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JACC April 5, 2016

Volume 67, Issue 13

Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT)

EFFECTS OF AEROBIC EXERCISE ON VASCULAR FUNCTION AND INFLAMMATION
Poster Contributions
Poster Area, South Hall A1
Saturday, April 02, 2016, 10:00 a.m.-10:45 a.m.

Session Title: Epidemiology, Physiology, and Noninvasive Assessments in Sports and Exercise
Abstract Category: 20. Arrhythmias and Clinical EP: Sports and Exercise
Presentation Number: 1113-253

Authors: Evangelos Oikonomou, Dimitrios Athanasiou, Gerasimos Siasos, Konstantinos Mourouzis, Gerasimos Terzis, Aggeliki Stasinaki,
Efstathios Dimitropoulos, Nikolaos Gouliopoulos, Eleni Kokkou, Panagiotis Tourikis, Konstantinos Spengos, Dimitris Tousoulis, 1st
Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece
Background: Chronic aerobic exercise is associated with favorable long term cardiovascular effects. We investigated the different impact
of continuous moderate-intensity aerobic exercise (CAE) and high intensity interval aerobic exercise (hIAE) on endothelial function, arterial
stiffness and inflammatory status in healthy subjects.
Methods: We recruited 20 healthy men in this cross-over study. Each subject participate in 2 exercise sessions: a) CAE: volume at 50%
of maximum aerobic work on a cycle ergometer for 30 min and b) hIAE: interval maximum aerobic work on a cycle ergometer for 30 min.
Endothelial function was evaluated by flow-mediated dilation (FMD) in the brachial artery. Carotid-femoral pulse wave velocity (cfPWV) and
femoral-dorsalis pedis PWV (fdPWV) were measured as indices of central aortic and peripheral arterial stiffness. Interleukin (IL)-17 was
measured with ELISA. Measurements were carried out before and immediately after each exercise session.
Results: There was no significant difference in baseline measurements before CAE and hIAE, regarding FMD, cfPWV and fdPWV and
IL-17 levels (p=NS for all). Both CAE (8.572.55% vs. 6.371.48% p<0.001) and hIAE (8.482.60% vs. 5.951.78% p<0.001) significantly
improved FMD, compared to baseline. The magnitude of FMD improvement was not different between CAE and hIAE (p=NS). Moreover,
compared to baseline measurements, CAE (9.271.11m/sec vs. 8.171.48m/sec, p=0.003) and hIAE (9.141.07m/sec vs. 8.260.8m/sec,
p<0.001) improved fdPWV. Though, CAE and hIAE had no impact in cfPWV, compared to baseline measurements (p=NS for both). Finally,
there was no significant difference in IL-17 levels after CAE [11(9-17)pg/ml vs. 16(12-22)pg/ml, p=0.23] and hIAE [12(9-17)pg/ml vs. 14(9-
15)pg/ml, p=0.61], compared to baseline measurements.
Conclusions: Both CAE and hIAE can favorably affect to a similar extent endothelial function suggesting another cardioprotective effect of
exercise on atherosclerosis progression. Though, these types of aerobic exercise have a different impact on central and peripheral arterial
stiffness. Whether both types of exercise exert similar long-term effects merits further investigation.
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