1. TAKSONOMI
- Domain : eukaryota
- Kingdom : Fungi
- Phylum : Ascomycota
- Class : Eurotiomycetes
- Order : Onygenales
- Family : Arthrodermactaceae
- Genus : Trichophyton
- Species : T.rubrum
- Synonim : T.fischeri, T.raubtschekii, T.kaneii
2. DESKRIPSI
- Penyebab dermatophytosis tersering
- Anthropophilic fungus
- Keratinophilic filamentous fungus
3. GENOME STRUCTURE
- Diketahui 5 kromosom
4. VARIANT
- Lokasi
o Africa&southern asia : Tinea corporis dan tinea capitis
o Global : tinea pedis, tinea cruris
- Kromosom
o T.megninii : portugal
o T.soudanese & T.gourvilli : subsahara africa
o T.raubitschekii : india, southeast asia, west Africa
5. COLONY STRUCTURE
- Typical : white-cream color pigemwnt with reverse side color (yellow-brown-red wine)
- Tekstur : flat and slightly raised
6. CELL STRUCTURE
- Repro : aseksual with conidiospora (mikro dan makro)
- Hyphae : thin walled septae w/bacillus shaped/cigar shaped
7. METABOLISM
- Memiliki protease (keratinase) ingesti keratin untuk pertumbuhan
- Optimal pada pH asam
8. ECOLOGY
- Anthrophilic dermatophyte : hidup di tempat lembab atau tinggi keratin di kulit manusia
- Bisa bertahan di bedding ataupun clothing
9. PATHOLOGY
dermatoohytosis
growth >> degradasi kertain
infection
MALASSEZIA FURFUR
1. TAKSONOMI
- Domain : eukaryota
- Kingdom : Fungi
- Division : Basidiomycota
- Subdivision : ustiaginomycotina
- Class : eksobasidiomycetes
- Order : Malasseziales
- Family : Malasseziacea
- Genus : Malasseziacea
- Species : M.furfur
- Synonim : pitysporum
2. DESKRIPSI
- 1.5-4.5m x 2-6 m
- Spherical (coccal)
- Bottle neck at one end
- Normal flora at human single cell individual (yeast)
- Pathogenic form filament form (spore)
- Lipophilic yeast butuh lemak dan minyak (35oC)
- Culture : cream-white color
3. STRUKTUR AND METABOLISM
- Coccal, (+) plasma membrane dengan laminar cell wall yang tebal (berisi chitin)
- Bottle neck shaped
- Butuh asam lemak dan sumber karbon
- Memproduksi
a. Tryptophan aminotransferase
L-triptophan indole pyruvat
b. B-glucosidase
Memecah selulosa glukosa
- Hyphae, induksi:
a. Cytokines induksi inflamasi
b. CHemokines direct cll movement
c. Adhesi molecule stick to epitel
4. PATOGENESIS
hidup normal di
kulit
konsumsi natural
oil and fat (sebum
dan keringat) >>
populasi M.furfur
melebihi normal
Dermatitis
Piyriasis vesicolor
seborroik
prevent
impede regulasi apoptosis interaksi dengan mediator
maturation UV absorbent
neutrophils melanosit EGFR inflamasi
dendritic cells
R.inflamasi
5. DIAGNOSIS