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VII.

PATHOPHYSIOLOGY OF SEVERE DEHYDRATION SECONDARY TO INFECTIOUS DIARRHEA, PCAP-B, UTI


A. Schematic Diagram
Figure 20.

PREDISPOSING FACTORS PRECIPITATING FACTORS

MODIFIABLE NON- MODIFIABLE 1. Dehydration


1. Poor environmental sanitation 1. Age: 6 mos. 2. Compromised immune system
2. Poor colostomy care 2.Gender: Male 3. Contamination of water
3. Bottle feeding 3. Low Birth Weight 4. Nosocomial Infection
4. Poor hospital ventilation 4. History of necroti-
5. Colostomy zing enterocolitis

Pathogen

Invasion of GI tract
Vomiting

Stimulation and destruction of


mucosal lining of bowel wall

Recognition of toxins in the Famotidine


body 2mg q 12
IVTT

59

A
A

Endotoxin production

Interacts with mucosa

PLR iL
ORS Profuse secretion of water
@ 35-40 and electrolyte
solution 1
cc/hr
sachet/ 250 - Frequent
MFD
cc water, Increase peristaltic defectation
BID movement of the bowel - Watery Stool

Feb. 15, 2017


Sunken eyeballs
Fluid Loss Stool Exam:
Sunken fontanel
Bacteria: Plenty
Dry Lips
Dry Skin
Severe Dehydration
- Metrinodazole
15 mg q 8 IVTT
Normal body defense - Lactobacillus
Acidophilus,
sachet, OD
Weak peripheral Vasoconstriction
IVTF: D5IMB pulses
500 cc @same
rate @ left arm
@ vol/vol Venous Collapse
replacement

Venous Cut
Down 60

B
B

- Yellowish
Compromised Immune color of urine Decreased amount of
System - Foul odor blood in the circulation
urine

Failure to defenses Difficulty elimination of


toxin through urine

Invasion of lower Feb. 16, 2017


respiratory tract Bacterial invasion
Urinalysis: TNTC
Bacteria: Moderate
Activation of B cells
Multiplication of bacteria
to urinary tract
Release of Antibody

Interruption in the normal


Antigen- Antibody
homeostatic environment
Reaction - Ceftriazone
of the urinary tract
30 mg q 24,
IVTT
- Amikacin 60
mg q 24 IVTT Cytokine and
prostaglandin release
Antigen-Antibody Initation of immune system -
complex adhere to the
mucosal lining of the Body induces the action
lower respiratory tract of cytokines and
prostaglandines

E 61
D
C
C
D E

Mucosal irritation Temporary vasodilation Irritation of the lining of Inflammation of the lining of the
the urinary tract urinary tract

Increase mucus Increased blood flow


production Narrow urine passage

Vasoconstriction
Accumulation of
mucus Poor emptying of bladder
Increase plasma
hydrostatic pressure
- Productive
cough Irritability
- Rhonki Increase capillary
Albuterol
permeability
Sulfate 112
mg q 8
Escape of plasma

Edema Urinary tract infection

Increased Narrowing of
RR= 50 Airways LEGEND
cpm

Signs & Symptoms Surgical


Intervention

Pediatric Acquired Community Pneumonia- B Laboratory Exams

62
Medicine/ IV