1, FEBRUARI 2011
ISSN : 2087-5045
ABSTRACT
The anti inflammatory effect of ethanolic extract of the kembang bulan (Tithonia
diversifolia A.Gray) leaves on female white mice has been done topically using
modification methode between making edema and granuloma pouch. Induction was done
by injectioning carragenin 2 %b/v in NaCl fisiologis subcutaneously. The extract was
given topically as ointment for 4 days in various concentration: 1%, 2.5% and 5%. The
parameter were observed include edema volume, totally of leucocytes cell on edema and
blood. The result of research showed that ethanolic extract of the kembang bulan
(Tithonia diversifolia A.Gray) leaves gives topically anti inflammatory effect. It can
reduced the edema volume and gives effect on decreasing leucocytes cell on edema and
can increased neutrofil cells and limpocyt cells on blood significantly (P<0,05). The
maximal effect of anti inflammatory was seeen at concentration 5% with the lowest
edema volume 0,03 ml, higher than anti inflammatory effect of hidrocortison acetat 2,5%
with edema volume 0,08 ml.
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Hasil
Tabel I. Hasil pengukuran volume eksudat dari radang punggung mencit putih betina
setelah pemberian ekstrak daun Tithonia diversifolia A.Gray secara topikal
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SCIENTIA VOL. 1 NO. 1, FEBRUARI 2011
ISSN : 2087-5045
Tabel II. Hasil perhitungan sel leukosit dari eksudat punggung mencit betina setelah
pemberian ekstrak daun Tithonia diversifolia A.Gray. secara topikal
Tabel III. Hasil perhitungan sel leukosit dari darah mencit putih betina setelah pemberian
ekstrak daun Tithonia diversifolia A.Gray secara topikal
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ISSN : 2087-5045
Pengembangan Obat
Tradisional. Oleh Husin, M.
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