I.

Perhitungan
Larutan stock untuk:
Antipiretik : 3 tikus
Analgetik : 3 tikus 9 tikus
Anti inflamsi : 3 tikus
Parasetamol dosis 500 mg/ 50 kg BB manusia
Berat tikus terbesar 256 gram
Untuk manusia 70 Kg == 70 Kg X 500 mg = 700 mg
50 Kg
Dosis untuk tikus 200 g = 700 mg x 0.018 = 12,6 mg/ 256 tikus
Dosis untuk tikus 256 gram = 246 g x 12,6 mg = 16.128 mg
200 g
C stock = Dosis BB tikus terbesar
.Vp
= 16.128 mg
. 5,0 ml
= 6.4512 mg/ml
Volume yang dibutuhkan = 2.5 ml x 9 tikus =22.5 ml ~ 25 ml
Parasetamol yang dibutuhkan 161.28 mg
Serbuk yang diambil = 161.28 mg x 521.2 mg = 168,15 mg
500 mg
Kosentrasi sebenarnya = 0.1685/25ml
= 6.74 mg/ml
II. Data Pengamatan

Suhu
Awal Suhu Perlakuan (0C)
Nama Obat (0C)
0 20 40 60 90 120 150 180
Kontrol positif 1. 34.9 34.8 35.3 35.4 35.5 35.5 35.6 35.6
34.9 34.8 35.3 35.4 35.5 35.5 35.6 35.6
Rata rata
Kontrol negative 1. 34.5 34.2 34.9 35.6 36.3 36.7 37.7 37.0
34.5 34.2 34.9 35.6 36.3 36.7 37.7 37.0
Rata rata
Parasetamol 1. 34.7 - 35.7 36.7 37.1 35.9 35.6 34.2
34.8 - 35.4 34.8 36.7 35.1 34.9 35.0
2.
3. 34.4 - 35.7 34.9 35.6 35.9 35.0 34.1
Rata rata 34.6 - 35.6 35.5 36.6 35.6 35.2 34.4
Ibuprofen 1. 35.4 - 36.3 34.9 35.6 34.3 36.7 34.6
36.2 - 35.4 36.6 35.4 33.6 34.9 35.7
2.
3. 35.2 - 34.7 35.4 34.3 33.5 34.8 34.5
Rata rata 35.6 - 35.5 35.6 35.1 33.8 35.5 34.9
Metilperdnisolon 1. 37.2 37.9 37.2 37.7 37.9 37.1 37.1 36.5
37.6 37.6 37.9 37.6 37.9 37.9 37.3 35.2
2.
3. 36.8 36.9 36.4 36.2 36.1 36.2 36.1 34.2
Rata rata 37.2 37.5 37.1 37.2 37.3 37.1 36.8 35.3
Na Diklofenak 1. 36.7 37 36.7 37.5 37.6 37.4 37.3 36.9
36.9 37.7 36.2 36.9 37.4 37.8 37.3 36.9
2.
3. 36.9 37 37.3 36.4 36.5 37.3 37.3 37
Rata rata 36.8 37.2 36.7 36.9 37.2 37.5 37.3 36.9
Asam Mefenamat 1. 37.4 37.9 37.9 37.9 37.4 37.7 37.4 37.4
37.5 37.5 37.4 37.5 37.3 37.5 37.4 37.4
2.
3. 37.4 37.3 37.4 37.3 37.2 37.4 37.5 37.4
Rata rata 37.4 37.6 37.6 37.6 37.3 37.5 37.4 37.4
Dexamethason 1 35.6 - 36.3 36.2 35.3 35.8 36.1 35.2
35.4 - - 36.7 35.8 36.3 36.4 35.3
2.
3. 36.5 - 36.4 37 35.8 36 36.2 35.9
Rata rata 35.8 - 36.4 36.6 35.6 36 36.2 35.5
Kurva
38

37

36 KONTOL POSITIF
KONTOL NEGATIF
35
suhu C

PARACETAMOL
34 IBUPROFEN
METILPREDNISOLON
33
NA DIKLOFENAK
32 DEXAMETHASON

31
0 20 40 60 90 120 150 180

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