in reconstituted endothelial cells. Arterioscler
Thromb Vasc Biol; 26:10151021.
Zhu J, Wang H, Bishop JM, Blackburn EH. 1999. Telomerase extends the
lifespan of virus-transformed human cells without net telomere
lengthening. Proc Natl Acad Sci; 96:37238.
Zulli A, Buxton BF, Black MJ, Ming Z, Cameron A, Hare DL. 2006. The
immunoquantification of caveolin-1 and eNOS in human and rabbit
diseased blood vessels. J Histochem Cytochem; 54:151159.
98